João E Fonseca

Summary

Country: Portugal

Publications

  1. pmc Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing
    Joana Caetano-Lopes
    Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal
    PLoS ONE 6:e16947. 2011
  2. ncbi request reprint At the moment of occurrence of a fragility hip fracture, men have higher mechanical properties values in comparison with women
    Ana C Vale
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    BMC Musculoskelet Disord 14:295. 2013
  3. pmc Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients
    Diana Carmona-Fernandes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Edificio Egas Moniz, Av, Prof, Egas Moniz, 1649 028 Lisboa, Portugal
    Arthritis Res Ther 13:R175. 2011
  4. ncbi request reprint Portuguese guidelines for the use of biological agents in rheumatoid arthritis - October 2011 update
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal
    Acta Reumatol Port 36:385-8. 2011
  5. pmc Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects
    Fernando M Pimentel-Santos
    Cedoc, Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Campo dos Mártires da Pátria, n 130, 1169 056 Lisboa, Portugal
    Arthritis Res Ther 13:R57. 2011
  6. doi request reprint Persistent low grade synovitis without erosive progression in magnetic resonance imaging of rheumatoid arthritis patients treated with infliximab over 1 year
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Edificio Egas Moniz, Av Professor Egas Moniz, 1649 028, Lisbon, Portugal
    Clin Rheumatol 28:1213-6. 2009
  7. pmc Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength
    J E Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av Professor Egas Moniz, 1649 028 Lisboa, Portugal
    Rheumatology (Oxford) 47:iv17-19. 2008
  8. pmc Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av, Professor Egas Moniz, 1649 028, Lisboa, Portugal
    Arthritis Res Ther 9:R37. 2007
  9. doi request reprint Interleukin-6 as a key player in systemic inflammation and joint destruction
    J E Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Autoimmun Rev 8:538-42. 2009
  10. ncbi request reprint Inflammatory cell infiltrate and RANKL/OPG expression in rheumatoid synovium: comparison with other inflammatory arthropathies and correlation with outcome
    J E Fonseca
    Rheumatology Department, Santa Maria Hospital, Lisbon, Portugal
    Clin Exp Rheumatol 23:185-92. 2005

