Aleksandra Szczepankiewicz

Summary

Affiliation: University of Medical Sciences
Country: Poland

Publications

  1. pmc Association of BDNF gene polymorphism with asthma in polish children
    Aleksandra Szczepankiewicz
    From the 1Laboratory of Cellular and Molecular Analysis, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poland 2Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poland
    World Allergy Organ J 3:235-8. 2010
  2. doi request reprint Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma
    Aleksandra Szczepankiewicz
    Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
    Respir Med 107:30-6. 2013
  3. doi request reprint Multilocus analysis of candidate genes involved in neurogenic inflammation in pediatric asthma and related phenotypes: a case-control study
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
    J Asthma 49:329-35. 2012
  4. ncbi request reprint No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
    Schizophr Res 76:187-93. 2005
  5. doi request reprint Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Third Department of Pediatrics, Poznan University of Medical Sciences, PL 60 572 Poznan, Poland
    Int Arch Allergy Immunol 149:343-9. 2009
  6. ncbi request reprint [Association of A/T polymorphism of the CHRM2 gene with bronchodilator response to ipratropium bromide in asthmatic children]
    Aleksandra Szczepankiewicz
    Klinika Pneumonologii, Alergologii Dzieciecej i Immunologii Klinicznej III Katedry Pediatrii Uniwersytetu Medycznego w Poznaniu Kierownik, Poznan
    Pneumonol Alergol Pol 77:5-10. 2009
  7. doi request reprint The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
    Hum Psychopharmacol 24:287-91. 2009
  8. doi request reprint FYN kinase gene: another glutamatergic gene associated with bipolar disorder?
    Aleksandra Szczepankiewicz
    Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    Neuropsychobiology 59:178-83. 2009
  9. ncbi request reprint No association of three GRIN2B polymorphisms with lithium response in bipolar patients
    Aleksandra Szczepankiewicz
    Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland
    Pharmacol Rep 61:448-52. 2009
  10. ncbi request reprint Role of ADRB2 gene polymorphism in asthma and response to beta(2)-agonists in Polish children
    A Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poland
    J Appl Genet 50:275-81. 2009

