Michał Zimecki

Summary

Country: Poland

Publications

  1. ncbi request reprint The lunar cycle: effects on human and animal behavior and physiology
    Michał Zimecki
    Department of Experimental Therapy, The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 60:1-7. 2006
  2. ncbi request reprint Potential therapeutic interventions via EP2/EP4 prostaglandin receptors
    Michał Zimecki
    Department of Experimental Therapy, The Institute of Immunology and Experimental Therapy, Wrocław, Poland mail
    Postepy Hig Med Dosw (Online) 66:287-94. 2012
  3. ncbi request reprint Restoration of immune system function is accelerated in immunocompromised mice by the B-cell-tropic isoxazole R-11
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 64:403-11. 2012
  4. doi request reprint A proline-rich polypeptide from ovine colostrum: colostrinin with immunomodulatory activity
    Michal Zimecki
    Institute of Immunology and Experimental Therapy, Wroclaw, Poland
    Adv Exp Med Biol 606:241-50. 2008
  5. ncbi request reprint Immunosuppressory activity of an isoxazolo[5,4-e]triazepine-compound RM-33 II. Effects on the carrageenan-induced inflammation
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 58:236-41. 2006
  6. ncbi request reprint The concerted action of lactoferrin and bacteriophages in the clearance of bacteria in sublethally infected mice
    Michał Zimecki
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
    Postepy Hig Med Dosw (Online) 62:42-6. 2008
  7. ncbi request reprint [Therapeutic properties of proteins and peptides from colostrum and milk]
    Michał Zimecki
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 59:309-23. 2005
  8. ncbi request reprint RM-11, an isoxazole derivative, accelerates restoration of the immune function in mice treated with cyclophosphamide
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 60:183-9. 2008
  9. pmc Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wrocław, Poland
    BMC Microbiol 9:169. 2009
  10. ncbi request reprint Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 61:705-10. 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The lunar cycle: effects on human and animal behavior and physiology
    Michał Zimecki
    Department of Experimental Therapy, The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 60:1-7. 2006
    ....
  2. ncbi request reprint Potential therapeutic interventions via EP2/EP4 prostaglandin receptors
    Michał Zimecki
    Department of Experimental Therapy, The Institute of Immunology and Experimental Therapy, Wrocław, Poland mail
    Postepy Hig Med Dosw (Online) 66:287-94. 2012
    ..This article presents a short overview of experimental approaches aimed at manipulation of signaling via EP2 and EP4 receptors that could have therapeutic utility...
  3. ncbi request reprint Restoration of immune system function is accelerated in immunocompromised mice by the B-cell-tropic isoxazole R-11
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 64:403-11. 2012
    ..Restoration of impaired immune response in immunocompromised patients is a crucial problem. In this study we evaluated the efficacy of isoxazole R-11 in reconstitution of the immune response in immunosuppressed mice...
  4. doi request reprint A proline-rich polypeptide from ovine colostrum: colostrinin with immunomodulatory activity
    Michal Zimecki
    Institute of Immunology and Experimental Therapy, Wroclaw, Poland
    Adv Exp Med Biol 606:241-50. 2008
    ..The trials demonstrated the therapeutic benefit of CLN in Alzheimer's disease (AD) patients by delaying progress of the disease...
  5. ncbi request reprint Immunosuppressory activity of an isoxazolo[5,4-e]triazepine-compound RM-33 II. Effects on the carrageenan-induced inflammation
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 58:236-41. 2006
    ..Together with our previous data, indicating the antagonistic action of RM-33 in the adjuvant-induced footpad inflammation in mice, the present results confirm the anti-inflammatory activity of RM-33 compound...
  6. ncbi request reprint The concerted action of lactoferrin and bacteriophages in the clearance of bacteria in sublethally infected mice
    Michał Zimecki
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
    Postepy Hig Med Dosw (Online) 62:42-6. 2008
    ..Both lactoferrin (LF) and bacteriophages are potent antibacterial agents. LF is contained in the secretory fluids of mammals and bacteriophages are specific bacterial viruses...
  7. ncbi request reprint [Therapeutic properties of proteins and peptides from colostrum and milk]
    Michał Zimecki
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 59:309-23. 2005
    ..In conclusion, preparations derived from milk and colostrum are effective, easily bioaccessible, and safe, finding wide application in prevention and therapy for newborns and adults...
