Paweł P Liberski

Summary

Affiliation: University of Lodz
Country: Poland

Publications

  1. pmc Boginia virus, a newfound hantavirus harbored by the Eurasian water shrew (Neomys fodiens) in Poland
    Se Hun Gu
    Pacific Center for Emerging Infectious Diseases Research, John A, Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, BSB320L, Honolulu, Hawaii 96813, USA
    Virol J 10:160. 2013
  2. doi request reprint Gerstmann-Sträussler-Scheinker disease
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Lodz, Poland
    Adv Exp Med Biol 724:128-37. 2012
  3. doi request reprint Kuru: the first prion disease
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Lodz, Poland
    Adv Exp Med Biol 724:143-53. 2012
  4. doi request reprint Tubulovesicular structures are a consistent (and unexplained) finding in the brains of humans with prion diseases
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, PL 92 216 Lodz, Poland
    Virus Res 132:226-8. 2008
  5. ncbi request reprint Prion diseases: from transmission experiments to structural biology--still searching for the cause
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Chair of Oncology, Medical University of Lodz
    Folia Neuropathol 42:15-32. 2004
  6. ncbi request reprint Kuru: a half-opened window onto the landscape of neurodegenerative diseases
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:3-14. 2004
  7. ncbi request reprint Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Czechoslowacka Street 8 10 pl 92 216 Lodz, Poland
    Int J Biochem Cell Biol 36:2473-90. 2004
  8. ncbi request reprint Exuberant cellular reaction of the optic nerves in experimental Creutzfeldt-Jakob disease
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Acta Neurobiol Exp (Wars) 63:309-18. 2003
  9. ncbi request reprint Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechosłowacka Str 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 46:1-25. 2008
  10. ncbi request reprint Amyloid plaques in transmissible spongiform encephalopathies (prion diseases)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:109-19. 2004

Collaborators

Detail Information

Publications92

  1. pmc Boginia virus, a newfound hantavirus harbored by the Eurasian water shrew (Neomys fodiens) in Poland
    Se Hun Gu
    Pacific Center for Emerging Infectious Diseases Research, John A, Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, BSB320L, Honolulu, Hawaii 96813, USA
    Virol J 10:160. 2013
    ....
  2. doi request reprint Gerstmann-Sträussler-Scheinker disease
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Lodz, Poland
    Adv Exp Med Biol 724:128-37. 2012
    ..In several families with GSS the responsible mutations are unknown...
  3. doi request reprint Kuru: the first prion disease
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Lodz, Poland
    Adv Exp Med Biol 724:143-53. 2012
    ..Neuropathologically, kuru is characterized by the presence of amyloid "kuru" plaques...
  4. doi request reprint Tubulovesicular structures are a consistent (and unexplained) finding in the brains of humans with prion diseases
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, PL 92 216 Lodz, Poland
    Virus Res 132:226-8. 2008
    ..This study confirms the TSE-specificity of TVS, the morphology of which suggests a possible pathogenetic role and relationship to recently described virion-like arrays of 25nm particles in scrapie-infected tissue cultures...
  5. ncbi request reprint Prion diseases: from transmission experiments to structural biology--still searching for the cause
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Chair of Oncology, Medical University of Lodz
    Folia Neuropathol 42:15-32. 2004
  6. ncbi request reprint Kuru: a half-opened window onto the landscape of neurodegenerative diseases
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:3-14. 2004
    ..Vin Zigas to Dr. John Gunter in 1956. In March 1957, Gajdusek joined Zigas, who at that time was a medical patrol officer in Kainantu, Eastern Highland District of the Territory of Papua New Guinea...
  7. ncbi request reprint Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Czechoslowacka Street 8 10 pl 92 216 Lodz, Poland
    Int J Biochem Cell Biol 36:2473-90. 2004
    ..On a basis of ultrastructural studies, we suggest that autophagy plays a major role in transmissible spongiform encephalopathies (TSEs) and may even participate in a formation of spongiform change...
  8. ncbi request reprint Exuberant cellular reaction of the optic nerves in experimental Creutzfeldt-Jakob disease
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Acta Neurobiol Exp (Wars) 63:309-18. 2003
    ..An analogous network of narrow cisterns was seen to surround whole segments of the myelinated fibers...
