- Basiliximab: efficacy and safety evaluation in kidney transplantation
Scientific Institute Humanitas, Division of Nephrology, Rozzano, CP, Via Ampere 126, 20131 Milano, Italy 0226112952
Expert Opin Drug Saf 13:373-81. 2014
..When administered intravenously at a dosage of 20 mg at the time of transplantation and 4 days later, basiliximab saturates the alpha chain of IL-2R for 4 weeks...
- De novo membranous nephropathy (MN) in kidney allografts. A peculiar form of alloimmune disease?
Division of Nephrology, Istituto Clinico Humanitas IRCCS, Milan, Italy
Transpl Int 25:1205-10. 2012
..These events can lead to the production of circulating antibodies and in situ formation of immune complexes (IC) and the morphological lesion of MN...
- Current and emerging treatments for idiopathic focal and segmental glomerulosclerosis in adults
Division of Nephrology, IRCCS Humanitas Hospital, Via Manzoni 56, 20089 Rozzano, Milano, Italy
Expert Rev Clin Immunol 9:251-61. 2013
..A number of new drugs, including rituximab, galactose and antifibrotic agents, are under investigation...
- Education and counseling of renal transplant recipients
Department of Internal Medicine, Division of Nephrology, Istituto Clinico Humanitas IRCCS Rozzano, Milan, Italy
J Nephrol 25:879-89. 2012
..Last but not least, abidance by hygienic measures may help in preventing cardiovascular and infectious complications...
- Proteinuria after kidney transplantation
Division of Nephrology, Humanitas Scientific Institute, Rozzano, Milano, Italy
Transpl Int 25:909-17. 2012
..Inhibitors of renin-angiotensin system (RAS) are useful in reversing microalbuminuria and can reduce proteinuria, but their efficacy in interfering with patient or graft survival is not demonstrated...
- Induction and maintenance therapy in proliferative lupus nephritis
Department of Nephrology, IRCCS Istituto Humanitas, Milan, Italy
J Nephrol 23:9-16. 2010
..These newer strategies may result in fewer adverse effects, better quality of life and better survival for patients with proliferative lupus nephritis...
- A randomized pilot trial comparing cyclosporine and azathioprine for maintenance therapy in diffuse lupus nephritis over four years
Division of Nephrology, IRCCS Ospedale Maggiore, Via Commenda 15, 20122 Milano, Italy
Clin J Am Soc Nephrol 1:925-32. 2006
..For patients with diffuse proliferative lupus nephritis, azathioprine or cyclosporine combined with corticosteroids demonstrated equal efficacy in the prevention of flares...
- The long-term outcome of 93 patients with proliferative lupus nephritis
Unita Operativa di Nefrologia e Dialisi, Fondazione Ospedale Maggiore Policlinco, Mangiagalli, Regina Elena IRCCS, Via F Sforza, Milano, and Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Italy
Nephrol Dial Transplant 22:2531-9. 2007
..Few data are available about the very long-term outcome of patients with proliferative lupus nephritis...
- Hypertension in kidney transplant recipients
Nephrology and Dialysis Unit, Istituto Clinico Humanitas, IRCCS, Via Manzoni 56, Rozzano Milano, Italy
Transpl Int 24:523-33. 2011
- A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy
Istituto Scientifico Auxologico Italiano, Milan, Italy
Am J Kidney Dis 47:233-40. 2006
..We conducted a pilot trial to compare the effectiveness and safety of 2 different treatments in patients with membranous nephropathy and nephrotic syndrome...
- Natural history of hepatitis B and C in renal allograft recipients
Divisione di Nefrologia e Dialisi, Unita Operativa Nefrologia e Dialisi, Ospedale Maggiore IRCCS, Milano, Italy
Transplantation 79:1132-6. 2005
..The natural history of hepatitis C and B was studied in 286 renal allograft recipients who received a kidney allograft between 1972 and 1989 when tests for anti-HCV became available...
- Changes in viremia and circulating interferon-alpha during hemodialysis in hepatitis C virus-positive patients: only coincidental phenomena?
Division of Nephrology, Istituto Clinico Humanitas, Milan, Italy
Am J Kidney Dis 42:143-50. 2003
..The aim of the present study in HCV-positive (HCV+) HD patients is to determine whether HD induces the production of interferon-alpha (IFN-alpha) and if such production can contribute to viremia reduction...
