Serguei G Popov

Summary

Publications

  1. ncbi request reprint Secreted neutral metalloproteases of Bacillus anthracis as candidate pathogenic factors
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110, USA
    J Biol Chem 281:31408-18. 2006
  2. ncbi request reprint Lethal toxin of Bacillus anthracis causes apoptosis of macrophages
    Serguei G Popov
    Hadron Advanced Biosystems, Inc, 10900 University Boulevard, MSN 1A8, Manassas, VA 20110, USA
    Biochem Biophys Res Commun 293:349-55. 2002
  3. doi request reprint Activation of plasminogen activator inhibitor implicates protease InhA in the acute-phase response to Bacillus anthracis infection
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    J Med Microbiol 58:737-44. 2009
  4. doi request reprint Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    FEMS Immunol Med Microbiol 54:309-18. 2008
  5. doi request reprint Platelets, inflammatory cells, von Willebrand factor, syndecan-1, fibrin, fibronectin, and bacteria co-localize in the liver thrombi of Bacillus anthracis-infected mice
    Taissia G Popova
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    Microb Pathog 52:1-9. 2012
  6. ncbi request reprint Effect of Bacillus anthracis lethal toxin on human peripheral blood mononuclear cells
    Serguei G Popov
    Advanced Biosystems, Inc, 10900 University Blvd, MSN 1A8, Manassas, VA 20110, USA
    FEBS Lett 527:211-5. 2002
  7. pmc Anthrolysin O and fermentation products mediate the toxicity of Bacillus anthracis to lung epithelial cells under microaerobic conditions
    Taissia G Popova
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA, USA
    FEMS Immunol Med Microbiol 61:15-27. 2011
  8. doi request reprint Bacillus anthracis-derived nitric oxide induces protein S-nitrosylation contributing to macrophage death
    Myung Chul Chung
    School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, 10650 Pyramid Place, Manassas, VA 20110, United States
    Biochem Biophys Res Commun 430:125-30. 2013
  9. doi request reprint Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, College of Sciences, George Mason University, 10900 University Boulevard, Manassas, VA 20110, USA
    J Biol Chem 283:9531-42. 2008
  10. pmc Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors
    Taissia G Popova
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    BMC Microbiol 6:8. 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Secreted neutral metalloproteases of Bacillus anthracis as candidate pathogenic factors
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110, USA
    J Biol Chem 281:31408-18. 2006
    ..anthracis are multifunctional pathogenic factors that may contribute to anthrax pathology through direct degradation of host tissues, increases in barrier permeability, and/or modulation of host defenses...
  2. ncbi request reprint Lethal toxin of Bacillus anthracis causes apoptosis of macrophages
    Serguei G Popov
    Hadron Advanced Biosystems, Inc, 10900 University Boulevard, MSN 1A8, Manassas, VA 20110, USA
    Biochem Biophys Res Commun 293:349-55. 2002
    ..We suggest that apoptosis rather than direct lysis is biologically relevant to lethal toxin intracellular activity...
  3. doi request reprint Activation of plasminogen activator inhibitor implicates protease InhA in the acute-phase response to Bacillus anthracis infection
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    J Med Microbiol 58:737-44. 2009
    ....
  4. doi request reprint Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    FEMS Immunol Med Microbiol 54:309-18. 2008
    ..We propose that antithrombin depletion proceeding through activation of neutrophils and massive shedding of heparin-like syndecan from the liver into circulation contribute to anthrax coagulopathy...
  5. doi request reprint Platelets, inflammatory cells, von Willebrand factor, syndecan-1, fibrin, fibronectin, and bacteria co-localize in the liver thrombi of Bacillus anthracis-infected mice
    Taissia G Popova
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    Microb Pathog 52:1-9. 2012
    ....
  6. ncbi request reprint Effect of Bacillus anthracis lethal toxin on human peripheral blood mononuclear cells
    Serguei G Popov
    Advanced Biosystems, Inc, 10900 University Blvd, MSN 1A8, Manassas, VA 20110, USA
