Claudio Ponticelli

Summary

Publications

  1. doi request reprint Basiliximab: efficacy and safety evaluation in kidney transplantation
    Claudio Ponticelli
    Scientific Institute Humanitas, Division of Nephrology, Rozzano, CP, Via Ampere 126, 20131 Milano, Italy 0226112952
    Expert Opin Drug Saf 13:373-81. 2014
  2. doi request reprint De novo membranous nephropathy (MN) in kidney allografts. A peculiar form of alloimmune disease?
    Claudio Ponticelli
    Division of Nephrology, Istituto Clinico Humanitas IRCCS, Milan, Italy
    Transpl Int 25:1205-10. 2012
  3. doi request reprint Current and emerging treatments for idiopathic focal and segmental glomerulosclerosis in adults
    Claudio Ponticelli
    Division of Nephrology, IRCCS Humanitas Hospital, Via Manzoni 56, 20089 Rozzano, Milano, Italy
    Expert Rev Clin Immunol 9:251-61. 2013
  4. doi request reprint Education and counseling of renal transplant recipients
    Claudio Ponticelli
    Department of Internal Medicine, Division of Nephrology, Istituto Clinico Humanitas IRCCS Rozzano, Milan, Italy
    J Nephrol 25:879-89. 2012
  5. doi request reprint Proteinuria after kidney transplantation
    Claudio Ponticelli
    Division of Nephrology, Humanitas Scientific Institute, Rozzano, Milano, Italy
    Transpl Int 25:909-17. 2012
  6. ncbi request reprint Induction and maintenance therapy in proliferative lupus nephritis
    Claudio Ponticelli
    Department of Nephrology, IRCCS Istituto Humanitas, Milan, Italy
    J Nephrol 23:9-16. 2010
  7. ncbi request reprint A randomized pilot trial comparing cyclosporine and azathioprine for maintenance therapy in diffuse lupus nephritis over four years
    Gabriella Moroni
    Division of Nephrology, IRCCS Ospedale Maggiore, Via Commenda 15, 20122 Milano, Italy
    Clin J Am Soc Nephrol 1:925-32. 2006
  8. ncbi request reprint The long-term outcome of 93 patients with proliferative lupus nephritis
    Gabriella Moroni
    Unita Operativa di Nefrologia e Dialisi, Fondazione Ospedale Maggiore Policlinco, Mangiagalli, Regina Elena IRCCS, Via F Sforza, Milano, and Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Italy
    Nephrol Dial Transplant 22:2531-9. 2007
  9. doi request reprint Hypertension in kidney transplant recipients
    Claudio Ponticelli
    Nephrology and Dialysis Unit, Istituto Clinico Humanitas, IRCCS, Via Manzoni 56, Rozzano Milano, Italy
    Transpl Int 24:523-33. 2011
  10. ncbi request reprint A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy
    Claudio Ponticelli
    Istituto Scientifico Auxologico Italiano, Milan, Italy
    Am J Kidney Dis 47:233-40. 2006

Collaborators

Detail Information

Publications50

  1. doi request reprint Basiliximab: efficacy and safety evaluation in kidney transplantation
    Claudio Ponticelli
    Scientific Institute Humanitas, Division of Nephrology, Rozzano, CP, Via Ampere 126, 20131 Milano, Italy 0226112952
    Expert Opin Drug Saf 13:373-81. 2014
    ..When administered intravenously at a dosage of 20 mg at the time of transplantation and 4 days later, basiliximab saturates the alpha chain of IL-2R for 4 weeks...
  2. doi request reprint De novo membranous nephropathy (MN) in kidney allografts. A peculiar form of alloimmune disease?
    Claudio Ponticelli
    Division of Nephrology, Istituto Clinico Humanitas IRCCS, Milan, Italy
    Transpl Int 25:1205-10. 2012
    ..These events can lead to the production of circulating antibodies and in situ formation of immune complexes (IC) and the morphological lesion of MN...