Collaborators

Detail Information

Publications38

  1. pmc Association of BDNF gene polymorphism with asthma in polish children
    Aleksandra Szczepankiewicz
    From the 1Laboratory of Cellular and Molecular Analysis, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poland 2Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poland
    World Allergy Organ J 3:235-8. 2010
    ..025). Our results suggest that genetic variation in the BDNF gene may contribute to asthma susceptibility in case of rs2030324 polymorphism and TTGC haplotype, however it does not influence asthma severity...
  2. doi request reprint Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma
    Aleksandra Szczepankiewicz
    Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
    Respir Med 107:30-6. 2013
    ..We aimed to investigate if levels of neurotrophins in serum of asthmatic children are influenced by the genotype of functional variants within genes encoding analysed neurotrophins and their specific receptors...
  3. doi request reprint Multilocus analysis of candidate genes involved in neurogenic inflammation in pediatric asthma and related phenotypes: a case-control study
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
    J Asthma 49:329-35. 2012
    ....
  4. ncbi request reprint No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
    Schizophr Res 76:187-93. 2005
    ..078 and p=0.162 respectively and for females: p=0.441 and p=0.315. Thus, our data indicate that variations in the BDNF gene are unlikely to be an important factor in susceptibility to schizophrenia...
  5. doi request reprint Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Third Department of Pediatrics, Poznan University of Medical Sciences, PL 60 572 Poznan, Poland
    Int Arch Allergy Immunol 149:343-9. 2009
    ..Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma...
  6. ncbi request reprint [Association of A/T polymorphism of the CHRM2 gene with bronchodilator response to ipratropium bromide in asthmatic children]
    Aleksandra Szczepankiewicz
    Klinika Pneumonologii, Alergologii Dzieciecej i Immunologii Klinicznej III Katedry Pediatrii Uniwersytetu Medycznego w Poznaniu Kierownik, Poznan
    Pneumonol Alergol Pol 77:5-10. 2009
    ....
  7. doi request reprint The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
    Hum Psychopharmacol 24:287-91. 2009
    ..The results are discussed in light of our previous studies on FYN gene in bipolar illness and BDNF gene in lithium response...
  8. doi request reprint FYN kinase gene: another glutamatergic gene associated with bipolar disorder?
    Aleksandra Szczepankiewicz
    Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    Neuropsychobiology 59:178-83. 2009
    ..86, D' = 0.93 with 95% CI = 0.9-0.97). The results suggest that the glutamatergic FYN gene may be associated with bipolar disorder, particularly with type I illness and early age of onset...
  9. ncbi request reprint No association of three GRIN2B polymorphisms with lithium response in bipolar patients
    Aleksandra Szczepankiewicz
    Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland
    Pharmacol Rep 61:448-52. 2009
    ..The authors conclude that polymorphisms of the GRIN2B gene did not show an association with the treatment response to lithium in bipolar patients...
  10. ncbi request reprint Role of ADRB2 gene polymorphism in asthma and response to beta(2)-agonists in Polish children
    A Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poland
    J Appl Genet 50:275-81. 2009
    ..This is the first report providing suggestive evidence for association of -1023A/G ADRB2 polymorphism with an increased risk of asthma. The analyzed SNPs may not play a major role in response to beta(2)-agonists in asthmatic children...
  11. doi request reprint Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poland
    J Affect Disord 134:138-44. 2011
    ..Therefore, we investigated if polymorphism of the glucocorticoid receptor gene (NR3C1), involved in the regulation of HPA axis, may alter susceptibility as well as the course of major depressive disorder and bipolar disorder...
  12. ncbi request reprint Glucocorticoid receptor polymorphism is associated with lithium response in bipolar patients
    Aleksandra Szczepankiewicz
    Department of Psychiatry, Poznan University of Medical Sciences, Poland
    Neuro Endocrinol Lett 32:545-51. 2011
    ..As glucocorticoid receptor may be possibly related to lithium action we aimed to investigate variation in the GR gene in association with response to lithium treatment in Polish population of bipolar patients...
  13. doi request reprint Are genes associated with energy metabolism important in asthma and BMI?
    Aleksandra Szczepankiewicz
    Clinics of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland
    J Asthma 46:53-8. 2009
    ..To our knowledge, there were no studies on a potential role of LEPR, LEP, and GHRL polymorphisms in asthma...
  14. doi request reprint Lack of association of three GRIN2B polymorphisms with bipolar disorder
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    World J Biol Psychiatry 10:469-73. 2009
    ..In linkage disequilibrium analysis we did not find linkage between the three polymorphisms of GRIN2B gene. The polymorphisms of GRIN2B gene analysed in this study are not likely to be associated with bipolar disorder...
  15. ncbi request reprint Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    Neuropsychobiology 53:51-6. 2006
    ..015 for genotypes and p=0.009 for alleles). In conclusion, this polymorphism may be associated with female gender in bipolar II disorder...
  16. ncbi request reprint Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patients
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poland
    World J Biol Psychiatry 7:158-61. 2006
    ..The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be related to the degree of prophylactic lithium response...
  17. ncbi request reprint Study of dopamine receptors genes polymorphisms in bipolar patients with comorbid alcohol abuse
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland
    Alcohol Alcohol 42:70-4. 2007
    ..Association analyses revealed several candidate genes acting in the dopaminergic pathway and polymorphisms in those genes that might be associated with both disorders...
  18. ncbi request reprint Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic children
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
    Pediatr Allergy Immunol 18:293-7. 2007
    ..041 for genotypes and p = 0.005 for alleles). The results may suggest a relationship between the BDNF gene and asthma and male gender of asthmatic children...
  19. doi request reprint No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids
    A Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, University of Medical Sciences, Poznan, Poland
    Adv Med Sci 53:245-50. 2008
    ..Therefore, we investigated if polymorphisms known to affect expression or function of the glucocorticoid receptor may be responsible for lower efficacy of steroid therapy and the need to use high doses of inhaled drug...
  20. ncbi request reprint Association analysis of tyrosine kinase FYN gene polymorphisms in asthmatic children
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland
    Int Arch Allergy Immunol 145:43-7. 2008
    ..The aim of this study was to analyze the possible relationship between three polymorphisms (-93A/G, Intron10+37C/T and Ex12+894T/G) in the FYN gene and asthma...
