M de Carvalho

Summary

Affiliation: Hospital de Santa Maria
Country: Portugal

Publications

  1. doi request reprint Fasciculation-cramp syndrome preceding anterior horn cell disease: an intermediate syndrome?
    Mamede de Carvalho
    Department of Neurosciences and Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 82:459-61. 2011
  2. doi request reprint Motor responses of the sternocleidomastoid muscle in patients with amyotrophic lateral sclerosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 38:1312-7. 2008
  3. doi request reprint Predicting respiratory insufficiency in amyotrophic lateral sclerosis: the role of phrenic nerve studies
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal
    Clin Neurophysiol 120:941-6. 2009
  4. pmc Orofacial apraxia in motor neuron disease
    Patrícia Pita Lobo
    Department of Neurosciences, Centro Hospitalar Lisboa Norte Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal
    Case Rep Neurol 5:47-51. 2013
  5. doi request reprint Neurologic complications of craniovertebral dislocation
    Mamede de Carvalho
    Department of Neurosciences, St Maria Hospital, Lisbon, Portugal Institute of Molecular Medicine, Lisbon, Portugal Electronic address
    Handb Clin Neurol 119:435-48. 2014
  6. doi request reprint Sensitivity of MUP parameters in detecting change in early ALS
    Mamede de Carvalho
    Translational Clinical Neurophysiology Unit, Instituto de Medicina Molecular and Institute of Physiology, Faculty of Medicine, University of Lisbon, Portugal Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal Electronic address
    Clin Neurophysiol 125:166-9. 2014
  7. doi request reprint Fasciculation potentials and earliest changes in motor unit physiology in ALS
    Mamede de Carvalho
    Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 84:963-8. 2013
  8. doi request reprint Motor unit firing in amyotrophic lateral sclerosis and other upper and lower motor neurone disorders
    Mamede de Carvalho
    Instituto de Medicina Molecular, Lisbon, Portugal
    Clin Neurophysiol 123:2312-8. 2012
  9. ncbi request reprint Abrupt onset of progressive muscular atrophy
    Raquel Gouveia
    Department of Neurology, Hospital de Santa Maria, Av Prof Egas Moniz, 1600 Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:61-2. 2004
  10. doi request reprint Amyotrophic lateral sclerosis: an update
    Mamede de Carvalho
    Neuromuscular Unit, Institute of Molecular Medicine, Hospital de Santa Maria, Lisbon, Portugal
    Curr Opin Neurol 24:497-503. 2011

Collaborators

Detail Information

Publications81

  1. doi request reprint Fasciculation-cramp syndrome preceding anterior horn cell disease: an intermediate syndrome?
    Mamede de Carvalho
    Department of Neurosciences and Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 82:459-61. 2011
    ..Our patient developed a limited form of anterior horn cell degeneration perhaps representing a syndrome transitional with amyotrophic lateral sclerosis. Cramp-FS merits more detailed study...
  2. doi request reprint Motor responses of the sternocleidomastoid muscle in patients with amyotrophic lateral sclerosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 38:1312-7. 2008
    ..We conclude that neck weakness is a clinical sign that indicates a poor prognosis, and the SCM CMAP can contribute to respiratory function evaluation in ALS patients...
  3. doi request reprint Predicting respiratory insufficiency in amyotrophic lateral sclerosis: the role of phrenic nerve studies
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal
    Clin Neurophysiol 120:941-6. 2009
    ..Respiratory function tests are used to detect early signs of hypoventilation in amyotrophic lateral sclerosis (ALS). However, there are few studies of the predictive value of these tests in detecting hypoventilation...
  4. pmc Orofacial apraxia in motor neuron disease
    Patrícia Pita Lobo
    Department of Neurosciences, Centro Hospitalar Lisboa Norte Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal
    Case Rep Neurol 5:47-51. 2013
    ..Orofacial, or buccofacial, apraxia is characterized by a loss of voluntary control of facial, lingual, pharyngeal and masticatory muscles in the presence of preserved reflexive and automatic functions of the same muscles...