  9. ncbi request reprint Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechosłowacka Str 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 46:1-25. 2008
    ..On the basis of ultrastructural studies, we suggest that autophagy may play a major role in transmissible spongiform encephalopathies and may even participate in the formation of spongiform change...
  10. ncbi request reprint Amyloid plaques in transmissible spongiform encephalopathies (prion diseases)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:109-19. 2004
    ..Ultrastructurally, plaques were recognised as areas of low electron density containing haphazardly-oriented fibrils which, when immunogold techniques were applied, were heavily decorated with PrP-conjugated gold particles...
  11. ncbi request reprint Disease-specific particles without prion protein in prion diseases - phenomenon or epiphenomenon?
    P P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Neuropathol Appl Neurobiol 33:395-7. 2007
    ..None of these observations distinguish between TVS as an entity critical to the infectious process, or as a highly specific ultrastructural epiphenomenon, but their consistent presence in all TSEs demands further research...
  12. ncbi request reprint Mechanisms of neuronal death in transmissible spongiform encephalopathies
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:89-95. 2004
    ..However, recently developed techniques and the careful examination of the molecular processes leading to different types of cell death should provide the answer in future...
  13. ncbi request reprint Ultrastructural pathology of prion diseases revisited: brain biopsy studies
    P P Liberski
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechoslowacka st 8 10, 92 216 Lodz, Poland
    Neuropathol Appl Neurobiol 31:88-96. 2005
    ..We conclude that TVS are readily found in FFI, vCJD and sCJD and that widespread neuritic degeneration is a part of ultrastructural pathology in prion diseases...
  14. ncbi request reprint Echigo-1: a panencephalopathic strain of creutzfeldt-jakob disease. I. neuropathological and immunohistochemical studies
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:161-6. 2004
    ..The third, and most striking, consisted of perineuronal deposits. These formed small dots and coarser globules which were densely situated on the neuronal membrane on both cell bodies and their processes...
  15. ncbi request reprint Gerstmann-Sträussler-Scheinker disease. I. Human diseases
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:120-40. 2004
    ..In the second part of this review the experimental data using experimental models of GSS in transgenic mice are summarised as well as structural biology of mutated PrP in GSS...
  16. ncbi request reprint Tubulovesicular structures--the ultrastructural hallmark for transmissible spongiform encephalopathies or prion diseases
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:96-108. 2004
    ..The composition of TVS is unknown but they are not composed of PrP. Their consistent presence in all TSEs suggests the role at least of TSE pathogenesis...
  17. ncbi request reprint An outline of the neuropathology of transmissible spongiform encephalopathies (prion diseases)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:39-58. 2004
    ..We also review the peculiarities of kuru, variant Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease...
  18. ncbi request reprint Spongiform change--an electron microscopic view
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:59-70. 2004
    ..We suggested that vacuoles may develop through process of autophagy...
  19. ncbi request reprint Astrocytes in transmissible spongiform encephalopathies (prion diseases)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:71-88. 2004
    ..An interesting interaction between astrocytes and oligodendrocytes is discussed in detail as well as a particular form of astrocytic reaction in panencephalopathic form of TSEs...
  20. ncbi request reprint Prion diseases: a riddle wrapped in a mystery inside an enigma
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Poland
    Folia Neuropathol 46:93-116. 2008
    ....
  21. doi request reprint Kuru: its ramifications after fifty years
    P P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Medical University Lodz, 92 216 Lodz, Poland
    Exp Gerontol 44:63-9. 2009
    ..And perhaps most importantly, the realization of 'protein-misfolding diseases', including not only the neurodegenerative but also an increasing number of non-neurological disorders, would have been delayed by decades...
  22. ncbi request reprint A special report I. Prion protein (PrP)--amyloid plaques in the transmissible spongiform encephalopathies, or prion diseases revisited
    P P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Medical Academy, Lodz, Poland
    Folia Neuropathol 39:217-35. 2001
    ..Occasional dystrophic neurites containing electron-dense inclusion bodies were seen within the plaque perimeter, which always remained PrP-negative...
  23. ncbi request reprint Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. I. Alterations of myelinated axons
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Poland
    Acta Neurobiol Exp (Wars) 62:121-9. 2002
    ..In contrast, mice infected with the panencephalopathic Fujisaki strain of CJD exhibited much more elaborate changes of myelinated fibres...
