Joaquim Ribeiro

Summary

Affiliation: Inst Pharmacol Neurosci, Fac Med and Unit Neurosci, Inst Mol Med
Location: Lisbon, Portugal
URL: www.neurociencias.pt
Summary:
2010 ? Coordinator (Vice-Rector) of the Health Sciences Strategic Area of the University of Lisbon
2009 ? Vice-President of the Institute of Molecular Medicine
2004 ? Vice-Dean of the Faculty of Medicine, University of Lisbon.
2004 ? PI at the Unit of Neurosciences, Institute of Molecular Medicine
2002 - Director of the Institute of Phamacology and Neurosciences, Faculty of Medicine, University of Lisbon.
1997 - Full Professor at the Faculty of Medicine, University of Lisbon
1997/00 ? Director of Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon.
1988/00 - Full Professor (invited) at the Institute for Biomedical Sciences Abel Salazar, University of Porto.
1985/87 - President of the Studies Committee of the Gulbenkian Institute of Science.
1983/85 - President of the Scientific Council of the Gulbenkian Institute of Science.
1982/97 - Head of the Laboratory of Pharmacology of the Gulbenkian Institute of Science.
Publications:
195. Costenla AR, Di?genes MJ, Canas PM, Rodrigues RJ, Nogueira C, Ribeiro JA, Maroco J, Agostinho PM, Cunha RA, de Mendon?a (2011). Enhanced role of adenosine A2A receptors controlling LTP in the rat hippocampus upon aging. Eur.J. Neurosci., accepted
194. Moreno, E., Sandra Vaz, Ning-Sheng Cai, Carla Ferrada, Cesar Quiroz, Nadine Kabbani, Enric I. Canela, Peter J. McCormick, Carme Lluis, Rafael Franco, Joaquim A Ribeiro, Ana M Sebasti?o, and Sergi Ferr? (2011). Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus (J Neurosci, accepted 5 April 2011)
193. Di?genes, M.J., Costenla, A.R., Lopes, L.V., Jer?nomo, A.S., Sousa, V.C., Fontinha, B.M., Ribeiro, J.A. and Sebasti?o, A.M. (2011). Enhancement of LTP in aged rats is dependent on endogenous BDNF (Neuropsychopharmacology, on line pub med).
192. Aroeira RI, Ribeiro JA, Sebasti?o AM and Valente CA (2011). Age-related changes of glycine receptor at the rat hippocampus: from the embryo to the adult. (J Neurochem, on line pub med).
191. Lopes, L.V., Sebasti?o, A.M. and Ribeiro, J.A. (2011). Adenosine and related drugs in brain diseases: present and future in clinical trials Curr Topics Med Chem (in press-18-5-2010)
190. Sebasti?o, A.M., Assaife-Lopes, N., Di?genes, M.J., Vaz, S., and Ribeiro, J.A., (2011) Modulation of brain-derived neurotrophic factor (BDNF) actions in the nervous system by adenosine A2A receptors and the role of lipid rafts BBA Biomembranes Biochimica et Biophysica Acta 1808, 1340?1349).
189. Sousa V C., Assaife-Lopes, N., Brett, R. R., Ribeiro J. A., Pratt, J A, Sebasti?o A. M. (2011). Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of Δ9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology, 36: 472-487.
188. Dias R Ribeiro J A and Sebastiao A M (2011). Enhancement of AMPA currents and GluR1 membrane expression through PKA-coupled adenosine A2A receptors (Hippocampus, in press on line).
187. Ribeiro J.A. (2010). Neuro?tica, a emerg?ncia de uma nova disciplina em neuroci?ncias. Sinapse, 40, 32-33.
186. Ribeiro, J. A. and Sebasti?o A. M. (2010). Modulation and MetaModulation of Synapses by Adenosine. Acta Physiol 199, 161-169.
185. Ribeiro J A and Sebastiao A M (2010). Caffeine and Adenosine. J Alzheim dis., 20, 3-15.
184. Assaife-Lopes, N., Sousa V. C., Pereira D. B, Ribeiro J. A., Chao M. V. and Sebasti?o A. M. (2010). Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation. J Neurosci., 30: 8468?8480.
183. Pedata, F , Pugliese, A M, Sebasti?o A M and Ribeiro J A. (2010). Adenosine A3 receptor signaling in the central nervous system. A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics, P.A. Borea (ed) , DOI 10.1007/1978-90-481-3144-0_1, Springer Science+Business Media B.V.
182. Pousinha, P.A., Sebasti?o, A.M and Ribeiro, J.A. (2010). Predominance of adenosine excitatory over inhibitory effects on transmission at the neuromuscular junction of infant rats J Pharmacol Exp Ther. 2010, 332:153-163.
181. Serpa, A., Ribeiro, J A and Sebasti?o, A M (2009). Cannabinoid CB1 and Adenosine A1 receptors independently inhibit hippocampal synaptic transmission Eur J Pharmacol 623, 41-46.
180. Sebasti?o AM and Ribeiro JA (2009). Tuning and Fine-tuning synapses with adenosine, Current Neuropharmacol, 7, 180-194..
179. Sebasti?o AM and Ribeiro J A (2009). Adenosine Receptors and the Central Nervous System, Handbook Exp Pharmacol, 193: 471-534.
178. Sebasti?o, A.M and Ribeiro, J.A. (2009). Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection Br J Pharmacol, 158: 15-22.
177. Fontinha, B, Delgado-Garc?a, J M, Madro?al, N. Ribeiro, J. A., Sebastiao, A. M. and Gruart A. (2009). Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice" Neuropsychopharmacology, 34:1865-1874
176. Cristov?o-Ferreira, S., Vaz, S., Ribeiro, J.A. and Sebasti?o, A.M. (2009). Adenosine A2A receptors, through PKA activation, restrain PKC inhibition of GAT-1-mediated GABA uptake by nerve terminals. J Neurochem., 109, 336-347.
175. Gomes CA, Sim?es PF, Canas PM, Quiroz C, Sebasti?o AM, Ferr? S, Cunha RA, Ribeiro JA. (2009). GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine a2a receptors. J Neurochem., 108, 1208-1219.
174. Serpa A., Ribeiro, J.A. e Sebasti?o, A.M. (2009). Adenosine A1 and cannabinoid CB1 receptors independently inhibit hippocampal synaptic transmission. Rev Fac Med Lisboa, 14, 59-64.
173. Ribeiro, JA (2008). Fine tuning neuromodulation by adenosine and neuroprotection. An R. Acad. Nac. Farm., 74, 387-408.
172. Fernandes, C., Pinto-Duarte, A. Ribeiro, J.A. And Sebasti?o, A.M. (2008) Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons. J Neurosci.,28, 5611-5618.
171. Vaz S. Ferreira, A:S., Ribeiro, J.A. And Sebasti?o, A.M. (2008). Brain-derived neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminals Brain Res., 1219:19-25
170. Fontinha B.M., Ribeiro, J.A. & Sebasti?o, A.M. (2008). Enhancement of long ?term potentiation by BDNF requires adenosine A2A receptor activation by endogenous adenosine Neuropharmacology, 54, 924-933.
169. Cunha-Reis, D., Ribeiro, J.A. & Sebasti?o, A.M. (2008). A(1) and A(2A) receptor activation by endogenous adenosine is required for VIP enhancement of K(+)-evoked [(3)H]-GABA release from rat hippocampal nerve terminals. Neurosci Letts 430, 207-212.
168. BIBER K, PINTO-DUARTE, A., WITTENDORP, MC, DOLGA, AM, FERNANDES, CC, KUNZEL JVFD, KEIJSER, JN, DEVRIES, R, IJZERMAN, AP, RIBEIRO, JA, EISEL, U, SEBASTI?O AM and BODDEKE, GM. (2008). Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection. Neuropsychopharmacology 33, 2237?2250.
167. DI?GENES, M.J., ASSAIFE-LOPES N. PINTO-DUARTE A, RIBEIRO, J.A.,& SEBASTI?O, A.M. (2007). Influence of age on BDNF modulation of hippocampal synaptic transmission: interplay with adenosine A2A receptors. Hippocampus, 2007;17:577-585.
166. CUNHA-REIS, D., FONTINHA, B., RIBEIRO, J.A. & SEBASTI?O, A.M. (2007). Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus. Neuropharmacology 52, 313-320.
165. QUIROZ, C., GOMES, C, PAK A.C., RIBEIRO J.A., GOLDBERG, S.R., HOPE, B.T. and FERR?, S. (2006). Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation. J. Neurosci., 18, 10808-10812.
164. GOMES, C.A.R.V., VAZ, S.H., RIBEIRO J.A. & SEBASTI?O, A.M (2006). Glial cell line-derived neurotrophic factor enhances dopamine release from striatal nerve endings in an adenosine A2A receptor dependent manner. Brain Res., 1113, 129-136.
163. CUNHA-REIS, D., RIBEIRO, J.A. & SEBASTI?O, A.M. (2006). VPAC2 receptor activation mediates VIP enhancement of population spikes in the CA1 area of the hippocampus. Ann NY Acad Sci., 1070, 210-214.
162. FRAGATA, I., RIBEIRO, J.A. & SEBASTI?O, A M. (2006). Nitric oxide mediates interactions between GABA-A receptors and adenosine A1 receptors in the rat hippocampus. Eur J Pharmacol., 543, 32-39.
161. POUSINHA, P.A., DI?GENES, M.J.,. RIBEIRO, J.A. & SEBASTI?O, A.M (2006). Triggering of BDNF facilitatory action on neuromuscular transmission by adenosine A2A receptors. Neurosci Letts, 404, 143-147.
160. COELHO J.E., REBOLA, N., FRAGATA, I., RIBEIRO, J.A. de MENDON?A, A. and CUNHA, R. A. (2006). Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus. Neuroscience, 138, 1195-1203.
159. CUNHA-REIS, D., SEBASTI?O, A.M. & RIBEIRO, J.A. (2005) VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors. Brain Res., 1049, 52-60.
158. SILVA, B.M., de MENDON?A, A. & RIBEIRO, J.A. (2005). Long-term depression is not modulated by ATP receptors in the rat CA1 hippocampal region. Neurosci. Letts, 383, 345-349.
