James D Pomonis

Summary

Publications

  1. ncbi Development and pharmacological characterization of a rat model of osteoarthritis pain
    James D Pomonis
    Discovery Research, Purdue Pharma, L P, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    Pain 114:339-46. 2005
  2. ncbi Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states
    Victor I Ilyin
    Discovery Research, Purdue Pharma LP, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 318:1083-93. 2006
  3. ncbi DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted Mu opioid agonist with antihyperalgesic activity: II. In vivo pharmacological characterization in the
    Garth T Whiteside
    Departments of Molecular Pharmacology and Neuropharmacology, Purdue Pharma Discovery Research, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 310:793-9. 2004
  4. ncbi N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
    James D Pomonis
    Pudue Pharma Discovery Research, 6 Cedarbrook Dr, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 306:387-93. 2003
  5. ncbi Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain
    Nancy M Luger
    Department of Preventive Sciences, Schools of Dentistry and Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 99:397-406. 2002
  6. ncbi Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS
    Scott D Rogers
    Molecular Neurobiology Laboratory, Veterans Affairs Medical Center, Minneapolis, Minnesota 55455, USA
    Glia 41:180-90. 2003
  7. ncbi Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis
    Christopher M Peters
    Department of Preventive Science, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 180:1-13. 2003

Collaborators

Detail Information

Publications7

  1. ncbi Development and pharmacological characterization of a rat model of osteoarthritis pain
    James D Pomonis
    Discovery Research, Purdue Pharma, L P, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    Pain 114:339-46. 2005
    ..We conclude that the iodoacetate model of OA is a relevant animal model to study pain associated with OA, and can be used to test potential therapeutic agents...
  2. ncbi Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states
    Victor I Ilyin
    Discovery Research, Purdue Pharma LP, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 318:1083-93. 2006
    ..Optimizing the biophysical parameters of broad-spectrum voltage-gated Na(+) channel blockers may lead to improved pain therapeutics...
  3. ncbi DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted Mu opioid agonist with antihyperalgesic activity: II. In vivo pharmacological characterization in the
    Garth T Whiteside
    Departments of Molecular Pharmacology and Neuropharmacology, Purdue Pharma Discovery Research, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 310:793-9. 2004
    ..This is the first report of a peripherally restricted, small-molecule mu opioid agonist that is nonsedating, antihyperalgesic, and effective against inflammatory and postsurgical pain when administered systemically...
  4. ncbi N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
    James D Pomonis
    Pudue Pharma Discovery Research, 6 Cedarbrook Dr, Cranbury, NJ 08512, USA
    J Pharmacol Exp Ther 306:387-93. 2003
    ..o.). BCTC did not affect motor performance on the rotarod after administration of doses up to 50 mg/kg p.o. These data suggest a role for VR1 in persistent and chronic pain arising from inflammation or nerve injury...
  5. ncbi Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain
    Nancy M Luger
    Department of Preventive Sciences, Schools of Dentistry and Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 99:397-406. 2002
    ..inflammatory pain. These results indicate that this model may be useful in defining drug therapies that are targeted for complex bone cancer pain syndromes...
  6. ncbi Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS
    Scott D Rogers
    Molecular Neurobiology Laboratory, Veterans Affairs Medical Center, Minneapolis, Minnesota 55455, USA
    Glia 41:180-90. 2003
    ..These data suggest that pharmacological blockade of astrocyte ET(B)R receptors following CNS injury modulates glial scar formation and may provide a more permissive substrate for neuronal survival and regeneration...
  7. ncbi Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis
    Christopher M Peters
    Department of Preventive Science, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 180:1-13. 2003
    ..Strategies aimed at blocking vascular ET(A)R/ET(B)R and astrocyte ET(B)Rs following spinal cord injury may reduce the resulting ischemia and astrogliosis and in doing so increase neuronal survival, regeneration, and function...