  24. ncbi request reprint Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. II. Astrocytic and macrophage reaction towards axonal destruction
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Poland
    Acta Neurobiol Exp (Wars) 62:131-9. 2002
    ..Several mylinated fibres were clearly engulfed by the cytoplasm of a macrophage containing unusual annulate lamellae...
  25. ncbi request reprint Transmissible mink encephalopathy - review of the etiology of a rare prion disease
    Paweł P Liberski
    Dept Molecular Pathology, Medical University Lodz, Czechoslowacka Street 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 47:195-204. 2009
    ..In addition, we show here for the first time confocal laser microscopy studies of co-localization of PrPd- amyloid plaques and GFAP-expressing astrocytes...
  26. ncbi request reprint How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Poland
    Acta Neurobiol Exp (Wars) 62:141-7. 2002
    ..Finally, a large area of the cytoplasm was transformed into a collection of autophagic vacuoles of different sizes. Virtually identical alterations, albeit with much lower frequency, were seen in terminally ill CJD-affected hamsters...
  27. doi request reprint Autophagy contributes to widespread neuronal degeneration in hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease and mice infected with the Fujisaki strain of Gerstmann-Sträussler-Scheinker (GSS) syndrome
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Ultrastruct Pathol 35:31-6. 2011
    ..The authors conclude that autophagy is an important part of neuropathology in prion disease. They also suggest that spongiform vacuoles, a hallmark for the whole group of prion diseases, may in reality originate from autophagic vacuoles...
  28. ncbi request reprint Prion diseases: a dual view of the prion hypothesis as seen from a distance
    Paweł P Liberski
    Laboratory of Electron Microscopic and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Department of Neurosurgery, Polish Mother Memorial Hospital, Łódź, Poland
    Acta Neurobiol Exp (Wars) 62:197-224; discussion 224-6. 2002
    ..The enormous impact of structural biological studies is also stressed...
  29. ncbi request reprint Reflections on a half-century in the field of transmissible spongiform encephalopathy
    Paul Brown
    Dept Molecular Pathology, Medical University Lodz, Czechoslowacka Street 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 47:95-103. 2009
    ..For obvious reasons, we should hope for the botanical alternative...
  30. ncbi request reprint Kuru and D. Carleton Gajdusek: a close encounter
    Paweł P Liberski
    Dept Molecular Pathology, Medical University Lodz, Czechoslowacka Street 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 47:114-37. 2009
    ..It was one of the greatest discoveries in biomedical sciences of the 20th century...
  31. ncbi request reprint Echigo-1: a panencephalopathic strain of Creutzfeldt-Jakob disease. II. Ultrastructural studies in hamsters
    Beata Sikorska
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:167-75. 2004
    ..The robust cellular reactions consisted of reactive astrocytes and macrophages filled with cellular debris. It is of note that complex autophagic vacuoles were observed in the cytoplasm of neurons...
  32. ncbi request reprint Is the prion structure solved?
    P P Liberski
    Department of Oncology, University Medical School, Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 45:121-40. 1997
    ..Thus, we discuss the nature of tubulovesicular structures (TVS), the only diseases-specific particles known so far and the association between TVS and PrP fibrils which was recently discovered...
  33. ncbi request reprint The evolution of views on the nosological position of transmissible spongiform encephalopathies
    P P Liberski
    Department of Oncology, School of Medicine, Lodz, Poland
    Folia Neuropathol 35:214-25. 1997
    ..While the nosological position of these diseases is well understood, the nature of the agent is still a matter of dispute. There is no doubt, however, that the gene for PrP plays a major role in the whole group of neurodegenerations...
  34. doi request reprint Ultrastructural characteristics (or evaluation) of Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies or prion diseases
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Ultrastruct Pathol 34:351-61. 2010
    ..e., composed of dystrophic neurites with little or no amyloid, were found only in a P102L case from the original Austrian family. In 2 cases of sporadic CJD, the kuru stellate plaque predominated...
  35. ncbi request reprint Fate of myelinated fibres in the optic nerves in experimental Creutzfeldt-Jakob disease in rodents: an ultrastructural study
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:101-5. 2004
    ..This finding suggests that myelin lamellae participate in the formation of vacuoles...
