Helena Canhao

Summary

Country: Portugal

Publications

  1. ncbi request reprint Factors influencing calcaneus quantitative ultrasound measurements in an urban population
    H Canhao
    Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal
    Clin Exp Rheumatol 26:67-72. 2008
  2. pmc Comparative effectiveness and predictors of response to tumour necrosis factor inhibitor therapies in rheumatoid arthritis
    Helena Canhao
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina de Lisboa, Av Egas Moniz, 1649 028 Lisbon, Portugal
    Rheumatology (Oxford) 51:2020-6. 2012
  3. ncbi request reprint [Portuguese recommendations for the use of methotrexate in the treatment of rheumatoid arthritis]
    Helena Canhao
    Servico de Reumatologia, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa
    Acta Reumatol Port 34:78-95. 2009
  4. ncbi request reprint [Protocol for clinical monitoring of juvenile idiopathic arthritis]
    Helena Canhao
    Servico de Reumatologia, Hospital de Santa Maria, Lisbon
    Acta Reumatol Port 32:277-81. 2007
  5. ncbi request reprint Assessment of laboratory measurements and -308 TNFalpha gene promoter polymorphisms in normal bone mineral density
    Helena Canhao
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Edifício Egas Moniz Av Prof Egas Moniz, 1649 028, Lisbon, Portugal
    Clin Rheumatol 27:301-7. 2008
  6. ncbi request reprint Reuma.pt - the rheumatic diseases portuguese register
    H Canhao
    Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa e Serviço de Reumatologia e Doenças Ósseas Metabólicas do CHLN Hospital de Santa Maria, Portugal
    Acta Reumatol Port 36:45-56. 2011
  7. ncbi request reprint [Eating habits and life styles in a Portuguese population--protective and risk factors for osteoporosis]
    Helena Canhao
    Unidade de lnvestigação em Reumatologia, Instituto de Medicina Molecular
    Acta Reumatol Port 31:331-9. 2006
  8. ncbi request reprint [Normative data for quantitative ultrasound measurement of the calcaneus in a Portuguese population]
    Helena Canhao
    Serviço de Higiene e Epidemiologia, Faculdade de Medicina, Universidade do Porto
    Acta Reumatol Port 31:65-73. 2006
  9. doi request reprint Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival
    Rita A Moura
    Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Rheumatology (Oxford) 50:278-82. 2011
  10. doi request reprint Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures
    Ana M Rodrigues
    Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon, Portugal
    Bone 51:981-9. 2012

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Factors influencing calcaneus quantitative ultrasound measurements in an urban population
    H Canhao
    Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal
    Clin Exp Rheumatol 26:67-72. 2008
    ..To estimate the effect of demographic, social, behavioural and anthropometric factors on quantitative ultrasound (QUS) parameters in an urban population...
  2. pmc Comparative effectiveness and predictors of response to tumour necrosis factor inhibitor therapies in rheumatoid arthritis
    Helena Canhao
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina de Lisboa, Av Egas Moniz, 1649 028 Lisbon, Portugal
    Rheumatology (Oxford) 51:2020-6. 2012
    ..Prior observational data are not consistent. We compared their effectiveness over 1 year in a prospective cohort...
  3. ncbi request reprint [Portuguese recommendations for the use of methotrexate in the treatment of rheumatoid arthritis]
    Helena Canhao
    Servico de Reumatologia, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa
    Acta Reumatol Port 34:78-95. 2009
    ..To develop Portuguese evidence-based recommendations for the use of methotrexate (MTX) in daily clinical practice in rheumatic disorders...
  4. ncbi request reprint [Protocol for clinical monitoring of juvenile idiopathic arthritis]
    Helena Canhao
    Servico de Reumatologia, Hospital de Santa Maria, Lisbon
    Acta Reumatol Port 32:277-81. 2007
    ....
