Affiliation: Campus de Gambelas
Laizé V, Gavaia P, Tarasco M, Viegas M, Caria J, Luís N, et al
. Osteotoxicity of 3-methylcholanthrene in fish. Ecotoxicol Environ Saf. 2018;161:721-728 pubmed publisher
..Data reported here demonstrated the osteotoxicity of 3-MC but also confirmed the suitability of fish systems to gain insights into the toxic mechanisms of compounds affecting skeletal and bone formation. ..
Rodrigues E, Pardal M, LaizÃ© V, Cancela M, Oliveira P, Serafim T. Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin. Environ Pollut. 2015;206:619-26 pubmed publisher
..To conclude, the H9c2 cell-based assay is reliable and represents a suitable ethical alternative to conventional fish assays for AZX, and could be used to get valuable insights into the toxic effects of other pesticides. ..
Rosa J, Cox C, Cancela M, Laizé V. Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism. Gene. 2018;645:137-145 pubmed publisher
..This study reports a new subfamily of short-chain dehydrogenases/reductases in vertebrates and, for the first time, provides evidence of a role for SDRs in bone metabolism, osteoblast differentiation and/or tissue mineralization. ..
Laizé V, Martel P, Viegas C, Price P, Cancela M. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem. 2005;280:26659-68 pubmed
..We also propose a highly specific pattern definition for the Gla domain of BGP and MGP. ..
Laizé V, Viegas C, Price P, Cancela M. Identification of an osteocalcin isoform in fish with a large acidic prodomain. J Biol Chem. 2006;281:15037-43 pubmed
Laizé V, Tiago D, Aureliano M, Cancela M. New insights into mineralogenic effects of vanadate. Cell Mol Life Sci. 2009;66:3831-6 pubmed publisher
Marques C, FernÃ¡ndez I, Viegas M, Cox C, Martel P, Rosa J, et al
. Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives. Cell Mol Life Sci. 2016;73:841-57 pubmed publisher
Marques C, Cancela M, LaizÃ© V. Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors. Gene. 2016;576:229-36 pubmed publisher
..Data reported here provides new insights toward the better understanding of the transcriptional regulation of BMP2 gene in a bone and cartilage context. ..