  36. ncbi request reprint Ultrastructural changes in the optic nerves of rodents with experimental Creutzfeldt-Jakob Disease (CJD), Gerstmann-Sträussler-Scheinker disease (GSS) or scrapie
    A Walis
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    J Comp Pathol 129:213-25. 2003
    ..In mice infected with the Fujisaki strain of GSS, fibres had undergone demyelination with stripping of the myelin lamellae, while others showed vesicular myelin degeneration...
  37. doi request reprint Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease
    B Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Neuropathol Appl Neurobiol 35:46-59. 2009
    ....
  38. pmc Screening for EGFR amplifications with a novel method and their significance for the outcome of glioblastoma patients
    Michał Bieńkowski
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland
    PLoS ONE 8:e65444. 2013
    ..To conclude, although the data presented here require validation in different groups of patients, they strongly advocate the consideration of the patient's tumour molecular characteristics in the selection of the therapy...
  39. ncbi request reprint Expression of immunohistochemical markers on microglia in Creutzfeldt-Jakob disease and Alzheimer's disease: morphometric study and review of the literature
    Marcin Wojtera
    Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, 8 10 Czechosłowacka St, 92 216 Lodz, Poland
    Folia Neuropathol 50:74-84. 2012
    ..g. Glia-Derived Neurotrophic Factor [GDNF]) or proinflammatory and neurotoxic (e.g. tumour necrosis factor alpha [TNF-α], interleukin 1β [IL-1β], nitric oxide [NO], superoxide, eicosanoids, quinolinic acid)...
  40. ncbi request reprint Neuronal autophagy and aggresomes constitute a consistent part of neurodegeneration in experimental scrapie
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Czechoslowacka Street 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 45:170-8. 2007
    ..In a few specimens there were round electron-dense structures that we identified as aggresomes. Aggresomes are not membrane-bound and were found in the cytoplasm of a few neurons...
  41. ncbi request reprint Codon 129 polymorphism of the PRNP gene in normal Polish population and in Creutzfeldt-Jakob disease, and the search for new mutations in PRNP gene
    J Bratosiewicz
    Department of Molecular Biology, Medical Academy Łódź, 8 10 Czechosłowacka St, 92 216 Łódź
    Acta Neurobiol Exp (Wars) 61:151-6. 2001
    ..3% were homozygous for methionine, 13.3% homozygous for valine and 13.3% were heterozygous. The novel missense mutation (ATG-->ACG) at codon 232 was identified in one of the samples with a GSS phenotype...
  42. ncbi request reprint Loss of chromosome 22 and proliferative potential in ependymomas
    Maria Debiec-Rychter
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 41:191-5. 2003
    ..6% and 6.0%, respectively, p = 0.05), indicating that loss of chromosome 22 may be associated with the subset of ependymomas characterised by low proliferative capacities...
  43. ncbi request reprint Bovine spongiform encephalopathy (BSE): the end of the beginning or the beginning of the end?
    Ray Bradley
    Department of Molecular Biology, Chair of Oncology, Medical Academy, Lodz, Poland
    Folia Neuropathol 42:55-68. 2004
    ..If all the advice is taken and measures enforced there is a prospect that BSE can be eliminated from countries and regions as a prelude to eradication from the world...
  44. pmc PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease
    Marcin Flirski
    Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland
    Prion 6:73-80. 2012
    ..A precise estimation of the exact significance of particular polymorphisms in BPSD etiology requires future studies on large populations...
  45. ncbi request reprint Subependymal plaques in scrapie-affected hamster brains--why are they so different from compact kuru plaques?
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Czechoslowacka Street 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 46:32-42. 2008
    ..Some microglial cells were observed in close contact with PrP-positive plaques, and secondary lysosomes within these cells were heavily decorated with gold particles...
  46. ncbi request reprint Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD
    E Golanska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Neurology 62:313-5. 2004
    ..A significant difference appeared also between early-onset (<70 years) and late-onset (> or = 70 years) AD patients in the PRND genotypes...
  47. ncbi request reprint Gerstmann-Sträussler-Scheinker disease. II. An effect of GSS mutation on PRP structure
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:140-52. 2004
  48. ncbi request reprint Ultrastructural alterations in the optic nerve in transmissible spongiform encephalopathies or prion diseases--a review
    Anna Waliś
    Department of Neurology, Mikolaj Kopernik memorial Regional Multidisciplinary Hospital, Lodz, Poland
    Folia Neuropathol 42:153-60. 2004
    ..It is of special note that in the cytoplasm of several cells as well as the axoplasm numerous autophagic vacuoles were seen...
