Janusz Witowski

Summary

Affiliation: University of Medical Sciences
Country: Poland

Publications

  1. ncbi request reprint Peritoneal cell culture: fibroblasts
    Janusz Witowski
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Perit Dial Int 26:292-9. 2006
  2. ncbi request reprint Interleukin-17: a mediator of inflammatory responses
    J Witowski
    Department of Pathophysiology, University Medical School, Swiecickiego 6, Collegium Anatomicum, 60 781, Poznan, Poland
    Cell Mol Life Sci 61:567-79. 2004
  3. ncbi request reprint Peritoneal dialysis with solutions low in glucose degradation products is associated with improved biocompatibility profile towards peritoneal mesothelial cells
    Janusz Witowski
    Department of Pathophysiology, University Medical School, ul Swiecickiego 6, 60 781 Poznan, Poland
    Nephrol Dial Transplant 19:917-24. 2004
  4. ncbi request reprint Effects of peritoneal dialysis solutions on the peritoneal membrane: clinical consequences
    Janusz Witowski
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Perit Dial Int 25:S31-4. 2005
  5. ncbi request reprint Oxidative stress-dependent increase in ICAM-1 expression promotes adhesion of colorectal and pancreatic cancers to the senescent peritoneal mesothelium
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Int J Cancer 127:293-303. 2010
  6. doi request reprint Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan Univ of Medical Sciences, Swiecickiego 6, 60 781 Poznan, Poland
    Am J Physiol Regul Integr Comp Physiol 296:R374-82. 2009
  7. doi request reprint Recovery of senescent endothelial cells from injury
    Katarzyna Korybalska
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    J Gerontol A Biol Sci Med Sci 68:250-7. 2013
  8. ncbi request reprint Accelerated senescence of human peritoneal mesothelial cells exposed to high glucose: the role of TGF-beta1
    Krzysztof Ksiazek
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Lab Invest 87:345-56. 2007
  9. ncbi request reprint Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Free Radic Biol Med 42:636-41. 2007
  10. pmc Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesion: the role of oxidative stress-induced fibronectin
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Swiecickiego 6, 60 781 Poznan, Poland
    Am J Pathol 174:1230-40. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Peritoneal cell culture: fibroblasts
    Janusz Witowski
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Perit Dial Int 26:292-9. 2006
    ..In this review, we describe procedures for establishing and identifying primary cultures of human peritoneal fibroblasts. We also briefly discuss the potential involvement of peritoneal fibroblasts in peritoneal pathology...
  2. ncbi request reprint Interleukin-17: a mediator of inflammatory responses
    J Witowski
    Department of Pathophysiology, University Medical School, Swiecickiego 6, Collegium Anatomicum, 60 781, Poznan, Poland
    Cell Mol Life Sci 61:567-79. 2004
    ..This review provides an overview of IL-17 activities, concentrating on those that lead to neutrophil recruitment...
  3. ncbi request reprint Peritoneal dialysis with solutions low in glucose degradation products is associated with improved biocompatibility profile towards peritoneal mesothelial cells
    Janusz Witowski
    Department of Pathophysiology, University Medical School, ul Swiecickiego 6, 60 781 Poznan, Poland
    Nephrol Dial Transplant 19:917-24. 2004
    ..The present study examines the impact on human peritoneal mesothelial cells (HPMCs) of equilibrated dialysates obtained during dialysis with either conventional or new PDFs...
  4. ncbi request reprint Effects of peritoneal dialysis solutions on the peritoneal membrane: clinical consequences
    Janusz Witowski
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Perit Dial Int 25:S31-4. 2005
    ..This review provides an overview of recent studies that show the clinical significance of biocompatibility of peritoneal dialysis fluids...
  5. ncbi request reprint Oxidative stress-dependent increase in ICAM-1 expression promotes adhesion of colorectal and pancreatic cancers to the senescent peritoneal mesothelium
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Int J Cancer 127:293-303. 2010
    ..These results indicate that increased oxidative stress and increased expression of ICAM-1 in senescent HOMCs may facilitate peritoneal adhesion of selected colorectal and pancreatic cancers...
  6. doi request reprint Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan Univ of Medical Sciences, Swiecickiego 6, 60 781 Poznan, Poland
    Am J Physiol Regul Integr Comp Physiol 296:R374-82. 2009
    ..These results indicate that compared with LP-9 cells, HOMCs undergo stress-induced telomere-independent premature senescence, which may result from increased vulnerability to oxidative DNA injury...
  7. doi request reprint Recovery of senescent endothelial cells from injury
    Katarzyna Korybalska
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    J Gerontol A Biol Sci Med Sci 68:250-7. 2013
    ..This secretory phenotype rather than the rate of wound closure per se may contribute to unfavorable vascular remodeling in the elderly undergoing coronary catheterization...
  8. ncbi request reprint Accelerated senescence of human peritoneal mesothelial cells exposed to high glucose: the role of TGF-beta1
    Krzysztof Ksiazek
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Lab Invest 87:345-56. 2007
    ....
  9. ncbi request reprint Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Free Radic Biol Med 42:636-41. 2007
    ..These results indicate that the accelerated senescence response in HPMC exposed to high glucose is strongly related to oxidative stress...
