Human papillomavirus types by age in cervical cancer precursors: predominance of human papillomavirus 16 in young womenCarolina Porras
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 300 Oeste del ICE, Piso 7, Sabana Norte, San Jose, Costa Rica
Cancer Epidemiol Biomarkers Prev 18:863-5. 2009
..It also has implications for prevention, including the need to vaccinate young women before exposure to HPV vaccine-containing types (HPV 16 and HPV 18) to prevent the majority of cervical cancer precursors...
Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)Carolina Porras
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 300 mts Oeste del ICE, planta baja frente al Lobby, Sabana Norte, San Jose, Costa Rica
Cancer Causes Control 24:209-15. 2013
..To investigate the potential determinants of Helicobacter pylori infection between adults 21-65 years old...
- Switch from cytology-based to human papillomavirus test-based cervical screening: implications for colposcopy
Carolina Porras
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Int J Cancer 130:1879-87. 2012
..Our data support the need for a nonvisual diagnostic method to guide management and treatment of HPV-positive women...
- Epidemiology of genital Chlamydia trachomatis infection among young women in Costa Rica
Carolina Porras
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, San Jose, Costa Rica
Sex Transm Dis 35:461-8. 2008
..To investigate Chlamydia trachomatis (Ct) epidemiology among 5829 women 18 to 25 years old, in Costa Rica...
- Determinants of seropositivity among HPV-16/18 DNA positive young women
Carolina Porras
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
BMC Infect Dis 10:238. 2010
..We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18...
A comparison of cervical and vaginal human papillomavirusPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7234, USA
Sex Transm Dis 34:849-55. 2007
..Previous studies have failed to present data on or detect a broad spectrum of HPV genotypes and/or have not carefully sampled the vagina, instead relying on self-collection that is likely contaminated with cervical cells...
- Evaluation of the FTA carrier device for human papillomavirus testing in developing countries
Paula Gonzalez
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Guanacaste, Costa Rica
J Clin Microbiol 50:3870-6. 2012
..FTA cartridges could provide a simpler and more cost-effective method for cervical cell collection, storage, and transportation for HPV-DNA detection in research settings in developing countries...
- Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e33619. 2012
..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer...
- Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer
Sophia S Wang
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 5104, Rockville, MD 20852 7234, USA
J Infect Dis 199:20-30. 2009
..We examined host genetic factors to identify those more common in individuals whose human papillomavirus (HPV) infections were most likely to persist and progress to cervical intraepithelial neoplasia grade 3 (CIN3) and cancer...
- Rationale and design of a community-based double-blind randomized clinical trial of an HPV 16 and 18 vaccine in Guanacaste, Costa Rica
Rolando Herrero
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 300 Oeste del ICE, Piso 7, Sabana Norte, San Jose, Costa Rica
Vaccine 26:4795-808. 2008
..4% agreement for all types, kappa 0.59). Follow up will continue with yearly or more frequent examinations for at least 4 years for each participant...
- Long-term risk of recurrent cervical human papillomavirus infection and precancer and cancer following excisional treatment
Aimee R Kreimer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, MD, USA
Int J Cancer 131:211-8. 2012
..Thus, persistence of HPV infection a median of six years after treatment was uncommon but, when present, posed a substantial risk of subsequent CIN2+. Serial follow-up data from other studies would further strengthen these conclusions...
- Human papillomavirus infection with multiple types: pattern of coinfection and risk of cervical disease
Anil K Chaturvedi
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072 Rockville, MD 20852, USA
J Infect Dis 203:910-20. 2011
..We investigated coinfection patterns for 25 human papillomavirus (HPV) types and assessed the risk conferred by multiple HPV types toward cervical disease...
- Determinants and correlation of systemic and cervical concentrations of total IgA and IgG
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:2672-6. 2009
..17 and 0.16, respectively). The lack of correlation between systemic and cervical total IgA and IgG suggests that systemic concentrations are not reflective of cervical levels...
- Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited
Jill Koshiol
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7248, USA
Cancer Epidemiol Biomarkers Prev 18:1631-7. 2009
..Although genetic variation in TP53 might affect the natural history of HPV and cervical cancer, further work is needed to elucidate the possible mechanism...
- Seroprevalence and correlates of human papillomavirus 16/18 seropositivity among young women in Costa Rica
Sarah Coseo
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS, Room 7079, Rockville, MD 20852, USA
Sex Transm Dis 37:706-14. 2010
..We investigated HPV16 and 18 seroepidemiology among young, unvaccinated women aged between 18 and 25...