  49. ncbi request reprint Prion protein (PrP) deposits in the tectum of experimental Gerstmann-Sträussler-Scheinker disease following intraocular inoculation
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, 8 10 Czechoslowacka St, 92 216 Lodz, Poland
    Folia Neuropathol 50:85-8. 2012
    ..As already reported, a few spongiform vacuoles were visible in the same area by conventional H and E staining. In several other sections, vacuoles were visible but no PrPd staining could be detected...
  50. doi request reprint Creutzfeldt-Jakob disease
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Lodz, Poland
    Adv Exp Med Biol 724:76-90. 2012
    ..PrP immunohistochemistry reveals different types of PrP(Sc) deposits - the most common is the synaptic-type, but perivacuolar, perineuronal and plaque-like deposits may be also detected...
  51. ncbi request reprint Kuru-fifty years later
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Medical University Lodz, Lodz, Poland
    Neurol Neurochir Pol 41:548-56. 2007
    ..In this review, we summarize some data on the epidemiology, neuropathology and clinical picture of kuru...
  52. pmc Glioblastoma-derived spheroid cultures as an experimental model for analysis of EGFR anomalies
    Monika Witusik-Perkowska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Czechoslowacka 8 10 str, 92 216 Lodz, Poland
    J Neurooncol 102:395-407. 2011
    ....
  53. pmc Polycomb genes expression as a predictor of poor clinical outcome in children with medulloblastoma
    Magdalena Zakrzewska
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Łódź, Czechosłowacka 8 10, Łódź, Poland
    Childs Nerv Syst 27:79-86. 2011
    ..PcG genes play an important role in developmental processes; they are also involved in the self-renewal of hematopoietic and neural stem cells as well as in malignant transformation...
  54. doi request reprint Selection of reference genes for gene expression studies in astrocytomas
    Sylwia M Gresner
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Anal Biochem 408:163-5. 2011
    ..Thus, GAPDH may be recommended for data normalization in gene expression studies in astrocytomas. Nevertheless, a preliminary validation of reference gene stability is required prior to every study...
  55. doi request reprint Prevalence of mutated TP53 on cDNA (but not on DNA template) in pleomorphic xanthoastrocytoma with positive TP53 immunohistochemistry
    Magdalena Zakrzewska
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechoslowacka 8 10, 92 216 Lodz, Poland
    Cancer Genet Cytogenet 193:93-7. 2009
    ..We suggest that the incidence of TP53 mutations in pleomorphic xanthoastrocytoma may be underestimated and that molecular approaches should be used for greater diagnostic precision...
  56. ncbi request reprint Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease
    P P Liberski
    Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Poland
    Folia Neuropathol 38:167-70. 2000
    ..Collectively, they are more similar to neuritic plaques of Alzheimer's disease than to kuru plaques of kuru--Creutzfeldt-Jakob disease--Gerstmann-Sträussler-Sheinker disease...
  57. ncbi request reprint Tubulovesicular structures: what are they really?
    P P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Lodz, Poland
    Microsc Res Tech 50:46-57. 2000
    ..The very existence of TVS and their correlation with infectivity, therefore, urgently needs an explanation...
  58. ncbi request reprint Ultrastructural pathology of Creutzfeldt-Jakob disease and fatal familial insomnia
    P P Liberski
    Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Poland
    Folia Neuropathol 38:171-3. 2000
    ..Tubulovesicular structures (TVS) were found in every case including FFI and nvCJD. Thus, TVS, as we suggested previously are important pathologic structure which significance should be more extensively studied...
  59. ncbi request reprint A special report I. Prion protein (Prp)--amyloid plaques in the transmissible spongiform encephalopathies (TSEs) or prion disease revisited
    P P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Institute Polish Mother Health Center, Łódź
    Pol J Pathol 52:169-86. 2001
    ..Occasional dystrophic neurites containing electron-dense inclusion bodies were seen within the plaque perimeter, which always remained PrP-negative...