  21. doi request reprint Clinical and pathogenic aspects of candidate genes for lithium prophylactic efficacy
    Janusz K Rybakowski
    Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    J Psychopharmacol 26:368-73. 2012
    ..Possible aspects of these genes with regard to the mechanism of lithium activity and pathogenesis of bipolar mood disorder are discussed...
  22. ncbi request reprint Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia
    Bartosz Kempisty
    Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
    Eur Psychiatry 22:39-43. 2007
    ..293; 95% CI=2.017-26.363; P=0.0005). Our results confirm association of BD and schizophrenia with the 1p36.3 MTHFR locus and with the methyl group transfer using folate-dependent one-carbon pathway...
  23. doi request reprint Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients
    Monika Dmitrzak-Weglarz
    Laboratory of Psychiatric Genetics, Department of Psychiatry, University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
    Pharmacogenomics 9:1595-603. 2008
    ..No association with lithium response was revealed with the polymorphism of NTRK2 gene, neither with interaction of BDNF and NTRK2 genes...
  24. ncbi request reprint Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene
    Janusz K Rybakowski
    Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    Psychiatry Clin Neurosci 60:70-6. 2006
    ..An association of this polymorphism with performance on the N-back test in schizophrenia and not in bipolar illness may suggest that in schizophrenia, the BDNF system may be connected with early phases of information processing...
  25. doi request reprint Suicide attempts and clinical risk factors in patients with bipolar and unipolar affective disorders
    Joanna Pawlak
    Laboratory of Psychiatric Genetics, Department of Psychiatry, University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
    Gen Hosp Psychiatry 35:427-32. 2013
    ..Suicide is an important clinical problem in psychiatric patients. The highest risk of suicide attempts is noted in affective disorders...
  26. doi request reprint No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder
    Anna Leszczynska-Rodziewicz
    Department of Adult Psychiatry, Poznan University of Medical Sciences, ul Szpitalna 27 33 60 572 Poznan, Poland
    Psychiatry Res 207:140-2. 2013
    ..No association was found for alleles, genotypes, or haplotype analysis for NR3C1, AVPR1b, and CRHR1 genes and melancholic depression...
  27. ncbi request reprint Brain derived neurotrophic factor gene Val66Met and -270C/T polymorphisms and personality traits predisposing to anorexia nervosa
    Filip Rybakowski
    Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poland
    Neuro Endocrinol Lett 28:153-8. 2007
    ..Several lines of molecular and biochemical evidence point to the role of BDNF in anorexia nervosa (AN). Personality traits may constitute the intermediate phenotypes between genes and vulnerability to AN...
  28. ncbi request reprint Association of 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophrenia
    Bartosz Kempisty
    Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
    Neurosci Lett 400:267-71. 2006
    ..393; 95% CI=1.429-4.006; P=0.0008 and OR=2.036; 95% CI=1.207-3.433; P=0.0073, respectively). This finding indicates possible association of BD and schizophrenia with the 1p36.3 MTHFR locus...
  29. doi request reprint Suicide attempts and psychological risk factors in patients with bipolar and unipolar affective disorder
    Joanna Pawlak
    Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poland
    Gen Hosp Psychiatry 35:309-13. 2013
    ..Protective role of cooperativeness was discovered. Patients with and without suicide attempt in lifetime history varied in self-esteem position in Value Survey...
  30. doi request reprint The study of candidate genes related to the neurodevelopmental hypothesis of anorexia nervosa: classical association study versus decision tree
    Monika Dmitrzak-Weglarz
    Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    Psychiatry Res 206:117-21. 2013
    ....
  31. doi request reprint Epistatic interaction between CRHR1 and AVPR1b variants as a predictor of major depressive disorder
    Aleksandra Szczepankiewicz
    aDepartment of Psychiatry, Laboratory of Psychiatric Genetics bDepartment of Adult Psychiatry cDepartment of Pulmonology, Pediatric Allergy, and Clinical Immunology, Laboratory of Molecular and Cell Biology, Poznan University of Medical Sciences, Poznan dDepartment of Individual Differences Psychology, Psychology Institute, Kazimierz Wielki University in Bydgoszcz, Bydgoszcz, Poland
    Psychiatr Genet 23:239-46. 2013
    ..The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD)...
  32. ncbi request reprint MTHFD 1958G>A and MTR 2756A>G polymorphisms are associated with bipolar disorder and schizophrenia
    Bartosz Kempisty
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland
    Psychiatr Genet 17:177-81. 2007
    ....
  33. doi request reprint Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features
    Anna Leszczynska-Rodziewicz
    Department of Adult Psychiatry, Poznan University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
    J Affect Disord 138:490-3. 2012
    ..NR3C1, CRHR1 and AVPR1b are the key components of this system. We investigated the possible involvement of the polymorphisms of those genes with the susceptibility to psychotic features in the course of BP I disorder...
  34. pmc Association, haplotype, and gene-gene interactions of the HPA axis genes with suicidal behaviour in affective disorders
    Anna Leszczynska-Rodziewicz
    Department of Psychiatric Genetics, Poznan University of Medical Sciences, Ulica Szpitalna 27 33, 60 572 Poznan, Poland
    ScientificWorldJournal 2013:207361. 2013
    ..Nonetheless, the inconsistencies with the previously published results indicate the importance of the further investigation of these polymorphisms with respect to the risk of suicide attempts. ..
  35. doi request reprint Association between OPCRIT dimensions and polymorphisms of HPA axis genes in bipolar disorder
    Anna Leszczynska-Rodziewicz
    Psychiatric Genetics Unit, Poznan University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland Electronic address
    J Affect Disord 151:744-7. 2013
    ..Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder...
  36. pmc Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study
    Aleksandra Szczepankiewicz
    Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poland
    Clin Mol Allergy 8:14. 2010
    ..We hypothesized that alleles leading to decreased enzyme activity and, therefore, decreased inactivation of histamine may be responsible for altered susceptibility to asthma...
  37. doi request reprint Altered microRNA expression profile during epithelial wound repair in bronchial epithelial cells
    Aleksandra Szczepankiewicz
    Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 27 33 Szpitalna St, 60 572 Poznan, Poland
    BMC Pulm Med 13:63. 2013
    ..We aimed to establish if the phased expression of specific miRNAs is correlated with the repair of mechanically induced damage to the epithelium...
  38. ncbi request reprint BDNF Met66 allele is associated with anorexia nervosa in the Polish population
    Monika Dmitrzak-Weglarz
    Psychiatr Genet 17:245-6. 2007