  5. doi request reprint Neurologic complications of craniovertebral dislocation
    Mamede de Carvalho
    Department of Neurosciences, St Maria Hospital, Lisbon, Portugal Institute of Molecular Medicine, Lisbon, Portugal Electronic address
    Handb Clin Neurol 119:435-48. 2014
    ..The treatment of this disorder is usually surgical, but traction and external immobilization is relevant in some cases. Specific conditions may require additional treatments such as radiotherapy, antibiotics, or chemotherapy. ..
  6. doi request reprint Sensitivity of MUP parameters in detecting change in early ALS
    Mamede de Carvalho
    Translational Clinical Neurophysiology Unit, Instituto de Medicina Molecular and Institute of Physiology, Faculty of Medicine, University of Lisbon, Portugal Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal Electronic address
    Clin Neurophysiol 125:166-9. 2014
    ..We aimed to identify the most appropriate MUP parameter to evaluate reinnervation in very early ALS...
  7. doi request reprint Fasciculation potentials and earliest changes in motor unit physiology in ALS
    Mamede de Carvalho
    Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 84:963-8. 2013
    ..There is little information on the earliest changes in motor unit (MU) physiology in amyotrophic lateral sclerosis (ALS) and the development of the classical neurophysiological features of ALS over time...
  8. doi request reprint Motor unit firing in amyotrophic lateral sclerosis and other upper and lower motor neurone disorders
    Mamede de Carvalho
    Instituto de Medicina Molecular, Lisbon, Portugal
    Clin Neurophysiol 123:2312-8. 2012
    ..We aimed to investigate firing rate in different disorders, testing the same target muscle with normal strength, to evaluate possible application in diagnosing upper motor neuron (UMN) lesion...
  9. ncbi request reprint Abrupt onset of progressive muscular atrophy
    Raquel Gouveia
    Department of Neurology, Hospital de Santa Maria, Av Prof Egas Moniz, 1600 Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:61-2. 2004
  10. doi request reprint Amyotrophic lateral sclerosis: an update
    Mamede de Carvalho
    Neuromuscular Unit, Institute of Molecular Medicine, Hospital de Santa Maria, Lisbon, Portugal
    Curr Opin Neurol 24:497-503. 2011
    ..The aim is to review recent publications on amyotrophic lateral sclerosis (ALS)...
  11. doi request reprint Percutaneous nocturnal oximetry in amyotrophic lateral sclerosis: periodic desaturation
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler 10:154-61. 2009
    ..We speculate that they have a central respiratory dysfunction and deserve special care...
  12. ncbi request reprint Cramps, muscle pain, and fasciculations: not always benign?
    Mamede de Carvalho
    EMG Laboratory, Institute of Molecular Medicine, University of Lisbon, Portugal
    Neurology 63:721-3. 2004
    ..This observation raises the possibility that lower motor neuron hyperexcitability may precede motor neuron death in motor neuron disease...
  13. ncbi request reprint Mutant fibrinogen A-alpha-chain associated with hereditary renal amyloidosis and peripheral neuropathy
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyloid 11:200-7. 2004
    ..This can be important for prognosis, in particular when liver transplantation is considered for treatment...
  14. doi request reprint Does the motor cortex influence denervation in ALS? EMG studies of muscles with both contralateral and bilateral corticospinal innervation
    Mamede de Carvalho
    Department of Neurosciences, St Maria Hospital, Lisbon, Portugal
    Clin Neurophysiol 122:629-35. 2011
    ..To evaluate the pattern of degeneration of lower motor neuron progression in ALS in relation to the contralateral and ipsilateral corticospinal innervation of the tested muscles...
  15. ncbi request reprint Quantitating progression in ALS
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Laboratory of Electromyography, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute of Molecular Medicine, Lisbon, Portugal
    Neurology 64:1783-5. 2005
    ..On assessing progression at 3, 6, and 12 months, MUNE, NI, and MVIC-ADM showed the highest rate of change. The NI is a potentially useful new neurophysiologic measurement...
  16. ncbi request reprint Neurophysiological measures in amyotrophic lateral sclerosis: markers of progression in clinical trials
    Mamede de Carvalho
    Department of Neurology at Hospital de Santa Maria, Institute for Molecular Medecine, University of Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:17-28. 2005
    ..We conclude that clinical neurophysiological techniques should now be used in measuring change in clinical trials in ALS...
