Janusz Błasiak

Summary

Affiliation: University of Lodz
Country: Poland

Publications

  1. ncbi DNA damage and repair in human lymphocytes and gastric mucosa cells exposed to chromium and curcumin
    J Błasiak
    Department of Molecular Genetics, University of Lodz, Poland
    Teratog Carcinog Mutagen 19:19-31. 1999
  2. ncbi Hyperthermia can differentially modulate the repair of doxorubicin-damaged DNA in normal and cancer cells
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Acta Biochim Pol 50:191-5. 2003
  3. pmc DNA damage/repair and polymorphism of the hOGG1 gene in lymphocytes of AMD patients
    Katarzyna Wozniak
    Department of Molecular Genetics, University of Lodz, 90 237 Lodz, Poland
    J Biomed Biotechnol 2009:827562. 2009
  4. ncbi [Philadelphia chromosome]
    Ireneusz Majsterek
    Katedra Genetyki Molekularnej Uniwersytetu Łódzkiego, ul Banacha 12 16, 90 237 Łódź
    Postepy Biochem 48:156-66. 2002
  5. ncbi Free radical scavengers can modulate the DNA-damaging action of alloxan
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Acta Biochim Pol 50:205-10. 2003
  6. ncbi Analysis of the G/C polymorphism in the 5'-untranslated region of the RAD51 gene in breast cancer
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Acta Biochim Pol 50:249-53. 2003
  7. ncbi Genotoxicity of acrylamide in human lymphocytes
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Chem Biol Interact 149:137-49. 2004
  8. ncbi Genotoxicity of streptozotocin in normal and cancer cells and its modulation by free radical scavengers
    J Błasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Cell Biol Toxicol 20:83-96. 2004
  9. ncbi Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, ul Banacha 12 16, 90 237, Poland
    Mutat Res 554:139-48. 2004
  10. ncbi DNA damage and repair in type 2 diabetes mellitus
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237, Poland
    Mutat Res 554:297-304. 2004