- Thrombotic microangiopathy after kidney transplantation
Department of Immunology, IRCCS, Istituto Auxologico Italiano, Milan, Italy
Transpl Int 19:789-94. 2006
..The prognosis is less severe than with recurrent TMA. Complete withdrawal of the offending drug may lead to improvement in many cases. The addition of plasma exchange may result in graft salvage in about 80% of cases...
- A randomized exploratory trial of steroid avoidance in renal transplant patients treated with everolimus and low-dose cyclosporine
Nephrology Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, 20122, Italy
Nephrol Dial Transplant 23:707-14. 2008
..In this randomized trial, we explored whether the use of everolimus associated with low-dose cyclosporine could allow an early avoidance of steroids in de novo renal transplant recipients...
- What happens after complete withdrawal of therapy in patients with lupus nephritis
Division of Nephrology, Fondazione Ca Granda Ospedale Maggiore IRCCS, Milano, Italy
Clin Exp Rheumatol 31:S75-81. 2013
..Whether and when is it possible to completely stop immunosuppression in patients with lupus nephritis is still poorly defined...
- Acute post-bacterial glomerulonephritis in renal transplant patients: description of three cases and review of the literature
Division of Nephrology and Dialysis Ospedale Maggiore Policlinico IRCCS, Milan, Italy
Am J Transplant 4:132-6. 2004
..It has an unusual presentation and may have a poor outcome in the long term. The role of therapy, if any, is still undefined...
- Chyluria associated with nephrotic-range proteinuria: pathophysiology, clinical picture and therapeutic options
Nephrology and Dialysis Unit, Istituto Clinico Humanitas IRCCS, Rozzano, Italy
Nephron Clin Pract 119:c248-53; discussion c254. 2011
..Among the medical alternatives, a low-fat diet supplemented with medium-chain triglycerides is often followed by complete clinical and biochemical remission...
- Withdrawal of therapy in patients with proliferative lupus nephritis: long-term follow-up
Division of Nephrology, Ospedale Maggiore IRCCS, Via Commenda 15, 20122 Milan, Italy
Nephrol Dial Transplant 21:1541-8. 2006
..Whether corticosteroid and immunosuppressive therapy may be safely withdrawn in patients with proliferative lupus nephritis is still unclear...
- Looking at appearance of urine before performing a renal biopsy in nephrotic syndrome
Nephrology and Dialysis Unit, Humanitas Clinical Institute, Via Manzoni 56, Rozzano Milan, Italy
J Nephrol 24:665-8. 2011
..The patient progressively gained body weight and improved quality of life. No relapses were observed after 3 years of follow-up. This case emphasizes the possible role of a noninvasive therapeutical option for patients with chyluria...
- Can mTOR inhibitors reduce the risk of late kidney allograft failure?
Department of Immunology, Istituto Auxologico Italiano, Milano, Italy
Transpl Int 21:2-10. 2008
..All of these characteristics offer a ray of hope for reducing the risk of long-term allograft failure...
- Long-term lamivudine monotherapy in renal-transplant recipients with hepatitis-B-related cirrhosis
Department of Gastroenterology and Endocrinology, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
Antivir Ther 10:709-13. 2005
..The aim of the study was to assess the efficacy and safety of long-term lamivudine monotherapy in renal-transplant recipients with HBV-related cirrhosis...
- Recurrence of secondary glomerular disease after renal transplantation
Division of Nephrology, Scientific Institute Humanitas, Rozzano, Milano, Italy
Clin J Am Soc Nephrol 6:1214-21. 2011
..The main issues in transplantation of patients with secondary GN are the infectious, cardiovascular, or hepatic complications associated with the original disease or its treatment...
- Other immunosuppressive agents for focal segmental glomerulosclerosis
Division of Nephrology, IRCCS, Ospedale Maggiore, Milano, Italy
Semin Nephrol 23:242-8. 2003
..The preliminary results with plasmapheresis or lipopheresis are promising but further studies are needed to assess the role of these treatments...
- Risk factors for late kidney allograft failure
Divisione di Nefrologia e Dialisi, and Epidemiologic Unit, IRCCS Ospedale Maggiore Milano, Milano, Italy
Kidney Int 62:1848-54. 2002
..We evaluated the causes of late failure in renal allograft recipients treated with cyclosporine A (CsA)...
