Mamede de Carvalho

Summary

Affiliation: Hospital de Santa Maria
Country: Portugal

Publications

  1. ncbi Monomelic neurogenic syndromes: a prospective study
    Mamede de Carvalho
    Department of Neurology, St Maria Hospital, Institute of Molecular Medicine, Faculty of Medicine, Lisbon, Portugal
    J Neurol Sci 263:26-34. 2007
  2. doi Motor unit changes in thoracic paraspinal muscles in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Department of Neurology and Neurophysiology, Santa Maria Hospital, Lisbon, Portugal
    Muscle Nerve 39:83-6. 2009
  3. ncbi Quantitating progression in ALS
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Laboratory of Electromyography, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute of Molecular Medicine, Lisbon, Portugal
    Neurology 64:1783-5. 2005
  4. ncbi Neurophysiological techniques to detect early small-fiber dysfunction in transthyretin amyloid polyneuropathy
    Isabel Conceição
    Department of Neurosciences, Centro Hospitalar Lisboa Norte Hospital de Santa Maria, Av Prof Egas Moniz, 1649 028, Lisbon, Portugal Translational and Clinical Physiology Unit, Instituto de Medicina Molecular, Faculty of Medicine, Lisbon, Portugal
    Muscle Nerve 49:181-6. 2014
  5. doi Motor responses of the sternocleidomastoid muscle in patients with amyotrophic lateral sclerosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 38:1312-7. 2008
  6. doi Association of paraspinal and diaphragm denervation in ALS
    Mamede de Carvalho
    Department of Neurology, St Maria Hospital, Institute of Molecular Medicine, Lisbon, Portugal
    Amyotroph Lateral Scler 11:63-6. 2010
  7. doi Primary lateral sclerosis: predicting functional outcome
    Vânia Almeida
    Department of Neurosciences, Hospital de Santa Maria CHLN, Av Prof Egas Moniz, Lisbon, Portugal
    Amyotroph Lateral Scler Frontotemporal Degener 14:141-5. 2013
  8. doi Symmetry of phrenic nerve motor response in amyotrophic lateral sclerosis
    Susana Pinto
    Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 42:822-5. 2010
  9. doi Fasciculation potentials and earliest changes in motor unit physiology in ALS
    Mamede de Carvalho
    Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 84:963-8. 2013
  10. doi Changes of the phrenic nerve motor response in amyotrophic lateral sclerosis: longitudinal study
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Clin Neurophysiol 120:2082-5. 2009

Collaborators

Detail Information

Publications74

  1. ncbi Monomelic neurogenic syndromes: a prospective study
    Mamede de Carvalho
    Department of Neurology, St Maria Hospital, Institute of Molecular Medicine, Faculty of Medicine, Lisbon, Portugal
    J Neurol Sci 263:26-34. 2007
    ..Multifocal motor neuropathy should be considered when there is progression, even years after onset...
  2. doi Motor unit changes in thoracic paraspinal muscles in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Department of Neurology and Neurophysiology, Santa Maria Hospital, Lisbon, Portugal
    Muscle Nerve 39:83-6. 2009
    ..These results confirm the value of paraspinal MUP analysis in the diagnosis of ALS...
  3. ncbi Quantitating progression in ALS
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Laboratory of Electromyography, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute of Molecular Medicine, Lisbon, Portugal
    Neurology 64:1783-5. 2005
    ..On assessing progression at 3, 6, and 12 months, MUNE, NI, and MVIC-ADM showed the highest rate of change. The NI is a potentially useful new neurophysiologic measurement...
  4. ncbi Neurophysiological techniques to detect early small-fiber dysfunction in transthyretin amyloid polyneuropathy
    Isabel Conceição
    Department of Neurosciences, Centro Hospitalar Lisboa Norte Hospital de Santa Maria, Av Prof Egas Moniz, 1649 028, Lisbon, Portugal Translational and Clinical Physiology Unit, Instituto de Medicina Molecular, Faculty of Medicine, Lisbon, Portugal
    Muscle Nerve 49:181-6. 2014
    ..We evaluated diagnostic accuracy of sural sensory nerve action potentials, plantar sympathetic skin response (SSR), and cortical laser-evoked potentials (LEP) to dorsal foot stimulation in the early diagnosis of TTR-FAP...
