Genomes and Genes


Celso Reis


Affiliation: Institute of Molecular Pathology and Immunology of the University of Porto
Location: , Portugal
Glycobiology and Disease,
Glycosylation and cancer
1. Reis CA, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, Sobrinho-Sim


  1. Mereiter S, Magalhães A, Adamczyk B, Jin C, Almeida A, Drici L, et al. Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer. Biochim Biophys Acta. 2016;1860:1795-808 pubmed publisher
    ..This article is part of a Special Issue entitled "Glycans in personalised medicine" Guest Editor: Professor Gordan Lauc. ..
  2. Duarte H, Freitas D, Gomes C, Gomes J, Magalhaes A, Reis C. Mucin-Type O-Glycosylation in Gastric Carcinogenesis. Biomolecules. 2016;6: pubmed publisher
    ..Altogether, mucin-type O-glycosylation alterations may represent promising biomarkers with potential screening and prognostic applications, as well as predictors of cancer patients' response to therapy. ..
  3. Balmaña M, Duran A, Gomes C, Llop E, López Martos R, Ortiz M, et al. Analysis of sialyl-Lewis x on MUC5AC and MUC1 mucins in pancreatic cancer tissues. Int J Biol Macromol. 2018;112:33-45 pubmed publisher
    ..Altogether, MUC5AC-SLex glycoform is present in PDAC and can be regarded as potential biomarker. ..
  4. Magalhães A, Duarte H, Reis C. Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis. Cancer Cell. 2017;31:733-735 pubmed publisher
    ..identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors. ..
  5. Gomes J, Mereiter S, Magalhaes A, Reis C. Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries. Cancer Cell. 2017;32:544-545 pubmed publisher that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14...
  6. Duarte H, Balmaña M, Mereiter S, Osorio H, Gomes J, Reis C. Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor. Int J Mol Sci. 2017;18: pubmed publisher
    ..Altogether, NCI-N87 cell line constitutes an appealing in vitro model to address glycan-mediated regulation of ErbB2 in GC. ..

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