Caroline B Appleyard

Summary

Affiliation: Ponce School of Medicine

Publications

  1. ncbi request reprint Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon
    Caroline B Appleyard
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, PR 00732 7004, USA
    Dig Dis Sci 53:220-8. 2008
  2. ncbi request reprint Basic epidemiology of inflammatory bowel disease in Puerto Rico
    Caroline B Appleyard
    Department of Physiology, Biostatistics Core Program, Ponce School of Medicine, Ponce, Puerto Rico
    Inflamm Bowel Dis 10:106-11. 2004
  3. pmc Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer
    Caroline B Appleyard
    Dept of Physiology and Pharmacology, Ponce School of Medicine, PO Box 7004, Ponce, Puerto Rico 00732 7004
    Am J Physiol Gastrointest Liver Physiol 301:G1004-13. 2011
  4. ncbi request reprint Experimental endometriosis in the rat is correlated with colonic motor function alterations but not with bacterial load
    Caroline B Appleyard
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, Puerto Rico
    Reprod Sci 14:815-24. 2007
  5. ncbi request reprint Regional variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon
    Caroline B Appleyard
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    Dig Dis Sci 51:506-16. 2006
  6. pmc Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model
    BEATRIZ PAGAN
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, PR 00732, United States
    World J Gastroenterol 17:4858-66. 2011
  7. ncbi request reprint Role of tumor necrosis factor receptors in an animal model of acute colitis
    Carmencita Rojas-Cartagena
    Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732 7004, USA
    Cytokine 32:85-93. 2005
  8. pmc Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer
    BEATRIZ PAGAN
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce PR 00732, USA
    Anticancer Res 30:3345-53. 2010
  9. pmc Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease
    Idhaliz Flores
    Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico
    Fertil Steril 87:1180-99. 2007
  10. ncbi request reprint Effect of bacterial chemotactic peptides on intestinal inflammation in animal models of acute and chronic "relapsed" colitis
    GERARDO A HERNANDEZ
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004
    Dig Dis Sci 50:1444-53. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon
    Caroline B Appleyard
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, PR 00732 7004, USA
    Dig Dis Sci 53:220-8. 2008
    ..Selective antagonism implies that this is region-specific, with the inflammatory process altering the relative contribution of the neurokinin receptor subtypes within each region of the rat colon...
  2. ncbi request reprint Basic epidemiology of inflammatory bowel disease in Puerto Rico
    Caroline B Appleyard
    Department of Physiology, Biostatistics Core Program, Ponce School of Medicine, Ponce, Puerto Rico
    Inflamm Bowel Dis 10:106-11. 2004
    ..The aim of this study was to estimate the incidence of IBD in Puerto Rico, a predominantly Hispanic population...
  3. pmc Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer
    Caroline B Appleyard
    Dept of Physiology and Pharmacology, Ponce School of Medicine, PO Box 7004, Ponce, Puerto Rico 00732 7004
    Am J Physiol Gastrointest Liver Physiol 301:G1004-13. 2011
    ....
  4. ncbi request reprint Experimental endometriosis in the rat is correlated with colonic motor function alterations but not with bacterial load
    Caroline B Appleyard
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, Puerto Rico
    Reprod Sci 14:815-24. 2007
    ..In summary, this study presents evidence for a significant effect of peritoneal endometriosis on colonic function and integrity, which may help explain the gastrointestinal symptoms associated with this disease...
  5. ncbi request reprint Regional variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon
    Caroline B Appleyard
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    Dig Dis Sci 51:506-16. 2006
    ..In conclusion, substance P-induced responses in the rat colon are region-specific and not mediated by a single NK receptor subtype common to both structures...
  6. pmc Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model
    BEATRIZ PAGAN
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, PR 00732, United States
    World J Gastroenterol 17:4858-66. 2011
    ..To investigate the role of epidermal growth factor receptor (EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor erlotinib...