  5. doi Motor responses of the sternocleidomastoid muscle in patients with amyotrophic lateral sclerosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 38:1312-7. 2008
    ..We conclude that neck weakness is a clinical sign that indicates a poor prognosis, and the SCM CMAP can contribute to respiratory function evaluation in ALS patients...
  6. doi Association of paraspinal and diaphragm denervation in ALS
    Mamede de Carvalho
    Department of Neurology, St Maria Hospital, Institute of Molecular Medicine, Lisbon, Portugal
    Amyotroph Lateral Scler 11:63-6. 2010
    ..Axial muscles denervation is related to diaphragm denervation and therefore to poor respiratory function in ALS. We suggest that medially located lower motor neurons are affected concurrently in ALS...
  7. doi Primary lateral sclerosis: predicting functional outcome
    Vânia Almeida
    Department of Neurosciences, Hospital de Santa Maria CHLN, Av Prof Egas Moniz, Lisbon, Portugal
    Amyotroph Lateral Scler Frontotemporal Degener 14:141-5. 2013
    ..In conclusion, age is the most critical prognostic factor for functional outcome in PLS...
  8. doi Symmetry of phrenic nerve motor response in amyotrophic lateral sclerosis
    Susana Pinto
    Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 42:822-5. 2010
    ..The ADM CMAP is asymmetric in upper-limb-onset patients. Unilateral stimulation is sufficient to monitor the phrenic nerve response; its degree of CMAP decrease does not correlate with other cervical muscle involvement...
  9. doi Fasciculation potentials and earliest changes in motor unit physiology in ALS
    Mamede de Carvalho
    Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 84:963-8. 2013
    ..There is little information on the earliest changes in motor unit (MU) physiology in amyotrophic lateral sclerosis (ALS) and the development of the classical neurophysiological features of ALS over time...
  10. doi Changes of the phrenic nerve motor response in amyotrophic lateral sclerosis: longitudinal study
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Clin Neurophysiol 120:2082-5. 2009
    ..Phrenic nerve motor amplitude (Diaphr Ampl) is predictive of hypoventilation in amyotrophic lateral sclerosis (ALS). We aimed to evaluate its change over disease course and to correlate it to other measurements...
  11. ncbi Can selection of rapidly progressing patients shorten clinical trials in amyotrophic lateral sclerosis?
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Arch Neurol 63:557-60. 2006
    ..The marked variability in progression of amyotrophic lateral sclerosis (ALS) requires large numbers of patients to detect a significant effect in current clinical trial designs...
  12. doi Sensitivity of MUP parameters in detecting change in early ALS
    Mamede de Carvalho
    Translational Clinical Neurophysiology Unit, Instituto de Medicina Molecular and Institute of Physiology, Faculty of Medicine, University of Lisbon, Portugal Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal Electronic address
    Clin Neurophysiol 125:166-9. 2014
    ..We aimed to identify the most appropriate MUP parameter to evaluate reinnervation in very early ALS...
  13. ncbi Respiratory apraxia in amyotrophic lateral sclerosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Lisbon, Portugal
    Amyotroph Lateral Scler 8:180-4. 2007
    ..ALS, particularly when of bulbar onset, can cause respiratory apraxia and EMG of the respiratory muscles can be useful to detect this condition...
  14. doi Decreased heart rate variability predicts death in amyotrophic lateral sclerosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 46:341-5. 2012
    ..Some patients with amyotrophic lateral sclerosis (ALS) die suddenly despite normal nocturnal pulse oximetry (NPO), possibly due to dysautonomia...
  15. doi Sensitivity of electrophysiological tests for upper and lower motor neuron dysfunction in ALS: a six-month longitudinal study
    Mamede de Carvalho
    Neuroscience Department and Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Santa Maria Hospital, Ave Egas Moniz, 1649 035, Lisbon, Portugal
    Muscle Nerve 41:208-11. 2010
    ..The CSP may be a useful variable in following UMN dysfunction in clinical practice and in clinical trials...
  16. doi Percutaneous nocturnal oximetry in amyotrophic lateral sclerosis: periodic desaturation
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler 10:154-61. 2009
    ..We speculate that they have a central respiratory dysfunction and deserve special care...