  10. pmc Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesion: the role of oxidative stress-induced fibronectin
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Swiecickiego 6, 60 781 Poznan, Poland
    Am J Pathol 174:1230-40. 2009
    ..These data indicate that oxidative stress that accompanies senescence may increase FN production by HOMCs and thus facilitate binding and dissemination of ovarian cancer cells...
  11. doi request reprint Interpretation of elevated serum VEGF concentrations in patients with myocardial infarction
    Katarzyna Korybalska
    Department of Pathophysiology, Poznan University of Medical Sciences, Poland
    Cytokine 54:74-8. 2011
    ..These data demonstrate that high levels of serum VEGF detected early in the course of STEMI may derive from activated platelets and may characterize patients with extensive intracoronary thrombosis...
  12. doi request reprint Impaired response to oxidative stress in senescent cells may lead to accumulation of DNA damage in mesothelial cells from aged donors
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Swiecickiego 6, 60 781 Poznan, Poland
    Biochem Biophys Res Commun 373:335-9. 2008
    ..These results indicate that increased 8-OH-dG levels in HPMCs from aged individuals may reflect the in vivo presence of senescent cells with increased vulnerability to oxidative stress-induced DNA damage...
  13. doi request reprint Senescence induces a proangiogenic switch in human peritoneal mesothelial cells
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Rejuvenation Res 11:681-3. 2008
    ..These results indicate that the senescent mesothelium exhibits increased angiogenic activity, which may contribute to accelerated intraperitoneal cancer progression in the aged...
  14. ncbi request reprint Correlation between the donor age and the proliferative lifespan of human peritoneal mesothelial cells in vitro: is TGF-beta1 a link?
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Exp Gerontol 42:840-3. 2007
    ....
  15. ncbi request reprint The role of the glyoxalase pathway in reducing mesothelial toxicity of glucose degradation products
    Katarzyna Korybalska
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Perit Dial Int 26:259-65. 2006
    ..We have therefore examined the GLO-I/GSH system in HPMC and assessed the impact of GLO-I/ GSH-treated PDF on the viability and function of HPMC...
  16. ncbi request reprint L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products
    Andrzej Breborowicz
    Department of Pathophysiology, Poznan Medical School, ul Swiecickiego 6, 60 781 Poznan, Poland
    Nephrol Dial Transplant 19:3005-11. 2004
    ..We examined whether L-2-oxothiazolidine-4-carboxylic acid (OTZ), a precursor for glutathione synthesis, reduces the cytotoxicity of GDP in human peritoneal mesothelial cells...
  17. doi request reprint Serum profiles of monocyte chemoattractant protein-1 as a biomarker for patients recovering from myocardial infarction
    Katarzyna Korybalska
    Department of Pathophysiology, Poznan University of Medical Sciences, Swiecickiego 6, 60 781, Poznan, Poland
    Clin Res Cardiol 99:315-22. 2010
    ..Monocyte chemoattractant protein-1 (MCP-1) plays a key role in the pathogenesis of atherosclerosis and has been proposed as a biomarker for patients with cardiovascular disease...
  18. doi request reprint Oxidative stress-mediated early senescence contributes to the short replicative life span of human peritoneal mesothelial cells
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Free Radic Biol Med 45:460-7. 2008
    ..These results indicate that a sudden onset of senescence in early-passage HPMCs is related to oxidative stress and may influence the replicative life span of the population as a whole...
  19. doi request reprint New insights into the biology of peritoneal mesothelial cells: the roles of epithelial-to-mesenchymal transition and cellular senescence
    Janusz Witowski
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Nephron Exp Nephrol 108:e69-73. 2008
    ..We discuss the potential significance of these processes for the peritoneal membrane function...
  20. ncbi request reprint Evidence for less irritation to the peritoneal membrane in rats dialyzed with solutions low in glucose degradation products
    Katarzyna Wieczorowska-Tobis
    Department of Pathophysiology, University of Medical Sciences, Poznan, Poland
    Perit Dial Int 24:48-57. 2004
    ..The present study examines the effects of long-term exposure to GDP and low pH by comparing conventional PDF and a new, neutral pH, low GDP solution...
  21. ncbi request reprint Early loss of proliferative potential of human peritoneal mesothelial cells in culture: the role of p16INK4a-mediated premature senescence
    Krzysztof Ksiazek
    Dept of Pathophysiology, Univ Medical School, Swiecickiego 6, 60 781 Poznan, Poland
    J Appl Physiol (1985) 100:988-95. 2006
    ..These results demonstrate that early onset of senescence in omentum-derived HPMC may be associated with oxidative stress-induced upregulation of p16INK4a...
  22. pmc Regulation of chemokine CCL5 synthesis in human peritoneal fibroblasts: a key role of IFN-γ
    Edyta Kawka
    Department of Nephrology and Medical Intensive Care, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany Department of Pathophysiology, Poznan University of Medical Sciences, Swiecickiego 6, 60 781 Poznan, Poland
    Mediators Inflamm 2014:590654. 2014
    ..HPFB-derived CCL5 may thus contribute to the intraperitoneal recruitment of mononuclear leukocytes during peritonitis...
