Hartmut Porst

Summary

Publications

  1. doi request reprint Effects of tadalafil on lower urinary tract symptoms secondary to benign prostatic hyperplasia and on erectile dysfunction in sexually active men with both conditions: analyses of pooled data from four randomized, placebo-controlled tadalafil clinical stu
    Hartmut Porst
    Private Practice of Urology and Andrology, Hamburg, Germany
    J Sex Med 10:2044-52. 2013
  2. doi request reprint Efficacy and safety of tadalafil 5 mg once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: subgroup analyses of pooled data from 4 multinational, randomized, placebo-controlled clinical studies
    Hartmut Porst
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 82:667-73. 2013
  3. doi request reprint SOP conservative (medical and mechanical) treatment of erectile dysfunction
    Hartmut Porst
    Private Urological Andrological Practice, Hamburg, Germany
    J Sex Med 10:130-71. 2013
  4. doi request reprint Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors
    Hartmut Porst
    Private Practice of Urology and Andrology, Neuer Jungfernstieg 6a, 20354 Hamburg, Germany
    J Androl 33:1305-22. 2012
  5. doi request reprint Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily
    Hartmut Porst
    Urology and Andrology Center, Neuer Jungfernstieg 6a, 20354 Hamburg, Germany
    Expert Opin Pharmacother 13:1481-94. 2012
  6. doi request reprint Effects of once-daily tadalafil on erectile function in men with erectile dysfunction and signs and symptoms of benign prostatic hyperplasia
    Hartmut Porst
    Eur Urol 56:727-35. 2009
  7. doi request reprint Long-term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction
    Hartmut Porst
    J Sex Med 5:2160-9. 2008
  8. ncbi request reprint Vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia
    Hartmut Porst
    Private Practice, Neuer Jungfernstieg 6a, 20354 Hamburg, Germany
    Curr Urol Rep 9:295-301. 2008
  9. ncbi request reprint Development and validation of the quality of erection questionnaire
    Hartmut Porst
    Private Practice of Urology Andrology, Hamburg, Germany
    J Sex Med 4:372-81. 2007
  10. ncbi request reprint [Premature ejaculation]
    H Porst
    Urologe A 48:663-74. 2009

Detail Information

Publications44

  1. doi request reprint Effects of tadalafil on lower urinary tract symptoms secondary to benign prostatic hyperplasia and on erectile dysfunction in sexually active men with both conditions: analyses of pooled data from four randomized, placebo-controlled tadalafil clinical stu
    Hartmut Porst
    Private Practice of Urology and Andrology, Hamburg, Germany
    J Sex Med 10:2044-52. 2013
    ..Erectile dysfunction (ED) and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) are common in aging males and frequently occur together. Tadalafil has demonstrated efficacy in treating both conditions...
  2. doi request reprint Efficacy and safety of tadalafil 5 mg once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: subgroup analyses of pooled data from 4 multinational, randomized, placebo-controlled clinical studies
    Hartmut Porst
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 82:667-73. 2013
    ....
  3. doi request reprint SOP conservative (medical and mechanical) treatment of erectile dysfunction
    Hartmut Porst
    Private Urological Andrological Practice, Hamburg, Germany
    J Sex Med 10:130-71. 2013
    ..ED is a chronic condition that exerts a negative impact on male self-esteem and nearly all life domains including interpersonal, family, and business relationships...
  4. doi request reprint Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors
    Hartmut Porst
    Private Practice of Urology and Andrology, Neuer Jungfernstieg 6a, 20354 Hamburg, Germany
    J Androl 33:1305-22. 2012
    ..These findings may contribute to a more comprehensive understanding of once-daily tadalafil's effects on phosphodiesterase type 5 inhibitor-naive men...
  5. doi request reprint Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily
    Hartmut Porst
    Urology and Andrology Center, Neuer Jungfernstieg 6a, 20354 Hamburg, Germany
    Expert Opin Pharmacother 13:1481-94. 2012
    ..Most clinical experience has been reported with on-demand use of PDE-5 inhibitors, but several studies have been able to demonstrate that tadalafil, given once-daily in low doses, is both highly effective and well tolerated...
  6. doi request reprint Effects of once-daily tadalafil on erectile function in men with erectile dysfunction and signs and symptoms of benign prostatic hyperplasia
    Hartmut Porst
    Eur Urol 56:727-35. 2009
    ..Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH; BPH-LUTS) may be associated with erectile dysfunction (ED)...