- Antiphospholipid antibodies are associated with an increased risk for chronic renal insufficiency in patients with lupus nephritis
Division of Nephrology and Dialysis, IRCCS Ospedale Maggiore, Milan, Italy
Am J Kidney Dis 43:28-36. 2004
..The aims of this study are to evaluate the prevalence of aPL antibodies in patients with lupus nephritis and assess their prognostic value for thrombosis and pregnancy morbidity and impact on long-term renal outcome...
- Renal replacement therapy in lupus nephritis
Division of Nephrology, IRCCS Maggiore Hospital, Milan, Italy
J Nephrol 16:787-91. 2003
..The recurrence risk of lupus nephritis ranged between 2% and 30% in different studies. The histological picture does not usually show severe features. Antiplatelet agents or anticoagulation can be advised for aPL patients...
- Gastrointestinal symptoms impair quality of life in Italian renal transplant recipients but are under-recognized by physicians
Nephrology and Dialysis Unit, Scientific Institute Humanitas, Rozzano, Milano, Italy
Transpl Int 23:1126-34. 2010
..816; P<0.0001). Gastrointestinal symptoms are frequent in renal transplant patients, are under-evaluated by physicians and may adversely impact on patient QOL...
- Kallikreins and lupus nephritis
Division of Nephrology, IRCCS Istituto Clinico Humanitas, Milan, Italy
J Clin Invest 119:768-71. 2009
- Clinical experience with everolimus (Certican): a summary
IRCCS, Istituto Auxologico Italiano, Milan, Italy
Transplantation 79:S93-4. 2005
- Posttransplant recurrence of primary glomerulonephritis
Division of Nephrology, Scientific Institute Humanitas, Milan, Italy
Clin J Am Soc Nephrol 5:2363-72. 2010
- The mechanisms of acute transplant rejection revisited
Division of Nephrology, Humanitas Institute, Rozzano, Milan, Italy
J Nephrol 25:150-8. 2012
..A number of therapeutic attempts have been tried to prevent or treat AMR. The still open question is whether the antibodies we detect are those responsible for tissue damage or not...
- Generic cyclosporine: a word of caution
IRCCS Istituto Auxologico, Milano, Italy
J Nephrol 17:S20-4. 2004
..A main problem is the absence of long-term studies with generic CsA, in the complex setting of organ transplantation...
- The kidney, a victim and culprit of autoimmune and alloimmune responses
Nephrology and Dialysis, Istituto Scientifico Humanitas, Rozzano, Italy
Nephron Clin Pract 119:c200-4. 2011
..Considering renal damage from a holistic point of view may favour exchange of news for two formerly considered non-communicant areas, i.e. glomerular disease and renal transplantation nephrology sections...
- Cyclosporine: from renal transplantation to autoimmune diseases
IRCCS Istituto Auxologico Italiano, FRCP, Via Ampere 126, 20131 Milan, Italy
Ann N Y Acad Sci 1051:551-8. 2005
..If these guidelines are followed, CsA may be safely used in autoimmune diseases...
- Corticosteroids, cyclophosphamide, and chlorambucil therapy of membranous nephropathy
Istituto Recovero e Cura Carattere Scientifico, Ospedale Maggiore, Milano, Italy
Semin Nephrol 23:355-61. 2003
..However, in patients with renal insufficiency side effects were frequent and severe. Moreover, in most cases renal function improved but did not return to normal...
- Altruistic living renal transplantation
Division of Nephrology, IRCCS Maggiore Hospital, Milan, Italy
J Nephrol 16:S6-9. 2003
..At present, there is no evidence that mononephrectomy in healthy subjects can expose them to an increased risk of renal failure, even in the long-term...
- Renal complications in transfusion-dependent beta thalassaemia
Division of Nephrology, Humanitas Scientific Institute, Milan, Italy
Blood Rev 24:239-44. 2010
..Future studies should aim to evaluate the natural history of kidney function in TM patients to help understand the mechanisms and long-term sequelae of the observed renal changes...
- Gastrointestinal complications in renal transplant recipients
Clinical Immunology Unit, IRCCS Istituto Auxologico Italiano, Milano, Italy
Transpl Int 18:643-50. 2005
..A particular gastric lymphoma called mucosa-associated lymphoid tissue (MALT) lymphoma may develop in renal transplant patients. It usually responds to the eradication of Helicobacter pylori...