  5. ncbi request reprint Assessment of laboratory measurements and -308 TNFalpha gene promoter polymorphisms in normal bone mineral density
    Helena Canhao
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Edifício Egas Moniz Av Prof Egas Moniz, 1649 028, Lisbon, Portugal
    Clin Rheumatol 27:301-7. 2008
    ..The remaining variables assessed had a similar distribution among the different studied groups. In our population, low serum levels of leptin and high serum levels of zinc, calcium, FSH, and LH were associated with a higher BMD...
  6. ncbi request reprint Reuma.pt - the rheumatic diseases portuguese register
    H Canhao
    Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa e Serviço de Reumatologia e Doenças Ósseas Metabólicas do CHLN Hospital de Santa Maria, Portugal
    Acta Reumatol Port 36:45-56. 2011
    ..The aim of this publication is to describe the structure of Reuma.pt and the population registered since June 2008...
  7. ncbi request reprint [Eating habits and life styles in a Portuguese population--protective and risk factors for osteoporosis]
    Helena Canhao
    Unidade de lnvestigação em Reumatologia, Instituto de Medicina Molecular
    Acta Reumatol Port 31:331-9. 2006
    ..Physical activity, calcium intake, coffee, alcohol and tobacco consumption can influence OP risk. These factors can be modifiable and, in some cases, their control may contribute for the OP prevention...
  8. ncbi request reprint [Normative data for quantitative ultrasound measurement of the calcaneus in a Portuguese population]
    Helena Canhao
    Serviço de Higiene e Epidemiologia, Faculdade de Medicina, Universidade do Porto
    Acta Reumatol Port 31:65-73. 2006
    ..Up to now there are no published normative data for QUS measurements in the Portuguese population...
  9. doi request reprint Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival
    Rita A Moura
    Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Rheumatology (Oxford) 50:278-82. 2011
    ....
  10. doi request reprint Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures
    Ana M Rodrigues
    Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon, Portugal
    Bone 51:981-9. 2012
    ..We also aimed to identify which of these factors were associated with worse mechanical behavior and with the hip fracture event...
  11. doi request reprint Smoking is a predictor of worse trabecular mechanical performance in hip fragility fracture patients
    Ana Maria Rodrigues
    Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon, Portugal
    J Bone Miner Metab 30:692-9. 2012
    ..In this population, the 10-year risk of fracture using CRFs with different weights only reflects bone mass loss but not trabecular mechanical properties...
  12. doi request reprint Ankylosing spondylitis susceptibility and severity--contribution of TNF gene promoter polymorphisms at positions -238 and -308
    Elsa Sousa
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Ann N Y Acad Sci 1173:581-8. 2009
    ..These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis...
  13. doi request reprint Tumor necrosis factor-alpha -308 genotypes influence inflammatory activity and TNF-alpha serum concentrations in children with juvenile idiopathic arthritis
    Ana Filipa Mourão
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av Professor Egas Moniz, 1649 028 Lisboa, Portugal
    J Rheumatol 36:837-42. 2009
    ..We investigated if clinical measures of JIA activity and TNF-alpha serum concentrations were associated with TNF-alpha -308 genotypes...
  14. doi request reprint Bilateral MR imaging of the hand and wrist in early and very early inflammatory arthritis: tenosynovitis is associated with progression to rheumatoid arthritis
    Márcio Navalho
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Radiology 264:823-33. 2012
    ....
  15. ncbi request reprint Portuguese recommendations for the use of biological therapies in patients with axial spondyloarthritis--December 2011 update
    Pedro Machado
    Servico de Reumatologia, Hospitais da Universidade de Coimbra, Praceta Prof Mota Pinto, 3000 075 Coimbra, Portugal
    Acta Reumatol Port 37:40-7. 2012
    ..To develop recommendations for the treatment of axial spondyloarthritis with biological therapies, endorsed by the Portuguese Society of Rheumatology...
