Cezary Cybulski

Summary

Affiliation: University of Szczecin
Country: Poland

Publications

  1. Cybulski C, Wokołorczyk D, Jakubowska A, Huzarski T, Byrski T, Gronwald J, et al. Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer. J Clin Oncol. 2011;29:3747-52 pubmed publisher
    ....
  2. Trubicka J, Grabowska Kłujszo E, Suchy J, Masojć B, Serrano Fernandez P, Kurzawski G, et al. Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility. BMC Cancer. 2010;10:420 pubmed publisher
    ..Three haplotypes were associated with altered cancer risk; one conferred protection and two were associated with an increased risk of disease. These observations should be confirmed in other populations. ..
  3. Suchy J, Kłujszo Grabowska E, Kładny J, Cybulski C, Wokołorczyk D, Szymanska Pasternak J, et al. Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk. BMC Cancer. 2008;8:112 pubmed publisher
    ..87; p = 0,02 for CRC cases above 60 yrs). The association of polymorphisms in genes involved in the inflammatory response and CRC onset suggest that there are genetic changes capable of influencing disease risk in older persons. ..
  4. Cybulski C, Gorski B, Huzarski T, Byrski T, Gronwald J, Debniak T, et al. CHEK2-positive breast cancers in young Polish women. Clin Cancer Res. 2006;12:4832-5 pubmed
    ..Three founder alleles in CHEK2 contribute to early-onset breast cancer in Poland. Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large. ..
  5. Cybulski C, Gorski B, Huzarski T, Byrski T, Gronwald J, Debniak T, et al. Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations. J Med Genet. 2009;46:132-5 pubmed publisher
    ..However, the presence of a CHEK2 mutation in women with a BRCA1 mutation may not increase their risk beyond that of the BRCA1 mutation alone. These suggestive findings need to be verified in other studies. ..
  6. Cybulski C, Huzarski T, Byrski T, Gronwald J, Debniak T, Jakubowska A, et al. Estrogen receptor status in CHEK2-positive breast cancers: implications for chemoprevention. Clin Genet. 2009;75:72-8 pubmed publisher
    ..01). Women with a CHEK2 mutation face a fourfold increase in the risk of ER-positive breast cancer and might be candidates for tamoxifen chemoprevention. ..
  7. Cybulski C, Gorski B, Debniak T, Gliniewicz B, Mierzejewski M, Masojc B, et al. NBS1 is a prostate cancer susceptibility gene. Cancer Res. 2004;64:1215-9 pubmed
    ....
  8. Cybulski C, Wokołorczyk D, Huzarski T, Byrski T, Gronwald J, Gorski B, et al. A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer. J Med Genet. 2006;43:863-6 pubmed
    ..It will be of interest to see to what extent this deletion is responsible for the burden of prostate cancer in other populations. ..

Locale

Detail Information

Publications8

  1. Cybulski C, Wokołorczyk D, Jakubowska A, Huzarski T, Byrski T, Gronwald J, et al. Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer. J Clin Oncol. 2011;29:3747-52 pubmed publisher
    ....
  2. Trubicka J, Grabowska Kłujszo E, Suchy J, Masojć B, Serrano Fernandez P, Kurzawski G, et al. Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility. BMC Cancer. 2010;10:420 pubmed publisher
    ..Three haplotypes were associated with altered cancer risk; one conferred protection and two were associated with an increased risk of disease. These observations should be confirmed in other populations. ..
  3. Suchy J, Kłujszo Grabowska E, Kładny J, Cybulski C, Wokołorczyk D, Szymanska Pasternak J, et al. Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk. BMC Cancer. 2008;8:112 pubmed publisher
    ..87; p = 0,02 for CRC cases above 60 yrs). The association of polymorphisms in genes involved in the inflammatory response and CRC onset suggest that there are genetic changes capable of influencing disease risk in older persons. ..
  4. Cybulski C, Gorski B, Huzarski T, Byrski T, Gronwald J, Debniak T, et al. CHEK2-positive breast cancers in young Polish women. Clin Cancer Res. 2006;12:4832-5 pubmed
    ..Three founder alleles in CHEK2 contribute to early-onset breast cancer in Poland. Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large. ..
  5. Cybulski C, Gorski B, Huzarski T, Byrski T, Gronwald J, Debniak T, et al. Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations. J Med Genet. 2009;46:132-5 pubmed publisher
    ..However, the presence of a CHEK2 mutation in women with a BRCA1 mutation may not increase their risk beyond that of the BRCA1 mutation alone. These suggestive findings need to be verified in other studies. ..
  6. Cybulski C, Huzarski T, Byrski T, Gronwald J, Debniak T, Jakubowska A, et al. Estrogen receptor status in CHEK2-positive breast cancers: implications for chemoprevention. Clin Genet. 2009;75:72-8 pubmed publisher
    ..01). Women with a CHEK2 mutation face a fourfold increase in the risk of ER-positive breast cancer and might be candidates for tamoxifen chemoprevention. ..
  7. Cybulski C, Gorski B, Debniak T, Gliniewicz B, Mierzejewski M, Masojc B, et al. NBS1 is a prostate cancer susceptibility gene. Cancer Res. 2004;64:1215-9 pubmed
    ....
  8. Cybulski C, Wokołorczyk D, Huzarski T, Byrski T, Gronwald J, Gorski B, et al. A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer. J Med Genet. 2006;43:863-6 pubmed
    ..It will be of interest to see to what extent this deletion is responsible for the burden of prostate cancer in other populations. ..