  8. ncbi request reprint RM-11, an isoxazole derivative, accelerates restoration of the immune function in mice treated with cyclophosphamide
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 60:183-9. 2008
    ..We conclude that RM11 may be of potential therapeutic value in restoration of the immune status in patients undergoing chemotherapy...
  9. pmc Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wrocław, Poland
    BMC Microbiol 9:169. 2009
    ..In this work we investigated the prophylactic efficacy of specific bacteriophages in CBA mice treated with cyclophosphamide (CP) and infected with Staphylococcus aureus...
  10. ncbi request reprint Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 61:705-10. 2009
    ..We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis...
  11. ncbi request reprint [The effect of psychic stress on the immune response]
    Michał Zimecki
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 58:166-75. 2004
    ..Our studies revealed a benefit of oral lactoferrin application in reversing stress-induced changes in the humoral and cellular immune response in mice...
  12. ncbi request reprint [Effect of methotrexate on the immune response in selected experimental models]
    Michał Zimecki
    Zakład Terapii Doświadczalnej, Instytutu Immunologii i Terapii Doświadczalnej PAN im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 58:226-35. 2004
    ..In summary, MTX has been an effective agent in suppressing immunological disorders (for 50 years) and is still finding many applications...
  13. ncbi request reprint Calf thymus extract attenuates severity of experimental encephalomyelitis in Lewis rats
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, Poland
    Folia Neuropathol 48:246-57. 2010
    ..We suggest that TFX® or TFX®-derived fractions have potential as therapeutics in treatment of neurodegenerative diseases such as multiple sclerosis...
  14. doi request reprint Prophylactic effect of bacteriophages on mice subjected to chemotherapy-induced immunosuppression and bone marrow transplant upon infection with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Med Microbiol Immunol 199:71-9. 2010
    ..The results suggest a potential benefit of phage therapy in immunocompromised patients subjected to bone marrow transplant procedures...
  15. ncbi request reprint Immunoregulatory function of lactoferrin in immunosuppressed and autoimmune animals
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy of the Polish Academy of Science, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 61:283-7. 2007
    ..In summary, in a series of studies we demonstrated a benefit of orally administered LF in immunocompromised animals...
  16. ncbi request reprint Effects of lactoferrin on the immune response modified by the immobilization stress
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 57:811-7. 2005
    ..This is the first report on the regulatory effect of LF on the immune response modified by the psychic stress and is consistent with other reports on antinociceptive and analgesic actions of LF in experimental animals...
  17. ncbi request reprint Lethality in LPS-induced endotoxemia in C3H/HeCr mice is associated with prevalence of proinflammatory cytokines: lack of protective action of lactoferrin
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences, Weigla 12, 53 114 Wroclaw, Poland
    FEMS Immunol Med Microbiol 42:167-72. 2004
    ..We also suggest that an association exists between the LF protective effect against endotoxic sequelae and the insult-induced systemic immune response...
  18. ncbi request reprint Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53 114 Wrocław, Poland
    J Neuroimmunol 182:160-6. 2007
    ..In summary, treatment of EAE Lewis rats with LF reduced the clinical symptoms and accelerated the recovery of animals...
  19. doi request reprint A novel immunosuppressory peptide originating from the ubiquitin sequence
    Paweł Pasikowski
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    Peptides 32:2418-27. 2011
    ..We also tested their immunosuppressory activity in in vitro experiments...
  20. doi request reprint The immunosuppressive activities of newly synthesized azaphenothiazines in human and mouse models
    Michał Zimecki
    Polish Academy of Sciences, Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, R Weigla 12, 53 114, Wrocław, Poland
    Cell Mol Biol Lett 14:622-35. 2009
    ..As there were only two subjects in this study, the effects of these compounds on human blood cells need to be confirmed. In this paper, we also discuss the structure-activity relationships of selected compounds...
  21. ncbi request reprint Immunomodulatory and anti-inflammatory activity of selected osthole derivatives
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, R Weigla str 12, 53 114, Wroclaw, Poland
    Z Naturforsch C 64:361-8. 2009
    ..5% and 68.3% inhibition, respectively). In summary, the compounds predominantly displayed suppressive and antiinflammatory activities in the investigated models...