Collaborators

Detail Information

Publications39

  1. pmc Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing
    Joana Caetano-Lopes
    Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal
    PLoS ONE 6:e16947. 2011
    ..The aim of our work was to study the sequence of gene expression events involved in inflammation and bone remodeling occurring in the early phases of callus formation in osteoporotic patients...
  2. ncbi request reprint At the moment of occurrence of a fragility hip fracture, men have higher mechanical properties values in comparison with women
    Ana C Vale
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    BMC Musculoskelet Disord 14:295. 2013
    ....
  3. pmc Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients
    Diana Carmona-Fernandes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Edificio Egas Moniz, Av, Prof, Egas Moniz, 1649 028 Lisboa, Portugal
    Arthritis Res Ther 13:R175. 2011
    ..Our aim was to assess serum OPG and soluble RANKL (sRANKL) levels as well as sRANKL/OPG ratio in female SLE patients and compare it with female controls...
  4. ncbi request reprint Portuguese guidelines for the use of biological agents in rheumatoid arthritis - October 2011 update
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal
    Acta Reumatol Port 36:385-8. 2011
    ..2 in the DAS28 score. Non-responders, in accordance to the Rheumatologist’s clinical opinion, should try a switch to another biological agent (tumour necrosis factor antagonist, abatacept, rituximab or tocilizumab)...
  5. pmc Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects
    Fernando M Pimentel-Santos
    Cedoc, Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Campo dos Mártires da Pátria, n 130, 1169 056 Lisboa, Portugal
    Arthritis Res Ther 13:R57. 2011
    ..We undertook a whole-genome microarray approach to identify candidate genes associated with AS and validated these gene-expression changes in a larger sample cohort...
  6. doi request reprint Persistent low grade synovitis without erosive progression in magnetic resonance imaging of rheumatoid arthritis patients treated with infliximab over 1 year
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Edificio Egas Moniz, Av Professor Egas Moniz, 1649 028, Lisbon, Portugal
    Clin Rheumatol 28:1213-6. 2009
    ..These results support the view that there might be an uncoupling process between inflammation and bone erosions when tumor necrosis factor alpha is targeted in RA...
  7. pmc Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength
    J E Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av Professor Egas Moniz, 1649 028 Lisboa, Portugal
    Rheumatology (Oxford) 47:iv17-19. 2008
    ..The overall effect is a rebalanced bone turnover in favour of improved bone geometry, cortical thickness, trabecular bone morphology and intrinsic bone tissue quality, which translates into enhanced bone strength...
  8. pmc Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av, Professor Egas Moniz, 1649 028, Lisboa, Portugal
    Arthritis Res Ther 9:R37. 2007
    ....
  9. doi request reprint Interleukin-6 as a key player in systemic inflammation and joint destruction
    J E Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Autoimmun Rev 8:538-42. 2009
    ..Given the pleiotropic function of IL-6 it can be anticipated that other inflammatory diseases and bone metabolic conditions might benefit from selective IL-6 signaling inhibition...
  10. ncbi request reprint Inflammatory cell infiltrate and RANKL/OPG expression in rheumatoid synovium: comparison with other inflammatory arthropathies and correlation with outcome
    J E Fonseca
    Rheumatology Department, Santa Maria Hospital, Lisbon, Portugal
    Clin Exp Rheumatol 23:185-92. 2005
    ....
  11. doi request reprint Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures
    Ana M Rodrigues
    Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon, Portugal
    Bone 51:981-9. 2012
    ..We also aimed to identify which of these factors were associated with worse mechanical behavior and with the hip fracture event...
  12. doi request reprint Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival
    Rita A Moura
    Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Rheumatology (Oxford) 50:278-82. 2011
    ....
  13. pmc Chronic arthritis leads to disturbances in the bone collagen network
    Joana Caetano-Lopes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisbon, Portugal
    Arthritis Res Ther 12:R9. 2010
    ..In this study we used a mice model of chronic arthritis to evaluate if bone fragility induced by chronic inflammation is associated with an imbalance in bone turnover and also a disorganization of the bone type I collagen network...
  14. pmc Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis
    Rita Cascão
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av Professor Egas Moniz, Lisboa 1649 028, Portugal
