Affiliation: Ponce School of Medicine
- Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathwaysMohitkumar R Gangwani
Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
J Neuroinflammation 10:136. 2013..The major objective of this study was to determine the effect of Vpr in induction of proinflammatory chemokine CCL5 in astrocytes and to define the underlying mechanism(s)...
- Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIVVanessa Rivera-Amill
AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
Virology 358:373-83. 2007..We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution...
- Short communication: Lack of immune response in rapid progressor morphine-dependent and SIV/SHIV-infected rhesus macaques is correlated with downregulation of TH1 cytokinesVanessa Rivera-Amill
AIDS Research Program, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004, USA
AIDS Res Hum Retroviruses 26:919-22. 2010..These results suggest that rapid disease progression in relation to morphine dependency may be the result of an altered cytokine profile...
- Accelerated evolution of SIV env within the cerebral compartment in the setting of morphine-dependent rapid disease progressionVanessa Rivera-Amill
Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004
Virology 398:201-7. 2010..This study provides additional insight into SIV envelope variation in the CNS of morphine-dependent macaques and genotypes that may have evolved in the brain and contributed to disease progression...
- Morphine and rapid disease progression in nonhuman primate model of AIDS: inverse correlation between disease progression and virus evolutionVanessa Rivera-Amill
Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732 7004
J Neuroimmune Pharmacol 5:122-32. 2010..Additionally, the studies presented could help enlighten the development of HIV vaccines that take into consideration viral diversity...
- Identification and molecular characterization of SIV Vpr R50G mutation associated with long term survival in SIV-infected morphine dependent and control macaquesIvelisse Rivera
Department of Microbiology, Ponce School of Medicine and Health Sciences, Ponce, PR 00716, USA
Virology 446:144-51. 2013..Our results, therefore, suggest that sequence changes within the SIV/17E-Fr vpr occur regardless of drug abuse but correlate with survival, and that they alter disease progression rates by affecting Vpr functions. ..
- Morphine-mediated deterioration of oxidative stress leads to rapid disease progression in SIV/SHIV-infected macaquesAntonio Pérez-Casanova
AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732
AIDS Res Hum Retroviruses 23:1004-7. 2007..The loss of these antioxidant systems was coincident with significantly increased plasma malondialdehyde upon viral infection that displayed a synergistic increase in conjunction with morphine and rapid disease...
- Analysis of the V1V2 region of the SIV envelope in the brains of morphine-dependent and control SIV/SHIV-infected macaquesVanessa Rivera-Amill
Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
AIDS Res Hum Retroviruses 25:531-4. 2009..Analysis of the sequences revealed that the diversity and divergence of the clones were higher in the control group as compared to the morphine-dependent macaques, although this difference was not statistically significant...
- Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaqueAntonio Pérez-Casanova
AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, USA
Mol Cell Biochem 308:169-75. 2008..Our results clearly suggest that morphine interaction with SIV/SHIV infection causes higher oxidative tissue injury that might have implication in the pathogenesis of AIDS in morphine-dependent macaques...
- Opiates, immune system, acquired immunodeficiency syndrome, and nonhuman primate modelRichard J Noel
Ponce School of Medicine, Ponce, Puerto Rico
J Neurovirol 14:279-85. 2008..In addition, the effects of opiates on disease progression in non-human primate model of AIDS is presented with at least one possible reason for rapid disease progression in multi-virus the challenge model...
- Astrocytic expression of HIV-1 Nef impairs spatial and recognition memoryGladys Chompré
Department of Biochemistry, Ponce School of Medicine and Health Sciences, Ponce, PR, USA
Neurobiol Dis 49:128-36. 2013..Therefore, the continued expression of Nef by astrocytes in the absence of viral replication has the potential to contribute to HIV associated cognitive impairment. ..
- Glutamate metabolism and HIV-associated neurocognitive disordersFabián J Vázquez-Santiago
Department of Microbiology, Ponce School of Medicine and Health Sciences, Ponce, 00716, Puerto Rico
J Neurovirol 20:315-31. 2014..In addition, discusses potential pharmacological strategies targeting the glutamatergic system that may help prevent and improve neurological outcomes in HIV-1-infected subjects...