Monica Bettencourt-Dias


Country: Portugal


  1. Pimenta Marques A, Bento I, Lopes C, Duarte P, Jana S, Bettencourt Dias M. A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster. Science. 2016;353:aaf4866 pubmed publisher
    ..We propose that regulation of this maintenance program is essential for successful sexual reproduction and defines centriole life span in different tissues in homeostasis and disease, thereby shaping the cytoskeleton. ..
  2. Cunha Ferreira I, Bento I, Pimenta Marques A, Jana S, Lince Faria M, Duarte P, et al. Regulation of autophosphorylation controls PLK4 self-destruction and centriole number. Curr Biol. 2013;23:2245-2254 pubmed publisher
    ..As ?TrCP, PLK4, and centriole number are deregulated in several cancers, our work provides novel links between centriole number control and tumorigenesis. ..
  3. Marteil G, Guerrero A, Vieira A, de Almeida B, Machado P, Mendonça S, et al. Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation. Nat Commun. 2018;9:1258 pubmed publisher
    ..Our screen establishes centriole amplification and size deregulation as recurrent features of cancer cells and identifies novel causes and consequences of those abnormalities. ..
  4. Ito D, Bettencourt Dias M. Centrosome Remodelling in Evolution. Cells. 2018;7: pubmed publisher
    ..Acentriolar centrosomes should continue to be a great model to understand how centrosomes evolved and how centrosome biogenesis is regulated. ..
  5. Jana S, Mendonça S, Machado P, Werner S, Rocha J, Pereira A, et al. Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity. Nat Cell Biol. 2018;20:928-941 pubmed publisher
    ..The differential expression of these cartwheel components contributes to diversity in basal body length. Our results offer a plausible explanation to how mutations in conserved ciliary base components lead to tissue-specific diseases. ..
  6. Lopes C, Mesquita M, Cunha A, Cardoso J, Carapeta S, Laranjeira C, et al. Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis. J Cell Biol. 2018;217:2353-2363 pubmed publisher
    ..Our work shows that centrosome amplification in human tumorigenesis can occur before transformation, being repressed by p53. These findings suggest centrosome amplification in humans can contribute to tumor initiation and progression. ..
  7. Bettencourt Dias M. Q&A: Who needs a centrosome?. BMC Biol. 2013;11:28 pubmed publisher
  8. Zitouni S, Francia M, Leal F, Montenegro Gouveia S, Nabais C, Duarte P, et al. CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis. Curr Biol. 2016;26:1127-37 pubmed publisher
  9. Loncarek J, Bettencourt Dias M. Building the right centriole for each cell type. J Cell Biol. 2018;217:823-835 pubmed publisher
    ..In this review, we provide an overview of our current understanding of centriole biogenesis and how variations around the same theme generate alternatives for centriole formation and function. ..

More Information


  1. Jana S, Mendonça S, Werner S, Bettencourt Dias M. Methods to Study Centrosomes and Cilia in Drosophila. Methods Mol Biol. 2016;1454:215-36 pubmed publisher
    ..This chapter describes protocols to visualize centrosomes and cilia by fluorescence and electron microscopy. ..
  2. request reprint
    Bettencourt Dias M, Carvalho Santos Z. Double life of centrioles: CP110 in the spotlight. Trends Cell Biol. 2008;18:8-11 pubmed
    ..This work paves the way to understanding centriole and cilia biogenesis, which are two processes misregulated in human diseases, such as cancer and polycystic kidney disease...
  3. Bettencourt Dias M, Hildebrandt F, Pellman D, Woods G, Godinho S. Centrosomes and cilia in human disease. Trends Genet. 2011;27:307-15 pubmed publisher
    ..Here, we give an overview of recent developments in this field, focusing on cancer, diseases of brain development and ciliopathies. ..
  4. Jana S, Marteil G, Bettencourt Dias M. Mapping molecules to structure: unveiling secrets of centriole and cilia assembly with near-atomic resolution. Curr Opin Cell Biol. 2014;26:96-106 pubmed publisher
    ..Here, we cover progress in this field, focusing on the mechanisms of centriole and cilia assembly. ..
  5. Lopes C, Jana S, Cunha Ferreira I, Zitouni S, Bento I, Duarte P, et al. PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space. Dev Cell. 2015;35:222-35 pubmed publisher
    ..Similar mechanisms enforcing the local concentration and/or activity of other centriole components are likely to contribute to the spatial control of centriole biogenesis under physiological conditions. ..
  6. Marteil G, Dias Louro M, Bettencourt Dias M. Centrosome Assembly: Reconstructing the Core Cartwheel Structure In Vitro. Curr Biol. 2017;27:R606-R609 pubmed publisher
    ..A recent study provides a new cell-free assay that reconstitutes the initial structure formed during centriole assembly - the cartwheel - and proposes a new model for its formation and growth. ..