  17. doi request reprint A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Neuroscience Department, Hospital de Santa Maria Centro Hospitalar Lisboa Norte, Lisbon, Portugal
    Amyotroph Lateral Scler 11:456-60. 2010
    ..In conclusion, the results of this study show that memantine is well tolerated and safe in ALS patients. We did not observe any evidence of efficacy for memantine but we cannot exclude a positive outcome on survival...
  18. pmc The onset of amyotrophic lateral sclerosis
    M de Carvalho
    Department of Neurology, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 77:388-9. 2006
    ..These unique observations show that ALS commences at a defined time, and that there is early generalisation with an initial phase of rapid progression...
  19. doi request reprint Electrophysiological studies in healthy subjects involving caffeine
    Mamede de Carvalho
    Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal Instituto de Medicina Molecular, Lisbon, Portugal
    J Alzheimers Dis 20:S63-9. 2010
    ..We present new data demonstrating that this effect is also observed in fatigued muscle. We conclude that CSP can be considered a surrogate marker of the effect of caffeine in the brain, in particular of its central ergogenic effect...
  20. doi request reprint Motor unit changes in thoracic paraspinal muscles in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Department of Neurology and Neurophysiology, Santa Maria Hospital, Lisbon, Portugal
    Muscle Nerve 39:83-6. 2009
    ..These results confirm the value of paraspinal MUP analysis in the diagnosis of ALS...
  21. doi request reprint An error of self-diagnosis--but what was the real diagnosis?
    Mamede de Carvalho
    Neurology Department, Santa Maria Hospital, Avenue Prof Egas Moniz, Lisbon, Portugal
    Pract Neurol 9:284-8. 2009
    ..The patient illustrates the confusion and difficulty in categorising an usual clinical syndrome...
  22. doi request reprint Sensitivity of electrophysiological tests for upper and lower motor neuron dysfunction in ALS: a six-month longitudinal study
    Mamede de Carvalho
    Neuroscience Department and Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Santa Maria Hospital, Ave Egas Moniz, 1649 035, Lisbon, Portugal
    Muscle Nerve 41:208-11. 2010
    ..The CSP may be a useful variable in following UMN dysfunction in clinical practice and in clinical trials...
  23. doi request reprint Association of paraspinal and diaphragm denervation in ALS
    Mamede de Carvalho
    Department of Neurology, St Maria Hospital, Institute of Molecular Medicine, Lisbon, Portugal
    Amyotroph Lateral Scler 11:63-6. 2010
    ..Axial muscles denervation is related to diaphragm denervation and therefore to poor respiratory function in ALS. We suggest that medially located lower motor neurons are affected concurrently in ALS...
  24. ncbi request reprint Long-term quantitative evaluation of liver transplantation in familial amyloid polyneuropathy (Portuguese V30M)
    Mamede de Carvalho
    Laboratory of Electromyography and Evoked Potentials of Centro de Estudos Egas Moniz, Faculty of Medicine, Lisbon, Portugal
    Amyloid 9:126-33. 2002
    ..The NSprogressed in the first year following LT, and subsequently it did not increase significantly. LT changed the natural course of FAP-I...
  25. ncbi request reprint Neurophysiological features of fasciculation potentials evoked by transcranial magnetic stimulation in amyotrophic lateral sclerosis
    M de Carvalho
    Department of Neurology, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol 247:189-94. 2000
    ....
  26. ncbi request reprint Cortical muscle representation in amyotrophic lateral sclerosis patients: changes with disease evolution
    M de Carvalho
    Department of Neurology, EMG Laboratory, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Av Prof Egas Moniz, 1600 Lisbon, Portugal
    Muscle Nerve 22:1684-92. 1999
    ..The changes in map parameters were attributed primarily to loss of cortical cells. These results indicate that map parameters may be more sensitive to cortical neuronal loss than other TMS parameters...