  3. doi request reprint Current and emerging treatments for idiopathic focal and segmental glomerulosclerosis in adults
    Claudio Ponticelli
    Division of Nephrology, IRCCS Humanitas Hospital, Via Manzoni 56, 20089 Rozzano, Milano, Italy
    Expert Rev Clin Immunol 9:251-61. 2013
    ..A number of new drugs, including rituximab, galactose and antifibrotic agents, are under investigation...
  4. doi request reprint Education and counseling of renal transplant recipients
    Claudio Ponticelli
    Department of Internal Medicine, Division of Nephrology, Istituto Clinico Humanitas IRCCS Rozzano, Milan, Italy
    J Nephrol 25:879-89. 2012
    ..Last but not least, abidance by hygienic measures may help in preventing cardiovascular and infectious complications...
  5. doi request reprint Proteinuria after kidney transplantation
    Claudio Ponticelli
    Division of Nephrology, Humanitas Scientific Institute, Rozzano, Milano, Italy
    Transpl Int 25:909-17. 2012
    ..Inhibitors of renin-angiotensin system (RAS) are useful in reversing microalbuminuria and can reduce proteinuria, but their efficacy in interfering with patient or graft survival is not demonstrated...
  6. ncbi request reprint Induction and maintenance therapy in proliferative lupus nephritis
    Claudio Ponticelli
    Department of Nephrology, IRCCS Istituto Humanitas, Milan, Italy
    J Nephrol 23:9-16. 2010
    ..These newer strategies may result in fewer adverse effects, better quality of life and better survival for patients with proliferative lupus nephritis...
  7. ncbi request reprint A randomized pilot trial comparing cyclosporine and azathioprine for maintenance therapy in diffuse lupus nephritis over four years
    Gabriella Moroni
    Division of Nephrology, IRCCS Ospedale Maggiore, Via Commenda 15, 20122 Milano, Italy
    Clin J Am Soc Nephrol 1:925-32. 2006
    ..For patients with diffuse proliferative lupus nephritis, azathioprine or cyclosporine combined with corticosteroids demonstrated equal efficacy in the prevention of flares...
  8. ncbi request reprint The long-term outcome of 93 patients with proliferative lupus nephritis
    Gabriella Moroni
    Unita Operativa di Nefrologia e Dialisi, Fondazione Ospedale Maggiore Policlinco, Mangiagalli, Regina Elena IRCCS, Via F Sforza, Milano, and Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Italy
    Nephrol Dial Transplant 22:2531-9. 2007
    ..Few data are available about the very long-term outcome of patients with proliferative lupus nephritis...
  9. doi request reprint Hypertension in kidney transplant recipients
    Claudio Ponticelli
    Nephrology and Dialysis Unit, Istituto Clinico Humanitas, IRCCS, Via Manzoni 56, Rozzano Milano, Italy
    Transpl Int 24:523-33. 2011
    ....
  10. ncbi request reprint A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy
    Claudio Ponticelli
    Istituto Scientifico Auxologico Italiano, Milan, Italy
    Am J Kidney Dis 47:233-40. 2006
    ..We conducted a pilot trial to compare the effectiveness and safety of 2 different treatments in patients with membranous nephropathy and nephrotic syndrome...
  11. ncbi request reprint Natural history of hepatitis B and C in renal allograft recipients
    Adriana Aroldi
    Divisione di Nefrologia e Dialisi, Unita Operativa Nefrologia e Dialisi, Ospedale Maggiore IRCCS, Milano, Italy
    Transplantation 79:1132-6. 2005
    ..The natural history of hepatitis C and B was studied in 286 renal allograft recipients who received a kidney allograft between 1972 and 1989 when tests for anti-HCV became available...
  12. ncbi request reprint Changes in viremia and circulating interferon-alpha during hemodialysis in hepatitis C virus-positive patients: only coincidental phenomena?