  17. doi Neurophysiological markers in familial amyloid polyneuropathy patients: early changes
    Isabel M Conceição
    Department of Neurology, Hospital de Santa Maria and Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Clin Neurophysiol 119:1082-7. 2008
    ..Reliable quantitative methods that could allow the determination of early changes in the peripheral nerve function are essential. Our aim was to find sensitive neurophysiological markers in FAP-I...
  18. doi Does the motor cortex influence denervation in ALS? EMG studies of muscles with both contralateral and bilateral corticospinal innervation
    Mamede de Carvalho
    Department of Neurosciences, St Maria Hospital, Lisbon, Portugal
    Clin Neurophysiol 122:629-35. 2011
    ..To evaluate the pattern of degeneration of lower motor neuron progression in ALS in relation to the contralateral and ipsilateral corticospinal innervation of the tested muscles...
  19. ncbi Clinical patterns in progressive muscular atrophy (PMA): a prospective study
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Neuromuscular Unit of Institute of Molecular Medicine, Faculty of Medicine in Lisbon, Portugal
    Amyotroph Lateral Scler 8:296-9. 2007
    ..Overall the pattern of change resembled that of ALS, although some patients progressed very slowly. Axial onset, however, predicts the early onset of respiratory failure, and a poor prognosis...
  20. doi Origin of fasciculations in amyotrophic lateral sclerosis and benign fasciculation syndrome
    Mamede de Carvalho
    Translational Clinical Neurophysiology Unit, Instituto de Medicina Molecular and Institute of Physiology, Faculty of Medicine, University of Lisbon, Lisbon, Portugal2Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal
    JAMA Neurol 70:1562-5. 2013
    ..We recorded FPs in the tibialis anterior using 2 concentric needle electrodes, ensuring by slight voluntary contraction and electrical nerve stimulation that each electrode recorded motor unit potentials innervated by different axons...
  21. doi Reduced myocardial 123-iodine metaiodobenzylguanidine uptake: a prognostic marker in familial amyloid polyneuropathy
    Maria C Azevedo Coutinho
    Departments of Cardiology and Neurosciences, Santa Maria University Hospital, Lisbon, Portugal University Clinic of Cardiology, Translational Clinical Physiology Unit, Instituto de Medicina Molecular, and Institute of Nuclear Medicine, Lisbon Medical School, University of Lisbon, Portugal and Programme for Advanced Medical Education, Lisbon, Portugal
    Circ Cardiovasc Imaging 6:627-36. 2013
    ..However, its prognostic significance was never evaluated. We aimed to study the long-term prognostic value of myocardial sympathetic denervation detected by MIBG imaging in transthyretin familial amyloid polyneuropathy...
  22. doi Motor unit firing in amyotrophic lateral sclerosis and other upper and lower motor neurone disorders
    Mamede de Carvalho
    Instituto de Medicina Molecular, Lisbon, Portugal
    Clin Neurophysiol 123:2312-8. 2012
    ..We aimed to investigate firing rate in different disorders, testing the same target muscle with normal strength, to evaluate possible application in diagnosing upper motor neuron (UMN) lesion...
  23. doi Respiratory exercise in amyotrophic lateral sclerosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Lisbon, Portugal
    Amyotroph Lateral Scler 13:33-43. 2012
    ..In conclusion, there was no clear positive or negative outcome of the respiratory exercise protocol we have proposed, but we cannot rule out a minor positive effect. Exercise regimes merit more detailed clinical evaluation in ALS...
  24. ncbi Cramps, muscle pain, and fasciculations: not always benign?
    Mamede de Carvalho
    EMG Laboratory, Institute of Molecular Medicine, University of Lisbon, Portugal
    Neurology 63:721-3. 2004
    ..This observation raises the possibility that lower motor neuron hyperexcitability may precede motor neuron death in motor neuron disease...
  25. doi A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Neuroscience Department, Hospital de Santa Maria Centro Hospitalar Lisboa Norte, Lisbon, Portugal
    Amyotroph Lateral Scler 11:456-60. 2010
    ..In conclusion, the results of this study show that memantine is well tolerated and safe in ALS patients. We did not observe any evidence of efficacy for memantine but we cannot exclude a positive outcome on survival...
  26. doi Acquired amyloid neuropathy in a Portuguese patient after domino liver transplantation
    Isabel Conceição
    Department of Neurosciences, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal
    Muscle Nerve 42:836-9. 2010
    ..Our report shows that FAP can develop in a recipient of an FAP liver. This suggests that careful longitudinal study is required to evaluate the risk of FAP polyneuropathy in patients who undergo domino liver transplantation...
