Richard J Noel

Summary

Affiliation: Ponce School of Medicine

Publications

  1. ncbi request reprint Virus replication and disease progression inversely correlate with SIV tat evolution in morphine-dependent and SIV/SHIV-infected Indian rhesus macaques
    Richard J Noel
    AIDS Research Program, Ponce School of Medicine, Ponce 00732, Puerto Rico
    Virology 346:127-38. 2006
  2. ncbi request reprint Correlation between SIV Tat evolution and AIDS progression in cerebrospinal fluid of morphine-dependent and control macaques infected with SIV and SHIV
    Richard J Noel
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, USA Department of Biochemistry, Ponce School of Medicine, Ponce, PR 00732
    Virology 349:440-52. 2006
  3. pmc Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV
    Vanessa Rivera-Amill
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
    Virology 358:373-83. 2007
  4. ncbi request reprint Morphine-mediated deterioration of oxidative stress leads to rapid disease progression in SIV/SHIV-infected macaques
    Antonio Pérez-Casanova
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732
    AIDS Res Hum Retroviruses 23:1004-7. 2007
  5. ncbi request reprint Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaque
    Antonio Pérez-Casanova
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, USA
    Mol Cell Biochem 308:169-75. 2008
  6. pmc Short communication: Lack of immune response in rapid progressor morphine-dependent and SIV/SHIV-infected rhesus macaques is correlated with downregulation of TH1 cytokines
    Vanessa Rivera-Amill
    AIDS Research Program, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004, USA
    AIDS Res Hum Retroviruses 26:919-22. 2010
  7. pmc Opiates, immune system, acquired immunodeficiency syndrome, and nonhuman primate model
    Richard J Noel
    Ponce School of Medicine, Ponce, Puerto Rico
    J Neurovirol 14:279-85. 2008
  8. pmc Correlation between CD4 T cell counts and virus compartmentalization in genital and systemic compartments of HIV-infected females
    Suman Chaudhary
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
    Virology 417:320-6. 2011
  9. pmc Accelerated evolution of SIV env within the cerebral compartment in the setting of morphine-dependent rapid disease progression
    Vanessa Rivera-Amill
    Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004
    Virology 398:201-7. 2010
  10. doi request reprint Morphine and rapid disease progression in nonhuman primate model of AIDS: inverse correlation between disease progression and virus evolution
    Vanessa Rivera-Amill
    Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732 7004
    J Neuroimmune Pharmacol 5:122-32. 2010

