James D Pomonis

Summary

Publications

  1. ncbi request reprint Development and pharmacological characterization of a rat model of osteoarthritis pain
    James D Pomonis
    Discovery Research, Purdue Pharma, L P, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    Pain 114:339-46. 2005
  2. ncbi request reprint Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states
    Victor I Ilyin
    Discovery Research, Purdue Pharma LP, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 318:1083-93. 2006
  3. ncbi request reprint DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted Mu opioid agonist with antihyperalgesic activity: II. In vivo pharmacological characterization in the
    Garth T Whiteside
    Departments of Molecular Pharmacology and Neuropharmacology, Purdue Pharma Discovery Research, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 310:793-9. 2004
  4. ncbi request reprint An industry perspective on the role and utility of animal models of pain in drug discovery
    Garth T Whiteside
    Discovery Research, Purdue Pharma L P, 6 Cedar Brook Drive, Cranbury, NJ 08512, United States
    Neurosci Lett 557:65-72. 2013
  5. ncbi request reprint N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
    James D Pomonis
    Pudue Pharma Discovery Research, 6 Cedarbrook Dr, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 306:387-93. 2003
  6. ncbi request reprint Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain
    Nancy M Luger
    Department of Preventive Sciences, Schools of Dentistry and Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 99:397-406. 2002
  7. ncbi request reprint Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS
    Scott D Rogers
    Molecular Neurobiology Laboratory, Veterans Affairs Medical Center, Minneapolis, Minnesota 55455, USA
    Glia 41:180-90. 2003
  8. ncbi request reprint Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis
    Christopher M Peters
    Department of Preventive Science, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 180:1-13. 2003

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Development and pharmacological characterization of a rat model of osteoarthritis pain
    James D Pomonis
    Discovery Research, Purdue Pharma, L P, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    Pain 114:339-46. 2005
    ..We conclude that the iodoacetate model of OA is a relevant animal model to study pain associated with OA, and can be used to test potential therapeutic agents...
  2. ncbi request reprint Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states
    Victor I Ilyin
    Discovery Research, Purdue Pharma LP, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 318:1083-93. 2006
    ..Optimizing the biophysical parameters of broad-spectrum voltage-gated Na(+) channel blockers may lead to improved pain therapeutics...
  3. ncbi request reprint DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted Mu opioid agonist with antihyperalgesic activity: II. In vivo pharmacological characterization in the
    Garth T Whiteside
    Departments of Molecular Pharmacology and Neuropharmacology, Purdue Pharma Discovery Research, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 310:793-9. 2004
    ..This is the first report of a peripherally restricted, small-molecule mu opioid agonist that is nonsedating, antihyperalgesic, and effective against inflammatory and postsurgical pain when administered systemically...
  4. ncbi request reprint An industry perspective on the role and utility of animal models of pain in drug discovery
    Garth T Whiteside
    Discovery Research, Purdue Pharma L P, 6 Cedar Brook Drive, Cranbury, NJ 08512, United States
    Neurosci Lett 557:65-72. 2013
    ....
  5. ncbi request reprint N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
    James D Pomonis
    Pudue Pharma Discovery Research, 6 Cedarbrook Dr, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 306:387-93. 2003
    ..o.). BCTC did not affect motor performance on the rotarod after administration of doses up to 50 mg/kg p.o. These data suggest a role for VR1 in persistent and chronic pain arising from inflammation or nerve injury...
  6. ncbi request reprint Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain
    Nancy M Luger
    Department of Preventive Sciences, Schools of Dentistry and Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 99:397-406. 2002
    ..inflammatory pain. These results indicate that this model may be useful in defining drug therapies that are targeted for complex bone cancer pain syndromes...
  7. ncbi request reprint Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS
    Scott D Rogers
    Molecular Neurobiology Laboratory, Veterans Affairs Medical Center, Minneapolis, Minnesota 55455, USA
    Glia 41:180-90. 2003
    ..These data suggest that pharmacological blockade of astrocyte ET(B)R receptors following CNS injury modulates glial scar formation and may provide a more permissive substrate for neuronal survival and regeneration...
  8. ncbi request reprint Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis
    Christopher M Peters
    Department of Preventive Science, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 180:1-13. 2003
    ..Strategies aimed at blocking vascular ET(A)R/ET(B)R and astrocyte ET(B)Rs following spinal cord injury may reduce the resulting ischemia and astrogliosis and in doing so increase neuronal survival, regeneration, and function...