  27. doi Fasciculation-cramp syndrome preceding anterior horn cell disease: an intermediate syndrome?
    Mamede de Carvalho
    Department of Neurosciences and Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 82:459-61. 2011
    ..Our patient developed a limited form of anterior horn cell degeneration perhaps representing a syndrome transitional with amyotrophic lateral sclerosis. Cramp-FS merits more detailed study...
  28. ncbi Clinical and neurophysiological evaluation of progression in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, EMG Laboratory, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute for Molecular Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 28:630-3. 2003
    ..We conclude that the NI, which requires no special technology and no new clinical or technical skills to use, is sensitive to change, and therefore may be useful in clinical trials, as well as in a clinical setting...
  29. ncbi Does surgery accelerate progression of amyotrophic lateral sclerosis?
    Susana Pinto
    Translational Clinical Physiology Unit, Faculty of Medicine, Instituto de Medicina Molecular, Institute of Physiology, University of Lisbon, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 85:643-6. 2014
    ..Surgery is not a recognised potential amyotrophic lateral sclerosis (ALS) risk factor that might modify the onset or course of ALS...
  30. ncbi Abrupt onset of progressive muscular atrophy
    Raquel Gouveia
    Department of Neurology, Hospital de Santa Maria, Av Prof Egas Moniz, 1600 Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:61-2. 2004
  31. ncbi Repetitive nerve stimulation in myasthenia gravis--relative sensitivity of different muscles
    Joao Costa
    Department of Neurology, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 Lisbon, Portugal
    Clin Neurophysiol 115:2776-82. 2004
    ..To correlate repetitive nerve stimulation (RNS) decrement in different muscles with the predominant clinical presentation in myasthenia gravis (MG), and to study single fibre EMG (SFEMG) sensitivity in ocular MG...
  32. ncbi Awaji criteria for the diagnosis of amyotrophic lateral sclerosis:a systematic review
    Joao Costa
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, 1649028 Lisbon, Portugal
    Arch Neurol 69:1410-6. 2012
    ....
  33. ncbi Clinical trials in ALS: a review of the role of clinical and neurophysiological measurements
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:202-12. 2005
    ..In the past some trials may have failed to demonstrate a treatment effect because the chosen endpoint measures and the trial design were inappropriate...
  34. doi Home telemonitoring of non-invasive ventilation decreases healthcare utilisation in a prospective controlled trial of patients with amyotrophic lateral sclerosis
    Anabela Pinto
    Department of Physical Medicine and Rehabilitation, Santa Maria Hospital, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 81:1238-42. 2010
    ..However, it requires a process of adaptation not always achieved due to poor compliance. The role of telemonitoring of NIV is not yet established...
  35. ncbi Machado-Joseph disease presenting as motor neuron disease
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal
    Amyotroph Lateral Scler 9:188-91. 2008
    ..Respiratory function was mildly affected. Cerebellar ataxia developed over time and the diagnosis of MJD was confirmed by genetic studies. MJD should be considered in the differential diagnosis of MND...
  36. ncbi Motor responses evoked by transcranial magnetic stimulation and peripheral nerve stimulation in the ulnar innervation in amyotrophic lateral sclerosis: the effect of upper and lower motor neuron lesion
    Mamede de Carvalho
    EMG Laboratory of Centro de Estudos Egas Moniz, Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Sci 210:83-90. 2003
    ..We suggest that expressing the data as an index and utilising the MEP/M wave amplitude ratio as a variable is a sensitive method for detecting UMN abnormality in ALS in particular in early affected muscles...
  37. ncbi Clinical variability in type I familial amyloid polyneuropathy (Val30Met): comparison between late- and early-onset cases in Portugal
    Isabel Conceição
    Department of Neurology and Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 028, Lisbon, Portugal
    Muscle Nerve 35:116-8. 2007
    ..Neurophysiological measurements were similar. FAP is a cause of neuropathy in elderly patients, in particular in those presenting with neuropathic pain...