  16. ncbi request reprint Markers of progression to rheumatoid arthritis: discriminative value of the new ACR/EULAR rheumatoid arthritis criteria in a Portuguese population with early polyarthritis
    Ana Filipa Mourão
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal
    Acta Reumatol Port 36:370-6. 2011
    ....
  17. ncbi request reprint [Practical guide for the use of biological agents in rheumatoid arthritis - December 2011 update]
    Ana Filipa Mourão
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal
    Acta Reumatol Port 36:389-95. 2011
    ..The authors review the practical aspects of biological therapy use for rheumatoid arthritis patients, commenting safety issues before and after treatment initiation and the best treatment strategies to optimize efficacy...
  18. doi request reprint BAFF and TACI gene expression are increased in patients with untreated very early rheumatoid arthritis
    Rita A Moura
    Rheumatology Research Unit, and the Cellular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    J Rheumatol 40:1293-302. 2013
    ....
  19. pmc Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis
    Rita Cascão
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av Professor Egas Moniz, Lisboa 1649 028, Portugal
    Arthritis Res Ther 12:R196. 2010
    ..The main goal of this work was to determine whether cytokines driving neutrophil and Th17 activation are dysregulated in very early rheumatoid arthritis patients with less than 6 weeks of disease duration and before treatment (VERA)...
  20. ncbi request reprint From a neutrophilic synovial tissue infiltrate to a challenging case of rheumatoid arthritis
    Ana Filipa Mourão
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon
    Acta Reumatol Port 35:228-31. 2010
    ....
  21. ncbi request reprint [Portuguese recommendations for pain management by pharmocotherapy in inflammatory arthritis]
    Inés Silva
    Serviço de Reumatologia do Centro Hospitalar de Lisboa Ocidental, EPE Hospital de Egas Moniz, Lisboa, Portugal
    Acta Reumatol Port 37:160-74. 2012
    ..To develop Portuguese evidence-based recommendations for pain management by pharmocotherapy in inflammatory arthritis...
  22. ncbi request reprint Portuguese recommendations for the use of biological therapies in children and adolescents with juvenile idiopathic arthritis--December 2011 update
    Maria Jose Santos
    Servico de Reumatologia, Hospital Garcia de Orta, Av Prof Torrado da Silva, 2800 Almada, Portugal
    Acta Reumatol Port 37:48-68. 2012
    ....
  23. doi request reprint Bilateral evaluation of the hand and wrist in untreated early inflammatory arthritis: a comparative study of ultrasonography and magnetic resonance imaging
    Márcio Navalho
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    J Rheumatol 40:1282-92. 2013
    ....
  24. pmc Anti-ribosomal P protein IgG autoantibodies in patients with systemic lupus erythematosus: diagnostic performance and clinical profile
    Diana Carmona-Fernandes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon Academic Medical Centre, Av, Prof, Egas Moniz, Edificio Egas Moniz, Lisboa, 1649 028, Portugal
    BMC Med 11:98. 2013
    ..This study was devised to assess the performance of anti-ribosomal P (anti-Rib-P) antibodies in the diagnosis of systemic lupus erythematosus (SLE) and the association of these antibodies with the clinical features of SLE...
  25. pmc Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av, Professor Egas Moniz, 1649 028, Lisboa, Portugal
    Arthritis Res Ther 9:R37. 2007
    ....
  26. doi request reprint Persistent low grade synovitis without erosive progression in magnetic resonance imaging of rheumatoid arthritis patients treated with infliximab over 1 year
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Edificio Egas Moniz, Av Professor Egas Moniz, 1649 028, Lisbon, Portugal
    Clin Rheumatol 28:1213-6. 2009
    ..These results support the view that there might be an uncoupling process between inflammation and bone erosions when tumor necrosis factor alpha is targeted in RA...
  27. doi request reprint Lymphotoxin-α 252 A>G polymorphism: a link between disease susceptibility and dyslipidemia in rheumatoid arthritis?
