Research Topics
| B OlasSummaryAffiliation: University of Lodz Country: Poland Publications
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Publications
Inhibitory effect of resveratrol on free radical generation in blood plateletsB Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
Acta Biochim Pol 46:961-6. 1999..05). We suggest that free radicals play an important role in the reduced reactivity of blood platelets induced by resveratrol...
Anti-platelet effects of different phenolic compounds from Yucca schidigera Roezl. barkBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
Platelets 13:167-73. 2002..These compounds also had an inhibitory effect on the thrombin-induced enzymatic platelet lipid peroxidation determined as the level of thiobarbituric acid reactive substances...
The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compoundsB Olas
Department of General Biochemistry, University of Lodz, Lodz, Poland
J Physiol Pharmacol 55:467-76. 2004..Resveratrol (after 30 min action) at the concentration of 25 microg/ml partly reduced the platinum compounds induced decrease of platelet thiols, particularly thiols in acid-soluble fraction...
[Do membrane lipid rafts take part in blood platelet activation?]Beata Olas
Katedra Biochemii Ogólnej, Uniwersytet Lódzki, ul Banacha 12 16, 90 237 Lodz
Postepy Biochem 50:144-52. 2004
Resveratrol inhibits polyphosphoinositide metabolism in activated plateletsBeata Olas
Department of General Biochemistry, Institute of Biochemistry, , Poland
Biochim Biophys Acta 1714:125-33. 2005..These observations show that resveratrol has a profound effect on phospholipids, particularly on polyphosphoinositide metabolism, and may decrease the amount of PtdIns-4,5-P2 available for signalling in these cells...
Interaction of resveratrol with membrane glycerophospholipids in model system in vitroBeata Olas
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Łódź, Pomorska 141 3, 90 236 Łódź, Poland Electronic address
Food Chem Toxicol 50:4028-34. 2012..This study has clearly shown interactions between resveratrol and glycerophospholipids on a molecular level and that these interactions are influenced by the acyl chain length, degree of unsaturation and head group of the lipids...
The polyphenol-rich extract from grape seeds inhibits platelet signaling pathways triggered by both proteolytic and non-proteolytic agonistsBeata Olas
Department of General Biochemistry, University of Lodz, Pomorska 141 143, 90 236 Lodz, Poland
Platelets 23:282-9. 2012..Thus, the polyphenol-rich extract from grape seeds can be useful as the protecting factor against cardiovascular diseases...
The oxidative stress may be induced by the elevated homocysteine in schizophrenic patientsAnna Dietrich-Muszalska
Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka 8 10, 92 216, Lodz, Poland
Neurochem Res 37:1057-62. 2012..Considering the data presented in this study, we suggest that the elevated Hcys in schizophrenic patients may stimulate the oxidative stress...
The effects of antioxidants on peroxynitrite-induced changes in platelet proteinsBeata Olas
Department of General Biochemistry, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland
Thromb Res 113:399-406. 2004
Resveratrol reduces oxidative stress induced by platinum compounds in blood plateletsB Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
Gen Physiol Biophys 23:315-26. 2004....
Studies on antioxidant properties of polyphenol-rich extract from berries of Aronia melanocarpa in blood plateletsB Olas
Department of General Biochemistry, University of Lodz, Poland
J Physiol Pharmacol 59:823-35. 2008..The extract from A. melanocarpa seems to be also useful as an antioxidant in patients with breast cancer...
Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitroBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
Platelets 17:354-60. 2006....
Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytesBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
Anticancer Drugs 16:659-65. 2005..Therefore, anti-oxidative activity of resveratrol may diminish oxidative stress and damage to cellular biomolecules (lipids, proteins and DNA) induced by platinum compounds...
Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombinBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
Thromb Res 107:141-5. 2002..In conclusion, we suggest that resveratrol present in human diet may be an important compound responsible for the reduction of platelet adhesion and changed reactivity of blood platelets in inflammatory process...
Comparative studies on homocysteine and its metabolite-homocysteine thiolactone action in blood platelets in vitroB Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Platelets 19:520-7. 2008..TL like Hcy (at concentrations corresponding to concentrations in blood during hyperhomocysteinemia) modifies platelet responses to an important physiological agonist--thrombin...
Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitroBeata Olas
Department of General Biochemistry, University of Lodz, 90 237 Lodz, Poland
Platelets 19:70-7. 2008..The tested extracts due to their anti-platelet effects may play an important role as components of human diet in prevention of cardiovascular or inflammatory diseases, where blood platelets are involved...
Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitriteBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, 90 237 Lodz, Poland
J Nutr Biochem 17:96-102. 2006..1 mM). The obtained results indicate that in vitro resveratrol, like well-known antioxidant DFO, has inhibitory effects on ONOO- -mediated oxidation of proteins and lipids in human plasma...
Comparative studies of the antioxidant effects of a naturally occurring resveratrol analogue -- trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene and resveratrol -- against oxidation and nitration of biomolecules in blood plateletsBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Cell Biol Toxicol 24:331-40. 2008....
Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood plateletsB Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
Gen Physiol Biophys 25:215-22. 2006..1 mmol/l), in the presence of resveratrol (0.25-0.1 mmol/l) is reduced. Resveratrol may scavenge ONOO(-), and may be useful in the prevention of ONOO(-)-related diseases, such as inflammatory and cardiovascular diseases...
Role of reactive nitrogen species in blood platelet functionsBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
Platelets 18:555-65. 2007....
D-glucaro 1,4-lactone and resveratrol as antioxidants in blood plateletsBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Cell Biol Toxicol 24:189-99. 2008....
[Metabolism of phosphoinositides in blood platelets]Beata Olas
, , Banacha 12/16,
Postepy Biochem 49:185-93. 2003
The effect of cis-diamminedichloroplatinum, selenite and a conjugate of cisplatin with selenite [(NH3)2Pt(SeO3)] on oxidative stress in blood platelets measured by chemiluminescence methodB Olas
Department of Biochemistry, Institute of Biochemistry, University of Lodz, Poland
J Physiol Pharmacol 50:299-308. 1999..Pre-treatment of blood platelets with buthionine sulfoximine (50 microM, 1 h, 37 degrees C) leading to a decrease of glutathione reduced the cisplatin-induced generation of free radicals in these cells (p < 0.05)...
The effects of granulocyte colony stimulating factor on chemiluminescence and lipid peroxidation of blood platelets treated with cisplatinB Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
Anticancer Drugs 11:79-84. 2000..8 microg/ml) cisplatin-induced generation of ROS was also reduced (p<0.05). This study demonstrates that G-CSF has a protective effect against the oxidative stress in blood platelets caused by cisplatin...
Vitamin C suppresses the cisplatin toxicity on blood plateletsB Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
Anticancer Drugs 11:487-93. 2000..It diminished platelet lipid peroxidation and reactive oxygen species generation induced by cisplatin. In the presence of vitamin C, the catalase activity was suppressed...
May modifications of human plasma proteins stimulated by homocysteine and its thiolactone induce changes of hemostatic function of plasma in vitro?Beata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
Gen Physiol Biophys 29:186-93. 2010..Moreover, our studies reported that not only Hcys (10-100 micromol/l), but also HTL (at lower concentrations than Hcys) modulates the coagulation properties of human plasma...
The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood plateletsBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
Platelets 22:345-52. 2011..However, in comparative studies the extract was not found to be a more effective antioxidant than the solution of pure resveratrol...
Homocysteine and its thiolactone may promote apoptotic events in blood platelets in vitroBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
Platelets 21:533-40. 2010..The obtained results indicate that Hcys and its thiolactone may promote in vitro apoptotic events in human gel-filtered platelets...
Resveratrol and vitamin C as antioxidants in blood plateletsBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
Thromb Res 106:143-8. 2002..Resveratrol as an antioxidant reduced oxidative stress in blood platelets caused by vitamin C at prooxidative dose (100 microM)...
Effects of polyphenol-rich extract from berries of Aronia melanocarpa on the markers of oxidative stress and blood platelet activationBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Platelets 21:274-81. 2010..Comparative studies indicate that the tested plant extract was found to be more reactive in blood platelets than the solution of pure resveratrol...
Inhibition of oxidative stress in blood platelets by different phenolics from Yucca schidigera Roezl. barkBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Nutrition 19:633-40. 2003....