  60. ncbi request reprint The morphometric analysis and recognition an amyloid plaque in microscope images by computer image processing
    A Grams
    Department of Psychiatry, Medical Academy of Lodz
    Folia Neuropathol 38:183-7. 2000
    ..The developed computer system will collect and store image data and exchange them by network with other collaborated systems...
  61. ncbi request reprint The ultrastructure of glial tumors of astrocytic lineage: a review
    P P Liberski
    Department of Molecular Biology, School of Medicine, Lodz
    Folia Neuropathol 36:161-77. 1998
    ..Secondary glioblastomas retained clear stigmata of astrocytic tumor but the nuclei seemed to be more intended, cisterns of the endoplasmic reticulum appeared to be distended and frequently intranuclear pseudoinclusions were observed...
  62. ncbi request reprint Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: a risk analysis
    P P Liberski
    Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Poland
    Folia Neuropathol 38:143-50. 2000
    ..In this review I covered recent data on the vCJD and BSE epidemic, the mode of BSE spreading to humans and, finally, the data on the PRNP analogue--the doppel gene (PRND)...
  63. ncbi request reprint Ultrastructure of meningiomas: autophagy is involved in the pathogenesis of "intranuclear vacuoles"
    Dariusz Jaskolski
    Department of Neurosurgery and Oncology of the Central Nervous System, Medical University of Lodz, Poland
    Folia Neuropathol 50:187-93. 2012
    ..In a case of anaplastic meningioma, a mitotic figure was found. In another case, empty rectangular spaces in the cytoplasm, suggestive of pre-existing crystalloid structures, were seen...
  64. ncbi request reprint Imperfect oligodendrocytic and neuronal differentiation of glioblastoma cells
    Magdalena Wolańczyk
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechoslowacka, Lodz, Poland
    Folia Neuropathol 48:27-34. 2010
    ..Our work confirmed that the neuronal differentiation of GBM was inhibited at the stage of the neuronal intermediate phenotype. Moreover, we showed that the oligodendrocytic differentiation of GBM cells is very inefficient...
  65. ncbi request reprint Mutational analysis of hSNF5/INI1 and TP53 genes in choroid plexus carcinomas
    Magdalena Zakrzewska
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechoslowacka 8 10, 92 216 Lodz, Poland
    Cancer Genet Cytogenet 156:179-82. 2005
    ..There was no coexistence of mutations in both analyzed genes. Our analysis confirms the presence of the hSNF5/INI1 mutations and proves involvement of TP53 mutations in sporadic cases of CPC...
  66. ncbi request reprint Ultrastructural findings in pigs experimentally infected with bovine spongiform encephalopathy agent
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, 8 10 Czechoslowacka St, 92 216 Lodz, Poland
    Folia Neuropathol 50:89-98. 2012
    ..Unusual crystalloids were observed in the white matter. In conclusion, experimental BSE in pigs demonstrated ultrastructural pathology in keeping with that observed in other spongiform encephalopathies...
  67. ncbi request reprint Plasma levels of alpha beta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease
    Tomasz Sobow
    Department of Psychiatry and Psychotic Disorders, Medical University of Lodz, Poland
    Acta Neurobiol Exp (Wars) 65:117-24. 2005
    ..According to ROC curve analysis the maximum accuracy in discriminating MCI versus both controls and AD subjects has been achieved using a cut-off value of 3.8...
  68. pmc Arrested neural and advanced mesenchymal differentiation of glioblastoma cells-comparative study with neural progenitors
    Piotr Rieske
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    BMC Cancer 9:54. 2009
    ....
  69. pmc cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer
    Malgorzata Szybka
    Department of Oncological Pathology, Medical University of Lodz, Lodz, Poland
    BMC Cancer 9:278. 2009
    ..Recently published data showed discrepancies between P53 cDNA and DNA sequencing in glioblastomas. We hypothesised that similar discrepancies may be observed in other human cancers...
  70. ncbi request reprint Clinico-pathological analysis of pilocytic astrocytomas and gangliogliomas
    T Fiks
    Department of Pathology, Medical Academy,
    Pol J Pathol 52:47-51. 2001
    ..These cases were reclassified as gangliogliomas (GG). None of the 11 tumors recognized as GG was reclassified as PA. The overall 5-year survival was 88.89% in the PA and 70% in GG groups...