157. RIBEIRO, J.A. (2005). What adenosine neuromodulation can do for neuroprotection. Curr.Drug Targets: CNS & Neurol. Disorders, 4, 327-331.
156. PINTO-DUARTE, A. COELHO, J.E:, CUNHA, R.A. RIBEIRO, J.A. & SEBASTI?O, A.M. (2005). Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus. J Neurochem. , 93, 595-604.
155. CUNHA-REIS, D., SEBASTI?O, A.M. WIRKNER, K. ILLES, P. & RIBEIRO, J.A. (2004). VIP enhances both pre- and postsynaptic GABAergic transmission to hippocampal interneurones leading to increased excitatory synaptic transmission to CA1 pyramidal cells. Br J Pharmacol., 143:733-744.
154. CANAS, N., PEREIRA, I.T., RIBEIRO, J.A. & SEBASTI?O, A.M. (2004) Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms. Brain Res 1016, 72-78
153. ILLES, P & RIBEIRO, J.A. (2004). Neuronal P2 receptors of the central nervous system. Cur Topics Med Chem, 4, 831-838.
152. DI?GENES, M.J., FERNANDES, C.C., SEBASTI?O, A.M. & RIBEIRO, J.A. (2004). Activation of adenosine A2A receptor facilitates BDNF modulation of synaptic transmission in hippocampal slices. J. Neurosci., 24, 2905-2913.
151. ILLES, P & RIBEIRO, J.A. (2004). Molecular physiology of P2 receptors in the central nervous system. Eur J Pharmacol., 483, 5-17.
150. CUNHA, R.A., RIBEIRO, J.A. & MALVA, J.O. (2004). Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid. Neurochem. Int., 44, 371-379.
149. ALMEIDA T, RODRIGUES RJ, de MENDONCA A, RIBEIRO JA, CUNHA RA. (2003). Purinergic P2 receptors trigger adenosine release leading to adenosine A(2A) receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Neuroscience. 122:111-121.
148. RIBEIRO, J.A, (2003) Fine tuning modulation of neurotransmission. J. Vet. Pharmacol. & Ther., 26, 6-11.
147. RIBEIRO, J.A, SEBASTI?O, A.M. de MENDON?A, A., (2003). Participation of adenosine receptors in neuroprotection Drug news & perspectives, 16, 80-86.
146 RIBEIRO, J.A. LOBO M.G.B. & SEBASTI?O, A.M. (2003 ). Endogenous adenosine modulation of 22Na uptake by rat brain synaptosomes.Neurochem Res, 28, 1589-1593.
145. ALMEIDA, C. G., de MENDON?A, A., CUNHA, R.A. & RIBEIRO, J.A. (2003). Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices. Neurosci. Lets, 339, 127-130.
144. REBOLA, N., SEBASTI?O, A.M., de MENDON?A, A., OLIVEIRA, C.R., RIBEIRO, J.A. & CUNHA, R.A, (2003). Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.J Neurophysiol., 90, 1295-1303.
143. LOPES, L.V., REBOLA, N., COSTENLA A.R., HALLDNER, L., JACOBSON, M.A., OLIVEIRA, C.R., RICHARDSON, P.J., FREDHOLM, B.B., RIBEIRO, J. A. & CUNHA, R.A. (2003). Adenosine A3 receptors in the rat hippocampus: lack of interaction with A1 receptors. Drug Develop. Res., 58, 428-438.
142. MAGALH?ES-CARDOSO, M.T., PEREIRA, M:F., OLIVEIRA; L., RIBEIRO, J.A., CUNHA, R.A. & CORREIA-de-S?, P. (2003). Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings. J. Physiol.Lond., 549, 399-408.
141. RIBEIRO, J.A, SEBASTI?O, A.M. de MENDON?A, A., (2003). Adenosine receptors in the nervous system: pathophysiological implications. Prog. Neurobiol. 68, 377-392.
140. CASCALHEIRA, J.F., SEBASTI?O, A.M. & RIBEIRO, J.A. (2002). Pertussis toxin-sensitive G proteins mediate the inhibition of basal phosphoinositide metabolism caused by adenosine A1 receptors in rat hippocampal slices. Neurochem. Res., 27, 1707-1711.
139. LOPES, L.V., CUNHA, R.A., KULL, B., FREDHOLM, B.B. & RIBEIRO, J. A. (2002). Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition. Neuroscience, 112, 319-329.
138. CUNHA, R.A., COELHO, J. E., COSTENLA, A.R., LOPES, L.. V., PARADA, A. de MENDON?A, A., SEBASTI?O, A.M. & RIBEIRO, J.A. (2002). Effects of carbamazepine and novel 10, 11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices. Pharmacol. & Toxicol., 90, 208-213.
137. DIAZ-HERNANDEZ, M., PEREIRA, M.F., PINTOR, J., CUNHA, R.A., RIBEIRO, J.A., & MIRAS-PORTUGAL, M.T., (2002). Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation, J Pharmacol Exp Ther.; 301: 441-50.
136. de MENDON?A, A.COSTENLA, A.R. & RIBEIRO, J. A. (2002). Persistence of the neuromodulatory effects of adenosine on synaptic transmission after long-term potentiation and long-term depression. Brain Res., 932, 56-60.
135. SEBASTI?O, A.M., DE MENDON?A, A., MOREIRA, T. & RIBEIRO, J.A. (2001). Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission upon reoxygenation. J. Neurosci., 21, 8564-8571.
134. CORREIA-DE-S?, P., TIM?TEO, M.A. & RIBEIRO, J.A. (2001). Synergism between A2A-adenosine receptors activation and vasoactive intestinal peptide to facilitate 3H-acetylcholine release from the rat motor nerve terminals. Neurosci. Letts, 309, 101-104.
133. RIBEIRO, J.A., CUNHA-REIS, D., LOPES, L.V., COELHO, J.E., COSTENLA, A.R., CORREIA-DE-S?, P., CUNHA, R.A., de MENDON?A, A. & SEBASTI?O, A.M. (2001). Adenosine receptor interactions in the hippocampus. Drug Develop. Res., 52, 337-345.
132. SEBASTI?O, A.M., DE MENDON?A, A. & RIBEIRO, J.A. (2001) Neuroprotection during hypoxic insults: role of adenosine. Drug Dev. Res., 52, 291-295.
131. DE MENDON?A, A. & RIBEIRO, J. A. (2001). Adenosine and Synaptic Plasticity. Drug Dev. Res., 52, 283-290.
130. COSTENLA, A.R., LOPES, L.V., de MENDON?A, A. & RIBEIRO, J.A. (2001). A functional role for adenosine A3 receptors: modulation of synaptic plasticity in the rat hippocampus Neurosci. Letts, 302, 53-57.
129. CUNHA, R.A., CONSTANTINO, M.D., FONSECA, E. & RIBEIRO, J.A. (2001). Age-dependent effects of cis-unsaturated free fatty acids on adenosine A1 receptors. Eur. J. Biochem., 268, 2939-2947.
128. CUNHA, R.A., ALMEIDA, T., & RIBEIRO, J.A. (2001). Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats. J Neurochem., 76, 372-382.
127. SEBASTI?O, A.M. CUNHA, R.A. DE MENDON?A, A. & RIBEIRO, J.A. (2000). Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats. Br. J. Pharmacol., 131, 1629-1634.
126. CUNHA, R.A., ALMEIDA, T., & RIBEIRO, J.A. (2000). Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus J. Biol. Chem., 275, 37572-37581.
125. PEREIRA, M.F., HERNANDEZ, M.D., PINTOR, J., MIRAS-PORTUGAL, M.T.., CUNHA, R.A. & RIBEIRO, J.A. (2000). Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals. Brain Res., 879, 50-54.
124. DE MENDON?A, A., SEBASTI?O, A.M. & RIBEIRO, J. A. (2000) Adenosine- does it have a neuroprotective role after all? Brain Res. Rev., 33, 258-274.
123. DE MENDON?A, A. & RIBEIRO, J. A. (2000). Long-term Potentiation observed upon blockade of adenosine A1 receptors in rat hippocampus is N-methyl-D-aspartate receptor-dependent. Neurosci. Letts, 291, 81-84.
122. CORREIA-DE-S?, P., TIM?TEO, M.A. & RIBEIRO, J.A. (2000). Influence of stimulation on Ca2+ recruitment triggering 3H acetylcholine release from the rat motor nerve endings. Eur. J. Pharmacol. , 406, 355-362.
121. SEBASTI?O, A.M. & RIBEIRO, J.A. (2000) Fine tuning neuromodulation by adenosine Trends Pharmacol. Sci., 21, 341-346.
120. SALGADO, A.I. CUNHA, R.A . & RIBEIRO, J. A . (2000) Facilitation by P2 receptor activation of acetylcholine release from rat motor nerve terminals: interaction with presynaptic nicotinic receptors. Brain Res., 877, 245-250.
119. CUNHA, R.A. & RIBEIRO, J.A. (2000) Adenosine A2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation Neurosci. Letts, 289, 127-130.
118. CUNHA, R.A. & & RIBEIRO, J. A. (2000) ATP as a presynaptic modulator (mini-review) Life Sci., 68, 119-137.
117. COELHO, J.E., DE MENDON?A, A. & RIBEIRO, J. A. (2000). Presynaptic inhibitory receptors mediate the depression of synaptic transmission upon hypoxia in rat hippocampal slices.Brain Res., 869, 158-165.
116. CORREIA-DE-S?, P., TIM?TEO, M.A. & RIBEIRO, J.A. (2000). A2A-adenosine receptor facilitation of neuromuscuar transmission: influence of stimulus paradigm on calcium mobilization. J Neurochem., 74, 2462-2469.
115. PEREIRA, M.F., CUNHA, R.A. & RIBEIRO, J.A. (2000). Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats. Neurochem. Int., 36, 563-566.
114. CUNHA, R.A. & RIBEIRO, J.A. (2000). Purinergic modulation of 3H GABA release from rat hippocampal nerve terminals. Neuropharmacol. 39, 1156-1167.
113. CUNHA, R.A., MALVA, J.O. & RIBEIRO, J.A. (2000). Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal 3H-GABA release. FEBS Lett, 469, 159-162.