  23. ncbi request reprint Preventing peritoneal fibrosis--an ace up our sleeve?
    Janusz Witowski
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Perit Dial Int 25:25-9. 2005
  24. ncbi request reprint [Mechanisms and medical implications of replicative senescence]
    Krzysztof Ksiazek
    Katedra i Zakład Patofizjologii Akademii Medycznej w Poznaniu
    Pol Arch Med Wewn 114:918-23. 2005
    ..In this review we describe recent advances in our knowledge on the mechanisms of replicative senescence and discuss its medical implications...
  25. ncbi request reprint Effect of heparin on blood vascular endothelial growth factor levels in patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention
    Małgorzata Pyda
    1st Department of Cardiology, University Medical School, Poznan, Poland
    Am J Cardiol 98:902-5. 2006
    ..In conclusion, these results suggest that a rapid decrease in blood VEGF after PCI may be related to the administration of heparin, which binds simultaneously to VEGF and endothelial cells...
  26. doi request reprint Relation of salivary antioxidant status and cytokine levels to clinical parameters of oral health in pregnant women with diabetes
    Anna Surdacka
    Department of Conservative Dentistry and Periodontology, Poznan University of Medical Sciences, Poznan, Poland
    Arch Oral Biol 56:428-36. 2011
    ..Both pregnancy and diabetes are thought to predispose to the impairment of oral health. As saliva contributes to oral homeostasis, we have characterised its properties and flow rate in pregnant women with or without diabetes...
  27. doi request reprint Setting up research in peritoneal dialysis
    Janusz Witowski
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Contrib Nephrol 178:200-4. 2012
    ..Here, we summarize some of such PD-inspired studies that addressed more general aspects of immunology and pathology and helped us to appreciate the complexity of peritoneal biology...
  28. ncbi request reprint Glucose-mediated induction of TGF-beta 1 and MCP-1 in mesothelial cells in vitro is osmolality and polyol pathway dependent
    Teresa Y H Wong
    Institute of Nephrology, University of Wales College of Medicine, Cardiff, United Kingdom
    Kidney Int 63:1404-16. 2003
    ..The contribution of the polyol pathway to mesothelial cell activation has, however, not been fully determined...
  29. pmc Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
    Rachel M McLoughlin
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Clin Invest 112:598-607. 2003
    ..These data emphasize a pivotal role for IFN-gamma in regulating innate immunity through control of both the recruitment and clearance phases of PMN trafficking...
  30. ncbi request reprint Mesothelial toxicity of peritoneal dialysis fluids is related primarily to glucose degradation products, not to glucose per se
    Janusz Witowski
    Department of Nephrology and Medical Intensive Care, Universitatsklinikum Charite, Campus Virchow Klinikum, Medizinische Fakultat der Humboldt Universitat zu Berlin, Germany
    Perit Dial Int 23:381-90. 2003
    ..In the present study we aimed at differentiating the respective roles of glucose and GDPs in the toxicity of PDF to mesothelial cells...
  31. ncbi request reprint Lessons from basic research for PD treatment
    Achim Jorres
    Department of Nephrology and Medical Intensive Care, Charite University Hospital, Campus Virchow Klinikum, Berlin, Germany
    Perit Dial Int 25:S35-8. 2005
    ..Here, we present how these research topics developed, discuss their significance for clinical science, and outline future challenges for peritoneal dialysis research...
  32. ncbi request reprint PD membrane: biological responses to different PD fluids
    Achim Jorres
    Department of Nephrology and Medical Intensive Care, Charite University Hospital, Campus Virchow Klinikum, Berlin, Germany
    Contrib Nephrol 150:48-53. 2006
    ..Results from recent prospective randomized studies suggest that chronic treatment with these novel PD fluids may indeed lead to a significant improvement of clinical outcomes in chronic PD patients...
  33. ncbi request reprint [Impaired insulin signaling and human ageing]
    Krzysztof Ksiazek
    Katedra i Zakład Patofi zjologii Uniwersytetu Medycznego w Poznaniu
    Postepy Hig Med Dosw (Online) 62:263-71. 2008
    ..Here, we review the mechanisms underlying the development of age-associated hyperglycemia, its impact on cellular senescence and the effect of insulin-signaling pathways on energy balance and ageing...
  34. ncbi request reprint Quality assurance in peritoneal dialysis
    Achim Jorres
    Department of Nephrology and Medical Intensive Care, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Perit Dial Int 27:S16-20. 2007
    ..The present article reviews current treatment targets for peritoneal dialysis (PD) and the various methods for evaluating adequacy with time on PD...
  35. doi request reprint Biocompatibility of a bicarbonate-buffered amino-acid-based solution for peritoneal dialysis
    Thorsten O Bender
    Department of Nephrology and Medical Intensive Care, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Pediatr Nephrol 23:1537-43. 2008
    ..In addition, exposure to Aminobic increased basal release of IL-6 and PGE(2). These data point to a favorable biocompatibility profile of the amino-acid-based bicarbonate-buffered PD solution toward HPMC...