Ana Luisa Carvalho
Silva M, Rodrigues B, Fernandes J, Santos S, Carreto L, Santos M, et al
. MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons. Proc Natl Acad Sci U S A. 2019;116:5727-5736 pubmed publisher
..Our findings elucidate an activity-dependent miRNA-mediated mechanism for regulation of AMPA receptor expression. ..
Mota S, Ferreira I, Valero J, Ferreiro E, Carvalho A, Oliveira C, et al
. Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus--linking NMDA receptors and the reelin pathway. Exp Neurol. 2014;261:698-709 pubmed publisher
..These data suggest deregulated Src-dependent signaling pathways involving GluN2B-composed NMDARs and post-synaptic actin cytoskeleton depolymerization in the hippocampus in early stages of AD. ..
Lima Caldeira G, Peca J, Carvalho A. New insights on synaptic dysfunction in neuropsychiatric disorders. Curr Opin Neurobiol. 2019;57:62-70 pubmed publisher
..Shedding light on the specific mechanisms impacted in neuropsychiatric disorders will undeniably contribute to the development of more directed and personalized therapies. ..
Vieira M, Schmidt J, Ferreira J, She K, Oku S, Mele M, et al
. Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia. Neurobiol Dis. 2016;89:223-34 pubmed publisher
..These mechanisms underlie the divergent roles of the GluN2A- and GluN2B-NMDARs in determining neuronal fate in cerebral ischemia. ..
Matos C, NÃ³brega C, Louros S, Almeida B, Ferreiro E, Valero J, et al
. Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models. J Cell Biol. 2016;212:465-80 pubmed publisher
..Our results suggest that S12 plays a role in the pathogenic pathways mediated by polyglutamine-expanded ataxin-3 and that phosphorylation of this residue protects against toxicity. ..
Vieira M, Fernandes J, Carreto L, Anuncibay Soto B, Santos M, Han J, et al
. Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3. Neurobiol Dis. 2014;68:26-36 pubmed publisher
Louros S, Hooks B, Litvina L, Carvalho A, Chen C. A role for stargazin in experience-dependent plasticity. Cell Rep. 2014;7:1614-1625 pubmed publisher
..Overall, our data reveal an important role for stargazin in regulating AMPAR abundance and composition at glutamatergic synapses during homeostatic and experience-dependent plasticity. ..
Ferreira J, Schmidt J, Rio P, Ãguas R, Rooyakkers A, Li K, et al
. GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome. J Neurosci. 2015;35:8462-79 pubmed publisher