112. SEBASTI?O, A.M., MACEDO, M.P. & RIBEIRO, J.A. (2000). Tonic activation of A2A adenosine receptors unmasks, and of A1 receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus. Brit. J. Pharmacol., 129, 374-380.
111. HERNANDEZ, J. LAORDEN, M.L., RUIZ, F.and RIBEIRO, J. A. (2000). b,y-Methylene ATP but not a,b-methylene ATP mimics the inhibitory effect of ATP on ventricular automaticity Pharmacol & Toxicol., 86, 68-70.
110. CUNHA; R.A., BRENDEL; P., ZIMMERMANN, H., & RIBEIRO, J.A. (2000). Immunologically distinct isoforms of ecto-5?-nucleotidase in nerve terminals of different areas of the rat hippocampus J. Neurochem. 74, 334-338.
109. MONTEIRO, E.C. & RIBEIRO, J.A. (2000). Adenosine-dopamine interactions and ventilation mediated through carotid body chemoreceptors. In: Adv. Exp. Med. Biol., 475, 671-684.
108. COSTENLA, A.R. DE MENDON?A, A. & RIBEIRO, J. A. (1999). Adenosine modulates synaptic plasticity in hippocampal slices from aged rats. Brain Res., 851, 228-234.
107. LOPES, L.V., CUNHA, R.A. & RIBEIRO, J. A. (1999). Cross Talk between A1 and A2A adenosine receptors in the hippocampus and cortex of young adult and old rats. J. Neurophysiol., 82, 3196-3203.
106. LOPES, L.V., CUNHA, R.A. & RIBEIRO, J. A. (1999). ZM 241385, an adenosine A2A receptor antagonist, inhibits hippocampal A1 receptor responses. Eur J. Pharmacol., 383, 393-395.
105. LOPES, L. V., CUNHA, R.A . & RIBEIRO, J. A . (1999). Increase in the number, G-protein coupling and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats. J Neurochem. 73, 1733-1738.
104. CUNHA, R.A., MALVA, J.O. & RIBEIRO, J.A. (1999). Kainate receptors coupled to Gi/Go proteins in the rat hippocampus. Molec. Pharmacol. 56, 429-433..
103. RIBEIRO, J.A. (1999). Adenosine A2A receptor interactions with receptors for other neurotransmitters and neuromodulators. Eur. J. Pharmacol., 375, 101-113.
102. CUNHA, R.A., CONSTANTINO, M.D. & RIBEIRO, J.A. (1999). G-protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors. Naunyn Schmiedberg?s Arch. Pharmacol., 359, 295-302.
101. SEBASTI?O, A.M., CUNHA, R.A., CASCALHEIRA, J.F. & RIBEIRO, J.A. (1999). Adenine nucleotides as inhibitors of synaptic transmission: role of localised ectonucleotidases. Prog. Brain Res., 120, 183-192..
100. CUNHA, R.A. & RIBEIRO, J.A. (1999). Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes. Eur. J. Neurosci., 11, 1-4.
99. ALMEIDA, T., CUNHA, R.A. & RIBEIRO, J.A. (1999). Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus. Brain Res., 826, 104-111.
98. COSTENLA, A.R., de MENDON?A, A., SEBASTI?O, A., M. & RIBEIRO, J.A. (!999). An adenosine analogue inhibits NMDA receptor-mediated responses in bipolar cells of the rat retina. Exp. Eye Res. 68, 367-370.
97. CUNHA, J.A., SEBASTI?O, A.M. & RIBEIRO, J. A. (1998). Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors J. Neurosci., 18, 1987-1995.
96. CUNHA, R.A., CONSTANTINO,M.D. & RIBEIRO, J.A. (1997). ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. Br. J. Pharmacol., 122, 1279-1284.
95. GON?ALVES, M.L., CUNHA, R.A. & RIBEIRO, J. A. (1997). Adenosine A2A receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes. Neurosci. Letts, 238, 73-77.
94. de MENDON?A, A. & RIBEIRO, J. A. (1997). Contribution of metabotropic glutamate receptors to the depression of excitatory postsynaptic potentials during hypoxia. Neuroreport, 8, 3667-3671.
93. LOBO, M.G.B., OLIVEIRA, D. G., SEBASTI?O, A.M. & RIBEIRO, J.A. (1997). On the high affinity of 8-cyclohexylcaffeine for the presynaptic inhibitory adenosine receptor present in rat motor nerve terminals. Pharmacol. & Toxicol., 80, 295-300.
92. LORENZEN, A., SEBASTI?O, A.M., SELLINK; A., VOGT, H., SCHWABE, U., RIBEIRO, J. A. & IJZERMAN, A:P. (1997). Biological activities of N6, C8-disubstituted adenosine derivatives as partial agonists of rat brain adenosine A1 receptors. Eur. J. Pharmacol., 334, 299-307.
91. de MENDON?A, A. & RIBEIRO, J. A. (1997). Influence of metabotropic glutamate receptors agonists on the inhibitory effects of adenosine A1 receptor activation in the rat hippocampus. Br. J.. Pharmacol.,121, 1541-1548.
90. CUNHA, R.A., CONSTANTINO, M.D. & RIBEIRO, J.A. (1997). Inhibition of 3HGABA release by kainate receptor activation in rat hippocampal synaptosomes. Eur. J. Pharmacol., 323, 167-172.
89. de MENDON?A, A., ALMEIDA, T., BASHIR, Z.I. & RIBEIRO, J.A. (1997). Endogenous adenosine attenuates long term depression and depotentiation. Neuropharmacology, 62, 385-390.
88. de MENDON?A, A. & RIBEIRO, J.A. (1997). Adenosine and neuronal plasticity. Life Sci., 60, 245-251.
87. RIBEIRO, J.A., de MENDON?A, A. CORREIA-DE-S?, P., CUNHA, R. & SEBASTI?O, A.M. (1996). Purinoceptors aqnd synaptic plasticity. Drug Develop. Res., 39, 353-360.
86. HERN?NDEZ, J. & RIBEIRO, J.A. (1996). Excitatory actions of adenosine on ventricular automaticity. Trends in Pharmacol. Sci., 17, 141-144.
85. SEBASTI?O, A.M. & RIBEIRO, J.A. (1996). A2 receptor mediated excitatory actions of adenosine in the nervous system. Prog. Neurobiol., 48, 167-189.
84. AFONSO, F., SEBASTI?O, A.M., PINHO, M.S., FERNANDES, P., RIBEIRO, J.A., MATA, L.R. & GULBENKIAN, S. (1996). Calcitonin gene-related peptide in the hamster seminal vesicle and coagulating gland: An immunohistochemical, autoradiographical and pharmacological study. Peptides, 17, 1189-1195.
83. LUCCHI, R., LATINI, S., de MENDON?A, A., SEBASTI?O, A.M. & RIBEIRO, J.A. (1996). Adenosine by activating A1 receptors prevents GABAA -mediated actions during hypoxia in the rat hippocampus Brain Res., 732, 261-266.
82. CORREIA-DE-S?, P., TIM?TEO, M.A. & RIBEIRO, J.A. (1996). Presynaptic A1-inhibitory/A2a-facilitatory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragm. J. Neurophysiol., 76, 3910-3919.
81. CUNHA, R.A., VIZI, E.S., RIBEIRO, J.A. & SEBASTI?O, A.M. (1996). Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high but not low frequency stimulation of rat hippocampal slices. J. Neurochem., 67, 2180-2187.
80. RIBEIRO, J.A., CUNHA, R.A., CORREIA-DE-S?, P. & SEBASTI?O, A.M. (1996). Purinergic regulation of acetylcholine release. Prog. Brain Res., 109, 231-241.
79. CUNHA, R.A., CORREIA-DE-S?, P., SEBASTI?O, A.M. & RIBEIRO, J.A. (1996). Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides. Br. J. Pharmacol., 119, 253-260.
78. GON?ALVES, M.L. & RIBEIRO, J.A. (1996). Adenosine A2-receptors activation facilitate 45Ca2+ uptake by rat brain synaptosomes. Eur. J. Pharmacol., 310, 257-261.
77. CORREIA-DE-S?, P. & RIBEIRO, J.A. (1996). Adenosine uptake and deamination regulate A2a-receptor facilitation of evoked [3H]-ACh release from the rat motor nerve terminals. Neuroscience, 73, 85-92.
76. HERNANDEZ, J. & RIBEIRO, J.A. (1995). Adenosine and ventricular automaticity. Life Sci., 57, 1393-1399.
75. CUNHA, R.A., CONSTANTINO, M.D., SEBASTI?O, A.M. & RIBEIRO, J.A. (1995). Modification of A1 and A2a receptor binding in aged striatum, hippocampus and cortex of the rat. Neuroreport, 6, 1583-1588.
74. CUNHA; R.A., JOHANSSON, B., FREDHOLM, B.B., RIBEIRO, J.A. & SEBASTI?O, A.M. (1995). Adenosine A2a receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neurosci. Letts, 196, 41-44.
73. de MENDON?A, A., SEBASTI?O, A.M. and RIBEIRO, J.A. (1995). Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurons by adenosine A1 receptor activation. NeuroReport, 6, 1097-1100.
72. OLIVEIRA, J.C., CONSTANTINO, M.D., SEBASTI?O, A.M. & RIBEIRO, J.A. (1995). Ascorbate/Fe3+-induced peroxidation and inhibition of the binding of A1 adenosine receptor ligands in rat brain membranes. Neurochem. Int., 26, 263-268.
71. MALVA, J.O., AMBR?SIO, A.F., CUNHA, R.A., RIBEIRO, J.A., CARVALHO, A.P. & CARVALHO, C.M. (1995). A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion. Neurosci. Letts, 185, 83-86.
70. RIBEIRO, J.A. (1995). Purinergic inhibition of neurotransmitter release in the central nervous system. Pharmacol. & Toxicol., 77, 299-305.
69. HERNANDEZ, J., PINTO, F. & RIBEIRO, J.A. (1994). Involvent of -adrenoceptors in the excitatory effect of the A2 adenosine receptor agonist, 5?-N-ethylcarboxamide adenosine (NECA) on cardiac automaticity in the isolated right ventricles of the rat. Naunyn-Schmiedebergs Arch. Pharmacol., .350, 632-637.