  7. ncbi request reprint Role of tumor necrosis factor receptors in an animal model of acute colitis
    Carmencita Rojas-Cartagena
    Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732 7004, USA
    Cytokine 32:85-93. 2005
    ..In addition, increased levels of sTNFRs in the PF of experimental rats--particularly sTNFRII--may be involved in the development of colitis by serving as a reservoir of TNF-alpha, and thus provide a novel therapeutic target for IBD...
  8. pmc Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer
    BEATRIZ PAGAN
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce PR 00732, USA
    Anticancer Res 30:3345-53. 2010
    ..The role of substance P and the neurokinin-1 receptor (NK-1R) in the transition from inflammation to dysplasia in inflammatory bowel disease is not clear...
  9. pmc Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease
    Idhaliz Flores
    Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico
    Fertil Steril 87:1180-99. 2007
    ..To validate a rat model of endometriosis using complimentary DNA (cDNA) microarrays by identifying common gene expression patterns between experimental and natural disease...
  10. ncbi request reprint Effect of bacterial chemotactic peptides on intestinal inflammation in animal models of acute and chronic "relapsed" colitis
    GERARDO A HERNANDEZ
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004
    Dig Dis Sci 50:1444-53. 2005
    ..Bacterial peptides such as fMLP appear to play a different role in the acute phase of inflammation compared with the chronic phase, depending on the integrity of the mucosal barrier...
  11. doi request reprint Stress exacerbates endometriosis manifestations and inflammatory parameters in an animal model
    MARIELLY CUEVAS
    Department of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, Ponce, PR 00716, USA
    Reprod Sci 19:851-62. 2012
    ....
  12. ncbi request reprint Bacterial load in animal models of acute and chronic 'reactivated' colitis
    GERARDO A HERNANDEZ
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    Digestion 67:161-9. 2003
    ..The involvement of enteropathogenic microorganisms in the pathogenesis of inflammatory bowel disease (IBD) and their importance in the different phases of inflammation are still unknown...
  13. ncbi request reprint Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer
    Cariluz Santiago
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, Puerto Rico
    Cancer Res 67:10766-73. 2007
    ..The prolonged reactivation group may be considered a new model of colitis-associated colon cancer, offering the potential to study cancer prevention strategies for patients with IBD...
  14. ncbi request reprint Molecular profiling of a rat model of colitis: validation of known inflammatory genes and identification of novel disease-associated targets
    Edelmarie Rivera
    Departments of Physiology and Pharmacology, Ponce School of Medicine, Ponce, Puerto Rico
    Inflamm Bowel Dis 12:950-66. 2006
    ..The most suitable animal model for studying this disease is still under debate. Microarray transcript profiling has the potential to illuminate the molecular processes that are involved in both the human condition and animal models...
  15. pmc An angiotensin II receptor antagonist reduces inflammatory parameters in two models of colitis
    Olga I Santiago
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, 00732, Puerto Rico
    Regul Pept 146:250-9. 2008
    ..The aim of this study was to evaluate the effect of valsartan (Diovan), an Ang II receptor antagonist, in two models of colitis...
  16. ncbi request reprint Experimental intestinal endometriosis is characterized by increased levels of soluble TNFRSF1B and downregulation of Tnfrsf1a and Tnfrsf1b gene expression
    Carmencita Rojas-Cartagena
    Department of Microbiology, Ponce School of Medicine, Puerto Rico
    Biol Reprod 73:1211-8. 2005
    ..Overexpression of TNF and target genes, underexpression of TNF-receptor genes, and increased shedding of TNFRSF1B in this animal model provide further evidence for involvement of the TNF system in the pathogenesis of endometriosis...
  17. ncbi request reprint Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis
    Caroline B Appleyard
    Department of Physiology, Ponce School of Medicine, Puerto Rico 00732, USA
    Dig Dis Sci 47:2007-14. 2002
    ..These data suggest that the role of lipid mediators in acute colitis is species-dependent and, although there are corresponding gross and microscopic changes in both models, these occur through disparate mechanisms...