  27. ncbi request reprint Reflex sympathetic dystrophy associated with amyotrophic lateral sclerosis
    M de Carvalho
    Department of Neurology, EMG laboratory Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Sci 169:80-3. 1999
    ..The complex relation of ALS with RSD is discussed. In all ALS patients pain followed by further loss of function should prompt a search for RSD...
  28. ncbi request reprint Reflex sympathetic dystrophy precipitated by brachial plexitis
    M de Carvalho
    Department of Neurology, EMG Laboratory, Hospital of Santa Maria, Lisbon, Portugal
    Electromyogr Clin Neurophysiol 38:459-61. 1998
    ..The neurologist must be aware of this association to guide the affected patient to a correct treatment...
  29. ncbi request reprint Medical technology assessment. Electrodiagnosis in motor neuron diseases and amyotrophic lateral sclerosis
    M de Carvalho
    Department of Neurology, EMG Laboratory of Centro de Estudos Egas Moniz, Hospital de Santa Maria, Av, Prof Egas Moniz, 1600 Lisbon, Portugal
    Neurophysiol Clin 31:341-8. 2001
    ..A wide discussion among neurophysiologists from different schools could create a sound consensus on early diagnosis of MND-ALS...
  30. ncbi request reprint Paralytic shellfish poisoning: clinical and electrophysiological observations
    M de Carvalho
    Department of Neurology EMG lab, Hospital de Santa Maria, Lisboa, Portugal
    J Neurol 245:551-4. 1998
    ..The typically transient and quickly reversible nerve dysfunction caused by ion channel blockade is reported...
  31. ncbi request reprint Fibrillation and sharp-waves: do we need them to diagnose ALS?
    M de Carvalho
    Department of Neurology EMG Laboratory, Hospital de Santa Maria, Av Prof Egas Moniz, 1600 Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 1:29-32. 1999
    ..We investigated how frequently an initial electrophysiological (EMG) evaluation, performed in ALS patients, revealed no fibs-sw...
  32. ncbi request reprint Sensory potential can be preserved in severe common peroneal neuropathy
    M de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Electromyogr Clin Neurophysiol 40:61-3. 2000
    ..A preserved SPSP should not exclude a CPN neuropathy...
  33. ncbi request reprint The corticomotor threshold is not dependent on disease duration in amyotrophic lateral sclerosis (ALS)
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria and EMG laboratory of Centro de Estudos Egas Moniz, Faculty of Medicine, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:39-42. 2002
    ..It is suggested that early in ALS the corticomotor threshold (CMT) is low, but increases with increasing duration of the disease...
  34. ncbi request reprint Upper limb tremor induced by peripheral nerve injury
    J Costa
    Department of Neurology, Hospital Santa Maria, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Neurology 67:1884-6. 2006
    ..Somatosensory evoked potentials, transcranial magnetic stimulation, and MRI of the cervical and thoracic spine were normal. Tremor persisted in REM and non-REM sleep. These findings suggest a peripheral generator...
  35. ncbi request reprint Pathophysiological significance of fasciculations in the early diagnosis of ALS
    M de Carvalho
    Neurology Department, Hospital of Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 1:S43-6. 2000
    ..Patients with denervation localized in one region and diffuse FPs should be strongly suspected of having ALS. With this strategy it should be possible to shorten the diagnosis time...
  36. ncbi request reprint Do bulbar-onset amyotrophic lateral sclerosis patients have an earlier respiratory involvement than spinal-onset amyotrophic lateral sclerosis patients?
    S Pinto
    Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Eura Medicophys 43:505-9. 2007
    ..The aim of the present study was to determine if bulbar-onset patients have an earlier respiratory impairment as compared with the spinal-onset ones...
  37. ncbi request reprint Can amyotrophic lateral sclerosis patients with respiratory insufficiency exercise?
    A C Pinto
    Department of Medical Rehabilitation, Hospital de Santa Maria, Av Prof Egas Moniz, 1600, Lisboa, Portugal
    J Neurol Sci 169:69-75. 1999
    ..02) and a significant difference in the slope of the RFT (P<0.008) were observed in the treated group, suggesting that exercise may be beneficial in ALS patients once Bipap is used to control peripheral and muscle oxygenation...