68. CORREIA-DE-S?, P. & RIBEIRO, J.A. (1994). Tonic adenosine A2A receptors activation modulates nicotinic autoreceptors function at the rat neuromuscular junction. Eur. J. Pharmacol., 271, 349-355. .
67. CANH?O, P., de MENDON?A, A. & RIBEIRO, J.A. (1994). 1,3-dipropyl-8-cyclopentylxanthine attenuates the NMDA response to hypoxia in the rat hippocampus. Brain Res., 661, 265-273.
66. CORREIA-DE-S?, P. & RIBEIRO, J.A. (1994). Evidence that the presynaptic A2a-adenosine receptor of the rat motor nerve endings is positively coupled to adenylate cyclase. Naunyn-Schmiedebergs Arch. Pharmacol., 350, 514-522.
65. de MENDON?A, A. & RIBEIRO, J.A. (1994). Endogenous adenosine modulates long-term potentiation in the hippocampus. Neuroscience, 62, 385-390.
64. CUNHA, R.A., JOHANSSON, B., van der PLOEG, I., SEBASTI?O, A.M., RIBEIRO, J.A. & FREDHOLM, B.B. (1994). Evidence for functionally important adenosine A2a receptors in the rat hippocampus. Brain Res., 649, 208-216.
63. HERNANDEZ, J., PINTO, F., FIGUEIRA, M.A. & RIBEIRO, J.A. (1994). Evidence for a cooperation between A2 receptors and *1-adrenoceptors on cardiac automaticity in the isolated right ventricle of the rat. Br. J. Pharmacol., 111, 1316-1320.
62. CUNHA, R.A., MILUSHEVA, E., VIZI, E.S., RIBEIRO, J.A. & SEBASTI?O, A.M. (1994). Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically-evoked [3H]-acetylcholine release from different areas of the rat hippocampus. J. Neurochem., 63, 207-214.
61. PINHO, M.S., SEBASTI?O, A.M., RODRIGUES, G., BARROSO, C.P., RIBEIRO, J.A., MATA, L.R. & GULBENKIAN, S. (1994). Vasoactive intestinal peptide (VIP) in the hamster seminal vesicle: distribution, binding sites and possible functions. Neuroscience, 59, 1083-1091.
60. CORREIA-DE-S?, P. & RIBEIRO, J.A. (1994). Tonic A2a-adenosine receptor activation potentiates CGRP facilitation of [3H]acetylcholine release from rat motor nerve endings Br. J. Pharmacol., 111, 582-588.
59. CUNHA, R.A., RIBEIRO, J.A. & SEBASTI?O, A.M. (1994). Purinergic modulation of the evoked release of [3H]acetylcholine from the hippocampus and cerebral cortex of the rat: role of the ecto-nucleotidases. Eur. J. Neurosci., 6, 33-42.
58. DE MENDON?A, A. & RIBEIRO, J.A. (1993). Adenosine inhibits the NMDA receptor-mediated excitatory post-synaptic potential in the hippocampus. Brain Res., 606, 351-356.
57. CORREIA-DE-SA, P. & RIBEIRO, J.A. (1993). Facilitation of [3H]-ACh release by forskolin depends on A2 adenosine receptor activation. Neurosci. Letts, 151, 21-24.
56. OLIVEIRA, J.C., SEBASTI?O, A.M. & RIBEIRO, J.A. (1993). On the high affinity binding site for [3H]-1,3-dipropyl-8- cyclopentylxanthine in frog brain membranes. Br. J. Pharmacol., 109, 518-523.
55. CUNHA, R.A., SEBASTI?O, A.M. & RIBEIRO, J.A. (1992). Ecto-5- nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat. J. Neurochem., 59, 657-666.
54. SEBASTI?O, A.M. & RIBEIRO, J.A. (1992). Evidence for the presence of excitatory A2 adenosine receptors in the rat hippocampus. Neurosci. Letts, 138, 41-44.
53. LOBO, M.G.B. & RIBEIRO, J.A. (1992). Effects of forskolin, dibutyryl cyclic AMP, and 5-N-ethylcarboxamide adenosine on 22Na uptake by rat brain synaptosomes stimulated by veratridine. J. Neurochem., 58, 1033-1037.
52. MONTEIRO, E.C. & RIBEIRO, J.A. (1991). Adenosine and the bradycardic response to vagus nerve stimulation. Eur. J. Pharmacol., 204, 193-202.
51. OLIVEIRA, J.C., SEBASTI?O, A.M. & RIBEIRO, J.A. (1991). Solubilized rat brain adenosine receptors have two high affinity binding sites for 1,3,-dipropyl-8- cyclopentylxanthine. J. Neurochem., 57, 1165-1171.
50. CORREIA-DE-S?, P., SEBASTI?O, A.M. & RIBEIRO, J.A. (1991). Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat. Br. J. Pharmacol., 103, 1614-1620.
49. RIBEIRO, J.A. & MONTEIRO, E.C. (1991). On the adenosine receptor involved in the excitatory action of adenosine on respiration: antagonist profile. Nucleosides & Nucleotides, 10, 945-953.
48. GON?ALVES, M.L., PINTO, F. & RIBEIRO, J.A. (1991). Effect of adenosine on 45Ca uptake by rat brain synaptosomes ellectrically stimulated. J. Neurochem., 56, 1769-1773.
47. DE MENDON?A, A. & RIBEIRO, J.A. (1990). 2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat. Neurosci.Letts, 118, 107-111.
46. SEBASTI?O, A.M., STONE, T.W. & RIBEIRO, J.A. (1990). On the inhibitory adenosine receptor at the neuromuscular junction and hippocampus of the rat: antagonism by 1,3,8-substituted xanthines. Br.J.Pharmacol., 101, 453-459.
45. SEBASTI?O, A.M. & RIBEIRO, J.A. (1990). Interactions between adenosine and phorbol esters or lithium at the frog neuromuscular junction. Br.J.Pharmacol., 100, 55-62.
44. DELICADO, E.G., RODRIGUES, A., SEN, R.P., SEBASTI?O, A.M., RIBEIRO, J.A. & MIRAS-PORTUGAL, M.T. (1990). Effect of N- ethylcarboxamidoadenosine (NECA) on adenosine transport in cultured chromaffin cells. J.Neurochem., 54, 1941-1946.
43. CUNHA, R.A., SEBASTI?O, A.M. & RIBEIRO, J.A. (1989). Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography. Chromatographia, 28, 610-612.
42. MONTEIRO, E.C. & RIBEIRO, J.A. (1989). Inhibition by 1,3- dipropyl-8-(p-sulfophenyl)xanthine of the respiratory stimulation induced by common carotid occlusion in rats. Life Sci., 45, 939-945.
41. MONTEIRO, E.C. & RIBEIRO, J.A. (1989). Adenosine deaminase and adenosine uptake inhibitons facilitate ventilation in rats. Naunyn-Schmiedebergs Arch.Pharmacol., 340, 230-238.
40. DE MENDON?A, A. & RIBEIRO, J.A. (1989). Diazepam enhances the inhibitory action of adenosine on transmission at the frog neuromuscular junction. Eur.J.Pharmacol., 164, 347-354.
39. HERNANDEZ, J. LAORDEN, M.L., RUIZ, F. & RIBEIRO, J.A. (1989). Effects of adenosine and its analogues on ventricular automaticity induced by a local injury: role of catecholamines and of cyclic AMP. Arch.int.Pharmacodyn., 297, 49-59.
38. SEBASTI?O, A.M. & RIBEIRO, J.A. (1989). 1,3,8- and 1,3,7- substituted xanthines: relative potency as adenosine receptor antagonists at the frog neuromuscular junctions. Br.J.Pharmacol., 96, 211-219.
37. RUIZ, F., HERNANDEZ, J. & RIBEIRO, J.A. (1988). Theophylline antagonizes the effect of diazepam on ventricular automaticity. Eur.J.Pharmacol., 155, 205-209.
36. SEBASTI?O, A.M. & RIBEIRO, J.A. (1988). On the adenosine receptor and adenosine inactivation at the rat diaphragm neuromuscular junction. Br.J.Pharmacol., 94, 109-120.
35. SIM?ES, A.P., OLIVEIRA, P.C., SEBASTI?O, A.M. & RIBEIRO, J.A. (1988). N6-cyclohexyladenosine inhibits veratridine- stimulated 22Na uptake by rat brain synaptosomes. J.Neurochem., 50, 899-903.
34. GON?ALVES, M.L. & RIBEIRO, J.A. (1987). The effects of purines and forskolin on haemolysis. Fundamental and Clinical Pharmacology, 1, 169-178.
33. MONTEIRO, E.C. & RIBEIRO, J.A. (1987). Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat. Naunyn Schmiedebergs Arch.Pharmacol., 335, 143-148.
32. RIBEIRO, J.A. & SEBASTI?O, A.M. (1987). On the role, inactivation and origin of endogenous adenosine at the frog neuromuscular junction. J.Physiol.Lond., 384, 571-585.
31. MCQUEEN, D.S. & RIBEIRO, J.A. (1986). Pharmacological characterization of the receptor involved in the chemoexcitation induced by adenosine. Br.J.Pharmacol., 88, 615-620.
30. LAORDEN, M.L., HERNANDEZ, J. & RIBEIRO, J.A. (1986). The effects of adenosine, ATP and ADP on ventricular automaticity induced by a local injury in the isolated right ventricle of the rat. Arch.int.Pharmacodyn., 279, 258-267.
29. RIBEIRO, J.A. & SEBASTI?O, A.M. (1986). Adenosine receptors and calcium: basis for proposing a third (A3) adenosine receptor. Prog.Neurobiol., 26, 179-209.
28. SEBASTI?O, A.M. & RIBEIRO, J.A. (1985). Enhancement of transmission at the frog neuromuscular junction by adenosine deaminase: evidence for an inhibitory role of endogenous adenosine on neuromuscular transmission. Neurosci.Letts., 62, 267-270.
27. FIGUEIRA, M.A. & RIBEIRO, J.A. (1985). Separation by thin layer chromatography of adenosine and its derivatives using silica gel. J.Chromatography, 325, 317-322.
