Affiliation: University of Lodz
Wawro M, Chojnacka K, Wieczorek Szukała K, Sobierajska K, Niewiarowska J. Invasive Colon Cancer Cells Induce Transdifferentiation of Endothelium to Cancer-Associated Fibroblasts through Microtubules Enriched in Tubulin-β3. Int J Mol Sci. 2018;20: pubmed publisher
Sobierajska K, Wieczorek K, Ciszewski W, Sacewicz Hofman I, Wawro M, Wiktorska M, et al
. ?-III tubulin modulates the behavior of Snail overexpressed during the epithelial-to-mesenchymal transition in colon cancer cells. Biochim Biophys Acta. 2016;1863:2221-33 pubmed publisher
Wawro M, Sobierajska K, Ciszewski W, Wagner W, Frontczak M, Wieczorek K, et al
. Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages. Cell Signal. 2017;38:26-38 pubmed publisher
..We believe that our results will be valuable for the development of effective new anti-fibrotic therapies. ..
Wieczorek K, Wiktorska M, Sacewicz Hofman I, Boncela J, Lewinski A, Kowalska M, et al
. Filamin A upregulation correlates with Snail-induced epithelial to mesenchymal transition (EMT) and cell adhesion but its inhibition increases the migration of colon adenocarcinoma HT29 cells. Exp Cell Res. 2017;359:163-170 pubmed publisher
..FLNA upregulation, which correlates with cell metastatic properties, maybe an additional target for combination therapy in colorectal carcinoma tumor progression. ..
Ciszewski W, Sobierajska K, Wawro M, Klopocka W, Chefczyńska N, Muzyczuk A, et al
. The ILK-MMP9-MRTF axis is crucial for EndMT differentiation of endothelial cells in a tumor microenvironment. Biochim Biophys Acta Mol Cell Res. 2017;1864:2283-2296 pubmed publisher
..Herein, we propose a new ILK-MMP9-MRTF axis that appears to be critical for EndMT differentiation of endothelial to CAF-like cells. Thus, it might be an attractive target for cancer treatment. ..