  22. doi request reprint Dimeric analogs of immunosuppressive decapeptide fragment of ubiquitin
    Alicja Kluczyk
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    J Pept Sci 18:456-65. 2012
    ..Our results suggest that such orientation of peptide components may correspond to orientation of the hypothetic ubiquitin receptors responsible for the immunomodulatory activity...
  23. pmc Lactoferrin restrains allergen-induced pleurisy in mice
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Wrocław, Poland
    Inflamm Res 61:1247-55. 2012
    ..The aim of this study was to assess the utility of lactoferrin (LF), a natural immunomodulator, to restrain allergen-induced pleurisy in mice...
  24. ncbi request reprint Immunoregulatory activities of lactoferrin in the delayed type hypersensitivity in mice are mediated by a receptor with affinity to mannose
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław
    Immunobiology 205:120-31. 2002
    ..Thus, we postulate, that MR is a primary receptor for lactoferrin in mediation of its some immunotropic activities...
  25. doi request reprint Effects of lactoferrin on elicitation of the antigen-specific cellular and humoral cutaneous response in mice
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 66:16-22. 2012
    ..The data strongly suggest that LF exerted differential actions on the activities of antigen-specific Th1 and Th2 cells involved in respective types of the cutaneous immune responses...
  26. ncbi request reprint New amides of 5-acylamino-3-methyl-4-isothiazolecarboxylic acid and their immunotropic activity
    Urszula Lipnicka
    Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Wrocław, Poland
    Arch Pharm (Weinheim) 338:322-8. 2005
    ..Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo...
  27. ncbi request reprint Lactoferrin inhibits the growth of nasal polyp fibroblasts
    Beata Nadolska
    Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Borowska 213, PL 50 556 Wrocław, Poland
    Pharmacol Rep 62:1139-47. 2010
    ..The significance of LF in nasal excretions in controlling polyp formation is discussed...
  28. ncbi request reprint Dimerization of the immunosuppressive peptide fragment of HLA-DR molecule enhances its potency
    Zbigniew Szewczuk
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    Peptides 25:207-15. 2004
    ..The results demonstrate that the dimerization of the nonapeptide fragment of HLA-DR results in enhanced immunosuppressory properties...
  29. ncbi request reprint Immunosuppressory activity of ubiquitin fragments containing retro-RGD sequence
    Zbigniew Szewczuk
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    Biopolymers 74:352-62. 2004
    ..The cyclization product selectively but strongly suppresses the cellular immune response. The results indicate that the 48-59 loop may serve as an important functional epitope in the ubiquitin molecule for intermolecular binding...
  30. ncbi request reprint Synthesis and immunomodulatory activites of new 5-hydrazino-3-methyl-4-isothiazolecarboxylic acid ethyl esters
    Urszula Lipnicka
    Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Grodzka 9, 50 137 Wrocław, Poland
    Acta Pol Pharm 66:501-11. 2009
    ..The immunotropic activities of the new isothiazole derivatives and potential application of the compounds in therapy are discussed...
  31. ncbi request reprint Search for new lead structures for low-molecular-weight immune response modifiers
    Stanisław Ryng
    Wrocław Medical University, Faculty of Pharmacy Dept Organic Chemistry, 9 Grodzka Str, 50 137 Wrocław, Poland
    Acta Pol Pharm 61:78-81. 2004
    ..The immunoregulatory activities were tested in the humoral and cellular immune response in mice. The compounds exhibited both immunostimulatory and immunosuppressory activities...
  32. ncbi request reprint Structure and immunological activity of disubstituted thiosemicarbazide isoxazole derivative
    Marcin Maczyński
    Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, 9 Grodzka Str, 50 137 Wrocław, Poland
    Acta Pol Pharm 61:82-3. 2004
    ..In the present study, we examined the effect of compound RM2 on the spontaneous proliferative response of splenocytes and mitogen-induced splenocyte proliferation. Synthesis and biological effect is reported...