26. RIBEIRO, J.A. & SEBASTI?O, A.M. (1985). Inhibitory effects of forskolin and papaverine on nerve conduction partially blocked by tetrodotoxin in the frog sciatic nerve. Br.J.Pharmacol., 85, 309-313.
25. RIBEIRO, J.A. & LIMA, M.S. (1985). The hypotensive effect of intracarotid injections of adenosine triphosphate depends on its hydrolysis to adenosine. Pharmacol.Res.Com., 17, 255-260.
24. RIBEIRO, J.A. & SEBASTI?O, A.M. (1985). On the type of receptor involved in the inhibitory action of adenosine at the neuromuscular junction. Br.J.Pharmacol., 84, 911-918.
23. RIBEIRO, J.A. & SEBASTI?O, A.M. (1984). Enhancement of tetrodotoxin-induced axonal blockade by adenosine, adenosine analogues, dibutyryl cyclic AMP and methylxanthines in the frog sciatic nerve. Br.J.Pharmacol., 83, 485-492.
22. RIBEIRO, J.A. & SA-ALMEIDA, A.M. (1984). Excitatory effects of dibutyryl cyclic AMP, noradrenaline and theophylline on 45Ca uptake by synaptosomes from rat brain. Arch.int.Pharmacodyn., 270, 215-321.
21. RIBEIRO, J.A. & SEBASTI?O, A.M. (1984). Antagonism of tetrodotoxin- and procaine-induced axonal blockade by adenine nucleotides in the frog sciatic nerve. Br.J.Pharmacol., 81, 277-282.
20. RIBEIRO, J.A. (1984). A ac??o excitat?ria do ATP na actividade quimio receptora do corpo carot?deo depende da sua hidr?lise pr?via em adenosina. J. Fisiol.Biof., 3, 35- 44.
19. McQUEEN, D.S. & RIBEIRO, J.A. (1983). On the specificity and type of receptor involved in carotid body chemoreceptor activation by adenosine. Br.J.Pharmacol., 80, 347-354.
18. McQUEEN, D.S. & RIBEIRO, J.A. (1983). Effects of ouabain on carotid body chemoreceptor activity in the cat. J.Physiol.Lond., 335, 221-235.
17. RIBEIRO, J.A. (1982). The decrease on neuromuscular transmission by adenosine depends on previous neuromuscular depression. Arch.int.Pharmacodyn., 255, 59-67.
16. McQUEEN, D.S. & RIBEIRO, J.A. (1981). Effect of adenosine on carotid body chemoreceptor activity in the cat. Br.J.Pharmacol., 74, 129-136.
15. RIBEIRO, J.A. (1981). The modulation of transmission by purinergic substances at the neuromuscular junction. Ann.N.Y.Acad.Sci., 377, 874-876.
14. RIBEIRO, J.A., DOMINGUEZ, M.L., SA-ALMEIDA, A.M. & GON?ALVES, M.J. (1981). The effects of imidazole on neuromuscular transmission and on synaptosomal calcium uptake in the rat. Arch.int.Pharmacodyn., 251, 260-284.
13. McQUEEN, D.S. & RIBEIRO, J.A. (1981). Effects of ?-endorphin, vasoactive intestinal polypeptide and cholecystokinin octapeptide on cat carotid body chemoreceptor activity. Quarterly J.exp.Physiol., 66, 273-284.
12. McQUEEN, D.S. & RIBEIRO, J.A. (1980). Inhibitory actions of methionine-enkephalin and morphine on the cat carotid body chemoreceptors. Br.J.Pharmacol., 71, 297-305.
11. PERES-GOMES, F. & RIBEIRO, J.A. (1979). Modification of the cardiotoxic effects of ouabain by acepromazine, tetrodotoxin and magnesium sulphate. Pharmacology, 18, 80-90.
10. RIBEIRO, J.A. (1979). Purinergic modulation of transmitter release. J.Theor.Biol., 80, 259-270.
9. RIBEIRO, J.A., SA-ALMEIDA, A.M. & NAMORADO, J.M. (1979). Adenosine and adenosine triphosphate decrease 45Ca uptake by synaptosomes stimulated by potassium. Biochem.Pharmacol., 28, 1297-1300.
8. RIBEIRO, J.A., DOMINGUEZ, M.L. & GON?ALVES, M.J. (1979). Purine effects at the neuromuscular junction and their modification by theophylline, imidazole and verapamil. Arch.int.Pharmacodyn., 238, 206-219.
7. RIBEIRO, J.A. (1978). ATP, related nucleotides and adenosine on neurotransmission. Life Sci., 22, 1373-1380.
6. RIBEIRO, J.A. & DOMINGUEZ, M.L. (1978). Mechanisms of depression of neuromuscular transmission by ATP and adenosine. J.Physiol.Paris, 74, 491-496.
5. RIBEIRO, J.A. & PERES-GOMES, F. (1977). Acetylcholine release in cerebrospinal fluid by ouabain. Neuropharmacology, 16, 695-698.
4. RIBEIRO, J.A. (1976). Effects of ouabain on arterial pressure and its modification by tetrodotoxin. J.Pharmac.Pharmacol., 28, 847-848.
3. RIBEIRO, J.A. & WALKER, J. (1975). The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions. Br.J.Pharmacol., 54, 213-218.
2. RIBEIRO, J.A. & WALKER, J. (1973). Action of adenosine triphosphate on endplate potentials recorded from muscle fibres of the rat-diaphragm and frog sartorius. Br.J.Pharmacol., 49, 724-725.
1. RIBEIRO, J.A. (1973). Ac??es cardiovasculares da uba?na mediadas pelo sistema
nervoso central. J.Soc. Ci?ncias M?d, Lisboa, 137, 319-344.


Letters to the editor (refereed):

3. RIBEIRO, J.A. & SEBASTI?O, A.M. (1994). Further evidence for adenosine A3 receptors. Trends in Pharmacol.Sci., 15, 13.
2. RIBEIRO, J.A. & SEBASTI?O, A.M. (1988). Is inhibition of neurotransmitter release mediated by A3 receptors? Subtypes of adenosine receptors. Trends in Pharmacol.Sci., 9, 279-280.
1. RIBEIRO, J.A. (1977). Potentiation of post-junctional cholinergic sensitivity of rat diaphragm muscle by high- energy phosphate adenine nucleotides. J. Membrane Biol., 33, 401-402.

Chapters in books:

32. RIBEIRO, J.A. (2008). Como a Uba?na uniu o Grupo do Professor Fernando Peres Gomes no Instituto Gulbenkian De Ciencia: Um tributo ? Professora Tice Anast?cio de Macedo. Pp 75-86. Coimbra
31 RIBEIRO, J.A. (2004). The Role of Adenosine as a Mediator of Cerebral Circulationl. In: Circulation, ed., M.V. Alves and A. Barbosa, pp 130-137. Museu de Medicina, Faculdade de Medicina de Lisboa.
30. RIBEIRO, A. (2004). General aspects of neuropharmacology in relation to brain repair following trauma. In: Brain Damage and Repair, Ed.T. Herdegen and J.M. Delgado-Garcia, pp 423-437. Kluwer Academic Publishers, The Netherlands.
29. de MENDON?A, A & RIBEIRO, J.A. (2001). Adenosine and neuroprotection. Arq. Port. Oftalmol.
28. RIBEIRO, J.A. (2000). Psicofarmacologia na disfun??o sexual:introdu??o. In: Sexualidade, pp. 129-131, Edit. A.Barbosa e J. Gomes-Pedro, Dep. Educa??o M?dica, FML, Lisboa
27. SEBASTI?O, A.M. e RIBEIRO, J.A. (2001). Sistema Purin?rgico In: Terap?utica Medicamentosa e suas Bases Farmacol?gicas, ed., W. Osswald and S. Guimar?es, pp 440-451. Porto Editora, Porto.
26. RIBEIRO, J.A. (2001). Estimulantes do Sistema Nervoso Central. Antagonistas dos receptores da adenosina: Alquilxantinas In: Terap?utica Medicamentosa e suas Bases Farmacol?gicas, ed., W. Osswald and S. Guimar?es, pp 139-146, Porto Editora, Porto.
25. LOPES, L:V., CUNHA, R. A. & RIBEIRO, J.A. (1999) Interaction between adenosine A1 and A2A receptors in the control of neurotransmitter release. In: Recent Research Developments in Neurochemistry, vol 2, part II, ed. S.J. Pandalai, Research Signpost, Trivandrum, 463-472.
24. SEBASTI?O, A.M., LUCCHI, R., LATINI, S., DE MENDON?A, A. & RIBEIRO, J.A. (1997). Functional negative interaction between adenosine (A1) and GABA (GABA A) during hypoxia in the rat hippocampus. In: The Role of Adenosine in the Nervous System, ed. Y. Okada, pp.177-184, Elsevier Science B.V., Amsterdam
23. DE MENDON?A, A. & RIBEIRO, J.A. (1997). Endogenous adenosine attenuates long-term depression in the hippocampus. In: The Role of Adenosine in the Nervous System, ed. Y. Okada, pp.121-125, Elsevier Science B.V., Amsterdam.
22. CORREIA-DE-S?, P., TIM?TEO, M.A. & RIBEIRO, J.A. (1997. Adenosine plays a key role on neuromuscular transmission to adjust the modulatory pattern (cholinergic vs peptidergic) to the conditions of motor nerve stimulation. In: The Role of Adenosine in the Nervous System, ed. Y. Okada, pp. 79-87, Elsevier Science B.V., Amsterdam.
21. RIBEIRO, J.A., CORREIA-DE-S?, P. CUNHA, R.A. & SEBASTI?O, A.M. (1997). Adenosine and neurotransmitter release: inhibition and facilitation. In: The Role of Adenosine in the Nervous System, ed. Y. Okada, pp. 13-24, Elsevier Science B.V., Amsterdam.
20. RIBEIRO, J.A. (1996). Novas Tend?ncias da Farmacologia. In: Livro do
Centen?rio do Servi?o de Oftalmologia do Hospital de Santo Ant?nio, Porto
19. LACKOVIC & RIBEIRO, J.A. (1996). CNS regulation of the autonomic nervous system. In report on Neurosciences Research in Europe.