- Comparison of two PCR-based human papillomavirus genotyping methods
Philip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5004, EPS MSC 7234, Bethesda, MD 20892 7234
J Clin Microbiol 46:3437-45. 2008
..Both approaches are suitable for monitoring the impact of HPV16/18 vaccines in clinical trials...
- Epidemiological study of anti-HPV16/18 seropositivity and subsequent risk of HPV16 and -18 infections
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Ste 550, Rockville, MD 20852, USA
J Natl Cancer Inst 102:1653-62. 2010
..Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown...
- Behavioral/lifestyle and immunologic factors associated with HPV infection among women older than 45 years
Paula Gonzalez
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre Sabana, 300 Oeste del ICE, Piso 7, Sabana Norte, San Jose, Costa Rica
Cancer Epidemiol Biomarkers Prev 19:3044-54. 2010
..Cervical human papilloma virus (HPV) detection increases after menopause, but its determinants need clarification...
- Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine
Aimee R Kreimer
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7084, Rockville, MD 20852, USA
J Natl Cancer Inst 103:1444-51. 2011
..Three-dose regimens for human papillomavirus (HPV) vaccines are expensive and difficult to complete, especially in settings where the need for cervical cancer prevention is greatest...
- Prevalence of and risk factors for anal human papillomavirus infection among young healthy women in Costa Rica
Felipe A Castro
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 206:1103-10. 2012
..Anal cancer is caused by human papillomavirus (HPV), yet little is known about anal HPV infection among healthy young women...
- Prevention of persistent human papillomavirus infection by an HPV16/18 vaccine: a community-based randomized clinical trial in Guanacaste, Costa Rica
Rolando Herrero
Proyecto Epidemiologico Guanacaste, Fundación Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, San Jose, Costa Rica
Cancer Discov 1:408-19. 2011
..Vaccination is most effective in women and girls before they initiate sexual activity, with programmatic and individual decision implications...
- Efficacy of a bivalent HPV 16/18 vaccine against anal HPV 16/18 infection among young women: a nested analysis within the Costa Rica Vaccine Trial
Aimee R Kreimer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Lancet Oncol 12:862-70. 2011
..Human papillomavirus (HPV) 16 and 18 infections cause most cases of anal cancer. We assessed efficacy of an AS04-adjuvanted HPV 16 and HPV 18 vaccine against anal infection with HPV 16, HPV 18, or both (HPV 16/18)...
- Comparison of the SPF10-LiPA system to the Hybrid Capture 2 Assay for detection of carcinogenic human papillomavirus genotypes among 5,683 young women in Guanacaste, Costa Rica
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
J Clin Microbiol 45:1447-54. 2007
..The crude agreement between the two assays was 88%, with a kappa value of 0.75 (95% confidence limits, 0.73 to 0.76). We observed very good agreement between HC2 and SPF(10)-LiPA for carcinogenic HPV type detection...
- Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: a randomized trial
Allan Hildesheim
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
JAMA 298:743-53. 2007
..Viruslike particle human papillomavirus (HPV) vaccines were designed to prevent HPV infection and development of cervical precancers and cancer. Women with oncogenic HPV infections might consider vaccination as therapy...
- HPV16 seropositivity and subsequent HPV16 infection risk in a naturally infected population: comparison of serological assays
Shih Wen Lin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 8:e53067. 2013
....
- Direct comparison of HPV16 serological assays used to define HPV-naïve women in HPV vaccine trials
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 21:1547-54. 2012
..Some of the variation in estimated vaccine efficacies may be due to the differences in these assays used to define the HPV-naïve subgroups. To guide the interpretation of published results, we compared these assays...
- Evaluation of the polyclonal ELISA HPV serology assay as a biomarker for human papillomavirus exposure
Sarah E Coseo
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Sex Transm Dis 38:976-82. 2011
..Overall performance of these assays, as a measure of HPV exposure, has not been evaluated...
- Risk of miscarriage with bivalent vaccine against human papillomavirus (HPV) types 16 and 18: pooled analysis of two randomised controlled trials
Sholom Wacholder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
BMJ 340:c712. 2010
..To assess whether vaccination against human papillomavirus (HPV) increases the risk of miscarriage...
- Establishment and operation of a biorepository for molecular epidemiologic studies in Costa Rica
Bernal Cortes
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 7mo piso, Sabana Norte, San Jose, Costa Rica
Cancer Epidemiol Biomarkers Prev 19:916-22. 2010
....
- Factors associated with fluctuations in IgA and IgG levels at the cervix during the menstrual cycle
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 199:455-63. 2009
..The objective of this analysis was to describe patterns and determinants of cervical immunoglobulin A (IgA) and G (IgG) levels during the menstrual cycle...