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Virus replication and disease progression inversely correlate with SIV tat evolution in morphine-dependent and SIV/SHIV-infected Indian rhesus macaques
    Richard J Noel
    AIDS Research Program, Ponce School of Medicine, Ponce 00732, Puerto Rico
    Virology 346:127-38. 2006
    ..Our results also suggest that in vivo morphine dependence can contribute to the pathogenesis of SIV/SHIV infection and that it may do so in conjunction with the evolution of viral proteins, such as Tat...
  2. ncbi request reprint Correlation between SIV Tat evolution and AIDS progression in cerebrospinal fluid of morphine-dependent and control macaques infected with SIV and SHIV
    Richard J Noel
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, USA Department of Biochemistry, Ponce School of Medicine, Ponce, PR 00732
    Virology 349:440-52. 2006
    ..Thus, morphine abuse may change the nature and extent of mutations that drive viral evolution...
  3. pmc Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV
    Vanessa Rivera-Amill
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
    Virology 358:373-83. 2007
    ..We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution...
  4. ncbi request reprint Morphine-mediated deterioration of oxidative stress leads to rapid disease progression in SIV/SHIV-infected macaques
    Antonio Pérez-Casanova
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732
    AIDS Res Hum Retroviruses 23:1004-7. 2007
    ..The loss of these antioxidant systems was coincident with significantly increased plasma malondialdehyde upon viral infection that displayed a synergistic increase in conjunction with morphine and rapid disease...
  5. ncbi request reprint Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaque
    Antonio Pérez-Casanova
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, USA
    Mol Cell Biochem 308:169-75. 2008
    ..Our results clearly suggest that morphine interaction with SIV/SHIV infection causes higher oxidative tissue injury that might have implication in the pathogenesis of AIDS in morphine-dependent macaques...
  6. pmc Short communication: Lack of immune response in rapid progressor morphine-dependent and SIV/SHIV-infected rhesus macaques is correlated with downregulation of TH1 cytokines
    Vanessa Rivera-Amill
    AIDS Research Program, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004, USA
    AIDS Res Hum Retroviruses 26:919-22. 2010
    ..These results suggest that rapid disease progression in relation to morphine dependency may be the result of an altered cytokine profile...
  7. pmc Opiates, immune system, acquired immunodeficiency syndrome, and nonhuman primate model
    Richard J Noel
    Ponce School of Medicine, Ponce, Puerto Rico
    J Neurovirol 14:279-85. 2008
    ..In addition, the effects of opiates on disease progression in non-human primate model of AIDS is presented with at least one possible reason for rapid disease progression in multi-virus the challenge model...
  8. pmc Correlation between CD4 T cell counts and virus compartmentalization in genital and systemic compartments of HIV-infected females
    Suman Chaudhary
    AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
    Virology 417:320-6. 2011
    ....
  9. pmc Accelerated evolution of SIV env within the cerebral compartment in the setting of morphine-dependent rapid disease progression
    Vanessa Rivera-Amill
    Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004
    Virology 398:201-7. 2010
    ..This study provides additional insight into SIV envelope variation in the CNS of morphine-dependent macaques and genotypes that may have evolved in the brain and contributed to disease progression...
  10. doi request reprint Morphine and rapid disease progression in nonhuman primate model of AIDS: inverse correlation between disease progression and virus evolution
    Vanessa Rivera-Amill
    Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732 7004
    J Neuroimmune Pharmacol 5:122-32. 2010
    ..Additionally, the studies presented could help enlighten the development of HIV vaccines that take into consideration viral diversity...
  11. pmc SIV Vpr evolution is inversely related to disease progression in a morphine-dependent rhesus macaque model of AIDS
    Richard J Noel
    Department of Biochemistry, Ponce School of Medicine, Ponce, PR 00716, USA
    Virology 359:397-404. 2007
    ..Interestingly, although our previous work with the accessory gene nef indicated no association between disease progression and evolution, the accessory factor, vpr, behaves similarly to the essential lentiviral genes tat and env...
  12. pmc Lack of correlation between SIV-Nef evolution and rapid disease progression in morphine-dependent nonhuman primate model of AIDS
    Richard J Noel
    Department of Biochemistry, Ponce School of Medicine, Ponce, PR 00716
    AIDS Res Hum Retroviruses 22:817-23. 2006
    ....
  13. ncbi request reprint Differential virus evolution in blood and genital tract of HIV-infected females: evidence for the involvement of drug and non-drug resistance-associated mutations
    Grissell Tirado
    Laboratory of Viral Immunology, Ponce School of Medicine, Ponce 00732, Puerto Rico
    Virology 324:577-86. 2004
    ..These non-drug-associated mutations were different between plasma and vaginal viruses, suggesting that evolution of HIV-1 was independent in these two compartments...
  14. ncbi request reprint Increased viral replication in simian immunodeficiency virus/simian-HIV-infected macaques with self-administering model of chronic alcohol consumption
    Rakesh Kumar
    Laboratory of Viral Immunology, Department of Microbiology, Ponce School of Medicine, San Juan, PR
    J Acquir Immune Defic Syndr 39:386-90. 2005
    ..The extent of CD4 cell loss in the alcohol group was significantly higher than that in the control animals at week 1 after infection...
  15. ncbi request reprint Compartmentalization of drug resistance-associated mutations in a treatment-naive HIV-infected female
    Grissell Tirado
    Laboratory of Viral Immunology, Ponce School of Medicine, PuertoRico 00732
    AIDS Res Hum Retroviruses 20:684-6. 2004
    ..In the absence of antiretroviral treatment, a drug-resistant mutant was thought to develop because of immune pressure. This is the first report describing the role of immune pressure in the development of a drug-resistant virus...