18. WHITE, T.D., RIBEIRO, J.A., EDWARDS, F.A., FREDHOLM, B.B. & PHILLIS, J.W. (1995). Role of purines in the central nervous system. In: Pharmacological Sciences: Perspectives for Research and Therapy in the late 1990s, ed. A.C. Cuello and B. Collier, pp.295-302, Birkhauser Verlag, Basel.
17. SEBASTI?O, A.M., CUNHA, R.A., CORREIA-DE-S?, P., de MENDON?A, A. & RIBEIRO, J.A. (1995). Role of A2a receptors in the hippocampus and motor nerve endings. In: Adenosine and Adenine Nucleotides: from molecular Biology to Integrative Physiology, ed. L. Belardinelli and A. Pelleg, pp.251-261,Kluwer Academic Publishers , Boston.
16. RIBEIRO, J.A. (1994). Purinas In: Terap?utica Medicamentosa e suas Bases Farmacol?gicas, ed. J. Garrett, W. Osswald and S. Guimar?es, vol. I, pp. 452-460, Porto Editora, Porto.
15. RIBEIRO, J.A. (1994). Alquilxantinas. In: Terap?utica Medicamentosa e suas Bases Farmacol?gicas, ed. J. Garrett, W. Osswald and S. Guimar?es, vol. I, pp. 156-164, Porto Editora, Porto.
14. RIBEIRO, J.A. & SEBASTI?O, A.M. (1991). Purinergic modulation of neurotransmitter release in the peripheral and central nervous systems. In: Presynaptic Regulation of Neurotransmitter Release: A Handbook, ed. J. Feigenbaum and M. Hanani, vol. I, pp.451-495, Freund Publishing House, Ltd, London.
13. RIBEIRO, J.A. (1991). Adenosine and the central nervous system control of autonomic function. In: Adenosine in the Nervous system, ed. T.W. Stone, Chapter 11, pp. 229-246, Academic Press, London.
12. RIBEIRO, J.A. (1991). Purinergic regulation of transmitter release. In: Adenosine and Adenine nucleotides as regulators of Cellular Function, ed. J.W. Phillis, Chapter 12, pp.155- 167, CRC Press inc., New York.
11. RIBEIRO, J.A., CORREIA-DE-S?, P., CUNHA, R.A., OLIVEIRA, J.C. & SEBASTI?O, A.M. (1991). Role of adenosine at the neuromuscular junction: effects mediated by presynaptic inhibitory and excitatory receptors. In: Role of Adenosine and Adenine Nucleotides in the Biological System, ed. S. Imai and M. Nakazawa, pp.691-702, Elsevier Sci. Publ., Amesterdam.
10. MONTEIRO, E.C. & RIBEIRO, J.A. (1990). Respiratory responses to common carotid occlusion in the rat: Evidence for involvement of adenosine. In Chemoreceptors and chemoreceptor reflexes, ed. H. Acker, A. Trzebski and R.G. ORegan, pp. 49- 56, Plenum Press, New York.
9. MONTEIRO, E.C. & RIBEIRO, J.A. (1990). Endogenous adenosine tonically excites respiration mediated by carotid body chemoreceptors in the rat. In: Arterial Chemoreception, ed. C. Eyzaguirre, S.J. Fidone, R.S. Fitzgerald, S. Lahiri and D.M. McDonald, pp. 174-180, Springer-Verlag, New York.
8. RIBEIRO, J.A. & SEBASTI?O, A.M. (1990). Adenosine receptors mediating inhibition of peripheral and central neurons. In: Purines in Cellular Signalling: Targets for New Drugs, ed. K.A. Jacobson, J.W. Daly and V. Manganiello, pp.166-173, Springer Verlag, New York.
7. RIBEIRO, J.A. & SEBASTI?O, A.M. (1989). Characterization of the adenosine receptor that mediates inhibition of transmitter release at the frog neuromuscular junction. In:Adenosine Receptors in the Nervous System, ed. J.A. Ribeiro, pp. 69-77, Taylor & Francis, London.
6. RIBEIRO, J.A., MONTEIRO, E.C. & McQUEEN, D.S. (1988). The actions of adenosine on respiration. In: Adenosine and Adenine Nucleotides. Physiology and Pharmacology, ed. D.M. Paton, pp.225-232, Taylor & Francis, London.
5. RIBEIRO, J.A. & SEBASTI?O, A.M. (1987). Adenosine, cyclic AMP and nerve conduction. In: Topics and Perspectives in Adenosine Research, eds. E. Gerlach and B.F. Becker, pp. 559- 573, Springer-Verlag, Berlin.
4. RIBEIRO, J.A. & McQUEEN, D.S. (1987). Chemoexcitation evoked by adenosine: pharmacological characterization of the receptor. In: Chemoreceptors in Respiratory Control, eds J.A. Ribeiro and D.J. Pallot, pp. 305-313, Croom Helm, London.
3. MONTEIRO, E.C. & RIBEIRO, J.A. (1987). Adenosine modulation of respiration mediated by carotid body chemoreceptors. In: Chemoreceptors in Respiratory Control, eds J.A. Ribeiro and D.J. Pallot, pp. 314-321, Croom Helm, London.
2. RIBEIRO, J.A. & McQUEEN, D.S. (1984). Effects of purines on carotid body chemoreceptors. In: The peripheral chemoreceptors, ed. D.J. Pallot, pp.383-390, Croom Helm, London.
1. RIBEIRO, J.A. & McQUEEN, D.S. (1983). On the neuromuscular depression and carotid body chemoreceptor activation caused by adenosine. In. Physiology and Pharmacology of Adenosine Derivatives, eds J.W. Daly, Y. Kuroda, J.W. Phillis, H. Shimizu & M. Ui., pp. 179-188. Raven Press, New York.


Edition of books:

2. Adenosine Receptors in the Nervous System, ed. J.A. Ribeiro, Taylor & Francis, London, 1989.
1. Chemoreceptors in Respiratory Control, ed. J.A. Ribeiro and D.J. Pallot, Croom Helm, London, 1987.

Publications

  1. pmc Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of Δ9-tetrahydrocannabinol on spatial memory
    Vasco C Sousa
    Faculty of Medicine, Institute of Pharmacology and Neurosciences, University of Lisbon, Lisbon, Portugal
    Neuropsychopharmacology 36:472-87. 2011
  2. ncbi request reprint VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors
    Diana Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Brain Res 1049:52-60. 2005
  3. ncbi request reprint Long-term depression is not modulated by ATP receptors in the rat CA1 hippocampal region
    Bruno M da Silva
    Laboratory of Neurosciences, Institute of Molecular Medicine and Faculty of Medicine of Lisbon, Lisbon, Portugal
    Neurosci Lett 383:345-9. 2005
  4. ncbi request reprint Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus
    António Pinto-Duarte
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
    J Neurochem 93:595-604. 2005
  5. pmc VIP enhances both pre- and postsynaptic GABAergic transmission to hippocampal interneurones leading to increased excitatory synaptic transmission to CA1 pyramidal cells
    Diana Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Institute of Molecular Medicine University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Br J Pharmacol 143:733-44. 2004
  6. ncbi request reprint Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms
    Nuno Canas
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, Lisbon 1649 028, Portugal
    Brain Res 1016:72-8. 2004
  7. ncbi request reprint Neuronal P2 receptors of the central nervous system
    Peter Illes
    Rudolf Boehm Institute of Pharmacology, University of Leipzig, Leipzig, Germany
    Curr Top Med Chem 4:831-8. 2004
  8. ncbi request reprint Molecular physiology of P2 receptors in the central nervous system
    Peter Illes
    Rudolf Boehm Institute of Pharmacology, University of Leipzig, Haertelstrasse 16 18, 04107 Leipzig, Germany
    Eur J Pharmacol 483:5-17. 2004
  9. ncbi request reprint Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid
    Rodrigo A Cunha
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 44:371-9. 2004
  10. ncbi request reprint Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices
    T Almeida
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, University of Coimbra, Coimbra, Portugal
    Neuroscience 122:111-21. 2003

Collaborators

Detail Information

Publications68

  1. pmc Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of Δ9-tetrahydrocannabinol on spatial memory
    Vasco C Sousa
    Faculty of Medicine, Institute of Pharmacology and Neurosciences, University of Lisbon, Lisbon, Portugal
    Neuropsychopharmacology 36:472-87. 2011
    ....
  2. ncbi request reprint VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors
    Diana Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Brain Res 1049:52-60. 2005
    ..VPAC1-mediated actions are dependent on PKC activity, and VPAC2-mediated actions are responsible for the PKA-dependent actions of VIP on CA1 hippocampal transmission...
  3. ncbi request reprint Long-term depression is not modulated by ATP receptors in the rat CA1 hippocampal region
    Bruno M da Silva
    Laboratory of Neurosciences, Institute of Molecular Medicine and Faculty of Medicine of Lisbon, Lisbon, Portugal
    Neurosci Lett 383:345-9. 2005
    ..6+/-5.2% for aCSF and of 18.7+/-5.2% for NF023). The present results suggest that ATP does not modulate activity-dependent homosynaptic LTD in the rat CA1 hippocampal region by activating P2 receptors...
  4. ncbi request reprint Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus
    António Pinto-Duarte
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
    J Neurochem 93:595-604. 2005
    ..These results indicate that A2A receptor activation facilitates the activity of nucleoside transporters, which have a preponderant role in modulating the extracellular adenosine levels available to activate A1 receptors...
  5. pmc VIP enhances both pre- and postsynaptic GABAergic transmission to hippocampal interneurones leading to increased excitatory synaptic transmission to CA1 pyramidal cells
    Diana Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Institute of Molecular Medicine University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Br J Pharmacol 143:733-44. 2004
    ..In conclusion, concerted pre- and postsynaptic actions of VIP lead to disinhibition of pyramidal cell dendrites causing an enhancement of synaptic transmission...
  6. ncbi request reprint Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms
    Nuno Canas
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, Lisbon 1649 028, Portugal
    Brain Res 1016:72-8. 2004
    ..It is concluded that BDNF influences in an opposite way, through distinct mechanisms, the release of glutamate and the release of GABA from hippocampal synaptosomes...
