Affiliation: Institute of Molecular Pathology and Immunology of the University of Porto
Location: , Portugal
Glycobiology and Disease,
Glycosylation and cancer
1. Reis CA, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, Sobrinho-Sim
Mereiter S, MagalhÃ£es A, Adamczyk B, Jin C, Almeida A, Drici L, et al
. Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer. Biochim Biophys Acta. 2016;1860:1795-808 pubmed publisher
..This article is part of a Special Issue entitled "Glycans in personalised medicine" Guest Editor: Professor Gordan Lauc. ..
Duarte H, Freitas D, Gomes C, Gomes J, Magalhaes A, Reis C. Mucin-Type O-Glycosylation in Gastric Carcinogenesis. Biomolecules. 2016;6: pubmed publisher
..Altogether, mucin-type O-glycosylation alterations may represent promising biomarkers with potential screening and prognostic applications, as well as predictors of cancer patients' response to therapy. ..
BalmaÃ±a M, Duran A, Gomes C, Llop E, LÃ³pez Martos R, Ortiz M, et al
. Analysis of sialyl-Lewis x on MUC5AC and MUC1 mucins in pancreatic cancer tissues. Int J Biol Macromol. 2018;112:33-45 pubmed publisher
..Altogether, MUC5AC-SLex glycoform is present in PDAC and can be regarded as potential biomarker. ..
MagalhÃ£es A, Duarte H, Reis C. Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis. Cancer Cell. 2017;31:733-735 pubmed publisher
..identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors. ..
Gomes J, Mereiter S, Magalhaes A, Reis C. Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries. Cancer Cell. 2017;32:544-545 pubmed publisher
..show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14...
Duarte H, Balmaña M, Mereiter S, Osorio H, Gomes J, Reis C. Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor. Int J Mol Sci. 2017;18: pubmed publisher
..Altogether, NCI-N87 cell line constitutes an appealing in vitro model to address glycan-mediated regulation of ErbB2 in GC. ..