Cezary Cybulski


Affiliation: University of Szczecin
Country: Poland


  1. Cybulski C, Masojc B, Oszutowska D, Jaworowska E, Grodzki T, Waloszczyk P, et al. Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers. Carcinogenesis. 2008;29:762-5 pubmed publisher
    ..g. p53 mutations) and have a high level of genotoxic DNA damage induced by tobacco smoke. We speculate that lung cancer cells with impaired CHEK2 function undergo increased rates of cell death. ..
  2. Cybulski C, Gorski B, Gronwald J, Huzarski T, Byrski T, Debniak T, et al. BRCA1 mutations and prostate cancer in Poland. Eur J Cancer Prev. 2008;17:62-6 pubmed
    ..1-11.3; P=0.045); in particular for familial prostate cancer (odds ratio=12; 95% confidence interval: 2.9-51; P=0.0004). We consider that the risk of prostate cancer in BRCA1 carriers varies with the position of the mutation. ..
  3. Cybulski C, Huzarski T, Gorski B, Masojć B, Mierzejewski M, Debniak T, et al. A novel founder CHEK2 mutation is associated with increased prostate cancer risk. Cancer Res. 2004;64:2677-9 pubmed
    ..Our results provide evidence that the two truncating mutations of CHEK2 confer a moderate risk of prostate cancer in Polish men and that the missense change appears to confer a modest risk. ..
  4. Kelemen L, Earp M, Fridley B, Chenevix Trench G, Fasching P, Beckmann M, et al. rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology. Int J Mol Sci. 2018;19: pubmed publisher
    ..51, p = 1.7 × 10-28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small. ..
  5. Cybulski C, Wokołorczyk D, Kładny J, Kurzawski G, Kurzwaski G, Suchy J, et al. Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?. Eur J Hum Genet. 2007;15:237-41 pubmed
    ..It is important that other studies of CHEK2 mutation carriers be conducted to confirm this hypothesis. ..
  6. Cybulski C, Wokołorczyk D, Jakubowska A, Huzarski T, Byrski T, Gronwald J, et al. Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer. J Clin Oncol. 2011;29:3747-52 pubmed publisher
  7. Trubicka J, Grabowska Kłujszo E, Suchy J, Masojć B, Serrano Fernandez P, Kurzawski G, et al. Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility. BMC Cancer. 2010;10:420 pubmed publisher
    ..Three haplotypes were associated with altered cancer risk; one conferred protection and two were associated with an increased risk of disease. These observations should be confirmed in other populations. ..
  8. Suchy J, Kłujszo Grabowska E, Kładny J, Cybulski C, Wokołorczyk D, Szymanska Pasternak J, et al. Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk. BMC Cancer. 2008;8:112 pubmed publisher
    ..87; p = 0,02 for CRC cases above 60 yrs). The association of polymorphisms in genes involved in the inflammatory response and CRC onset suggest that there are genetic changes capable of influencing disease risk in older persons. ..
  9. Cybulski C, Gorski B, Huzarski T, Byrski T, Gronwald J, Debniak T, et al. CHEK2-positive breast cancers in young Polish women. Clin Cancer Res. 2006;12:4832-5 pubmed
    ..Three founder alleles in CHEK2 contribute to early-onset breast cancer in Poland. Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large. ..

More Information


  1. Cybulski C, Gorski B, Huzarski T, Byrski T, Gronwald J, Debniak T, et al. Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations. J Med Genet. 2009;46:132-5 pubmed publisher
    ..However, the presence of a CHEK2 mutation in women with a BRCA1 mutation may not increase their risk beyond that of the BRCA1 mutation alone. These suggestive findings need to be verified in other studies. ..
  2. Cybulski C, Huzarski T, Byrski T, Gronwald J, Debniak T, Jakubowska A, et al. Estrogen receptor status in CHEK2-positive breast cancers: implications for chemoprevention. Clin Genet. 2009;75:72-8 pubmed publisher
    ..01). Women with a CHEK2 mutation face a fourfold increase in the risk of ER-positive breast cancer and might be candidates for tamoxifen chemoprevention. ..
  3. Cybulski C, Gorski B, Debniak T, Gliniewicz B, Mierzejewski M, Masojc B, et al. NBS1 is a prostate cancer susceptibility gene. Cancer Res. 2004;64:1215-9 pubmed
  4. Cybulski C, Wokołorczyk D, Huzarski T, Byrski T, Gronwald J, Gorski B, et al. A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer. J Med Genet. 2006;43:863-6 pubmed
    ..It will be of interest to see to what extent this deletion is responsible for the burden of prostate cancer in other populations. ..