  7. ncbi request reprint Neuronal P2 receptors of the central nervous system
    Peter Illes
    Rudolf Boehm Institute of Pharmacology, University of Leipzig, Leipzig, Germany
    Curr Top Med Chem 4:831-8. 2004
    ..Finally, the enzymatic degradation of ATP may lead to the local generation of adenosine which can modulate ATP-related neurotransmission via activation of A(1) or A(2A) receptors...
  8. ncbi request reprint Molecular physiology of P2 receptors in the central nervous system
    Peter Illes
    Rudolf Boehm Institute of Pharmacology, University of Leipzig, Haertelstrasse 16 18, 04107 Leipzig, Germany
    Eur J Pharmacol 483:5-17. 2004
    ..Finally, the enzymatic degradation of ATP may lead to the local generation of adenosine which can modulate via A(1) or A(2A) receptor-activation the ATP effect...
  9. ncbi request reprint Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid
    Rodrigo A Cunha
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 44:371-9. 2004
    ..These results indicate that AA directly inhibits presynaptic kainate receptor controlling glutamate release in the CA1 area of the rat hippocampus...
  10. ncbi request reprint Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices
    T Almeida
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, University of Coimbra, Coimbra, Portugal
    Neuroscience 122:111-21. 2003
    ..These results suggest that ATP analogues facilitate LTP through P2 receptor activation that mainly triggers adenosine release leading to the activation of adenosine A(2A) receptors...
  11. ncbi request reprint Endogenous adenosine modulation of 22Na uptake by rat brain synaptosomes
    Joaquim Alexandre Ribeiro
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Portugal
    Neurochem Res 28:1591-5. 2003
    ..It is suggested that adenosine is tonically inhibiting sodium uptake by rat brain synaptosomes...
  12. ncbi request reprint Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats
    Nelson Rebola
    Center for Neurosciences of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Portugal
    J Neurophysiol 90:1295-303. 2003
    ....
  13. ncbi request reprint Participation of adenosine receptors in neuroprotection
    J A Ribeiro
    Neurosciences Laboratory, Faculty of Medicine, University of Lisbon, Portugal
    Drug News Perspect 16:80-6. 2003
    ..The therapeutic implications for neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy and multiple sclerosis are discussed...
  14. pmc Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings
    M Teresa Magalhães-Cardoso
    Laboratório de Farmacologia UMIB, Instituto de Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Portugal
    J Physiol 549:399-408. 2003
    ....
  15. ncbi request reprint Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus
    J E Coelho
    Laboratory of Neurosciences, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, 1649 028 Lisboa, Portugal
    Neuroscience 138:1195-203. 2006
    ....
  16. ncbi request reprint Triggering of BDNF facilitatory action on neuromuscular transmission by adenosine A2A receptors
    Paula A Pousinha
    Instituto de Farmacologia e Neurociências, Faculdade de Medicina e Instituto de Medicina Molecular, Universidade de Lisboa, Portugal
    Neurosci Lett 404:143-7. 2006
    ....
  17. ncbi request reprint VPAC2 receptor activation mediates VIP enhancement of population spikes in the CA1 area of the hippocampus
    Diana Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Ann N Y Acad Sci 1070:210-4. 2006
    ..In conclusion, VPAC2 receptor activation mediates VIP enhancement of PS amplitude in the hippocampus essentially through a PKA-dependent mechanism...
  18. doi request reprint Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation
    Natália Assaife-Lopes
    Institute of Pharmacology and Neuroscience, Faculty of Medicine, University of Lisbon, 1649 028 Lisbon, Portugal
    J Neurosci 30:8468-80. 2010
    ....
  19. doi request reprint Modulation and metamodulation of synapses by adenosine
    J A Ribeiro
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
    Acta Physiol (Oxf) 199:161-9. 2010
    ..Most of these interactions occur through A2A receptors, which in spite of their low density in some brain areas, such as the hippocampus, may function as amplifiers of the signalling of other mediators at synapses...
  20. doi request reprint Caffeine and adenosine
    Joaquim A Ribeiro
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
    J Alzheimers Dis 20:S3-15. 2010
    ..In conclusion, targeting approaches that involve ARs will enhance the possibilities to correct brain dysfunctions, via the universally consumed substance that is caffeine...
  21. doi request reprint Predominance of adenosine excitatory over inhibitory effects on transmission at the neuromuscular junction of infant rats
    Paula A Pousinha
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    J Pharmacol Exp Ther 332:153-63. 2010
    ....
  22. doi request reprint Cannabinoid CB(1) and adenosine A(1) receptors independently inhibit hippocampal synaptic transmission
    André Serpa
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisboa, Portugal
    Eur J Pharmacol 623:41-6. 2009
    ....
  23. pmc Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection
    Ana M Sebastião
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Br J Pharmacol 158:15-22. 2009
    ..The growing evidence that tonic adenosine A2A receptor activity is a crucial step to allow actions of neurotrophic factors in neurones will be reviewed and discussed in the light of therapeutic strategies for neurodegenerative diseases...
  24. doi request reprint Adenosine A(2A) receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
    Bruno M Fontinha
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
    Neuropsychopharmacology 34:1865-74. 2009
    ..In conclusion, the endogenous activation of adenosine A(2A) receptors plays a pivotal effect on the associative learning process and its relevant hippocampal circuits, including activity-dependent changes at the CA3-CA1 synapse...
  25. doi request reprint Brain-derived neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminals
    Sandra H Vaz
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, and Unit of Neuroscience, Institute of Molecular Medicine, University of Lisbon, Portugal
    Brain Res 1219:19-25. 2008
    ..It is concluded that BDNF, through TrkB and PLCgamma signalling inhibits GAT-1-mediated GABA transport by nerve endings and that this action is not dependent on, but can be enhanced by, TrkB/A(2A) receptor cross talk...
  26. doi request reprint Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons
    Catarina C Fernandes
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, 1649 028 Lisbon, Portugal
    J Neurosci 28:5611-8. 2008
    ..The present findings disclose a novel target for rapid actions of BDNF that might play important roles on synaptic transmission and plasticity in the brain...
  27. ncbi request reprint A1 and A2A receptor activation by endogenous adenosine is required for VIP enhancement of K+ -evoked [3H]-GABA release from rat hippocampal nerve terminals
    Diana Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Avenida Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Neurosci Lett 430:207-12. 2008
    ....
  28. ncbi request reprint Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection
    Knut Biber
    Department of Medical Physiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Neuropsychopharmacology 33:2237-50. 2008
    ..Taken together, these results suggest that IL-6 minimizes the consequences of excitotoxic episodes on brain function through the enhancement of endogenous adenosinergic signaling...
  29. ncbi request reprint Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
    Cesar Quiroz
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:10808-12. 2006
    ..The results indicate that A2A receptors strongly modulate the efficacy of glutamatergic synapses on striatal enkephalinergic neurons...
  30. ncbi request reprint Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus
    D Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Neuropharmacology 52:313-20. 2007
    ..This differential sensitivity to adenosine modulation might be due to the different VIP circuits contributing to VIP effects on pyramidal cell dendrites and pyramidal cell bodies...
  31. ncbi request reprint Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices
    Claudia G Almeida
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, Avenue Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Neurosci Lett 339:127-30. 2003
    ..7+/-5.8% of control (n=5). The blockade of A(2A) receptors was devoid of effect (n=4). Adenosine is released by ROS-generating systems, and attenuates the deleterious cellular consequences of ROS through A(1) receptor activation...
  32. ncbi request reprint Adenosine receptors in the nervous system: pathophysiological implications
    J A Ribeiro
    Laboratory of Neurosciences, Faculty of Medicine, Institute for Molecular Medicine, University of Lisbon, Lisbon, Portugal
    Prog Neurobiol 68:377-92. 2002
    ..Whenever this homeostasis is disrupted, pathology may be installed and selective receptor antagonism or agonism required...
  33. ncbi request reprint Pertussis toxin-sensitive G proteins mediate the inhibition of basal phosphoinositide metabolism caused by adenosine A1 receptors in rat hippocampal slices
    José F Cascalheira
    Laboratory of Biochemistry, Department of Chemistry, University Beira Interior, 6200 Covilhã, Portugal
    Neurochem Res 27:1707-11. 2002
    ..It is concluded that the inhibition of the basal phosphatidylinositol metabolism by adenosine A1 receptor activation is independent of neurotransmission and involves a PTX-sensitive G protein, probably of the Gi/Go family...
  34. ncbi request reprint Purinergic modulation of [(3)H]GABA release from rat hippocampal nerve terminals
    R A Cunha
    University of Lisbon, Faculty of Medicine, Laboratory of Neurosciences, Av Prof Egas Moniz, 1649 028, Lisbon, Portugal
    Neuropharmacology 39:1156-67. 2000
    ..Thus, the adenosine A(2A) receptor system appears to be one of the first presynaptic neuromodulatory systems able to enhance the evoked release of GABA from hippocampal nerve terminals...
  35. ncbi request reprint Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [(3)H]GABA release
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028, Lisbon, Portugal
    FEBS Lett 469:159-62. 2000
    ..Thus, domoate inhibition of GABA release recruits G(i)/G(o) proteins and a protein kinase C pathway...
  36. pmc Tonic activation of A(2A) adenosine receptors unmasks, and of A(1) receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus
    A M Sebastiao
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Br J Pharmacol 129:374-80. 2000
    ....
  37. ncbi request reprint Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve terminals of different areas of the rat hippocampus
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Portugal
    J Neurochem 74:334-8. 2000
    ..Taken together, these results suggest that immunological isoforms of ecto-5'-nucleotidase exist in the rat hippocampal nerve terminals, with predominance in the CA3 area...
  38. ncbi request reprint ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A(1) receptor responses
    L V Lopes
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, 1649 028, Lisbon, Portugal
    Eur J Pharmacol 383:395-8. 1999
    ..8 to 1.9 microM. These results question the usefulness of ZM 241385 to define adenosine A(2A) receptors actions in functional studies...
  39. ncbi request reprint Adenosine A2A receptor interactions with receptors for other neurotransmitters and neuromodulators
    J A Ribeiro
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Portugal
    Eur J Pharmacol 375:101-13. 1999
    ....
  40. ncbi request reprint Fine-tuning neuromodulation by adenosine
    A M Sebastiao
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Trends Pharmacol Sci 21:341-6. 2000
    ....