  71. ncbi request reprint Apoptosis in non-astrocytic brain tumours in children
    Jarosław Buczyński
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 40:155-9. 2002
    ..012 with a standard deviation (SD) of 0.032, for medulloblastomas 0.021 (SD 0.04), for ependymomas 0.001 (SD 0.002) and for anaplastic ependymomas 0.004 (SD 0.003)...
  72. doi request reprint Assessment of OPG/RANK/RANKL gene expression levels in peripheral blood mononuclear cells (PBMC) after treatment with strontium ranelate and ibandronate in patients with postmenopausal osteoporosis
    Michal Stuss
    Department of Endocrine Disorders and Bone Metabolism, Medical University of Lodz, 90 752 Łódź, Ul Zeligowskiego 7 9, Poland
    J Clin Endocrinol Metab 98:E1007-11. 2013
    ..Recent research results have confirmed the high significance of the OPG/RANK/RANKL system in the development of bone diseases...
  73. ncbi request reprint Historical overview of prion diseases: a view from afar
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, 8 10 Czechoslowacka St, PL 92 216 Lodz, Poland
    Folia Neuropathol 50:1-12. 2012
    ..This theory had been recently extended to cover other neurodegenerations which are caused by misfolded proteins; these disease are called prionoids...
  74. ncbi request reprint Doppel: the prion's double
    Ewa Golańiska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:47-54. 2004
    ..Therefore, the role of the PRND gene in CJD and other diseases still remains unexplained...
  75. ncbi request reprint Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease: a brain biopsy study
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Int J Biochem Cell Biol 36:2563-73. 2004
    ..Autophagic vacuoles are formed in many synapses in all categories of human transmissible encephalopathies. We conclude that synaptic autophagy contributes to overall synaptic loss in brains affected in prion diseases...
  76. ncbi request reprint Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc
    Monika Witusik
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, 8 10 Czechoslowacka str, Lodz, Poland
    Brain Res 1186:65-73. 2007
    ..Of note, glial and neuronal cells showed a very large heterogeneity of PrP(c) expression. Our results provide the basis for studying the role of PrP(c) in cell differentiation and neurogenesis from human GFAP-positive progenitor cells...
  77. ncbi request reprint Ultrastructural heterogeneity of gangliogliomas
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Lodz, Poland
    Ultrastruct Pathol 31:9-14. 2007
    ..The most intriguing ultrastructural finding was abundant presence of autophagic vacuoles. In 4 cases, multivesicular bodies were observed. All of the tumors with multivesicular bodies also contained abundant autophagic vacuoles...
  78. ncbi request reprint KCTD11 expression in medulloblastoma is lower than in adult cerebellum and higher than in neural stem cells
    Izabela Zawlik
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechoslowacka 8 10, 92 216 Lodz, Poland
    Cancer Genet Cytogenet 170:24-8. 2006
    ..We argue that recognition of the gene or genes important in MB tumorigenesis depends in part on defining an appropriate control...
  79. doi request reprint Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes
    Ewa Golanska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    J Alzheimers Dis 17:359-68. 2009
    ..Moreover, there may be multiple sufficient risk sets for AD. Looking at multiple genes together rather than analyzing them individually, may improve identification of risk alleles...
  80. pmc Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
    M Szybka
    Department of Pathology, Medical University of Lodz, Paderewskiego 4, Lodz 93 509, Poland
    Br J Cancer 98:1431-3. 2008
    ..These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene...
  81. ncbi request reprint Regulation of PrPC expression: nerve growth factor (NGF) activates the prion gene promoter through the MEK1 pathway in PC12 cells
    Izabela Zawlik
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, 8 10 Czechoslowacka str, 92 216 Lodz, Poland
    Neurosci Lett 400:58-62. 2006
    ..These results improve the understanding of the regulation of the Prnp gene promoter, a DNA regulatory element controlling the expression of PrP(C), a protein involved in several neurological diseases...
  82. ncbi request reprint Pilocytic astrocytoma as a predominant component of a recurrent complex type DNT
    Krzysztof Zakrzewski
    Department of Neurosurgery, Polish Mother s Memorial Hospital Research Institute, 93 338 Lodz, Poland
    Folia Neuropathol 47:284-8. 2009
    ..We conclude that patients with incompletely removed DNT may suffer local recurrence of that tumour. In rare cases development of a secondary, histologically different neoplasm may also occur...