    Arthritis Res Ther 12:R196. 2010
    ..The main goal of this work was to determine whether cytokines driving neutrophil and Th17 activation are dysregulated in very early rheumatoid arthritis patients with less than 6 weeks of disease duration and before treatment (VERA)...
  15. ncbi request reprint BAFF and TACI gene expression are increased in patients with untreated very early rheumatoid arthritis
    Rita A Moura
    Rheumatology Research Unit, and the Cellular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    J Rheumatol 40:1293-302. 2013
    ....
  16. doi request reprint Lymphotoxin-α 252 A>G polymorphism: a link between disease susceptibility and dyslipidemia in rheumatoid arthritis?
    Maria J Santos
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    J Rheumatol 38:1244-9. 2011
    ..We examined the role of the single-nucleotide polymorphism at position 252 of the LTA gene in the genetic background of RA and dyslipidemia...
  17. ncbi request reprint [Juvenile cutaneous polyarteritis nodosa associated with streptococcal infection]
    F Ramos
    Serviço de Reumatologia e Doenças Osseas Metabólicas do Hospital de Santa Maria
    Acta Reumatol Port 31:83-8. 2006
    ..We present the case of a 6-year-old child who developed cutaneous polyarteritis nodosa following a probable streptococcal infection...
  18. ncbi request reprint Factors influencing calcaneus quantitative ultrasound measurements in an urban population
    H Canhao
    Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal
    Clin Exp Rheumatol 26:67-72. 2008
    ..To estimate the effect of demographic, social, behavioural and anthropometric factors on quantitative ultrasound (QUS) parameters in an urban population...
  19. doi request reprint Alterations on peripheral blood B-cell subpopulations in very early arthritis patients
    Rita A Moura
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av Professor Egas Moniz, 1649 028 Lisboa, Portugal
    Rheumatology (Oxford) 49:1082-92. 2010
    ..To characterize circulating B-cell subpopulations of arthritis patients with <6 weeks of disease duration...
  20. doi request reprint Biomechanical effects of inflammatory diseases on bone-rheumatoid arthritis as a paradigm
    S Abdulghani
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Autoimmun Rev 8:668-71. 2009
    ..This evidence suggests that one of the major explanations for the increased fracture risk in RA is related to the changes on bone components induced by inflammation that result in compromised biomechanical properties...
  21. doi request reprint Pachydermoperiostosis in an African patient caused by a Chinese/Japanese SLCO2A1 mutation-case report and review of literature
    João A C Madruga Dias
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal Rheumatology Department, Santa Maria Hospital, C H L N, Lisbon, Portugal Electronic address
    Semin Arthritis Rheum 43:566-9. 2014
    ..Two genes have been associated, HPGD and recently SLCO2A1. We present a detailed clinical and genetic description of an African pachydermoperiostosis patient with a SLCO2A1 mutation...
  22. pmc Influence of human leucocyte antigen-DRB1 on the susceptibility to rheumatoid arthritis and on the production of anti-cyclic citrullinated peptide antibodies in a Portuguese population
    D Ligeiro
    Centro de Histocompatibilidade do Sul, Lisboa, Portugal
    Ann Rheum Dis 66:246-8. 2007
    ..To clarify the influence of the HLA-DRB1 locus on the susceptibility to rheumatoid arthritis and the production of anti-cyclic citrullinated peptide antibodies (anti-CCP) in a Portuguese population...
  23. doi request reprint To B or not to B the conductor of rheumatoid arthritis orchestra
    Rita A Moura
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av Professor Egas Moniz, 1649 028, Lisbon, Portugal
    Clin Rev Allergy Immunol 43:281-91. 2012
    ....
  24. ncbi request reprint Cross-sectional study of 50 patients with calcium pyrophosphate dihydrate crystal arthropathy
    H Canhao
    Hospital de Santa Maria, Lisbon, Portugal
    Clin Rheumatol 20:119-22. 2001
    ..The knee meniscus calcifications were the most sensitive single finding for establishing the diagnosis of CPPA. Almost all our patients had sporadic idiopathic CPPA without associated pathological conditions...
  25. ncbi request reprint Low bone mineral density in professional scuba divers
    J A Pereira Silva
    Rheumatology Unit, Santa Maria Hospital, Av Prof Egas Moniz, 1600, Lisbon, Portugal
    Clin Rheumatol 23:19-20. 2004
    ..Our results suggest that diving is also an activity where the unloading effect alters bone metabolism, leading to a reduction in BMD...
  26. ncbi request reprint Multiplexed immunoassay for detection of rheumatoid factors by FIDISTM technology
    I Abreu
    Faculty of Medical Sciences, Department of Immunology, New University of Lisbon, Lisbon, Portugal