  41. ncbi request reprint G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Portugal
    Naunyn Schmiedebergs Arch Pharmacol 359:295-302. 1999
    ..These results indicate that CGS 21680 does not bind to A1 receptors and that limbic CGS 21680 binding sites differ from striatal-like A2A receptors since they couple to G(i)/G(o) proteins, as well as to G(s) proteins...
  42. ncbi request reprint Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, Department of Chemistry and Biochemistry, University of Lisbon, Lisboa, Portugal
    Eur J Neurosci 11:2171-4. 1999
    ..Thus, AA can no longer be considered solely a facilitatory neuromodulator in the hippocampus, as this AA-facilitation of the release of the main inhibitory neurotransmitter may predominate under certain circumstances...
  43. ncbi request reprint Facilitation of [3H]-ACh release by forskolin depends on A2-adenosine receptor activation
    P Correia-de-Sá
    Laboratory of Pharmacology, ICBAS, University of Oporto, Portugal
    Neurosci Lett 151:21-4. 1993
    ..It is concluded that the excitatory effect of FSK on evoked [3H]-ACh release depends on tonic A2-adenosine receptor activation...
  44. pmc On the high affinity binding site for [3H]-1,3-dipropyl-8-cyclopentylxanthine in frog brain membranes
    J C Oliveira
    Laboratory of Pharmacology, Gulbenkian Institute of Science, Oeiras, Portugal
    Br J Pharmacol 109:518-23. 1993
    ..6. The present results suggest that the adenosine binding site in the frog brain membranes is G-protein coupled, but that the antagonist affinities and the pharmacological profile is different from the Al or A2 adenosine receptors...
  45. ncbi request reprint Ascorbate/Fe(3+)-induced peroxidation and inhibition of the binding of A1 adenosine receptor ligands in rat brain membranes
    J C Oliveira
    Laboratory of Pharmacology, Gulbenkian Institute of Science, Oeiras, Portugal
    Neurochem Int 26:263-8. 1995
    ..The results suggest that when brain membranes suffer free radical oxidative damage, the adenosine modulation of neuronal activity through A1 receptors could be less efficient...
  46. ncbi request reprint N6-cyclohexyladenosine inhibits veratridine-stimulated 22Na uptake by rat brain synaptosomes
    A P Simões
    Laboratory of Pharmacology, Gulbenkian Institute of Science, Oeiras, Portugal
    J Neurochem 50:899-903. 1988
    ..The possibility that the adenosine analogue, by activating a xanthine-sensitive adenosine receptor, can operate inhibition of the voltage-dependent sodium channels is discussed...
  47. ncbi request reprint Solubilized rat brain adenosine receptors have two high-affinity binding sites for 1,3-dipropyl-8-cyclopentylxanthine
    J C Oliveira
    Laboratory of Pharmacology, Gulbenkian Institute of Science, Oeiras, Portugal
    J Neurochem 57:1165-71. 1991
    ....
  48. ncbi request reprint Adenosine A2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028, Lisboa, Portugal
    Neurosci Lett 289:127-30. 2000
    ..These results indicate that adenosine A(2A) receptor facilitation of hippocampal synaptic transmission involves protein kinase C rather than protein kinase A activation...
  49. ncbi request reprint Persistence of the neuromodulatory effects of adenosine on synaptic transmission after long-term potentiation and long-term depression
    Alexandre de Mendonca
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Brain Res 932:56-60. 2002
    ..7 (1.4-2.0) microM, n=6). In conclusion, the neuromodulatory action of adenosine seems to be maintained in the presence of substantial variations in long-term synaptic efficiency during LTP or LTD...
  50. ncbi request reprint Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Portugal
    J Neurochem 76:372-82. 2001
    ....
  51. ncbi request reprint ATP as a presynaptic modulator
    R A Cunha
    Department of Chemistry and Biochemistry, Faculty of Sciences, Lisbon, Portugal
    Life Sci 68:119-37. 2000
    ..We now review evidence to suggest that ATP may also act presynaptically rather than solely postsynaptically in the nervous system...
  52. ncbi request reprint Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition
    L V Lopes
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Neuroscience 112:319-29. 2002
    ..This might be a fine-tuning role for adenosine A(2A) receptors to allow frequency-dependent plasticity phenomena without compromising the A(1) receptor-mediated neuroprotective role of adenosine...
  53. ncbi request reprint Influence of stimulation on Ca(2+) recruitment triggering [3H]acetylcholine release from the rat motor-nerve endings
    P Correia-de-Sá
    Laboratorio de Farmacologia, Instituto de Ciências Biomédicas de Abel Salazar ICBAS Universidade do Porto, L Prof Abel Salazar, 2, 4099 003, Porto, Portugal
    Eur J Pharmacol 406:355-62. 2000
    ..The results suggest that, depending on the stimulus paradigm, both internal (thapsigargin-sensitive) and external (either P- or L-type channels) Ca(2+) pools can be mobilized to promote acetylcholine release from motor nerve terminals...
  54. ncbi request reprint Adenosine: does it have a neuroprotective role after all?
    A de Mendonca
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, Av Professor Egas Moniz, 1649 035, Lisbon, Portugal
    Brain Res Brain Res Rev 33:258-74. 2000
    ..If these aspects are understood, adenosine should remain an interesting target for therapeutical neuroprotective approaches after all...
  55. ncbi request reprint Long-term potentiation observed upon blockade of adenosine A1 receptors in rat hippocampus is N-methyl-D-aspartate receptor-dependent
    A de Mendonca
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, Avenue Prof Egas Moniz, 1649 028, Lisbon, Portugal
    Neurosci Lett 291:81-4. 2000
    ..Thus LTP, but not LTD, observed upon blockade of adenosine A(1) receptors is dependent upon NMDA receptor activation...
  56. ncbi request reprint Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, and Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, 1649 028 Lisbon, Portugal
    J Biol Chem 275:37572-81. 2000
    ..These results indicate that AA increases tonic adenosine modulation as a possible feedback loop to limit AA facilitation of neuronal excitability...
  57. ncbi request reprint Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices
    Rodrigo A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisboa, Portugal
    Pharmacol Toxicol 90:208-13. 2002
    ..These results indicate that carbamazepine and its analogues mostly inhibit synaptic transmission through inhibition of conduction, although carbamazepine, but not BIA2-093 and BIA2-024, may also depress NMDA receptor-mediated responses...
  58. ncbi request reprint A functional role for adenosine A3 receptors: modulation of synaptic plasticity in the rat hippocampus
    A R Costenla
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, Avenue Professor Egas Moniz, 1649-028, Lisbon, Portugal
    Neurosci Lett 302:53-7. 2001
    ..The selective adenosine A3 receptor antagonist, MRS 1191 (5-10 microM), prevented the effects of Cl-IBMECA. These findings indicate a functional role for adenosine A3 receptors in the modulation of synaptic plasticity...
  59. pmc Early changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onset
    Mariana C Rocha
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
    PLoS ONE 8:e73846. 2013
    ..These early changes in the neuromuscular transmission of SOD1(G93A) mice suggest that the ALS associated events start long before symptoms onset. ..
  60. ncbi request reprint Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on reoxygenation
    A M Sebastiao
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, 1649 028 Lisbon, Portugal
    J Neurosci 21:8564-71. 2001
    ....
  61. doi request reprint Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine
    B M Fontinha
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Neuropharmacology 54:924-33. 2008
    ..Since extracellular adenosine accumulates upon high-frequency neuronal firing, the present results reveal a key process to allow the influence of BDNF upon synaptic plasticity...
  62. ncbi request reprint Age-dependent decrease in adenosine A1 receptor binding sites in the rat brain. Effect of cis unsaturated free fatty acids
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    Eur J Biochem 268:2939-47. 2001
    ..Also, the observed saturation of the control by AA of A1 receptors may contribute to the decreased adaptability of neuromodulation to different firing conditions in aged rats...
  63. ncbi request reprint Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus
    R A Cunha
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Portugal
    Mol Pharmacol 56:429-33. 1999
    ..These results indicate that hippocampal kainate receptors are coupled to G(i)/G(o) proteins...
  64. ncbi request reprint From A1 to A3 en passant through A(2A) receptors in the hippocampus: pharmacological implications
    Ana M Sebastião
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, and Unit of Neurosciences, Institute of Molecular Medicine, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    CNS Neurol Disord Drug Targets 11:652-63. 2012
    ..Therefore, A1 and A2A receptors constitute a must in the discussion about adenosine receptors in the hippocampus, and consequently, about the potential implications of their pharmacological manipulation and drug targeting...
  65. ncbi request reprint What can adenosine neuromodulation do for neuroprotection?
    J A Ribeiro
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, Institute of Molecular Medicine, University of Lisboa, 1649 028 Lisboa, Portugal
    Curr Drug Targets CNS Neurol Disord 4:325-9. 2005
    ..This is the orientation of much of current basic and clinical research. During the past decade considerable experimental and clinical data have been accumulated regarding cellular and biochemical events associated with brain repair...
  66. ncbi request reprint Adenosine and related drugs in brain diseases: present and future in clinical trials
    Luisa V Lopes
    Institute of Pharmacology and Neurosciences, Instituto de Medicina Molecular, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Curr Top Med Chem 11:1087-101. 2011
    ..The evidence herein reviewed highlights the promising potential of adenosine or adenosine receptor ligands as therapeutic agents in several brain disorders...
  67. pmc Potentiation by tonic A2a-adenosine receptor activation of CGRP-facilitated [3H]-ACh release from rat motor nerve endings
    P Correia-de-Sá
    Laboratory of Pharmacology, ICBAS, University of Oporto, Portugal
    Br J Pharmacol 111:582-8. 1994
    ..Since both CGRP and A2a-adenosine receptors are positively coupled to the adenylate cyclase/cyclic AMP system, cooperation between these receptors might occur at the second messenger transduction system level...
  68. ncbi request reprint Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation
    Miguel Diaz-Hernandez
    Departamento de Bioquimica, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
    J Pharmacol Exp Ther 301:441-50. 2002
    ..These results clearly demonstrate that the activation of presynaptic adenosine receptors is able to modulate the dinucleotide response in hippocampal nerve terminals...