  7. doi request reprint Long-term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction
    Hartmut Porst
    J Sex Med 5:2160-9. 2008
    ..With once-daily administration of tadalafil, dosing and sexual activity would no longer need to be temporally linked for patients with erectile dysfunction (ED)...
  8. ncbi request reprint Vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia
    Hartmut Porst
    Private Practice, Neuer Jungfernstieg 6a, 20354 Hamburg, Germany
    Curr Urol Rep 9:295-301. 2008
    ..For vardenafil, nonclinical experiments and initial, preliminary clinical data suggest that the underlying effect may occur on the detrusor and not the prostate...
  9. ncbi request reprint Development and validation of the quality of erection questionnaire
    Hartmut Porst
    Private Practice of Urology Andrology, Hamburg, Germany
    J Sex Med 4:372-81. 2007
    ..There are no psychometrically validated assessment tools designed to solely and specifically evaluate satisfaction with the quality of erections...
  10. ncbi request reprint [Premature ejaculation]
    H Porst
    Urologe A 48:663-74. 2009
    ....
  11. doi request reprint [Chronic PDE-5 inhibition in patients with erectile dysfunction: new treatment approach using once daily Tadalafil]
    H Porst
    Praxis für Urologie und Andrologie, Hamburg, Deutschland
    Urologe A 48:1318, 1320-9. 2009
    ..Interestingly in a pilot study of on-demand versus chronic administration of Tadalafil for 4 weeks, only regular dosing improved several markers of endothelial function...
  12. doi request reprint Standards for clinical trials in male sexual dysfunctions
    Hartmut Porst
    J Sex Med 7:414-44. 2010
    ..Clinical trials in male sexual dysfunction (MSD) are expanding. Consequently, there is a need for consensus standards in this area...
  13. doi request reprint Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: integrated analyses of two phase 3 dapoxetine trials
    Hartmut Porst
    J Sex Med 7:2231-42. 2010
    ....
  14. doi request reprint Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results of an international randomized, double-blind, placebo-controlled trial
    Hartmut Porst
    Eur Urol 60:1105-13. 2011
    ..Tadalafil is being investigated for the treatment of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH-LUTS)...
  15. doi request reprint An overview of pharmacotherapy in premature ejaculation
    Hartmut Porst
    Private Urology and Andrology Practice and Hospital, Hamburg, Germany
    J Sex Med 8:335-41. 2011
    ..With increasing interest and clinical research in male sexual disorders, it has become clear that not only psychological but also organic, neurobiological, and genetic factors may play an important role in premature ejaculation (PE)...
  16. ncbi request reprint The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking
    Hartmut Porst
    Eur Urol 51:816-23; discussion 824. 2007
    ..This study evaluated the associated comorbidities and patient satisfaction with treatment options for premature ejaculation (PE), a common sexual dysfunction...
  17. ncbi request reprint Extended duration of efficacy of vardenafil when taken 8 hours before intercourse: a randomized, double-blind, placebo-controlled study
    Hartmut Porst
    Urological Practice, Hamburg, Germany
    Eur Urol 50:1086-94; discussion 1094-5. 2006
    ..This study explored the efficacy of vardenafil in men with erectile dysfunction (ED) when taken 8 hours before sexual intercourse...
  18. ncbi request reprint Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5mg and 10mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial
    Hartmut Porst
    Private Practice of Urology and Andrology, Hamburg, Germany
    Eur Urol 50:351-9. 2006
    ..Because the 17.5-h half-life of tadalafil enables therapeutic plasma levels to be sustained with daily administration, tadalafil is a good candidate for once daily dosing therapy...
  19. ncbi request reprint [Therapy of erectile dysfunction in 2005]
    H Porst
    Hamburg
    Urologe A 42:1330-6. 2003
    ..Elevation of the cGMP levels and improvement of endothelial function as a result of this approach also promises benefits in cardiovascular diseases and in LUTS...
  20. doi request reprint Durability of response following cessation of tadalafil taken once daily as treatment for erectile dysfunction
    Hartmut Porst
    Private Urological Practice, Hamburg, Germany
    J Sex Med 7:3487-94. 2010
    ..Research has focused on improvement of erectile function during treatment with phosphodiesterase type 5 (PDE5) inhibitors, but less is known about what occurs after treatment cessation...