    Salvatore Badalamenti
    Division of Nephrology, Istituto Clinico Humanitas, Milan, Italy
    Am J Kidney Dis 42:143-50. 2003
    ..The aim of the present study in HCV-positive (HCV+) HD patients is to determine whether HD induces the production of interferon-alpha (IFN-alpha) and if such production can contribute to viremia reduction...
  13. ncbi request reprint Thrombotic microangiopathy after kidney transplantation
    Claudio Ponticelli
    Department of Immunology, IRCCS, Istituto Auxologico Italiano, Milan, Italy
    Transpl Int 19:789-94. 2006
    ..The prognosis is less severe than with recurrent TMA. Complete withdrawal of the offending drug may lead to improvement in many cases. The addition of plasma exchange may result in graft salvage in about 80% of cases...
  14. ncbi request reprint A randomized exploratory trial of steroid avoidance in renal transplant patients treated with everolimus and low-dose cyclosporine
    Giuseppe Montagnino
    Nephrology Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, 20122, Italy
    Nephrol Dial Transplant 23:707-14. 2008
    ..In this randomized trial, we explored whether the use of everolimus associated with low-dose cyclosporine could allow an early avoidance of steroids in de novo renal transplant recipients...
  15. ncbi request reprint What happens after complete withdrawal of therapy in patients with lupus nephritis
    Gabriella Moroni
    Division of Nephrology, Fondazione Ca Granda Ospedale Maggiore IRCCS, Milano, Italy
    Clin Exp Rheumatol 31:S75-81. 2013
    ..Whether and when is it possible to completely stop immunosuppression in patients with lupus nephritis is still poorly defined...
  16. ncbi request reprint Acute post-bacterial glomerulonephritis in renal transplant patients: description of three cases and review of the literature
    Gabriella Moroni
    Division of Nephrology and Dialysis Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    Am J Transplant 4:132-6. 2004
    ..It has an unusual presentation and may have a poor outcome in the long term. The role of therapy, if any, is still undefined...
  17. doi request reprint Chyluria associated with nephrotic-range proteinuria: pathophysiology, clinical picture and therapeutic options
    Giorgio Graziani
    Nephrology and Dialysis Unit, Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Nephron Clin Pract 119:c248-53; discussion c254. 2011
    ..Among the medical alternatives, a low-fat diet supplemented with medium-chain triglycerides is often followed by complete clinical and biochemical remission...
  18. ncbi request reprint Withdrawal of therapy in patients with proliferative lupus nephritis: long-term follow-up
    Gabriella Moroni
    Division of Nephrology, Ospedale Maggiore IRCCS, Via Commenda 15, 20122 Milan, Italy
    Nephrol Dial Transplant 21:1541-8. 2006
    ..Whether corticosteroid and immunosuppressive therapy may be safely withdrawn in patients with proliferative lupus nephritis is still unclear...
  19. doi request reprint Looking at appearance of urine before performing a renal biopsy in nephrotic syndrome
    Giorgio Graziani
    Nephrology and Dialysis Unit, Humanitas Clinical Institute, Via Manzoni 56, Rozzano Milan, Italy
    J Nephrol 24:665-8. 2011
    ..The patient progressively gained body weight and improved quality of life. No relapses were observed after 3 years of follow-up. This case emphasizes the possible role of a noninvasive therapeutical option for patients with chyluria...
  20. ncbi request reprint Can mTOR inhibitors reduce the risk of late kidney allograft failure?
    Claudio Ponticelli
    Department of Immunology, Istituto Auxologico Italiano, Milano, Italy
    Transpl Int 21:2-10. 2008
    ..All of these characteristics offer a ray of hope for reducing the risk of long-term allograft failure...