  83. ncbi request reprint CYP46: a risk factor for Alzheimer's disease or a coincidence?
    Ewa Golanska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Neurosci Lett 383:105-8. 2005
    ..However, considering the extreme divergence of results obtained by different authors, a clear connection between the CYP46 gene and AD is questionable...
  84. ncbi request reprint Gliomas: association of histology and molecular genetic analysis of chromosomes 1p, 10q, and 19q
    Sylwia M Gresner
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Czechoslowacka 8 10, 92 216 Lodz, Poland
    Acta Neurobiol Exp (Wars) 67:103-12. 2007
    ..05). Our data provide evidence that use of molecular genetic analyses of chromosomes 1p, 19q, and 10q might improve the diagnosis of gliomas...
  85. pmc Successful elimination of non-neural cells and unachievable elimination of glial cells by means of commonly used cell culture manipulations during differentiation of GFAP and SOX2 positive neural progenitors (NHA) to neuronal cells
    Monika Witusik
    Medical University of Lodz, Department of Molecular Pathology and Neuropathology, 8 10 Czechoslowacka str, 92 216 Lodz, Poland
    BMC Biotechnol 8:56. 2008
    ..To this end, we strived to obtain stabilized protocol of NHA cells differentiation - allowing for an increase in percentage yield of neuronal cells...
  86. doi request reprint Analysis of APBB2 gene polymorphisms in sporadic Alzheimer's disease
    Ewa Golanska
    Department of Molecular Pathology, Medical University of Lodz, 8 10 Czechoslowacka str, 92 216 Lodz, Poland
    Neurosci Lett 447:164-6. 2008
    ..43%, p=0.03). The association between the hCV1558625 G allele and susceptibility for AD at relatively young ages needs to be confirmed in other samples...
  87. doi request reprint High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations
    Emilia Jesien-Lewandowicz
    Department of Radiation Oncology, Chair of Oncology, Copernicus Memorial Hospital, Lodz, Poland
    Cancer Genet Cytogenet 188:77-82. 2009
    ....
  88. ncbi request reprint Angioganglioglioma: a transitional form between angioglioma and gangioglioma?
    Dorota Jesionek Kupnicka
    Department of Tumour Pathology, Medical University of Lodz, Lodz, Poland
    Ultrastruct Pathol 27:423-32. 2003
    ..Further, it may constitute a new distinct clinicopathological entity with neoplastic and hamartomatous features...
  89. pmc Molecular heterogeneity of meningioma with INI1 mutation
    P Rieske
    Department of Molecular Pathology and Neurology, Medical University, 92 216 Lodz, Poland
    Mol Pathol 56:299-301. 2003
    ..INI1 (hSNF5) mutations are linked to rhabdoid tumours, but mutations in meningiomas with hot spot mutations in position 377 have also been reported...
  90. ncbi request reprint Molecular abnormalities in pediatric embryonal brain tumors--analysis of loss of heterozygosity on chromosomes 1, 5, 9, 10, 11, 16, 17 and 22
    M Zakrzewska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Clin Neuropathol 23:209-17. 2004
    ..LOH on 10q and 17p was found in both primary and recurrent tumor, while losses on 11p, 16p, and 16q occurred only in the recurrent tumor. No evidence of alteration in TP53 exon 4 was identified...
  91. ncbi request reprint Apoptosis in relation to neuronal loss in experimental Creutzfeldt-Jakob disease in mice
    D Jesionek-Kupnicka
    Department of Molecular Biology, Medical Academy, , 8/10 Czechoslowacka St, , Poland
    Acta Neurobiol Exp (Wars) 61:13-9. 2001
    ..Compared to the extensive neuronal loss (30-50%), the number of apoptotic cells detected by in situ end labelling seems to be very low, and the process of neuronal death become more intensive during the progression of the disease...
  92. ncbi request reprint Molecular analysis of chromosome 1, 10 and 19 abnormalities in human oligodendroglial tumors: relationship between frequency of LOH grade, age and gender
    S M Gresner
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Clin Neuropathol 25:18-24. 2006
    ..Loss of heterozygosity (LOH) on 1p and 19q is observed in most oligodendroglial tumors. LOH on 10q appears to be less common in these tumors as compared to other gliomas...