- New therapies for lupus nephritis
Istituto Auxologico Italiano, Via Ampere 126, 20131 Milano, Italy
Clin J Am Soc Nephrol 1:863-8. 2006
- Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults
Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore Policlinico, Milano, Italy
Nephrol Dial Transplant 17:1204-11. 2002
..Infection-associated glomerulonephritis is rare in adults and its long-term prognosis is undefined...
- The pleiotropic effects of mTor inhibitors
IRCCS Istituto Auxologico, Milano, Italy
J Nephrol 17:762-8. 2004
- BK polyomavirus interstitial nephritis in a renal transplant patient with no previous acute rejection episodes
Nephrology and Dialysis Division, Maggiore Hospital IRCCS, Milan, Italy
J Nephrol 15:313-6. 2002
..This case shows that even in the absence of vigorous anti-rejection therapy an immunosuppressive regimen based on tacrolimus and MMF may involve the risk of BK polyoma virus- associated interstitial nephritis...
- Successful treatment of hemolytic uremic syndrome after liver-kidney transplantation
Liver Transplant Unit, IRCCS Maggiore Hospital, Milan, Italy
J Nephrol 16:586-90. 2003
..The syndrome is a well-recognized complication in bone marrow transplantation, and has been likewise described in several cases of solid organs transplantation, but never in patients receiving combined liver and kidney transplantation...
- Biological dynamics of hepatitis B virus load in dialysis population
Nephrology and Dialysis Division, Institute of Hygiene and Preventive Medicine, Maggiore Hospital, IRCCS, Milano, Italy
Am J Kidney Dis 41:1278-85. 2003
..The aim of this study is to measure monthly HBV viral load (HBV DNA) in a large cohort (n = 29) of hepatitis B surface antigen (HBsAg)-positive chronic dialysis patients during 12 months...
- Oxidative stress in kidney transplant patients
U O Nefrologia, IRCCS Ospedale Maggiore, Milan, Italy
Transplantation 76:1474-8. 2003
..Little information is available about the role of oxidative stress in renal transplant patients. To evaluate the prevalence and severity of oxidative stress in renal transplantation, the authors conducted a cross-sectional study...
- Management of idiopathic membranous nephropathy
Humanitas Hospital, Division of Nephrology, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Expert Opin Pharmacother 11:2163-75. 2010
..Idiopathic membranous nephropathy (IMN) can have a variable natural course. Treatments able to induce remission can improve the long-term prognosis. However, the optimal therapy for IMN remains controversial...
- Glomerular diseases: membranous nephropathy--a modern view
Division of Nephrology, IRCCS Humanitas Hospital, Rozzano, Milan, Italy, David Geffen School of Medicine, University of California, Los Angeles, California
Clin J Am Soc Nephrol 9:609-16. 2014
..Patients with moderate renal insufficiency may also benefit from treatment, but at a price of frequent and serious side effects. With these limitations in mind, idiopathic MN may be considered a treatable disease in many patients. ..
- Calcium and phosphate plasma levels in dialysis patients after dietary Ca-P overload. Role of gastric acid secretion
Division of Internal Medicine, Nephrology and Dialysis, Istituto Clinico Humanitas, Via Manzoni 56, I 20089 Rozzano, Milan, Italy
Nephron 91:474-9. 2002
..In contrast, with the "trade off" hypothesis we did not observe any postprandial phosphate peak after the dietary load, and, in contrast with normal subjects, omeprazole administration did not influence the phosphate profile...
- Increased levels of circulating endothelial cells in chronic periaortitis as a marker of active disease
Division of Nephrology, Ospedale Maggiore IRCCS, Milan, Italy
Kidney Int 68:562-8. 2005
..To clarify the role of vascular damage we looked for the presence and the surface phenotype of circulating endothelial cells (CECs) in the peripheral blood of patients with chronic periaortitis...
- Nonneoplastic mucocutaneous lesions in organ transplant recipients
Division of Nephrology, Istituto Scientifico Humanitas, Rozzano, Milan, Italy
Transpl Int 24:1041-50. 2011
..However, subcutaneous infections may cause a necrotizing fasciculitis which is a life-threatening disorder, usually sustained by polymicrobial pathogens...