  21. ncbi request reprint Long-term lamivudine monotherapy in renal-transplant recipients with hepatitis-B-related cirrhosis
    Mauro Vigano
    Department of Gastroenterology and Endocrinology, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Antivir Ther 10:709-13. 2005
    ..The aim of the study was to assess the efficacy and safety of long-term lamivudine monotherapy in renal-transplant recipients with HBV-related cirrhosis...
  22. doi request reprint Recurrence of secondary glomerular disease after renal transplantation
    Claudio Ponticelli
    Division of Nephrology, Scientific Institute Humanitas, Rozzano, Milano, Italy
    Clin J Am Soc Nephrol 6:1214-21. 2011
    ..The main issues in transplantation of patients with secondary GN are the infectious, cardiovascular, or hepatic complications associated with the original disease or its treatment...
  23. ncbi request reprint Other immunosuppressive agents for focal segmental glomerulosclerosis
    Claudio Ponticelli
    Division of Nephrology, IRCCS, Ospedale Maggiore, Milano, Italy
    Semin Nephrol 23:242-8. 2003
    ..The preliminary results with plasmapheresis or lipopheresis are promising but further studies are needed to assess the role of these treatments...
  24. ncbi request reprint Risk factors for late kidney allograft failure
    Claudio Ponticelli
    Divisione di Nefrologia e Dialisi, and Epidemiologic Unit, IRCCS Ospedale Maggiore Milano, Milano, Italy
    Kidney Int 62:1848-54. 2002
    ..We evaluated the causes of late failure in renal allograft recipients treated with cyclosporine A (CsA)...
  25. ncbi request reprint Antiphospholipid antibodies are associated with an increased risk for chronic renal insufficiency in patients with lupus nephritis
    Gabriella Moroni
    Division of Nephrology and Dialysis, IRCCS Ospedale Maggiore, Milan, Italy
    Am J Kidney Dis 43:28-36. 2004
    ..The aims of this study are to evaluate the prevalence of aPL antibodies in patients with lupus nephritis and assess their prognostic value for thrombosis and pregnancy morbidity and impact on long-term renal outcome...
  26. ncbi request reprint Renal replacement therapy in lupus nephritis
    Gabriella Moroni
    Division of Nephrology, IRCCS Maggiore Hospital, Milan, Italy
    J Nephrol 16:787-91. 2003
    ..The recurrence risk of lupus nephritis ranged between 2% and 30% in different studies. The histological picture does not usually show severe features. Antiplatelet agents or anticoagulation can be advised for aPL patients...
  27. doi request reprint Gastrointestinal symptoms impair quality of life in Italian renal transplant recipients but are under-recognized by physicians
    Claudio Ponticelli
    Nephrology and Dialysis Unit, Scientific Institute Humanitas, Rozzano, Milano, Italy
    Transpl Int 23:1126-34. 2010
    ..816; P<0.0001). Gastrointestinal symptoms are frequent in renal transplant patients, are under-evaluated by physicians and may adversely impact on patient QOL...
  28. pmc Kallikreins and lupus nephritis
    Claudio Ponticelli
    Division of Nephrology, IRCCS Istituto Clinico Humanitas, Milan, Italy
    J Clin Invest 119:768-71. 2009
    ....
  29. ncbi request reprint Clinical experience with everolimus (Certican): a summary
    Claudio Ponticelli
    IRCCS, Istituto Auxologico Italiano, Milan, Italy
    Transplantation 79:S93-4. 2005
  30. doi request reprint Posttransplant recurrence of primary glomerulonephritis
    Claudio Ponticelli
    Division of Nephrology, Scientific Institute Humanitas, Milan, Italy
    Clin J Am Soc Nephrol 5:2363-72. 2010
    ....
  31. doi request reprint The mechanisms of acute transplant rejection revisited
    Claudio Ponticelli
    Division of Nephrology, Humanitas Institute, Rozzano, Milan, Italy
    J Nephrol 25:150-8. 2012
    ..A number of therapeutic attempts have been tried to prevent or treat AMR. The still open question is whether the antibodies we detect are those responsible for tissue damage or not...