  21. ncbi request reprint IC351 (tadalafil, Cialis): update on clinical experience
    H Porst
    Urological Practice, Hamburg, Germany
    Int J Impot Res 14:S57-64. 2002
    ..The long half-life (>17 h), with a comfortably long window of opportunity, releases couples from the need to plan sexual activities and therefore provides the highest amount of spontaneity for sexual activities...
  22. ncbi request reprint The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial
    H Porst
    Urological Practice, Hamburg, Germany
    Int J Impot Res 13:192-9. 2001
    ..Vardenafil treatment resulted in a high efficacy and low adverse-event profile in a population with mixed ED etiologies...
  23. ncbi request reprint Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction
    H Porst
    Neuer Jungfernstieg 6a, 20354 Hamburg, Germany
    Int J Impot Res 12:S91-S100. 2000
    ..Emphasis is placed on the efficacy, mechanism of action and side effect profiles of approved and experimental injectable pharmacotherapy for ED. International Journal of Impotence Research (2000) 12, Suppl 4, S91-S100...
  24. ncbi request reprint [Erectile dysfunction. New drugs with special consideration of the PDE 5 inhibitors]
    H Porst
    Hamburg
    Urologe A 43:820-8. 2004
    ..Possible new developments in the management of ED with a time frame of 5-8 years until their market approval are guanylate cyclase activators, Rho-kinase inhibitors, melanocortin receptor agonists, gene therapy, and tissue engineering...
  25. ncbi request reprint Efficacy and tolerability of vardenafil for treatment of erectile dysfunction in patient subgroups
    Hartmut Porst
    Urological Practice, Hamburg, Germany
    Urology 62:519-23; discussion 523-4. 2003
    ..To assess whether vardenafil would improve erectile function irrespective of etiology, baseline severity, or patient age. The consistency of the response over time was also evaluated...
  26. doi request reprint A randomised, placebo-controlled study to assess the efficacy of twice-daily vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia
    Christian G Stief
    Department of Urology, Ludwig Maximilians University, Munich, Germany
    Eur Urol 53:1236-44. 2008
    ..This randomised, double-blind, placebo-controlled study investigated the effects of vardenafil on LUTS and QoL in men with BPH/LUTS, with or without concomitant ED...
  27. ncbi request reprint Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial
    Hartmut Porst
    Private Urological Practice, Hamburg, Germany
    Urology 62:121-5; discussion 125-6. 2003
    ..To examine the therapeutic effects of tadalafil on erectile dysfunction (ED) at 24 and 36 hours after dosing...
  28. ncbi request reprint Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study
    Herbert Sperling
    Department of Urology, University Hospital Essen, Germany
    J Urol 169:1048-51. 2003
    ..We investigated a potential association of the G protein beta 3 subunit (GNB3) C825T polymorphism, a determinant of intracellular signal transduction, with the drug response to sildenafil in patients with erectile dysfunction...
  29. doi request reprint Systematic review of combination drug therapy for non-neurogenic male lower urinary tract symptoms
    Claudius Fullhase
    Department of Urology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Eur Urol 64:228-43. 2013
    ..The combination of different compounds, each of which targets a different aspect of LUTS, seems appealing. However, only few clinical trials have evaluated the effects of combination therapies...
  30. doi request reprint Tadalafil once daily in men with erectile dysfunction: an integrated analysis of data obtained from 1913 patients from six randomized, double-blind, placebo-controlled, clinical studies
    Hartmut Porst
    Private Practice of Urology Andrology, Hamburg, Germany
    Eur Urol 65:455-64. 2014
    ..This analysis explores tadalafil once-daily treatment for 12 wk in clinical subpopulations of men with erectile dysfunction (ED)...
  31. ncbi request reprint The future of erectile dysfunction (ED)
    Hartmut Porst
    European Society for Sexual Medicine Standards Committee for Sexual Medicine of the International Society for Sexual Medicine, Hamburg, Germany
    Arch Esp Urol 63:740-7. 2010
    ..Promising targets for ED therapy in the future is gene therapy with several targets as well as stem cell therapy with adipose-derived or muscle-derived stem cells...
  32. ncbi request reprint Expression of nitric oxide-sensitive guanylyl cyclase subunits in human corpus cavernosum
    S Behrends
    Institut fur Experimentelle und Klinische Pharmakologie, Universitat Hamburg, D 20251, Hamburg, Germany
    Biochem Pharmacol 59:713-7. 2000
    ..In conclusion, our findings suggest the presence of different subunit mRNAs of NO-sensitive guanylyl cyclase in human corpus cavernosum...
