Margarida Gama-Carvalho

Summary

Affiliation: Faculdade de Medicina
Country: Portugal

Publications

  1. ncbi request reprint Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF
    M Gama-Carvalho
    Institute of Histology and Embryology, Faculty of Medicine, University of Lisbon, 1649 028 Lisbon, Portugal
    J Biol Chem 276:13104-12. 2001
  2. ncbi request reprint Regulation of adenovirus alternative RNA splicing correlates with a reorganization of splicing factors in the nucleus
    Margarida Gama-Carvalho
    Institute of Molecular Medicine, Faculty of Medicine, University of Libson, 1649 028 Lisbon, Portugal
    Exp Cell Res 289:77-85. 2003
  3. pmc Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors
    Margarida Gama-Carvalho
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av, Prof, Egas Moniz, 1649 028 Lisboa, Portugal
    Genome Biol 7:R113. 2006
  4. pmc An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion
    Pedro Moura-Alves
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 6:e19829. 2011

Collaborators

  • Maria Carmo-Fonseca
  • Alexander S Brodsky
  • Pedro Moura-Alves
  • Helena Raquel
  • Teresa Raquel Pacheco
  • Nir Hacohen
  • Iris Cadima-Couto
  • Luis F Moita
  • Angelo Chora
  • Mariana Oliveira
  • Bruno D'Almeida
  • Raquel Rodrigues
  • Ana Neves-Costa

Detail Information

Publications4

  1. ncbi request reprint Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF
    M Gama-Carvalho
    Institute of Histology and Embryology, Faculty of Medicine, University of Lisbon, 1649 028 Lisbon, Portugal
    J Biol Chem 276:13104-12. 2001
    ..Shuttling of U2AF between nucleus and cytoplasm possibly represents a means to control the availability of this factor to initiate spliceosome assembly and therefore contribute to regulate splicing...
  2. ncbi request reprint Regulation of adenovirus alternative RNA splicing correlates with a reorganization of splicing factors in the nucleus
    Margarida Gama-Carvalho
    Institute of Molecular Medicine, Faculty of Medicine, University of Libson, 1649 028 Lisbon, Portugal
    Exp Cell Res 289:77-85. 2003
    ..This observation raises the possibility that the subnuclear organization of splicing factors may be regulated in response to events that lead to the activation of alternative splicing programs...
  3. pmc Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors
    Margarida Gama-Carvalho
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av, Prof, Egas Moniz, 1649 028 Lisboa, Portugal
    Genome Biol 7:R113. 2006
    ..This observation raises the question of whether U2AF associates with mature mRNA-ribonucleoprotein particles in transit to the cytoplasm, participating in additional cellular functions...
  4. pmc An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion
    Pedro Moura-Alves
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 6:e19829. 2011
    ..Silencing of SFRS3 increased IL-1β secretion due to elevation of IL-1β and caspase-1 mRNA in addition to active caspase-1 levels. This study points to the relevance of splicing in the regulation of auto-inflammatory diseases...