Affiliation: University of Warmia and Mazury
Zglejc Waszak K, Waszkiewicz E, Franczak A. Periconceptional undernutrition affects the levels of DNA methylation in the peri-implantation pig endometrium and in embryos. Theriogenology. 2018;123:185-193 pubmed publisher
..The levels of methylation in other studied endometrial and embryonic genes were unchanged. DNA methylation levels in both the peri-implantation pig endometrium and embryos may be altered in response to female nutritional restriction. ..
Franczak A, Zglejc Waszak K, Martyniak M, Waszkiewicz E, Kotwica G. Peri-conceptional nutritional restriction alters transcriptomic profile in the peri-implantation pig embryos. Anim Reprod Sci. 2018;197:305-316 pubmed publisher
..The insight into embryonic transcriptome indicates that female under-nutrition during the peri-conceptional period may create alterations in the pattern of genes expressed in the peri-implantation embryos. ..
Franczak A, Kotwica G. Secretion of estradiol-17beta by porcine endometrium and myometrium during early pregnancy and luteolysis. Theriogenology. 2008;69:283-9 pubmed
..These data suggest active estrogen production by the myometrium and endometrium as an alternative source for this signal for recognition of pregnancy in the pig. ..
Franczak A, Zmijewska A, Kurowicka B, Wojciechowicz B, Kotwica G. Interleukin 1?-induced synthesis and secretion of prostaglandin E? in the porcine uterus during various periods of pregnancy and the estrous cycle. J Physiol Pharmacol. 2010;61:733-42 pubmed
..The profile of COX-2 mRNA expression in the myometrium differs from its profile in the endometrium. This work provides new insight on the role of IL-1? in PGE? production to overcome luteolysis in pregnant pigs. ..
Franczak A, Wojciechowicz B, Kolakowska J, Zglejc K, Kotwica G. Transcriptomic analysis of the myometrium during peri-implantation period and luteolysis--the study on the pig model. Funct Integr Genomics. 2014;14:673-82 pubmed publisher
..Therefore, the importance of the myometrium as an active embryo signal-responsive tissue during early pregnancy cannot be underestimated. ..
Franczak A. Endometrial and myometrial secretion of androgens and estrone during early pregnancy and luteolysis in pigs. Reprod Biol. 2008;8:213-28 pubmed
..These data demonstrated the presence of the active steroid pathway in porcine endometrium and myometrium which may serve as an alternative source of androgens and estrogens in pigs. ..
Franczak A, Kotwica G. Androgens and estradiol-17beta production by porcine uterine cells: In vitro study. Theriogenology. 2010;73:232-41 pubmed publisher
..The results indicate an active steroidogenic pathway in porcine uterine cells. The epithelial cells, stromal cells, and myocytes participate in steroid production as an alternative source for their action in pigs. ..
Koziorowska A, Waszkiewicz E, Romerowicz Misielak M, Zglejc Waszak K, Franczak A. Extremely low-frequency electromagnetic field (EMF) generates alterations in the synthesis and secretion of oestradiol-17? (E2) in uterine tissues: An in vitro study. Theriogenology. 2018;110:86-95 pubmed publisher
..We suspect that this observed phenomenon might lead to changes in the intrauterine milieu of oestrogen, which is crucial for the proper activity of uterine tissues during the mid-luteal phase of the oestrous cycle. ..
Franczak A, Wojciechowicz B, Kotwica G. Transcriptomic analysis of the porcine endometrium during early pregnancy and the estrous cycle. Reprod Biol. 2013;13:229-37 pubmed publisher
..The bioinformatic analysis revealed information about the meaning of differentially expressed genes. The data provided new insight into the dynamic changes of the endometrial gene expression profile during days 15-16 of pregnancy...