  38. ncbi request reprint Lesion of the deep palmar branch of the ulnar nerve: causes and clinical outcome
    V Almeida
    Department of Neurosciences, Hospital de Santa Maria, Lisbon 1649 028, Portugal
    Neurophysiol Clin 40:159-64. 2010
    ..We aim to describe the clinical and neurophysiological characteristics of a group of patients with a clinical diagnosis of deep palmar branch lesion of the ulnar nerve. We report the clinical and neurophysiological outcome...
  39. ncbi request reprint Does caffeine modify corticomotor excitability?
    V Cerqueira
    Dementia Group, Institute of Molecular Medicine, Faculty of Medicine of Lisbon and Hospital de Santa Maria, Portugal
    Neurophysiol Clin 36:219-26. 2006
    ..To test the influence of caffeine on the lower and upper motor neuron excitability...
  40. ncbi request reprint Allgrove syndrome in adulthood
    C Bentes
    Department of Neurology, EMG Laboratory, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1600, Lisboa, Portugal
    Muscle Nerve 24:292-6. 2001
    ..One year later, the patient developed dysautonomic symptoms. Following confirmation of adrenal insufficiency, a diagnosis of Allgrove syndrome was made. This is a rare case, and we emphasize its clinical similarity with ALS...
  41. ncbi request reprint Reproducibility of neurophysiological and myometric measurement in the ulnar nerve-abductor digiti minimi system
    M de Carvalho
    Department of Neurology, Hospital de Santa Maria, EMG Laboratory of Centro de Estudos Egas Moniz, Lisbon, Portugal
    Muscle Nerve 24:1391-5. 2001
    ..The reliability of these neurophysiological and strength measurements in the same nerve/muscle system suggests they may be useful in comparing the dynamics of weakness and neurophysiological change in neuromuscular disease...
  42. ncbi request reprint Increased creatine kinase and spontaneous activity on electromyography, in amyotrophic lateral sclerosis
    A F Lima
    Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, IMM, Portugal
    Electromyogr Clin Neurophysiol 43:189-92. 2003
    ..Although the determinants of increased the CK in ALS remain uncertain, we hypothesize that fasciculations and muscle denervation can be involved by damaging the muscle fibre...
  43. doi request reprint Symmetry of phrenic nerve motor response in amyotrophic lateral sclerosis
    Susana Pinto
    Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 42:822-5. 2010
    ..The ADM CMAP is asymmetric in upper-limb-onset patients. Unilateral stimulation is sufficient to monitor the phrenic nerve response; its degree of CMAP decrease does not correlate with other cervical muscle involvement...
  44. ncbi request reprint Motor responses evoked by transcranial magnetic stimulation and peripheral nerve stimulation in the ulnar innervation in amyotrophic lateral sclerosis: the effect of upper and lower motor neuron lesion
    Mamede de Carvalho
    EMG Laboratory of Centro de Estudos Egas Moniz, Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Sci 210:83-90. 2003
    ..We suggest that expressing the data as an index and utilising the MEP/M wave amplitude ratio as a variable is a sensitive method for detecting UMN abnormality in ALS in particular in early affected muscles...
  45. ncbi request reprint Sympathetic sudomotor function and amyotrophic lateral sclerosis
    M Santos-Bento
    Department of Neurology, , Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 2:105-8. 2001
    ..The abnormalities were more frequent in very weak limbs, and could be ascribed to lack of use. CONCLUSION: Although significant sudomotor hypofunction does not occur in ALS, mild subclinical changes can be observed in weak limbs...
  46. doi request reprint Accessory nerve stimulation: motor response of the sternocleidomastoid muscle
    S Pinto
    Neuromuscular Unit, Faculty of Medicine, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
    Neurophysiol Clin 38:133-6. 2008
    ..The aim of this study is to describe a method for recording compound muscle action potential (CMAP) from the sternocleidomastoid (SCM) in response to accessory-nerve stimulation...
  47. doi request reprint Neurophysiological markers in familial amyloid polyneuropathy patients: early changes
    Isabel M Conceição
    Department of Neurology, Hospital de Santa Maria and Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Clin Neurophysiol 119:1082-7. 2008
    ..Reliable quantitative methods that could allow the determination of early changes in the peripheral nerve function are essential. Our aim was to find sensitive neurophysiological markers in FAP-I...