    Ann N Y Acad Sci 1050:357-63. 2005
    ..2%; ELISA human 93.2%, 95.5%; and ELISA animal 74.6%, 91.3%. The results showed the efficiency of FIDIS with analytical performance equivalent to the conventional methods, but having the advantage of giving quantitative results (IU/mL)...
  27. ncbi request reprint Chronic arthritis directly induces quantitative and qualitative bone disturbances leading to compromised biomechanical properties
    J Caetano-Lopes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisbon, Portugal
    Clin Exp Rheumatol 27:475-82. 2009
    ..This study used an animal model of chronic arthritis to evaluate the direct impact of chronic inflammation on biomechanical properties and structure of bone...
  28. doi request reprint Osteoimmunology--the hidden immune regulation of bone
    J Caetano-Lopes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Autoimmun Rev 8:250-5. 2009
    ..Chronic inflammation strongly influences osteoimmunology determining profound metabolic, structural and functional changes in bone...
  29. ncbi request reprint Delayed neutrophil apoptosis in very early rheumatoid arthritis patients is abrogated by methotrexate therapy
    P Weinmann
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Clin Exp Rheumatol 25:885-7. 2007
    ..To analyse the activation state and apoptosis of circulating neutrophils in untreated very early rheumatoid arthritis (VERA) and after exposure to low dose corticosteroids and methotrexate (MTX)...
  30. ncbi request reprint The Portuguese version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)
    J A Melo-Gomes
    Infantile, Adolescent and Young Adult Rheumatology Unit Instituto Português de Reumatologia, Lisbon, Portugal
    Clin Exp Rheumatol 19:S126-30. 2001
    ..In conclusion the Portuguese version of the CHAQ-CHQ is a reliable, and valid tool for the functional, physical and psychosocial assessment of children with JIA...
  31. ncbi request reprint Global functional status in rheumatoid arthritis: disease duration and patient age
    J E Fonseca
    Unidade de Reumatologia, Medicina IV, Santa Maria Hospital, Lisbon, Portugal
    Clin Rheumatol 21:32-4. 2002
    ....
  32. ncbi request reprint Neutrophils: warriors and commanders in immune mediated inflammatory diseases
    R Cascão
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa
    Acta Reumatol Port 34:313-26. 2009
    ..The herein review is focused in neutrophil biology in a general perspective and its contribution to the course of immune mediated inflammatory diseases...
  33. doi request reprint Vasculitis-like syndrome associated with Borrelia lusitaniae infection
    I Lopes de Carvalho
    Center for Vector and Infectious Diseases Research, Instituto Nacional de Saude Dr Ricardo Jorge, Lisbon, Portugal
    Clin Rheumatol 27:1587-91. 2008
    ..In order to prevent the occurrence of more serious disease manifestations via timely treatment, the analysis by molecular methods may be a useful approach when antibody titres are uninformative...
  34. ncbi request reprint Evaluation of bone mechanical strenght and fracture risk assessment (Frax) in patients with hip joint replacement surgery
    A Rodrigues
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Acta Reumatol Port 34:504-10. 2009
    ..However, how it reflects bone quality is unknown. The aim of this study was to correlate the WHO clinical fracture risk assessment tool, FRAX, with bone mechanical properties...
  35. ncbi request reprint Neutrophils in rheumatoid arthritis: More than simple final effectors
    R Cascão
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
    Autoimmun Rev 9:531-5. 2010
    ..The herein article reviews recent progresses in the understanding of the immunopathology of RA with a special emphasis on the role of neutrophils...
  36. ncbi request reprint Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments
    J E Fonseca
    University College London, London, UK
    Arthritis Rheum 46:1210-6. 2002
    ..We assessed CD163 expression in microenvironments within rheumatoid arthritis (RA) synovium to clarify the relationships among CD4+ T lymphocytes, IFNgamma, and macrophage function in RA...
  37. pmc Polymorphism at position -308 of the tumour necrosis factor alpha gene and rheumatoid arthritis pharmacogenetics
    J E Fonseca
    Ann Rheum Dis 64:793-4. 2005
  38. ncbi request reprint [Protocol for clinical monitoring of rheumatoid arthritis [PMAR]--December 2007 update]
    J E Fonseca
    Unidade de Investigação em Reumatologia Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa
    Acta Reumatol Port 32:367-74. 2007
    ....
  39. ncbi request reprint Dual effects of caspase-1, interleukin-1 beta, tumour necrosis factor-alpha and nerve growth factor receptor in inflammatory myopathies
    Z Mackiewicz
    Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki, Finland
    Clin Exp Rheumatol 21:41-8. 2003
    ....