    Maria J Santos
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    J Rheumatol 38:1244-9. 2011
    ..We examined the role of the single-nucleotide polymorphism at position 252 of the LTA gene in the genetic background of RA and dyslipidemia...
  28. doi request reprint At the moment of occurrence of a fragility hip fracture, men have higher mechanical properties values in comparison with women
    Ana C Vale
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    BMC Musculoskelet Disord 14:295. 2013
    ....
  29. pmc Early vascular alterations in SLE and RA patients--a step towards understanding the associated cardiovascular risk
    Maria Jose Santos
    Rheumatology Research Unit, Instituto de Medicina Molecular da Faculdade de Medicina de Lisboa, Lisbon, Portugal
    PLoS ONE 7:e44668. 2012
    ..Early vascular alterations are more pronounced in SLE which is in line with the higher CV risk of these patients...
  30. ncbi request reprint Portuguese guidelines for the use of biological agents in rheumatoid arthritis - October 2011 update
    Joao Eurico Fonseca
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal
    Acta Reumatol Port 36:385-8. 2011
    ..2 in the DAS28 score. Non-responders, in accordance to the Rheumatologist’s clinical opinion, should try a switch to another biological agent (tumour necrosis factor antagonist, abatacept, rituximab or tocilizumab)...
  31. pmc Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing
    Joana Caetano-Lopes
    Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal
    PLoS ONE 6:e16947. 2011
    ..The aim of our work was to study the sequence of gene expression events involved in inflammation and bone remodeling occurring in the early phases of callus formation in osteoporotic patients...
  32. doi request reprint Alterations on peripheral blood B-cell subpopulations in very early arthritis patients
    Rita A Moura
    Rheumatology Research Unit, Instituto de Medicina Molecular, Edificio Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av Professor Egas Moniz, 1649 028 Lisboa, Portugal
    Rheumatology (Oxford) 49:1082-92. 2010
    ..To characterize circulating B-cell subpopulations of arthritis patients with <6 weeks of disease duration...
  33. ncbi request reprint 2011 Portuguese recommendations for the use of biological therapies in patients with psoriatic arthritis
    Pedro Machado
    Servico de Reumatologia, Hospitais da Universidade de Coimbra, Praceta Prof Mota Pinto, 3000 075 Coimbra, Portugal
    Acta Reumatol Port 37:26-39. 2012
    ..To develop recommendations for the treatment of psoriatic arthritis (PsA) with biological therapies, endorsed by the Portuguese Society of Rheumatology...
  34. doi request reprint Primary biliary cirrhosis in a rheumatoid arthritis patient treated with rituximab, a case-based review
    Joaquim Polido-Pereira
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    Clin Rheumatol 31:385-9. 2012
    ..Based on this clinical report, a detailed review of the clinical aspects of PBC is presented as well as its association with other immune-mediated inflammatory diseases, particularly, with RA...
  35. doi request reprint Hemorheological parameters are related to subclinical atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis patients
    Maria Jose Santos
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal
    Atherosclerosis 219:821-6. 2011
    ..This work examines the relationship between blood rheology, traditional cardiovascular (CV) risk factors, inflammation and subclinical atherosclerosis in SLE and RA...
  36. doi request reprint Dynamic contrast-enhanced 3-T magnetic resonance imaging: a method for quantifying disease activity in early polyarthritis
    Márcio Navalho
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Skeletal Radiol 41:51-9. 2012
    ..To determine whether measurement of synovial enhancement and thickness quantification parameters with 3.0-Tesla magnetic resonance imaging (3-T MRI) can reliably quantify disease activity in patients with early polyarthritis...
  37. doi request reprint A1.74 Serum levels of CXCL13 are increased in untreated patients with rheumatoid arthritis from the first weeks of disease development
    Rita A Moura
    Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon, Portugal
    Ann Rheum Dis 73:A32-3. 2014
    ..The aim of this study was to quantify CXCL13 serum levels in untreated very early polyarthritis patients to understand the dynamics of B-cell trafficking since early disease onset...
