Paulo Pereira

Summary

Affiliation: Faculty of Medicine
Country: Portugal

Publications

  1. pmc Methylglyoxal alters the function and stability of critical components of the protein quality control
    Carla Figueira Bento
    Center of Ophthalmology and Vision Sciences, Institute for Biomedical Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    PLoS ONE 5:e13007. 2010
  2. pmc The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal
    Carla Figueira Bento
    Center of Ophthalmology and Vision Sciences COCV, Institute for Biomedical Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    PLoS ONE 5:e15062. 2010
  3. doi request reprint Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal
    Steve Catarino
    Centre of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Biochem J 437:255-67. 2011
  4. doi request reprint Eps15 interacts with ubiquitinated Cx43 and mediates its internalization
    Henrique Girao
    Centre of Ophthalmology and Visual Sciences, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Sta Comba 3000 354 Coimbra, Portugal
    Exp Cell Res 315:3587-97. 2009
  5. ncbi request reprint The proteasome regulates the interaction between Cx43 and ZO-1
    Henrique Girao
    Centre of Ophthalmology, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, 3000 354 Coimbra, Portugal
    J Cell Biochem 102:719-28. 2007
  6. doi request reprint Reactive oxygen species downregulate glucose transport system in retinal endothelial cells
    Rosa Fernandes
    Center of Opththalmology and Vision Sciences, Institute for Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Portugal
    Am J Physiol Cell Physiol 300:C927-36. 2011
  7. pmc Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation
    Henrique Girao
    Center of Ophthalmology, Biomedical Institute for Research in Light and Image, University of Coimbra, Portugal
    Invest Ophthalmol Vis Sci 46:1386-92. 2005
  8. ncbi request reprint Oxidative stress upregulates ubiquitin proteasome pathway in retinal endothelial cells
    Rosa Fernandes
    Center of Ophthalmology, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Mol Vis 12:1526-35. 2006
  9. doi request reprint Methylglyoxal promotes oxidative stress and endothelial dysfunction
    Cristina M Sena
    Institute of Physiology, University of Coimbra, Portugal IBILI, Faculty of Medicine, University of Coimbra, Portugal
    Pharmacol Res 65:497-506. 2012
  10. doi request reprint Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation
    Lisa Rodrigues
    Laboratory of Physiology IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Physiol Biochem 70:173-84. 2014