  38. ncbi Hereditary sensory neuropathy type 1 in a Portuguese family-electrodiagnostic and autonomic nervous system studies
    Ruth Geraldes
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Sci 227:35-8. 2004
    ..This report documents the lesion of the motor nerve fibers in this disease, as well as the preservation of the autonomic nervous system function, therefore suggesting that HSNA is an inappropriate name for this disorder...
  39. ncbi Evidence for central abnormality in respiratory control in primary lateral sclerosis
    Raquel Gil Gouveia
    Department of Neurology, Neuromuscular Unit, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler 7:57-60. 2006
    ..PNO and polysomnography suggest that respiratory central drive dysfunction can occur when upper motor neurons are severely affected, in PLS. However, we did not verify progression on follow-up...
  40. ncbi Economic cost of home-telemonitoring care for BiPAP-assisted ALS individuals
    J Pedro Lopes de Almeida
    Department of Physical Medicine and Rehabilitation, Santa Maria Hospital, Lisbon, Portugal
    Amyotroph Lateral Scler 13:533-7. 2012
    ..In conclusion, at the cost of an initial financial constraint to the hospital per year (non-significant), telemonitoring is cost-effective, representing major cost savings to the NHS in the order of 700 euros/patient/year...
  41. doi Amyotrophic lateral sclerosis: an update
    Mamede de Carvalho
    Neuromuscular Unit, Institute of Molecular Medicine, Hospital de Santa Maria, Lisbon, Portugal
    Curr Opin Neurol 24:497-503. 2011
    ..The aim is to review recent publications on amyotrophic lateral sclerosis (ALS)...
  42. doi A case of asymptomatic cytoplasmic body myopathy revealed by sinvastatin
    Teresinha Evangelista
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Neuromuscul Disord 19:66-8. 2009
    ..This case supports the role of muscle biopsy in patients that develop muscular necrosis while on statin treatment...
  43. doi Electrophysiological studies in healthy subjects involving caffeine
    Mamede de Carvalho
    Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal Instituto de Medicina Molecular, Lisbon, Portugal
    J Alzheimers Dis 20:S63-9. 2010
    ..We present new data demonstrating that this effect is also observed in fatigued muscle. We conclude that CSP can be considered a surrogate marker of the effect of caffeine in the brain, in particular of its central ergogenic effect...
  44. doi An error of self-diagnosis--but what was the real diagnosis?
    Mamede de Carvalho
    Neurology Department, Santa Maria Hospital, Avenue Prof Egas Moniz, Lisbon, Portugal
    Pract Neurol 9:284-8. 2009
    ..The patient illustrates the confusion and difficulty in categorising an usual clinical syndrome...
  45. ncbi Gelsolin-related familial amyloidosis, Finnish type, in a Portuguese family: clinical and neurophysiological studies
    Isabel Conceição
    Department of Neurology, Hospital de Santa Maria, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute for Molecular Medicine, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Muscle Nerve 28:715-21. 2003
    ..The Finnish mutation of gelsolin protein (G654A) was detected in five family members. The utility of neurophysiological testing in the evaluation and follow-up of this type of amyloidosis is discussed...
  46. ncbi The corticomotor threshold is not dependent on disease duration in amyotrophic lateral sclerosis (ALS)
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria and EMG laboratory of Centro de Estudos Egas Moniz, Faculty of Medicine, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:39-42. 2002
    ..It is suggested that early in ALS the corticomotor threshold (CMT) is low, but increases with increasing duration of the disease...
  47. ncbi Long-term quantitative evaluation of liver transplantation in familial amyloid polyneuropathy (Portuguese V30M)
    Mamede de Carvalho
    Laboratory of Electromyography and Evoked Potentials of Centro de Estudos Egas Moniz, Faculty of Medicine, Lisbon, Portugal
    Amyloid 9:126-33. 2002
    ..The NSprogressed in the first year following LT, and subsequently it did not increase significantly. LT changed the natural course of FAP-I...
  48. ncbi Transcranial magnetic stimulation: summary
    Mamede de Carvalho
    Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:S117-8. 2002
  49. ncbi Neurophysiological measures in amyotrophic lateral sclerosis: markers of progression in clinical trials
    Mamede de Carvalho
    Department of Neurology at Hospital de Santa Maria, Institute for Molecular Medecine, University of Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:17-28. 2005
    ..We conclude that clinical neurophysiological techniques should now be used in measuring change in clinical trials in ALS...