Protective effects of D-glucaro 1,4-lactone against oxidative/nitrative modifications of plasma proteinsBeata Olas
Department of General Biochemistry, University of Lodz, Lodz, Poland
Nutrition 23:164-71. 2007..We also investigated the effects of 1,4-GL on the level of total free thiol groups and low-molecular-weight thiols (glutathione and homocysteine) in plasma treated with ONOO- (0.1 mM)...
Antioxidant activity of resveratrol in endotoxin-stimulated blood plateletsB Olas
Department of General Biochemistry, Institute of Biochemistry, , Poland
Cell Biol Toxicol 17:117-25. 2001..We have shown that resveratrol (6.25-100 microg/ml) inhibits chemiluminescence and generation of O2.- in blood platelets. It has an inhibitory effect on the production of ROS and TBARS in platelets caused by LPS or thrombin...
The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombinB Olas
Department of General Biochemistry, , Poland
Microbios 105:7-13. 2001..05), but it significantly stimulated the liberation of proteins from blood platelets activated by LPS (p <0.05)...
Generation of reactive oxygen species in blood plateletsB Wachowicz
Department of General Biochemistry, Institute of Biochemistry, , Poland
Platelets 13:175-82. 2002..Our results support the importance of ROS in platelet function...
Antioxidant properties of trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene against modification of variety of biomolecules in human blood cells treated with platinum compoundsBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Nutrition 22:1202-9. 2006..05). The trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene can also be useful as a protective factor against platinum compounds during chemotherapy or cancer prophylaxis...
Comparative cytotoxicity of cisplatin, sodium selenite and selenium-cisplatin conjugate [(NH3)2Pt(SeO3)]; changes of blood platelet activationB Wachowicz
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Poland
Gen Physiol Biophys 16:263-72. 1997..The tested compound seems to be less toxic than cisplatin alone, and has no effect on blood platelet activation...
The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood plateletsJ Saluk-Juszczak
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
Curr Microbiol 54:27-30. 2007..After incubating platelets with LPS, we also observed a distinct increase in platelet protein nitration (3-nitrotyrosine)...
Role of phosphoinositide 3-kinase in adhesion of platelets to fibrinogen stimulated by cancer procoagulantB Olas
Department of General Biochemistry, Institute of Biochemistry, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
Platelets 12:431-5. 2001..We conclude that in adhesion of platelets to fibrinogen stimulated by CP PI 3-K take place...
Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. barkBeata Olas
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Nutrition 21:199-206. 2005..CONCLUSIONS: Resveratrol and yucca extract were more reactive in decreasing these processes than were other tested phenolic compounds...
An extract from berries of Aronia melanocarpa modulates the generation of superoxide anion radicals in blood platelets from breast cancer patientsMagdalena Kedzierska
Department of General Biochemistry, University of Lodz, Lodz, Poland
Planta Med 75:1405-9. 2009..Considering the data presented in this study, we have demonstrated the protective role of the extract from A. melanocarpa in patients with breast cancer in vitro...
Resveratrol protects against peroxynitrite-induced thiol oxidation in blood plateletsBeata Olas
Department of General Biochemistry, , , Poland
Cell Mol Biol Lett 9:577-87. 2004..In conclusion, we suggest that the resveratrol present in the human diet may partially protect -SH groups from oxidation and may be responsible for redox regulation and control in platelets...
Oxidative/nitrative modifications of plasma proteins and thiols from patients with schizophreniaAnna Dietrich-Muszalska
2nd Department of Psychiatry, Medical University of Lodz, Lodz, Poland
Neuropsychobiology 59:1-7. 2009..According to DSM-IV criteria, all patients had a diagnosis of paranoid type. They were treated with antipsychotic drugs (clozapine, risperidone, olanzapine). The mean duration of schizophrenia was about 5 years...
Effects of the extract from Conyza canadensis on human blood platelet aggregationJ Saluk-Juszczak
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
Gen Physiol Biophys 26:150-2. 2007..Polysaccharide part isolated from plant extract had the strongest inhibitory effect on aggregation stimulated by collagen and seems to be responsible for antiaggregatory properties...
Modifications of blood platelet proteins of patients with schizophreniaAnna Dietrich-Muszalska
II Department of Psychiatry, Medical University of Lodz, Lodz, Poland
Platelets 20:90-6. 2009..The consequence of these modifications may be the alteration of platelet protein structure and function...