    FEBS Lett 527:211-5. 2002
    ..These findings may be explained by LeTx expression within phagocytes and support an important role of LeTx as an early intracellular virulence factor contributing to bacterial dissemination and disease progression...
  7. pmc Anthrolysin O and fermentation products mediate the toxicity of Bacillus anthracis to lung epithelial cells under microaerobic conditions
    Taissia G Popova
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA, USA
    FEMS Immunol Med Microbiol 61:15-27. 2011
    ..This mechanism of metabolic toxicity is relevant to the late-stage conditions of hypoxia and acidosis found in anthrax patients and might operate at anatomical locations of the host deprived from oxygen supply...
  8. doi request reprint Bacillus anthracis-derived nitric oxide induces protein S-nitrosylation contributing to macrophage death
    Myung Chul Chung
    School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, 10650 Pyramid Place, Manassas, VA 20110, United States
    Biochem Biophys Res Commun 430:125-30. 2013
    ..This novel mechanism of anthrax pathogenesis may offer specific approach to the development of therapeutics...
  9. doi request reprint Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, College of Sciences, George Mason University, 10900 University Boulevard, Manassas, VA 20110, USA
    J Biol Chem 283:9531-42. 2008
    ..Our results suggest a new mechanism of anthrax coagulopathy affecting the levels and functional activities of both VWF and its natural regulator ADAMTS13. This mechanism may contribute to hemorrhage and thrombosis typical in anthrax...
  10. pmc Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors
    Taissia G Popova
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    BMC Microbiol 6:8. 2006
    ..We tested if acceleration of Synd1 shedding takes place in vitro upon treatment of epithelial cells with B. anthracis hemolysins, as well as in vivo during anthrax infection in mice...
  11. doi request reprint In vivo murine and in vitro M-like cell models of gastrointestinal anthrax
    Jessica H Tonry
    National Center for Biodefense and Infectious Diseases, George Mason University, 10650 Pyramid Place, Manassas, VA 20110, USA
    Microbes Infect 15:37-44. 2013
    ..Here, we developed an in vivo murine model of GI anthrax and an in vitro M-like cell model that could be used to further our knowledge of GI anthrax pathogenesis...
  12. pmc Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry
    Nathan P Manes
    The National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110 2201, USA
    Mol Cell Proteomics 10:M110.000927. 2011
    ....
  13. pmc Effective antiprotease-antibiotic treatment of experimental anthrax
    Serguei G Popov
    Advanced Biosystems, Inc, Manassas, VA, USA
    BMC Infect Dis 5:25. 2005
    ..anthracis distinct from lethal toxin...
  14. ncbi request reprint Systemic cytokine response in murine anthrax
    Serguei G Popov
    Advanced Biosystems Inc, Manassas, VA 20110, USA
    Cell Microbiol 6:225-33. 2004
    ..Administration of caspase inhibitors z-VAD-fmk and ac-YVAD-cmk improved survival in Sterne-challenged mice indicating a pathogenic role of apoptosis in anthrax...
  15. ncbi request reprint Anaerobic induction of Bacillus anthracis hemolytic activity
    Vladimir I Klichko
    Advanced Biosystems, Inc, 10900 University Boulevard, Manassas, VA 20110, USA
    Biochem Biophys Res Commun 303:855-62. 2003
    ..These findings imply Anls as B. anthracis pathogenic determinants and highlight oxygen limitation as environmental factor controlling their expression at both early and late stages of infection...
  16. pmc Targeting the inflammasome and adenosine type-3 receptors improves outcome of antibiotic therapy in murine anthrax
    Serguei G Popov
    Serguei G Popov, Taissia G Popova, Fatah Kashanchi, Charles Bailey, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, Untied States
    World J Biol Chem 2:98-104. 2011
    ..To establish whether activation of adenosine type-3 receptors (A3Rs) and inhibition of interleukin-1β-induced inflammation is beneficial in combination with antibiotic therapy to increase survival of mice challenged with anthrax spores...