Research Topics
Genomes and Genes
| Aleksandra SzczepankiewiczSummaryAffiliation: University of Medical Sciences Country: Poland Publications
| Collaborators
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Detail Information
Publications
Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthmaAleksandra Szczepankiewicz
Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
Respir Med 107:30-6. 2013..We aimed to investigate if levels of neurotrophins in serum of asthmatic children are influenced by the genotype of functional variants within genes encoding analysed neurotrophins and their specific receptors...- Multilocus analysis of candidate genes involved in neurogenic inflammation in pediatric asthma and related phenotypes: a case-control studyAleksandra Szczepankiewicz
Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
J Asthma 49:329-35. 2012.... 
No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophreniaAleksandra Szczepankiewicz
Laboratory of Psychiatric Genetics, University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
Schizophr Res 76:187-93. 2005..078 and p=0.162 respectively and for females: p=0.441 and p=0.315. Thus, our data indicate that variations in the BDNF gene are unlikely to be an important factor in susceptibility to schizophrenia...- Are genes associated with energy metabolism important in asthma and BMI?Aleksandra Szczepankiewicz
Clinics of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland
J Asthma 46:53-8. 2009..To our knowledge, there were no studies on a potential role of LEPR, LEP, and GHRL polymorphisms in asthma... - Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic familiesAleksandra Szczepankiewicz
Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Third Department of Pediatrics, Poznan University of Medical Sciences, PL 60 572 Poznan, Poland
Int Arch Allergy Immunol 149:343-9. 2009..Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma... - [Association of A/T polymorphism of the CHRM2 gene with bronchodilator response to ipratropium bromide in asthmatic children]Aleksandra Szczepankiewicz
Klinika Pneumonologii, Alergologii Dzieciecej i Immunologii Klinicznej III Katedry Pediatrii Uniwersytetu Medycznego w Poznaniu Kierownik, Poznan
Pneumonol Alergol Pol 77:5-10. 2009.... - The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patientsAleksandra Szczepankiewicz
Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
Hum Psychopharmacol 24:287-91. 2009..The results are discussed in light of our previous studies on FYN gene in bipolar illness and BDNF gene in lithium response... - FYN kinase gene: another glutamatergic gene associated with bipolar disorder?Aleksandra Szczepankiewicz
Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Neuropsychobiology 59:178-83. 2009..86, D' = 0.93 with 95% CI = 0.9-0.97). The results suggest that the glutamatergic FYN gene may be associated with bipolar disorder, particularly with type I illness and early age of onset... - No association of three GRIN2B polymorphisms with lithium response in bipolar patientsAleksandra Szczepankiewicz
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland
Pharmacol Rep 61:448-52. 2009..The authors conclude that polymorphisms of the GRIN2B gene did not show an association with the treatment response to lithium in bipolar patients... - Role of ADRB2 gene polymorphism in asthma and response to beta(2)-agonists in Polish childrenA Szczepankiewicz
Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poland
J Appl Genet 50:275-81. 2009..This is the first report providing suggestive evidence for association of -1023A/G ADRB2 polymorphism with an increased risk of asthma. The analyzed SNPs may not play a major role in response to beta(2)-agonists in asthmatic children... - Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorderAleksandra Szczepankiewicz
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poland
J Affect Disord 134:138-44. 2011..Therefore, we investigated if polymorphism of the glucocorticoid receptor gene (NR3C1), involved in the regulation of HPA axis, may alter susceptibility as well as the course of major depressive disorder and bipolar disorder... - Glucocorticoid receptor polymorphism is associated with lithium response in bipolar patientsAleksandra Szczepankiewicz
Department of Psychiatry, Poznan University of Medical Sciences, Poland
Neuro Endocrinol Lett 32:545-51. 2011..As glucocorticoid receptor may be possibly related to lithium action we aimed to investigate variation in the GR gene in association with response to lithium treatment in Polish population of bipolar patients... - Lack of association of three GRIN2B polymorphisms with bipolar disorderAleksandra Szczepankiewicz
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
World J Biol Psychiatry 10:469-73. 2009..In linkage disequilibrium analysis we did not find linkage between the three polymorphisms of GRIN2B gene. The polymorphisms of GRIN2B gene analysed in this study are not likely to be associated with bipolar disorder... - No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoidsA Szczepankiewicz
Department of Pediatric Pulmonology, Allergy and Clinical Immunology, University of Medical Sciences, Poznan, Poland
Adv Med Sci 53:245-50. 2008..Therefore, we investigated if polymorphisms known to affect expression or function of the glucocorticoid receptor may be responsible for lower efficacy of steroid therapy and the need to use high doses of inhaled drug... - Association analysis of tyrosine kinase FYN gene polymorphisms in asthmatic childrenAleksandra Szczepankiewicz
Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland
Int Arch Allergy Immunol 145:43-7. 2008..The aim of this study was to analyze the possible relationship between three polymorphisms (-93A/G, Intron10+37C/T and Ex12+894T/G) in the FYN gene and asthma... - Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorderAleksandra Szczepankiewicz
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Neuropsychobiology 53:51-6. 2006..015 for genotypes and p=0.009 for alleles). In conclusion, this polymorphism may be associated with female gender in bipolar II disorder... - Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic childrenAleksandra Szczepankiewicz
Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
Pediatr Allergy Immunol 18:293-7. 2007..041 for genotypes and p = 0.005 for alleles). The results may suggest a relationship between the BDNF gene and asthma and male gender of asthmatic children... - Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patientsAleksandra Szczepankiewicz
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poland
World J Biol Psychiatry 7:158-61. 2006..The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be related to the degree of prophylactic lithium response... - Study of dopamine receptors genes polymorphisms in bipolar patients with comorbid alcohol abuseAleksandra Szczepankiewicz
Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland
Alcohol Alcohol 42:70-4. 2007..Association analyses revealed several candidate genes acting in the dopaminergic pathway and polymorphisms in those genes that might be associated with both disorders... - Clinical and pathogenic aspects of candidate genes for lithium prophylactic efficacyJanusz K Rybakowski
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
J Psychopharmacol 26:368-73. 2012..Possible aspects of these genes with regard to the mechanism of lithium activity and pathogenesis of bipolar mood disorder are discussed... - Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophreniaBartosz Kempisty
Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
Eur Psychiatry 22:39-43. 2007..293; 95% CI=2.017-26.363; P=0.0005). Our results confirm association of BD and schizophrenia with the 1p36.3 MTHFR locus and with the methyl group transfer using folate-dependent one-carbon pathway... - Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patientsMonika Dmitrzak-Weglarz
Laboratory of Psychiatric Genetics, Department of Psychiatry, University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
Pharmacogenomics 9:1595-603. 2008..No association with lithium response was revealed with the polymorphism of NTRK2 gene, neither with interaction of BDNF and NTRK2 genes... - Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor geneJanusz K Rybakowski
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Psychiatry Clin Neurosci 60:70-6. 2006..An association of this polymorphism with performance on the N-back test in schizophrenia and not in bipolar illness may suggest that in schizophrenia, the BDNF system may be connected with early phases of information processing... - Brain derived neurotrophic factor gene Val66Met and -270C/T polymorphisms and personality traits predisposing to anorexia nervosaFilip Rybakowski
Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poland
Neuro Endocrinol Lett 28:153-8. 2007..Several lines of molecular and biochemical evidence point to the role of BDNF in anorexia nervosa (AN). Personality traits may constitute the intermediate phenotypes between genes and vulnerability to AN... - Association of 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophreniaBartosz Kempisty
Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
Neurosci Lett 400:267-71. 2006..393; 95% CI=1.429-4.006; P=0.0008 and OR=2.036; 95% CI=1.207-3.433; P=0.0073, respectively). This finding indicates possible association of BD and schizophrenia with the 1p36.3 MTHFR locus... - MTHFD 1958G>A and MTR 2756A>G polymorphisms are associated with bipolar disorder and schizophreniaBartosz Kempisty
Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland
Psychiatr Genet 17:177-81. 2007.... - The study of candidate genes related to the neurodevelopmental hypothesis of anorexia nervosa: classical association study versus decision treeMonika Dmitrzak-Weglarz
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Psychiatry Res 206:117-21. 2013.... - Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic featuresAnna Leszczynska-Rodziewicz
Department of Adult Psychiatry, Poznan University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
J Affect Disord 138:490-3. 2012..NR3C1, CRHR1 and AVPR1b are the key components of this system. We investigated the possible involvement of the polymorphisms of those genes with the susceptibility to psychotic features in the course of BP I disorder... - Association of BDNF gene polymorphism with asthma in polish childrenAleksandra Szczepankiewicz
From the 1Laboratory of Cellular and Molecular Analysis, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poland 2Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poland
World Allergy Organ J 3:235-8. 2010..025). Our results suggest that genetic variation in the BDNF gene may contribute to asthma susceptibility in case of rs2030324 polymorphism and TTGC haplotype, however it does not influence asthma severity... 
Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control studyAleksandra Szczepankiewicz
Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poland
Clin Mol Allergy 8:14. 2010..We hypothesized that alleles leading to decreased enzyme activity and, therefore, decreased inactivation of histamine may be responsible for altered susceptibility to asthma...- BDNF Met66 allele is associated with anorexia nervosa in the Polish populationMonika Dmitrzak-Weglarz
Psychiatr Genet 17:245-6. 2007