Collaborators

Detail Information

Publications41

  1. ncbi DNA damage and repair in human lymphocytes and gastric mucosa cells exposed to chromium and curcumin
    J Błasiak
    Department of Molecular Genetics, University of Lodz, Poland
    Teratog Carcinog Mutagen 19:19-31. 1999
    ..Moreover, curcumin itself can damage DNA of these cells and the total effect of chromium and curcumin is additive. Further studies are needed to establish the role of interaction of curcumin with DNA in carcinogenesis...
  2. ncbi Hyperthermia can differentially modulate the repair of doxorubicin-damaged DNA in normal and cancer cells
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Acta Biochim Pol 50:191-5. 2003
    ..These features may be exploited in cancer chemotherapy to increase the effectiveness of the treatment and reduce unwanted effects of anticancer drugs in normal cells and fight DNA repair-based drug resistance of cancer cells...
  3. pmc DNA damage/repair and polymorphism of the hOGG1 gene in lymphocytes of AMD patients
    Katarzyna Wozniak
    Department of Molecular Genetics, University of Lodz, 90 237 Lodz, Poland
    J Biomed Biotechnol 2009:827562. 2009
    ..The results obtained suggest that oxidative DNA damage and inefficient DNA repair can be associated with AMD and the variability of the hOOG1 gene may not contribute to this association...
  4. ncbi [Philadelphia chromosome]
    Ireneusz Majsterek
    Katedra Genetyki Molekularnej Uniwersytetu Łódzkiego, ul Banacha 12 16, 90 237 Łódź
    Postepy Biochem 48:156-66. 2002
  5. ncbi Free radical scavengers can modulate the DNA-damaging action of alloxan
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Acta Biochim Pol 50:205-10. 2003
    ..The results also suggest that alloxan can generate oxidized DNA bases with a preference for purines and contribute to their alkylation...
  6. ncbi Analysis of the G/C polymorphism in the 5'-untranslated region of the RAD51 gene in breast cancer
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Acta Biochim Pol 50:249-53. 2003
    ..05). Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer and so it may not be useful as an independent marker in this disease...
  7. ncbi Genotoxicity of acrylamide in human lymphocytes
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Chem Biol Interact 149:137-49. 2004
    ..As normal lymphocytes contain cyp2e1 and P450, engaged in the bioactivation of ACM to glicidamide it is uncertain whether acrylamide causes all of measured effect per se or this is the result of the action of its metabolites...
  8. ncbi Genotoxicity of streptozotocin in normal and cancer cells and its modulation by free radical scavengers
    J Błasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Cell Biol Toxicol 20:83-96. 2004
    ..The drug can also alkylate DNA bases. This broad range of DNA damage induced by STZ indicates that the drug may seriously affect genomic stability in normal and pathological cells...
  9. ncbi Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, ul Banacha 12 16, 90 237, Poland
    Mutat Res 554:139-48. 2004
    ..Moreover, the comet assay may be applied to evaluate the suitability of a particular mode of chemotherapy to a particular cancer patient...
  10. ncbi DNA damage and repair in type 2 diabetes mellitus
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237, Poland
    Mutat Res 554:297-304. 2004
    ..These features may contribute to a link between diabetes and cancer and metrics of DNA damage and repair, measured by the comet assay, may be markers of risk of cancer in diabetes...
  11. ncbi Polymorphisms of the DNA mismatch repair gene HMSH2 in breast cancer occurence and progression
    Tomasz Poplawski
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237, Lodz, Poland
    Breast Cancer Res Treat 94:199-204. 2005
    ..39; 95% confidence interval 1.44-48.8) was found. Therefore, MMR may play a role in the breast carcinogenesis and the Gly322Asp polymorphism of the hMSH2 gene may be considered as a potential marker in breast cancer...
  12. ncbi Polymorphisms of the BRCA2 and RAD51 genes in breast cancer
    Tomasz Sliwinski
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Breast Cancer Res Treat 94:105-9. 2005
    ..Therefore, the Met1915Thr polymorphism in the BRCA2 gene may be considered as an independent marker of breast cancer...
  13. ncbi Iron and age-related macular degeneration
    Janusz Błasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Klin Oczna 111:174-7. 2009
    ....
  14. ncbi Amifostine differentially modulates DNA damage evoked by idarubicin in normal and leukemic cells
    Janusz Błasiak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Leuk Res 26:1093-6. 2002
    ..Our results suggest that the reaction of the cell to DNA damage may contribute to its diverse response to amifostine combined with anticancer drugs and that p53 and fusion tyrosine kinases may be involved in this diversity...
  15. ncbi In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and the gastrointestinal tract mucosa cells
    J Blasiak