Cancer procoagulant and blood platelet activationB Olas
Department of General Biochemistry, Institute of Biochemistry, , Banacha 12/16, 90-237, , Poland
Cancer Lett 169:165-71. 2001..In comparison with thrombin action, CP stimulates secretory process to a smaller extent than thrombin alone. In the presence of CP, the thrombin action is suppressed (P < 0.05). We noticed that CP does not induce platelet aggregation...
Resveratrol, a phenolic antioxidant with effects on blood platelet functionsBeata Olas
Department of General Biochemistry, Institute of Biochemistry, , Poland
Platelets 16:251-60. 2005....
Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasmaJoanna Kolodziejczyk
Department of General Biochemistry, University of Lodz, Lodz, Poland
Platelets 20:487-92. 2009..Garcinol and guttiferone K can be also useful as protecting factors against diseases associated with oxidative stress...
[Biological activity of resveratrol]B Olas
Katedra Biochemii Ogólnej, Uniwersytet Łódzki
Postepy Hig Med Dosw 55:71-9. 2001..Resveratrol is a phytoalexin found in many plants, mainly in grapes. It has been shown to prevent coronary heart diseases and to exert a variety of anti-cancer and anti-inflammatory effects...
The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipidsPaweł Nowak
Department of General Biochemistry, University of Łódź, Łódź, Poland
Cell Mol Biol Lett 11:1-11. 2006..1 mM). The obtained results indicate that in vitro bis(2-aminophenyl)-diselenide and ebselen have very similar protective effects against peroxynitrite-induced oxidative/nitrative damage to human plasma proteins and lipids...
The lipid peroxidation in breast cancer patientsMagdalena Kedzierska
Department of General Biochemistry, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
Gen Physiol Biophys 29:208-10. 2010..Considering the data presented in this study, we suggest that free radicals induce peroxidation of unsaturated fatty acid in patients with breast cancer...
Protective effects of D-glucaro-1,4-lactone against oxidative modifications in blood plateletsJoanna Saluk-Juszczak
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
Nutr Metab Cardiovasc Dis 18:422-8. 2008..However, the effect of this compound on platelet activation is unknown...
L-carnitine modulates blood platelet oxidative stressJoanna Saluk-Juszczak
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Cell Biol Toxicol 26:355-65. 2010..Moreover, our results in vitro demonstrate that carnitine may protect against oxidation of thiol groups induced by ONOO(-). Thus, carnitine may have some protectory effects against oxidative changes induced in blood platelets...
Peroxynitrite-induced changes of thiol groups in human blood plateletsPaweł Nowak
Department of General Biochemistry, University of Łódź, Poland
Platelets 14:375-9. 2003..The presented results suggest that oxidation of thiols and depletion of GSH in platelets caused by peroxynitrite may be responsible for cytotoxic effects of this compound...
[Oxidative stress in haemostasis]Paweł Nowak
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, 12 16 Banacha St, 90 237 Lodz, Poland
Postepy Biochem 56:239-47. 2010..Oxidative/nitrative modifications of different components of haemostasis system have been observed in several cardiovascular diseases...
Mechanism of action of homocysteine and its thiolactone in hemostasis systemK Karolczak
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland
Physiol Res 58:623-33. 2009....
Inhibitory effects of polyphenol compounds on lipid peroxidation caused by antipsychotics (haloperidol and amisulpride) in human plasma in vitroAnna Dietrich-Muszalska
Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka, Lodz, Poland
World J Biol Psychiatry 11:276-81. 2010....
[Hyperhomocysteinemia and the disturbance of haemostasis--facts and mythes]Joanna Malinowska
Department of General Biochemistry, University of Lodz, Poland
Pol Merkur Lekarski 27:413-8. 2009....
The effects of the second generation antipsychotics and a typical neuroleptic on collagen-induced platelet aggregation in vitroAnna Dietrich-Muszalska
Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland
World J Biol Psychiatry 11:293-9. 2010..Aggregation of platelets was measured after stimulation of platelets with 1 microl of collagen (2 microg/ml)...
Biochemical properties of platelet microparticle membranes formed during exocytosis resemble organelles more than plasma membraneBeata Olas
Department of Biochemistry and Molecular Biology, University of Bergen, Arstadveien 19, 5009, Bergen, Norway
FEBS Lett 525:29-32. 2002....
