Isabel Pereira Castro
Affiliation: Institute of Molecular Pathology and Immunology
- ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancerGinesa Garcia-Rostan
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
J Clin Oncol 21:3226-35. 2003..ras oncogenic activation has long been demonstrated in thyroid carcinomas of follicular cell derivation, but no consistent relationship has been shown between mutations and clinicopathologic features...
- Mutation of the PIK3CA gene in anaplastic thyroid cancerGinesa Garcia-Rostan
Institute of Molecular Pathology and Immunology of Porto University, Porto, Portugal
Cancer Res 65:10199-207. 2005..These findings indicate that mutant PIK3CA is likely to function as an oncogene among ATC and less frequently well-differentiated thyroid carcinomas. The data also argue for a role of PIK3CA targeting in the treatment of ATC patients...
- Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell linesAna Margarida Meireles
Institute of Pathology and Molecular Immunology, University of Porto IPATIMUP, Porto, Portugal
Thyroid 17:707-15. 2007..Our aim was to characterize the molecular and genotypic profile of eight thyroid carcinoma-derived cell lines-TPC1, FB2, B-CPAP, K1, XTC-1, C643, 8505C, and Hth74-in order to use them as in vitro models of thyroid carcinogenesis...
- High frequency of germline succinate dehydrogenase mutations in sporadic cervical paragangliomas in northern Spain: mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlationsJorge Lima
Institute of Molecular Pathology and Immunology of University of Porto, University of Porto, 4200 465 Porto, Portugal
J Clin Endocrinol Metab 92:4853-64. 2007....