  38. pmc Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs?
    Vasco Crispim Romão
    Rheumatology Research Unit, Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa, Edifício Egas Moniz Av, Prof, Egas Moniz, Lisboa 1649 028, Portugal
    BMC Med 11:17. 2013
    ..In this review we summarize current evidence on predictors of response to MTX and other synthetic DMARDs, discuss possible causes for the heterogeneity observed and address its translation into daily clinical practice...
  39. pmc Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients
    Diana Carmona-Fernandes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Edificio Egas Moniz, Av, Prof, Egas Moniz, 1649 028 Lisboa, Portugal
    Arthritis Res Ther 13:R175. 2011
    ..Our aim was to assess serum OPG and soluble RANKL (sRANKL) levels as well as sRANKL/OPG ratio in female SLE patients and compare it with female controls...
  40. ncbi request reprint [Diagnosis and treatment of osteoporosis in childhood]
    Helena Canhao
    Servico de Reumatologia, Hospital de Santa Maria, Lisboa
    Acta Med Port 17:385-90. 2004
    ..The authors review osteoporosis definition, the techniques to quantify bone mass, the assessment of therapy efficacy and the drugs used to manage osteoporosis in paediatric ages...
  41. doi request reprint Rituximab use in pediatric autoimmune diseases: four case reports
    Joaquim Polido-Pereira
    Hospital de Santa Maria, Serviço de Reumatologia e Doenças Osseas Metabólicas, Lisboa, Portugal
    Ann N Y Acad Sci 1173:712-20. 2009
    ..However, our fourth case, a patient with ITP and renal failure, was treated with RTX without either hematologic or renal response...
  42. pmc Chronic arthritis leads to disturbances in the bone collagen network
    Joana Caetano-Lopes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisbon, Portugal
    Arthritis Res Ther 12:R9. 2010
    ..In this study we used a mice model of chronic arthritis to evaluate if bone fragility induced by chronic inflammation is associated with an imbalance in bone turnover and also a disorganization of the bone type I collagen network...
  43. ncbi request reprint Recommendations for the diagnosis and treatment of latent and active tuberculosis in inflammatory joint diseases candidates for therapy with tumor necrosis factor alpha inhibitors: March 2008 update
    Joao Eurico Fonseca
    Rheumatoid Arthritis Study Group Grupo de Estudos de Artrite Reumatoide GEAR of the Portuguese Society of Rheumatology Sociedade Portuguesa de Reumatologia SPR, Lisbon, Portugal
    Acta Reumatol Port 33:77-85. 2008
    ..If TST is performed in immunossuppressed IJD patients, LTBI treatment should be offered to the patient before starting anti-TNFalpha therapy, even in the presence of a negative test, after risk/benefit assessment...
  44. ncbi request reprint Osteoblasts and bone formation
    Joana Caetano-Lopes
    Unidade Investigacão em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal
    Acta Reumatol Port 32:103-10. 2007
    ..It can act through the central nervous system and diminish osteoblasts activity, or can have an osteogenic effect by binding directly to its receptors on the surface of osteoblast cells...
  45. ncbi request reprint [Tuberculosis in rheumatic patients treated with tumour necrosis factor alpha antagonists: the Portuguese experience]
    Joao Eurico Fonseca
    Servico de Reumatologia, Hospital de Santa Maria
    Acta Reumatol Port 31:247-53. 2006
    ..In two cases (one treated with adalimumab and the other with infliximab), paradoxical response to treatment occurred. None of the patients has restarted biological therapy after TB treatment...
  46. ncbi request reprint Prevalence of fatigue in a group of airline pilots
    Cátia Reis
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    Aviat Space Environ Med 84:828-33. 2013
    ..The hypothesis that medium/short-haul pilots may currently present different levels of fatigue than long-haul pilots was also tested...