  32. ncbi request reprint Generic cyclosporine: a word of caution
    Claudio Ponticelli
    IRCCS Istituto Auxologico, Milano, Italy
    J Nephrol 17:S20-4. 2004
    ..A main problem is the absence of long-term studies with generic CsA, in the complex setting of organ transplantation...
  33. doi request reprint The kidney, a victim and culprit of autoimmune and alloimmune responses
    Claudio Ponticelli
    Nephrology and Dialysis, Istituto Scientifico Humanitas, Rozzano, Italy
    Nephron Clin Pract 119:c200-4. 2011
    ..Considering renal damage from a holistic point of view may favour exchange of news for two formerly considered non-communicant areas, i.e. glomerular disease and renal transplantation nephrology sections...
  34. ncbi request reprint Cyclosporine: from renal transplantation to autoimmune diseases
    Claudio Ponticelli
    IRCCS Istituto Auxologico Italiano, FRCP, Via Ampere 126, 20131 Milan, Italy
    Ann N Y Acad Sci 1051:551-8. 2005
    ..If these guidelines are followed, CsA may be safely used in autoimmune diseases...
  35. ncbi request reprint Corticosteroids, cyclophosphamide, and chlorambucil therapy of membranous nephropathy
    Patrizia Passerini
    Istituto Recovero e Cura Carattere Scientifico, Ospedale Maggiore, Milano, Italy
    Semin Nephrol 23:355-61. 2003
    ..However, in patients with renal insufficiency side effects were frequent and severe. Moreover, in most cases renal function improved but did not return to normal...
  36. ncbi request reprint Altruistic living renal transplantation
    Claudio Ponticelli
    Division of Nephrology, IRCCS Maggiore Hospital, Milan, Italy
    J Nephrol 16:S6-9. 2003
    ..At present, there is no evidence that mononephrectomy in healthy subjects can expose them to an increased risk of renal failure, even in the long-term...
  37. doi request reprint Renal complications in transfusion-dependent beta thalassaemia
    Claudio Ponticelli
    Division of Nephrology, Humanitas Scientific Institute, Milan, Italy
    Blood Rev 24:239-44. 2010
    ..Future studies should aim to evaluate the natural history of kidney function in TM patients to help understand the mechanisms and long-term sequelae of the observed renal changes...
  38. ncbi request reprint Gastrointestinal complications in renal transplant recipients
    Claudio Ponticelli
    Clinical Immunology Unit, IRCCS Istituto Auxologico Italiano, Milano, Italy
    Transpl Int 18:643-50. 2005
    ..A particular gastric lymphoma called mucosa-associated lymphoid tissue (MALT) lymphoma may develop in renal transplant patients. It usually responds to the eradication of Helicobacter pylori...
  39. ncbi request reprint New therapies for lupus nephritis
    Claudio Ponticelli
    Istituto Auxologico Italiano, Via Ampere 126, 20131 Milano, Italy
    Clin J Am Soc Nephrol 1:863-8. 2006
  40. ncbi request reprint Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults
    Gabriella Moroni
    Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore Policlinico, Milano, Italy
    Nephrol Dial Transplant 17:1204-11. 2002
    ..Infection-associated glomerulonephritis is rare in adults and its long-term prognosis is undefined...
  41. ncbi request reprint The pleiotropic effects of mTor inhibitors
    Claudio Ponticelli
    IRCCS Istituto Auxologico, Milano, Italy
    J Nephrol 17:762-8. 2004
    ....
  42. ncbi request reprint BK polyomavirus interstitial nephritis in a renal transplant patient with no previous acute rejection episodes
    Attilio Elli
    Nephrology and Dialysis Division, Maggiore Hospital IRCCS, Milan, Italy
    J Nephrol 15:313-6. 2002
    ..This case shows that even in the absence of vigorous anti-rejection therapy an immunosuppressive regimen based on tacrolimus and MMF may involve the risk of BK polyoma virus- associated interstitial nephritis...