  48. doi request reprint Changes of the phrenic nerve motor response in amyotrophic lateral sclerosis: longitudinal study
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Clin Neurophysiol 120:2082-5. 2009
    ..Phrenic nerve motor amplitude (Diaphr Ampl) is predictive of hypoventilation in amyotrophic lateral sclerosis (ALS). We aimed to evaluate its change over disease course and to correlate it to other measurements...
  49. ncbi request reprint F-Waves and the corticospinal lesion in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:131-6. 2002
    ....
  50. ncbi request reprint Chronic inflammatory demyelinating polyneuropathy, phrenic nerve and respiratory symptoms
    J Costa
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Eur J Neurol 12:64-6. 2005
    ..The second case illustrates that the temporal dispersion of the motor responses can be misleading, and EMG of diaphragm should be performed to confirm the loss of motor units...
  51. doi request reprint Finite element studies of the mechanical behaviour of the diaphragm in normal and pathological cases
    M P M Pato
    Instituto Superior de Engenharia de Lisboa, Rua Conselheiro Emídio Navarro, Lisbon, Portugal
    Comput Methods Biomech Biomed Engin 14:505-13. 2011
    ..Furthermore, numerical results for the diaphragmatic floor under pressure and active contraction in normal and pathological cases are presented...
  52. ncbi request reprint New transthyretin mutation V28M in a Portuguese kindred with amyloid polyneuropathy
    M de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, and EMG Laboratory, Centro de Estudos Egas Moniz, Lisbon, Portugal
    Muscle Nerve 23:1016-21. 2000
    ..This case confirms that TTR mutation screening should be considered in patients with a clinical disorder consistent with amyloid neuropathy even in the absence of a family history...
  53. ncbi request reprint Respiratory disorders in ALS: sleep and exercise studies
    A C Pinto
    Department of Medical Rehabilitation, Hospital de Santa Maria, Av Prof Egas Moniz, 1600, Lisbon, Portugal
    J Neurol Sci 169:61-8. 1999
    ..MOP and ET should also be used in evaluation protocols of ALS/MND...
  54. ncbi request reprint Monomelic neurogenic syndromes: a prospective study
    Mamede de Carvalho
    Department of Neurology, St Maria Hospital, Institute of Molecular Medicine, Faculty of Medicine, Lisbon, Portugal
    J Neurol Sci 263:26-34. 2007
    ..Multifocal motor neuropathy should be considered when there is progression, even years after onset...
  55. ncbi request reprint Respiratory apraxia in amyotrophic lateral sclerosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Lisbon, Portugal
    Amyotroph Lateral Scler 8:180-4. 2007
    ..ALS, particularly when of bulbar onset, can cause respiratory apraxia and EMG of the respiratory muscles can be useful to detect this condition...
  56. ncbi request reprint Can selection of rapidly progressing patients shorten clinical trials in amyotrophic lateral sclerosis?
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Arch Neurol 63:557-60. 2006
    ..The marked variability in progression of amyotrophic lateral sclerosis (ALS) requires large numbers of patients to detect a significant effect in current clinical trial designs...
  57. ncbi request reprint Hereditary sensory neuropathy type 1 in a Portuguese family-electrodiagnostic and autonomic nervous system studies
    Ruth Geraldes
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    J Neurol Sci 227:35-8. 2004
    ..This report documents the lesion of the motor nerve fibers in this disease, as well as the preservation of the autonomic nervous system function, therefore suggesting that HSNA is an inappropriate name for this disorder...
  58. ncbi request reprint Transcranial magnetic stimulation: summary
    Mamede de Carvalho
    Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:S117-8. 2002
  59. ncbi request reprint Compound muscle action potential: pro
    Mamede de Carvalho
    Hospital de Santa Maria, Lisbon, 1600 Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:S103-4. 2002
  60. ncbi request reprint Clinical and therapeutic implications of presymptomatic gene testing for familial amyloidotic polyneuropathy (FAP)
    Maria de Lourdes Sales-Luís
    Department of Neurology, University Hospital of Santa Maria Centro de Estudos Egas Moniz, IMM of Faculty of Medicine of Lisbon, Lisbon, Portugal
    Amyloid 10:26-31. 2003
    ..In conclusion, presymptomatic gene testing for FAP may have a positive impact on candidate quality and prolongation of life, and on the future of disease studies...