Collaborators

Detail Information

Publications16

  1. pmc Methylglyoxal alters the function and stability of critical components of the protein quality control
    Carla Figueira Bento
    Center of Ophthalmology and Vision Sciences, Institute for Biomedical Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    PLoS ONE 5:e13007. 2010
    ..In this study, the effect of MGO on the function of the ubiquitin-proteasome system (UPS) and on molecular chaperones, two cooperative mechanisms associated with protein quality control, was investigated...
  2. pmc The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal
    Carla Figueira Bento
    Center of Ophthalmology and Vision Sciences COCV, Institute for Biomedical Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    PLoS ONE 5:e15062. 2010
    ..Moreover, we suggest that accumulation of MGO is likely to be the link between high glucose and the loss of cell response to hypoxia in diabetes...
  3. doi request reprint Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal
    Steve Catarino
    Centre of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Biochem J 437:255-67. 2011
    ..Furthermore, the internalization of Cx43 induced by Cx43-Ub was shown to depend on its interaction with epidermal growth factor receptor substrate 15...
  4. doi request reprint Eps15 interacts with ubiquitinated Cx43 and mediates its internalization
    Henrique Girao
    Centre of Ophthalmology and Visual Sciences, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Sta Comba 3000 354 Coimbra, Portugal
    Exp Cell Res 315:3587-97. 2009
    ..This provides the basis for future studies aiming at identifying the molecular players and mechanisms involved in Cx43 internalization and degradation...
  5. ncbi request reprint The proteasome regulates the interaction between Cx43 and ZO-1
    Henrique Girao
    Centre of Ophthalmology, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, 3000 354 Coimbra, Portugal
    J Cell Biochem 102:719-28. 2007
    ..Data presented in this article suggest a new pathway whereby alterations in proteasome activity may impact on GJIC as well as on non-junctional communication with extracellular environment, contributing to cell and tissue dysfunction...
  6. doi request reprint Reactive oxygen species downregulate glucose transport system in retinal endothelial cells
    Rosa Fernandes
    Center of Opththalmology and Vision Sciences, Institute for Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Portugal
    Am J Physiol Cell Physiol 300:C927-36. 2011
    ..Thus subcellular redistribution of GLUT1 under conditions of oxidative stress is likely to contribute to the disruption of glucose homeostasis in diabetes...
  7. pmc Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation
    Henrique Girao
    Center of Ophthalmology, Biomedical Institute for Research in Light and Image, University of Coimbra, Portugal
    Invest Ophthalmol Vis Sci 46:1386-92. 2005
    ..The primary nuclear localization of the UPP components in the differentiating fibers supports the hypothesis that the UPP may play a role in elimination of nuclei and other organelles during differentiation and maturation of lens fibers...
  8. ncbi request reprint Oxidative stress upregulates ubiquitin proteasome pathway in retinal endothelial cells
    Rosa Fernandes
    Center of Ophthalmology, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Mol Vis 12:1526-35. 2006
    ..To establish whether oxidative stress in retinal endothelial cells upregulates the ubiquitin proteasome pathway (UPP) leading to increased protein degradation in diabetes...
  9. doi request reprint Methylglyoxal promotes oxidative stress and endothelial dysfunction
    Cristina M Sena
    Institute of Physiology, University of Coimbra, Portugal IBILI, Faculty of Medicine, University of Coimbra, Portugal
    Pharmacol Res 65:497-506. 2012
    ..The present study provides further evidence for methylglyoxal as one of the causative factors in the pathogenesis of atherosclerosis and development of macrovascular diabetic complication...
  10. doi request reprint Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation
    Lisa Rodrigues
    Laboratory of Physiology IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Physiol Biochem 70:173-84. 2014
    ..MG accumulation specifically impaired several of the renal disease markers progressively observed in diabetic rats, and thus, it contributes to the progression of diabetic nephropathy...
  11. ncbi request reprint Downregulation of retinal GLUT1 in diabetes by ubiquitinylation
    Rosa Fernandes
    Biomedical Institute for Research in Light and Image, Center of Ophthalmology, University of Coimbra, Coimbra, Portugal
    Mol Vis 10:618-28. 2004
    ..To investigate the effect of chronic hyperglycemia on the levels of the glucose transporter GLUT1 in retina and its ubiquitinylation...
  12. doi request reprint Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid
    Vera Francisco
    Center for Neurosciences and Cell Biology, University of Coimbra, Azinhaga de Santa Comba, 3004 517 Coimbra, Portugal
    J Ethnopharmacol 148:126-34. 2013
    ..Cymbopogon citratus (DC.) Stapf leaves infusion is used in traditional medicine for the treatment of inflammatory conditions, however little is known about their bioactive compounds...
  13. pmc Diabetes mellitus: new challenges and innovative therapies
    Cristina M Sena
    Institute of Physiology, Faculty of Medicine, University of Coimbra, Subunit 1, polo 3, Azinhaga de Santa Comba, Celas, 3000 354 Coimbra, Portugal IBILI, University of Coimbra, Coimbra, Portugal
    EPMA J 1:138-63. 2010
    ..In conclusion, treatment of diabetes faces now a new era that is characterized by a variety of innovative therapeutic approaches that will improve quality-life and allow personalized therapy-planning in the near future...
  14. doi request reprint Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons
    Margarida V Caldeira
    University of Coimbra, Largo Marques de Pombal, Coimbra, Portugal
    Biochim Biophys Acta 1832:263-74. 2013
    ..These results indicate that excitotoxic stimulation with glutamate has multiple effects on the ubiquitin-proteasome system which may contribute to the demise process in brain ischemia and in other neurological disorders...
  15. ncbi request reprint High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism
    Rosa Fernandes
    Centre of Ophthalmology, Biomedical Institute for Research in Light and Image, Faculty of Medicine, University of Coimbra, 3000 354 Coimbra, Portugal
    J Biol Chem 279:27219-24. 2004
    ..Increased degradation of Cx43 and reduction of GJIC in high glucose may be of physiological importance by contributing to endothelial cell dysfunction associated with the breakdown of the blood-retinal barrier in diabetic retinopathy...
  16. doi request reprint Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells
    Steve Catarino
    Centre of Ophthalmology and Vision Sciences COCV, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Acta Ophthalmol 90:e255-63. 2012
    ..This study aimed at elucidating the molecular mechanisms involved in the regulation of IL-8 production by several oxysterols in retinal pigment epithelium (RPE) cells...