  50. ncbi Clinical and therapeutic implications of presymptomatic gene testing for familial amyloidotic polyneuropathy (FAP)
    Maria de Lourdes Sales-Luís
    Department of Neurology, University Hospital of Santa Maria Centro de Estudos Egas Moniz, IMM of Faculty of Medicine of Lisbon, Lisbon, Portugal
    Amyloid 10:26-31. 2003
    ..In conclusion, presymptomatic gene testing for FAP may have a positive impact on candidate quality and prolongation of life, and on the future of disease studies...
  51. doi Implementation of a wireless device for real-time telemedical assistance of home-ventilated amyotrophic lateral sclerosis patients: a feasibility study
    Jos Pedro Lopes de Almeida
    Department of Physical Medicine and Rehabilitation, University of Lisbon Medical School, Santa Maria Hospital, Lisbon, Portugal
    Telemed J E Health 16:883-8. 2010
    ..This portable telemonitoring device provides an opportune approach to better understand and recognize a ventilatory pattern through long-term ventilation monitoring in the home environment...
  52. doi Neurologic complications of craniovertebral dislocation
    Mamede de Carvalho
    Department of Neurosciences, St Maria Hospital, Lisbon, Portugal Institute of Molecular Medicine, Lisbon, Portugal Electronic address
    Handb Clin Neurol 119:435-48. 2014
    ..The treatment of this disorder is usually surgical, but traction and external immobilization is relevant in some cases. Specific conditions may require additional treatments such as radiotherapy, antibiotics, or chemotherapy. ..
  53. ncbi Mutant fibrinogen A-alpha-chain associated with hereditary renal amyloidosis and peripheral neuropathy
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyloid 11:200-7. 2004
    ..This can be important for prognosis, in particular when liver transplantation is considered for treatment...
  54. ncbi Nocturnal pulse oximetry: a new approach to establish the appropriate time for non-invasive ventilation in ALS patients
    Anabela Pinto
    Department of Physical Medicine and Rehabilitation, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:31-5. 2003
    ..002). We concluded that NPO is a valuable screening test to establish the need for NIV. Our results also suggest that the early diagnosis of RI and the early use of NIV increase patient compliance with NIV...
  55. ncbi Young-onset sporadic amyotrophic lateral sclerosis: a distinct nosological entity?
    Liliana Olim Gouveia
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler 8:323-7. 2007
    ..Young-onset ALS seems to be a distinct clinical syndrome but its aetiological background is largely unknown...
  56. doi Electrodiagnostic criteria for diagnosis of ALS
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal
    Clin Neurophysiol 119:497-503. 2008
    ..Methods for detection of upper motor neuron abnormality appear sensitive but require further study, particularly regarding their value when clinical signs of upper motor neuron lesion are uncertain...
  57. doi Pseudobulbar syndrome in two patients with human immunodeficiency virus infection
    Vânia Almeida
    Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler 11:220-2. 2010
    ..Patient 1 shows that PML is a possible cause for pseudobulbar syndrome, and our second patient demonstrates that ALS may also occur by chance in patients with HIV infection...
  58. ncbi Amyotrophic lateral sclerosis patients and ocular ptosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal
    Clin Neurol Neurosurg 110:168-70. 2008
    ..We discuss the association between ALS and ocular myasthenia gravis in these cases...
  59. pmc Orofacial apraxia in motor neuron disease
    Patrícia Pita Lobo
    Department of Neurosciences, Centro Hospitalar Lisboa Norte Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal
    Case Rep Neurol 5:47-51. 2013
    ..Orofacial, or buccofacial, apraxia is characterized by a loss of voluntary control of facial, lingual, pharyngeal and masticatory muscles in the presence of preserved reflexive and automatic functions of the same muscles...
  60. ncbi F-Waves and the corticospinal lesion in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:131-6. 2002
    ....
  61. ncbi Longstanding right-hand weakness in a patient with myasthenia gravis
    Mamede de Carvalho
    Muscle Nerve 34:670-1. 2006
  62. ncbi Ventilation in ALS
    Mamede de Carvalho
    Amyotroph Lateral Scler 7:3-4. 2006
  63. ncbi Compound muscle action potential: pro
    Mamede de Carvalho
    Hospital de Santa Maria, Lisbon, 1600 Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:S103-4. 2002
  64. ncbi The Neurophysiological Index in ALS
    Michael Swash
    Royal London Hospital, UK
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:108-10. 2004
    ..In combination with relevant measures of clinical benefit, such as ALS-FRS and a QoL measure, this could simplify trial design and allow more rapid determination of the efficacy of putative new therapies in clinical trials...