  61. ncbi request reprint Gelsolin-related familial amyloidosis, Finnish type, in a Portuguese family: clinical and neurophysiological studies
    Isabel Conceição
    Department of Neurology, Hospital de Santa Maria, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute for Molecular Medicine, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Muscle Nerve 28:715-21. 2003
    ..The Finnish mutation of gelsolin protein (G654A) was detected in five family members. The utility of neurophysiological testing in the evaluation and follow-up of this type of amyloidosis is discussed...
  62. ncbi request reprint Nocturnal pulse oximetry: a new approach to establish the appropriate time for non-invasive ventilation in ALS patients
    Anabela Pinto
    Department of Physical Medicine and Rehabilitation, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:31-5. 2003
    ..002). We concluded that NPO is a valuable screening test to establish the need for NIV. Our results also suggest that the early diagnosis of RI and the early use of NIV increase patient compliance with NIV...
  63. ncbi request reprint Clinical variability in type I familial amyloid polyneuropathy (Val30Met): comparison between late- and early-onset cases in Portugal
    Isabel Conceição
    Department of Neurology and Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 028, Lisbon, Portugal
    Muscle Nerve 35:116-8. 2007
    ..Neurophysiological measurements were similar. FAP is a cause of neuropathy in elderly patients, in particular in those presenting with neuropathic pain...
  64. doi request reprint Exercise and amyotrophic lateral sclerosis
    J P Lopes de Almeida
    Department of Physical Medicine and Rehabilitation, University of Lisbon Medical School, Santa Maria Hospital, Lisbon, Portugal
    Neurol Sci 33:9-15. 2012
    ....
  65. ncbi request reprint Clinical patterns in progressive muscular atrophy (PMA): a prospective study
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Neuromuscular Unit of Institute of Molecular Medicine, Faculty of Medicine in Lisbon, Portugal
    Amyotroph Lateral Scler 8:296-9. 2007
    ..Overall the pattern of change resembled that of ALS, although some patients progressed very slowly. Axial onset, however, predicts the early onset of respiratory failure, and a poor prognosis...
  66. ncbi request reprint Clinical and neurophysiological evaluation of progression in amyotrophic lateral sclerosis
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, EMG Laboratory, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute for Molecular Medicine, University of Lisbon, Lisbon, Portugal
    Muscle Nerve 28:630-3. 2003
    ..We conclude that the NI, which requires no special technology and no new clinical or technical skills to use, is sensitive to change, and therefore may be useful in clinical trials, as well as in a clinical setting...
  67. ncbi request reprint Clinical trials in ALS: a review of the role of clinical and neurophysiological measurements
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:202-12. 2005
    ..In the past some trials may have failed to demonstrate a treatment effect because the chosen endpoint measures and the trial design were inappropriate...
  68. ncbi request reprint Motor-axonal polyneuropathy associated with hepatitis C virus
    J Costa
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Eur J Neurol 10:183-5. 2003
    ..1996)--especially when associated with cryoglobulinemia. We report, for the first time, the association between pure motor-axonal polyneuropathy and HCV infection without cryoglobulinemia...
  69. ncbi request reprint [Two myopathy cases]
    A Verdelho
    Servicio de Neurologia, Hospital de Santa Maria, Lisboa, Portugal
    Rev Neurol 28:1059-61. 1999
    ..Early diagnosis and therapeutic measures of frequent pathologies like hyperthyroidism made their neurological complications less frequent. In spite of well known, these neurological complications are some times forgotten...
  70. ncbi request reprint Evidence for central abnormality in respiratory control in primary lateral sclerosis
    Raquel Gil Gouveia
    Department of Neurology, Neuromuscular Unit, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler 7:57-60. 2006
    ..PNO and polysomnography suggest that respiratory central drive dysfunction can occur when upper motor neurons are severely affected, in PLS. However, we did not verify progression on follow-up...
