João Paulo Capela

Summary

Country: Portugal

Publications

  1. ncbi request reprint Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia
    João Paulo Capela
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030 Porto, Portugal
    J Pharmacol Exp Ther 316:53-61. 2006
  2. doi request reprint The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons
    João Paulo Capela
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 313 Porto, Portugal
    Neurotoxicology 34:254-63. 2013
  3. doi request reprint Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview
    João Paulo Capela
    REQUIMTE Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030, Porto, Portugal
    Mol Neurobiol 39:210-71. 2009
  4. ncbi request reprint Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons
    João Paulo Capela
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030 Porto, Portugal
    Neurotoxicology 28:868-75. 2007
  5. ncbi request reprint Neurotoxicity mechanisms of thioether ecstasy metabolites
    J P Capela
    REQUIMTE Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Neuroscience 146:1743-57. 2007
  6. ncbi request reprint Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia
    J P Capela
    Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Neuroscience 139:1069-81. 2006
  7. doi request reprint Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells
    Patrícia Silva Ferreira
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 313 Porto, Portugal
    Toxicol Lett 216:159-70. 2013
  8. pmc Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes
    Daniel José Barbosa
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Br J Pharmacol 165:1017-33. 2012
  9. doi request reprint Toxicity of amphetamines: an update
    Márcia Carvalho
    REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Portugal
    Arch Toxicol 86:1167-231. 2012
  10. doi request reprint 5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures
    João Paulo Capela
    REQUIMTE Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030 Porto, Portugal
    Eur J Pharmacol 588:232-8. 2008

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia
    João Paulo Capela
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030 Porto, Portugal
    J Pharmacol Exp Ther 316:53-61. 2006
    ..These data suggest that MDMA metabolites, especially under hyperthermic conditions, contribute to MDMA-induced neurotoxicity...
  2. doi request reprint The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons
    João Paulo Capela
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 313 Porto, Portugal
    Neurotoxicology 34:254-63. 2013
    ..Death was dependent, at least in part, on the stimulation of the 5-HT(2A)-receptors...
  3. doi request reprint Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview
    João Paulo Capela
    REQUIMTE Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030, Porto, Portugal
    Mol Neurobiol 39:210-71. 2009
    ....
  4. ncbi request reprint Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons
    João Paulo Capela
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030 Porto, Portugal
    Neurotoxicology 28:868-75. 2007
    ..In conclusion, direct MDMA 5-HT(2A)-receptor stimulation produces intracellular oxidative stress that leads to neuronal apoptosis accompanied by caspase 3 activation...
  5. ncbi request reprint Neurotoxicity mechanisms of thioether ecstasy metabolites
    J P Capela
    REQUIMTE Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Neuroscience 146:1743-57. 2007
    ..This study provides new insights into the neurotoxicity mechanisms of thioether MDMA metabolites and highlights their importance in "ecstasy" neurotoxicity...
  6. ncbi request reprint Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia
    J P Capela
    Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Neuroscience 139:1069-81. 2006
    ....
  7. doi request reprint Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells
    Patrícia Silva Ferreira
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 313 Porto, Portugal
    Toxicol Lett 216:159-70. 2013
    ..In conclusion, MDMA catechol metabolites promote differential toxic effects to differentiated dopaminergic human SH-SY5Y cells...
  8. pmc Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes
    Daniel José Barbosa
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Br J Pharmacol 165:1017-33. 2012
    ....
  9. doi request reprint Toxicity of amphetamines: an update
    Márcia Carvalho
    REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Portugal
    Arch Toxicol 86:1167-231. 2012
    ....
  10. doi request reprint 5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures
    João Paulo Capela
    REQUIMTE Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030 Porto, Portugal
    Eur J Pharmacol 588:232-8. 2008
    ..Finally, we have established a robust model of primary raphe neuronal culture to evaluate serotonergic neurons development and the mechanisms of toxicity involving this neuronal population...
  11. pmc Differential Effects of Methyl-4-Phenylpyridinium Ion, Rotenone, and Paraquat on Differentiated SH-SY5Y Cells
    João Barbosa Martins
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050 313 Porto, Portugal
    J Toxicol 2013:347312. 2013
    ..PQ neurotoxicity occurred through exacerbated oxidative stress, with involvement of uptake through the dopamine transporter and protein synthesis...