  65. ncbi Pain and calf hypertrophy associated with spontaneous repetitive discharges treated with botulinum toxin
    Joao Costa
    Department of Neurology, Santa Maria Hospital Institute of Molecular Medicine Faculty of Medicine Lisbon Portugal
    Clin Neurophysiol 116:2847-52. 2005
    ..To report a case of neurogenic calf hypertrophy associated with root lesion responsive to botulinum toxin (BTX). In addition, we systematically review the literature for cases of muscle hypertrophy associated with radiculopathy...
  66. ncbi Pathophysiology inferred from electrodiagnostic nerve tests and classification of polyneuropathies. Suggested guidelines
    Hatice Tankisi
    Department of Neurophysiology, Aarhus University Hospital, Aarhus, Denmark
    Clin Neurophysiol 116:1571-80. 2005
    ..To present criteria for pathophysiological interpretation of motor and sensory nerve conduction studies and for pathophysiological classification of polyneuropathies suggested by a group of European neurophysiologists...
  67. ncbi Randomised controlled trial in non-invasive ventilation: what trial?
    Anabela Pinto
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:255-6. 2004
  68. ncbi Sleep characteristics of amyotrophic lateral sclerosis in patients with preserved diaphragmatic function
    António Atalaia
    Laboratory of Clinical Neurophysiology, British Hospital Lisbon XXI, Lisbon Portugal
    Amyotroph Lateral Scler 8:101-5. 2007
    ..In conclusion, the most common sleep disordered breathing was periodic mild O(2) desaturation independent of the sleep stage (REM, NREM). This might represent central drive dysfunction or respiratory muscle fatigue in ALS...
  69. ncbi Clinical and genetic characterization of families with triple A (Allgrove) syndrome
    Henry Houlden
    Department of Clinical Neurology, Institute of Neurology, London, UK
    Brain 125:2681-90. 2002
    ..Identifying further mutations and defining their phenotype along with functional protein analysis will help to characterize this neuroendocrine gene...
  70. doi Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis
    Joao Costa
    Serviço de Neurologia Piso 7, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 035 Lisboa
    J Neurol 255:545-50. 2008
    ..Sialorrhea is a disabling problem in bulbaronset amyotrophic lateral sclerosis (ALS). Botulinum toxin (BTX) type A and B have been proposed as alternatives to traditional treatments...
  71. doi A prospective multicentre study on sural nerve action potentials in ALS
    Kirsten Pugdahl
    Department of Clinical Neurophysiology, Aarhus University Hospital, Nørrebrogade 44, Aarhus C, Denmark
    Clin Neurophysiol 119:1106-10. 2008
    ..To evaluate sensory nerve conduction studies in ALS in a prospective multicentre study involving 7 neurophysiologists from 6 European countries...
  72. ncbi Influence of peer review medical audit on pathophysiological interpretation of nerve conduction studies in polyneuropathies
    Hatice Tankisi
    Department of Clinical Neurophysiology, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Clin Neurophysiol 117:979-83. 2006
    ..To evaluate the possible influence of peer review medical audit on experienced physicians' pathophysiological interpretation of nerve conduction studies in polyneuropathy patients...
  73. ncbi Biochemical characterization of plasma in amyotrophic lateral sclerosis: amino acid and protein composition
    Angelina Palma
    Laboratory of Glycobiology, Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:104-10. 2005
    ..The results obtained suggested that diet supplementation with His and Ala and modulation of alpha2-M might have some beneficial effects on the course of ALS...
  74. ncbi Influence of medical audit on electrodiagnostic evaluation of polyneuropathy. A multicentre study
    Kirsten Pugdahl
    Department of Clinical Neurophysiology, Aarhus University Hospital, Nørrebrogade 44, Building 10, 8000 Aarhus C, Denmark
    Clin Neurophysiol 116:49-55. 2005
    ..This study assesses whether the collaboration that includes peer review medical audit has influenced the involved physicians' electrodiagnostic criteria for polyneuropathy (PNP) diagnosing and classification...