    Department of Molecular Genetics, University of Lodz, 12 16, 90 237 Lodz, Banacha, Poland
    Toxicol In Vitro 14:287-95. 2000
    ..There were no differences in the sensitivity to acetaldehyde of all the cell types. Our results clearly indicate that ethanol and acetaldehyde can contribute to cancers of the digestive tract...
  16. ncbi DNA damage and repair in human lymphocytes exposed to three anticancer platinum drugs
    J Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Teratog Carcinog Mutagen 20:119-31. 2000
    ..Severe cytotoxic and genotoxic effects exerted by Se-Pt in normal human lymphocytes preclude its intravenous application in cancer therapy. Teratogenesis Carcinog. Mutagen. 20:119-131, 2000...
  17. ncbi In vitro studies on the genotoxicity of the organophosphorus insecticide malathion and its two analogues
    J Błasiak
    Department of Molecular Genetics, University of Lodz, Poland
    Mutat Res 445:275-83. 1999
    ..Therefore, malathion can be regarded as a potential mutagen/carcinogen and requires further investigation...
  18. ncbi A comparison of the in vitro genotoxicity of tri- and hexavalent chromium
    J Blasiak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237, Lodz, Poland
    Mutat Res 469:135-45. 2000
    ..The comet assay did not indicate the involvement of oxidative mechanisms in the DNA-damaging activity of trivalent chromium and we speculate that its binding to cellular ligands may play a role in its genotoxicity...
  19. ncbi Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is not associated with breast cancer
    J Błasiak
    Department of Molecular Genetics, University of Lodz, Poland
    Acta Biochim Pol 47:191-9. 2000
    ..The 4G/5G polymorphism may not be linked with elevated level of PAI-1 observed in breast cancer and therefore may not be associated with appearance and/or progression of breast cancer...
  20. ncbi Synergistic effect of vitamin C on DNA damage induced by cadmium
    J Błasiak
    Department of Molecular Genetics, University of Lodz, Poland
    Gen Physiol Biophys 19:373-9. 2000
    ..05), so cadmium and vitamin C can be considered to have synergistic effects. The results obtained can be partly explained by the participation of cadmium in the Fenton reaction and reduction of its oxidized form by vitamin C...
  21. ncbi Inhibition of telomerase activity in endometrial cancer cells by selenium-cisplatin conjugate despite suppression of its DNA-damaging activity by sodium ascorbate
    Janusz Błasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Teratog Carcinog Mutagen 22:73-82. 2002
    ..The results obtained indicate that (NH(3))(2)Pt(SeO(3)) may specifically inhibit telomerase activity in endometrial cancer cells...
  22. ncbi Genotoxicity of idarubicin and its modulation by vitamins C and E and amifostine
    Janusz Błasiak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, Poland
    Chem Biol Interact 140:1-18. 2002
    ..Vitamin C can be considered as protective agents against DNA damage in normal cells in persons receiving idarubicin-based chemotherapy, but the use of vitamin E cannot be recommended and at least needs further research...
  23. ncbi A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone
    Janusz Błasiak
    Department of Molecular Genetics, University of Lodz, Poland
    Acta Biochim Pol 49:145-55. 2002
    ..The observed in normal lymphocytes much lesser genotoxicity of mitoxantrone compared to idarubicin should be taken into account in planning chemotherapeutic strategies...
  24. ncbi DNA damage in human colonic mucosa cells evoked by nickel and protective action of quercetin - involvement of free radicals?
    J Błasiak
    Department of Molecular Genetics, University of Lodz, Poland
    Cell Biol Toxicol 18:279-88. 2002
    ....
  25. ncbi Free radicals-mediated induction of oxidized DNA bases and DNA-protein cross-links by nickel chloride
    Katarzyna Wozniak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237, Lodz, Poland
    Mutat Res 514:233-43. 2002
    ..Nickel chloride can also alkylate DNA bases. Our results support thesis on multiple, free radicals-based genotoxicity pathways of nickel...
  26. ncbi TEL/JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine
    Ewa Gloc
    Department of Molecular Genetics, University of Lodz, Poland
    Acta Biochim Pol 49:121-8. 2002
    ..Moreover, TEL/JAK2 tyrosine kinase might be involved in cellular response to DNA damage. Amifostine could promote apoptosis or lower the threshold for apoptosis induction dependent on TEL/JAK2 activation...
  27. ncbi DNA damage in human colonic mucosa cells induced by bleomycin and the protective action of vitamin E
    Katarzyna Wozniak
    Department of Molecular Genetics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Cell Mol Biol Lett 9:31-45. 2004
    ..Vitamin E ((+)-alpha -tocopherol) decreased DNA damage induced by bleomycin. The results obtained suggest that hydrogen peroxide might not be involved in the formation of DNA lesions induced by bleomycin in the colonic mucosa cells...
  28. ncbi Recognition and repair of DNA-cisplatin adducts
    Katarzyna Wozniak