  33. ncbi request reprint Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction
    Ridwan Shabsigh
    Department of Urology, Columbia Presbyterian Medical Center, New York, New York 10032, USA
    Urology 68:689-96. 2006
  34. ncbi request reprint Comparing vardenafil and sildenafil in the treatment of men with erectile dysfunction and risk factors for cardiovascular disease: a randomized, double-blind, pooled crossover study
    Eusebio Rubio-Aurioles
    Asociacion Mexicana para la Salud Sexual AC, Tlalpan, Mexico
    J Sex Med 3:1037-49. 2006
    ....
  35. ncbi request reprint Earliest time to onset of action leading to successful intercourse with vardenafil determined in an at-home setting: a randomized, double-blind, placebo-controlled trial
    Francesco Montorsi
    Department of Urology, Universita Vita Salute San Raffaele, Milan, Italy
    J Sex Med 1:168-78. 2004
    ..Of considerable interest to patients and physicians is an understanding of the time required after dosing to attain penile erection sufficient for successful sexual intercourse...
  36. doi request reprint Comparable efficacy of once-daily versus on-demand vardenafil in men with mild-to-moderate erectile dysfunction: findings of the RESTORE study
    Jurgen Zumbe
    Klinikum Leverkusen, Leverkusen, Germany
    Eur Urol 54:204-10. 2008
    ..Phosphodiesterase (type) 5 (PDE5) inhibitors are currently administered on demand for treatment of erectile dysfunction (ED). Once-daily dosing has been suggested to benefit patients...
  37. ncbi request reprint ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction
    Andreas Eisenhardt
    Department of Pharmacology, University Hospital Essen, Essen, Germany
    Urology 62:152-7. 2003
    ..An insertion/deletion (I/D) polymorphism in the gene encoding the ACE and a single nucleotide exchange polymorphism (G894T) in the gene NOS3 encoding endothelial nitric oxide synthase have been associated with cardiovascular disorders...
  38. ncbi request reprint Vardenafil improves satisfaction rates, depressive symptomatology, and self-confidence in a broad population of men with erectile dysfunction
    Dimitrios Hatzichristou
    Department of Urology and Center for Sexual and Reproductive Health, Aristotle University of Thessaloniki, Greece
    J Sex Med 2:109-16. 2005
    ..Fixed-dose and flexible-dose studies have previously established the efficacy and tolerability of vardenafil...
  39. ncbi request reprint Sustained efficacy and safety of vardenafil for treatment of erectile dysfunction: a randomized, double-blind, placebo-controlled study
    Luc Valiquette
    Service d Urologie, Hôpital St Luc du CHUM, 1058 rue Saint Denis, Montreal, Quebec, Canada
    Mayo Clin Proc 80:1291-7. 2005
    ..To evaluate the reliability, efficacy, and safety of vardenafil, 10 mg, for patients with erectile dysfunction...
  40. ncbi request reprint The efficacy and safety of flexible-dose vardenafil (levitra) in a broad population of European men
    Dimitrios Hatzichristou
    Department of Urology and Center for Sexual and Reproductive Health, Aristotle University of Thessaloniki, 77 Mitropoleos str, 546 22 Thessaloniki, Greece
    Eur Urol 45:634-41; discussion 641. 2004
    ..In fixed-dose studies, vardenafil 5, 10, and 20mg improves erectile function in men with erectile dysfunction (ED). Here, the efficacy and tolerability of vardenafil when used in a flexible-dose regimen was assessed...
  41. doi request reprint An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    J Sex Med 5:1590-606. 2008
    ....
  42. ncbi request reprint An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    BJU Int 102:338-50. 2008
    ..To develop a contemporary, evidence-based definition of premature ejaculation (PE)...
  43. ncbi request reprint Pharmacotherapy for erectile dysfunction
    Harin Padma-Nathan
    J Sex Med 1:128-40. 2004
    ..Advances in understanding of the biochemistry and physiology of penile erection have led to breakthroughs in pharmacotherapy of erectile dysfunction...
  44. ncbi request reprint Premature ejaculation: results from a five-country European observational study
    Francois Giuliano
    Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    Eur Urol 53:1048-57. 2008
    ..To characterize premature ejaculation (PE) in five European countries using intravaginal ejaculatory latency time (IELT) and the Premature Ejaculation Profile (PEP)...