  33. ncbi request reprint Threonine at position 6 is not essential for the immunosuppressive activity of HLA-DQ(beta164-172)-hexapeptide
    Piotr Stefanowicz
    Faculty of Chemistry, University of Wrocław, ul F Joliot Curie 14, 50 383 Wrocław, Poland
    Mol Immunol 41:911-7. 2004
    ..Interestingly, a simple analogue, pentapeptide amide H-Arg-Gly-Asp-Val-Tyr-NH2 possessed high immunosuppressive potency, comparable to that of cyclosporine...
  34. ncbi request reprint New derivatives of 5-amino-3-methyl-4-isothiazolecarboxylic acid and their immunological activity
    Urszula Lipnicka
    Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Grodzka 9, 50 137 Wrocław, Poland
    Acta Pol Pharm 64:233-40. 2007
    ....
  35. ncbi request reprint The synthesis, physicochemical properties and immunological activity of 5-amino-3-methylisoxazolo[5,4-d]4-pyrimidinone derivatives
    Marcin Maczyński
    Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Grodzka 9, 50 137 Wroclaw, Poland
    Cell Mol Biol Lett 10:613-23. 2005
    ..The compounds exhibited differential inhibitory activities in the described models, depending on the character and location of the substituted groups. We suggest that the compounds affect the early stages of the immune response...
  36. ncbi request reprint Synthesis, immunological activity and computational study of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides
    Marcin Maczyński
    Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, 50 137 Wrocław, 9 Grodzka Str, Poland
    Acta Pol Pharm 65:543-9. 2008
    ..Structure/activity relationships, regarding the studied compounds, were discussed...
  37. ncbi request reprint A new class of isoxazole derivatives: the M 1-9 series of compounds with immunotropic activity
    Marcin Maczyński
    Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, 50 137 Wrocław, 9 Grodzka Str, Poland
    Acta Pol Pharm 65:241-4. 2008
    ..The biological effect of these compounds on the proliferative response of human mononuclear peripheral blood cells to phytohemagglutinin A (PHA) was described...
  38. doi request reprint Synthesis and pharmacological screening of derivatives of isoxazolo[4,5-d]pyrimidine
    Edwin Wagner
    Department of Drugs Technology, Wroclaw Medical University, pl Nankiera 1, 50 140 Wroclaw, Poland
    Eur J Med Chem 43:2498-504. 2008
    ..The results indicated that compound 10f was a universal inhibitor of the immune response, while compound 8g selectively suppressed the humoral immune response...
  39. ncbi request reprint Bacteriophage therapy for the treatment of infections
    Andrzej Gorski
    Polish Academy of Sciences, Phage Therapy Unit, L Hirszfeld Institute of Immunology and Experimental Therapy, Weigla 12, Wroclaw, Poland
    Curr Opin Investig Drugs 10:766-74. 2009
    ..This review discusses the current status of bacteriophage therapy, including the experience of one expert center specializing in this form of treatment...
  40. doi request reprint The immunosuppressive activity and solution structures of ubiquitin fragments
    Lukasz Jaremko
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    Biopolymers 91:423-31. 2009
    ..Although the peptide exhibited a well-defined conformation in methanol, its structure was distinct from the corresponding 50-59 fragment in the native ubiquitin molecule. (c) 2009 Wiley Periodicals, Inc. Biopolymers 91: 423-431, 2009...
  41. ncbi request reprint The effects of lactoferrin on myelopoiesis: can we resolve the controversy?
    Jolanta Artym
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 61:129-50. 2007
    ..The aim of this article is to review the available literature data regarding the effects of LF on myelopoiesis in mice and humans. Possible reasons for opposing views on this subject are presented...
  42. ncbi request reprint Effect of lactoferrin on the methotrexate-induced suppression of the cellular and humoral immune response in mice
    Jolanta Artym
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Anticancer Res 24:3831-6. 2004
    ..It seems that LF also prevents the block of the activity of T memory cells in the secondary, humoral immune response. Taken together, we demonstrated that LF given orally can reduce the toxic effects of MTX...
  43. ncbi request reprint Milk-derived proteins and peptides of potential therapeutic and nutritive value
    Michal Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53 114 Wroclaw, Poland
    J Exp Ther Oncol 6:89-106. 2007
    ..6) Lactoperoxidase--shows antibacterial properties. In conclusion, milk-derived proteins and peptides are bio-accessible and safe for the prevention and treatment of numerous disorders in humans...