Ana Moleirinho

Summary

Affiliation: Institute of Molecular Pathology and Immunology
Country: Portugal

Publications

  1. pmc Evolutionary constraints in the β-globin cluster: the signature of purifying selection at the δ-globin (HBD) locus and its role in developmental gene regulation
    Ana Moleirinho
    Institute of Molecular Pathology and Immunology of University of Porto IPATIMUP, Porto, Portugal
    Genome Biol Evol 5:559-71. 2013
  2. pmc Gains, losses and changes of function after gene duplication: study of the metallothionein family
    Ana Moleirinho
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    PLoS ONE 6:e18487. 2011
  3. pmc Distinctive Patterns of Evolution of the δ-Globin Gene (HBD) in Primates
    Ana Moleirinho
    Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IPATIMUP Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal
    PLoS ONE 10:e0123365. 2015
  4. doi request reprint Evolutionary history and functional diversification of phosphomannomutase genes
    Rita Quental
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias, s n 4200 465, Porto, Portugal
    J Mol Evol 71:119-27. 2010
  5. pmc DivStat: a user-friendly tool for single nucleotide polymorphism analysis of genomic diversity
    Ines Soares
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, 4200 465, Porto, Portugal
    PLoS ONE 10:e0119851. 2015
  6. pmc Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components
    Luisa Azevedo
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    BMC Genomics 10:266. 2009
  7. doi request reprint Relative frequency of known causes of multiple mtDNA deletions: two novel POLG mutations
    Mariana Ferreira
    Centro de Genética Médica Jacinto de Magalhães, Instituto Nacional Saúde Ricardo Jorge, Porto, Portugal
    Neuromuscul Disord 21:483-8. 2011

Collaborators

Detail Information

Publications7

  1. pmc Evolutionary constraints in the β-globin cluster: the signature of purifying selection at the δ-globin (HBD) locus and its role in developmental gene regulation
    Ana Moleirinho
    Institute of Molecular Pathology and Immunology of University of Porto IPATIMUP, Porto, Portugal
    Genome Biol Evol 5:559-71. 2013
    ....
  2. pmc Gains, losses and changes of function after gene duplication: study of the metallothionein family
    Ana Moleirinho
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    PLoS ONE 6:e18487. 2011
    ..Altogether our findings provide novel data on the evolution and diversification of MT gene duplicates, a valuable resource for understanding the vast set of biological processes in which these proteins are involved...
  3. pmc Distinctive Patterns of Evolution of the δ-Globin Gene (HBD) in Primates
    Ana Moleirinho
    Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IPATIMUP Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal
    PLoS ONE 10:e0123365. 2015
    ..Collectively, these findings suggest that sequence change at the δ-globin gene has been under strong selective constraints over 65 Myr of primate evolution, likely due to a regulatory role in ontogenic switches of gene expression. ..
  4. doi request reprint Evolutionary history and functional diversification of phosphomannomutase genes
    Rita Quental
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias, s n 4200 465, Porto, Portugal
    J Mol Evol 71:119-27. 2010
    ..Altogether, these results provide new data into the evolutionary history of PMM1 and PMM2 duplicates and highlight the most probable sites that evolved to distinct functional specificities...
  5. pmc DivStat: a user-friendly tool for single nucleotide polymorphism analysis of genomic diversity
    Ines Soares
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, 4200 465, Porto, Portugal
    PLoS ONE 10:e0119851. 2015
    ..Here, we present a new and potent tool to deal with large data sets allowing the computation of a variety of summary statistics of population genetic data, increasing the speed of data analysis. ..
  6. pmc Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components
    Luisa Azevedo
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    BMC Genomics 10:266. 2009
    ..In this current study, we focused on the molecular mechanism underlying the epistatic compensatory process in mammalian mitochondrial OXPHOS proteins using a combination of in-depth structural and sequence analyses...
  7. doi request reprint Relative frequency of known causes of multiple mtDNA deletions: two novel POLG mutations
    Mariana Ferreira
    Centro de Genética Médica Jacinto de Magalhães, Instituto Nacional Saúde Ricardo Jorge, Porto, Portugal
    Neuromuscul Disord 21:483-8. 2011
    ....