Affiliation: Faculdade de Medicina
- Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AFM Gama-Carvalho
Institute of Histology and Embryology, Faculty of Medicine, University of Lisbon, 1649 028 Lisbon, Portugal
J Biol Chem 276:13104-12. 2001..Shuttling of U2AF between nucleus and cytoplasm possibly represents a means to control the availability of this factor to initiate spliceosome assembly and therefore contribute to regulate splicing...
- Regulation of adenovirus alternative RNA splicing correlates with a reorganization of splicing factors in the nucleusMargarida Gama-Carvalho
Institute of Molecular Medicine, Faculty of Medicine, University of Libson, 1649 028 Lisbon, Portugal
Exp Cell Res 289:77-85. 2003..This observation raises the possibility that the subnuclear organization of splicing factors may be regulated in response to events that lead to the activation of alternative splicing programs...
- Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factorsMargarida Gama-Carvalho
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av, Prof, Egas Moniz, 1649 028 Lisboa, Portugal
Genome Biol 7:R113. 2006..This observation raises the question of whether U2AF associates with mature mRNA-ribonucleoprotein particles in transit to the cytoplasm, participating in additional cellular functions...
- An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretionPedro Moura-Alves
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
PLoS ONE 6:e19829. 2011..Silencing of SFRS3 increased IL-1β secretion due to elevation of IL-1β and caspase-1 mRNA in addition to active caspase-1 levels. This study points to the relevance of splicing in the regulation of auto-inflammatory diseases...