  71. doi request reprint Home telemonitoring of non-invasive ventilation decreases healthcare utilisation in a prospective controlled trial of patients with amyotrophic lateral sclerosis
    Anabela Pinto
    Department of Physical Medicine and Rehabilitation, Santa Maria Hospital, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 81:1238-42. 2010
    ..However, it requires a process of adaptation not always achieved due to poor compliance. The role of telemonitoring of NIV is not yet established...
  72. doi request reprint Acquired amyloid neuropathy in a Portuguese patient after domino liver transplantation
    Isabel Conceição
    Department of Neurosciences, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal
    Muscle Nerve 42:836-9. 2010
    ..Our report shows that FAP can develop in a recipient of an FAP liver. This suggests that careful longitudinal study is required to evaluate the risk of FAP polyneuropathy in patients who undergo domino liver transplantation...
  73. doi request reprint A case of asymptomatic cytoplasmic body myopathy revealed by sinvastatin
    Teresinha Evangelista
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Neuromuscul Disord 19:66-8. 2009
    ..This case supports the role of muscle biopsy in patients that develop muscular necrosis while on statin treatment...
  74. ncbi request reprint Machado-Joseph disease presenting as motor neuron disease
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal
    Amyotroph Lateral Scler 9:188-91. 2008
    ..Respiratory function was mildly affected. Cerebellar ataxia developed over time and the diagnosis of MJD was confirmed by genetic studies. MJD should be considered in the differential diagnosis of MND...
  75. ncbi request reprint Repetitive nerve stimulation in myasthenia gravis--relative sensitivity of different muscles
    Joao Costa
    Department of Neurology, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 Lisbon, Portugal
    Clin Neurophysiol 115:2776-82. 2004
    ..To correlate repetitive nerve stimulation (RNS) decrement in different muscles with the predominant clinical presentation in myasthenia gravis (MG), and to study single fibre EMG (SFEMG) sensitivity in ocular MG...
  76. ncbi request reprint Motor excitability measurements: The influence of gender, body mass index, age and temperature in healthy controls
    I Casanova
    Clinical and translational physiology unit, Physiology Institute, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Avenue Professor Egas Moniz, 1649 028 Lisbon, Portugal
    Neurophysiol Clin 44:213-8. 2014
    ..We aimed to investigate variability of the motor excitability measurements in healthy controls, taking into account age, gender, body mass index (BMI) and small changes in skin temperature...
  77. doi request reprint Pseudobulbar syndrome in two patients with human immunodeficiency virus infection
    Vânia Almeida
    Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler 11:220-2. 2010
    ..Patient 1 shows that PML is a possible cause for pseudobulbar syndrome, and our second patient demonstrates that ALS may also occur by chance in patients with HIV infection...
  78. doi request reprint Electrodiagnostic criteria for diagnosis of ALS
    Mamede de Carvalho
    Department of Neurology, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal
    Clin Neurophysiol 119:497-503. 2008
    ..Methods for detection of upper motor neuron abnormality appear sensitive but require further study, particularly regarding their value when clinical signs of upper motor neuron lesion are uncertain...
  79. doi request reprint Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis
    Joao Costa
    Serviço de Neurologia Piso 7, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 035 Lisboa
    J Neurol 255:545-50. 2008
    ..Sialorrhea is a disabling problem in bulbaronset amyotrophic lateral sclerosis (ALS). Botulinum toxin (BTX) type A and B have been proposed as alternatives to traditional treatments...
  80. ncbi request reprint Young-onset sporadic amyotrophic lateral sclerosis: a distinct nosological entity?
    Liliana Olim Gouveia
    Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
    Amyotroph Lateral Scler 8:323-7. 2007
    ..Young-onset ALS seems to be a distinct clinical syndrome but its aetiological background is largely unknown...
  81. ncbi request reprint Amyotrophic lateral sclerosis patients and ocular ptosis
    Susana Pinto
    Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal
    Clin Neurol Neurosurg 110:168-70. 2008
    ..We discuss the association between ALS and ocular myasthenia gravis in these cases...