    Department of Molecular Genetics, University of Łódź, S Banacha 12 16, 90 237 Łódź, Poland
    Acta Biochim Pol 49:583-96. 2002
    ..The formation of complexes between DNA and proteins in the presence of cisplatin and the changes in the cell architecture may account for the drug cytotoxicity...
  29. ncbi Nickel impairs the repair of UV- and MNNG-damaged DNA
    Katarzyna Wozniak
    Department of Molecular Genetics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Cell Mol Biol Lett 9:83-94. 2004
    ..Our results suggest that nickel(II) at non-cytotoxic concentrations can inhibit various steps of DNA excision repair, and this may contribute to its genotoxicity...
  30. ncbi [Base excision repair]
    Tomasz Sliwinski
    Department of Molecular Genetics, University of Lodz, 12 16 Banacha St, 90 237 Lodz, Poland
    Postepy Biochem 51:120-9. 2005
    ..BER consist of two repair pathways (short or long) in which one or more nucleotides are introduced respectively. In conclusion, it seems to be likely that BER pathways are essential for genomic repair and stability in living cells...
  31. ncbi [Involvement of nuclear domains in the cellular response to DNA damage]
    Daniel Wysokinski
    Department of Molecular Genetics, University of Lodz, 12 16 Banacha St, 90 237 Lodz, Poland
    Postepy Biochem 56:328-40. 2010
    ..These changes are not limited to the sites of DNA damage, but involve whole cell nucleus, including its domains: PML bodies, nucleolus and Cajal bodies...
  32. ncbi [DNA computing]
    Janusz Błasiak
    Katedra Genetyki Molekularnej, Uniwersytet Łódzki, ul Pomorska 141 143, 90 236 Łódź
    Postepy Biochem 57:13-23. 2011
    ..The idea of DNA computing is still in progress in research both in vitro and in vivo and at least promising results of these research allow to have a hope for a breakthrough in the computer science...
  33. pmc UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib
    Ewelina Synowiec
    Department of Molecular Genetics, University of Lodz, Pomorska 141 143, 90 236 Lodz, Poland
    Int J Mol Sci 16:18111-28. 2015
    ....
  34. pmc Variation in DNA Base Excision Repair Genes in Fuchs Endothelial Corneal Dystrophy
    Katarzyna A Wójcik
    Department of Molecular Genetics, University of Łódź, Łódź, Poland
    Med Sci Monit 21:2809-27. 2015
    ..CONCLUSIONS Our results suggest that the c.1196A>G polymorphism in the XRCC1 gene may be an independent genetic risk factor for FECD. ..
  35. ncbi Association between the 25129A > C polymorphism of the nuclear respiratory factor 2 gene and age-related macular degeneration
    Tomasz Sliwinski
    Department of Molecular Genetics, University of Lodz, Poland
    Klin Oczna 115:96-102. 2013
    ..In this study we examined the association between age-related macular degeneration risk and the 25129A > C polymorphism of the gene encoding nuclear respiratory factor 2 (rs12594956)...
  36. ncbi [Tyrosine kinase inhibitor STI571--a breakthrough in leukemia treatment?]
    Agnieszka Czechowska
    Katedra Genetyki Molekularnej Uniwersytetu Łódzkiego, ul Banacha 12 16, 90 237 Łódź
    Postepy Biochem 49:157-67. 2003
  37. ncbi [Perspectives of RNA interference application in the therapy of diseases associated with defects in alternative RNA splicing]
    Daniel Wysokinski
    Katedra Genetyki Molekularnej Uniwersytetu Łódzkiego, ul Pomorska 141 143, 90 236 Łódź, Poland
    Postepy Hig Med Dosw (Online) 66:683-95. 2012
    ..Initial successes in the attempts of silencing the expression of faulty protein isoforms support the idea of using RNA interference in targeting disease related to disturbances in alternative splicing of RNA...
  38. ncbi [Eukaryotic DNA polymerases]
    Agnieszka Czechowska
    Department of Molecular Genetics, University of Lodz, 12 16 Banacha St, 90 237 Lodz, Poland
    Postepy Biochem 51:130-9. 2005
    ..On the other hand, it have been shown that there are also negative aspects of the activity of DNA polymerases. Lack of some DNA polymerases or even their altered functions may lead to carcinogenesis and accelerate the process of ageing...
  39. ncbi [Role of SUMO modification in the maintenance of genome stability]
    Ewelina Synowiec
    Department of Molecular Genetics, University of Lodz, 12 16 Banacha St, 90 237 Lodz, Poland
    Postepy Biochem 54:234-41. 2008
    ..The influence of SUMO modifications on genomic stability and chromatin structure may be fundamental for cell's viability, therefore the mechanisms of SUMOylation are worth studying...
  40. ncbi [Beta3-adrenergic receptor]
    Katarzyna Babol
    Department of Molecular Genetics, University of Lodz, 12 16 Banacha St, 90 237 Lodz, Poland
    Postepy Biochem 51:80-7. 2005
    ..Since obesity is a serious problem as a civilization-related disease, it is very important to investigate genes suspected to be connected with it...
  41. pmc Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Arch Med Sci 8:1065-75. 2012
    ..In the present work we investigated the association between polymorphisms of two HRR genes, XRCC2 and RAD51, and tobacco- and alcohol-related larynx cancer in a Polish population...