  43. ncbi request reprint Successful treatment of hemolytic uremic syndrome after liver-kidney transplantation
    Stefano Gatti
    Liver Transplant Unit, IRCCS Maggiore Hospital, Milan, Italy
    J Nephrol 16:586-90. 2003
    ..The syndrome is a well-recognized complication in bone marrow transplantation, and has been likewise described in several cases of solid organs transplantation, but never in patients receiving combined liver and kidney transplantation...
  44. ncbi request reprint Biological dynamics of hepatitis B virus load in dialysis population
    Fabrizio Fabrizi
    Nephrology and Dialysis Division, Institute of Hygiene and Preventive Medicine, Maggiore Hospital, IRCCS, Milano, Italy
    Am J Kidney Dis 41:1278-85. 2003
    ..The aim of this study is to measure monthly HBV viral load (HBV DNA) in a large cohort (n = 29) of hepatitis B surface antigen (HBsAg)-positive chronic dialysis patients during 12 months...
  45. ncbi request reprint Oxidative stress in kidney transplant patients
    Mariarosaria Campise
    U O Nefrologia, IRCCS Ospedale Maggiore, Milan, Italy
    Transplantation 76:1474-8. 2003
    ..Little information is available about the role of oxidative stress in renal transplant patients. To evaluate the prevalence and severity of oxidative stress in renal transplantation, the authors conducted a cross-sectional study...
  46. doi request reprint Management of idiopathic membranous nephropathy
    Claudio Ponticelli
    Humanitas Hospital, Division of Nephrology, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Expert Opin Pharmacother 11:2163-75. 2010
    ..Idiopathic membranous nephropathy (IMN) can have a variable natural course. Treatments able to induce remission can improve the long-term prognosis. However, the optimal therapy for IMN remains controversial...
  47. doi request reprint Glomerular diseases: membranous nephropathy--a modern view
    Claudio Ponticelli
    Division of Nephrology, IRCCS Humanitas Hospital, Rozzano, Milan, Italy, David Geffen School of Medicine, University of California, Los Angeles, California
    Clin J Am Soc Nephrol 9:609-16. 2014
    ..Patients with moderate renal insufficiency may also benefit from treatment, but at a price of frequent and serious side effects. With these limitations in mind, idiopathic MN may be considered a treatable disease in many patients. ..
  48. ncbi request reprint Calcium and phosphate plasma levels in dialysis patients after dietary Ca-P overload. Role of gastric acid secretion
    Giorgio Graziani
    Division of Internal Medicine, Nephrology and Dialysis, Istituto Clinico Humanitas, Via Manzoni 56, I 20089 Rozzano, Milan, Italy
    Nephron 91:474-9. 2002
    ..In contrast, with the "trade off" hypothesis we did not observe any postprandial phosphate peak after the dietary load, and, in contrast with normal subjects, omeprazole administration did not influence the phosphate profile...
  49. ncbi request reprint Increased levels of circulating endothelial cells in chronic periaortitis as a marker of active disease
    Gabriella Moroni
    Division of Nephrology, Ospedale Maggiore IRCCS, Milan, Italy
    Kidney Int 68:562-8. 2005
    ..To clarify the role of vascular damage we looked for the presence and the surface phenotype of circulating endothelial cells (CECs) in the peripheral blood of patients with chronic periaortitis...
  50. doi request reprint Nonneoplastic mucocutaneous lesions in organ transplant recipients
    Claudio Ponticelli
    Division of Nephrology, Istituto Scientifico Humanitas, Rozzano, Milan, Italy
    Transpl Int 24:1041-50. 2011
    ..However, subcutaneous infections may cause a necrotizing fasciculitis which is a life-threatening disorder, usually sustained by polymicrobial pathogens...