G Bartosz

Summary

Affiliation: University of Lodz
Country: Poland

Publications

  1. ncbi request reprint Antioxidant activity: what do we measure?
    G Bartosz
    Department of Molecular Biophysics, University of Lodz, Poland
    Acta Biochim Pol 46:23-9. 1999
  2. ncbi request reprint Total antioxidant capacity
    Grzegorz Bartosz
    Department of Molecular Biophysics, University of Lodz, Lodz, Poland
    Adv Clin Chem 37:219-92. 2003
  3. doi request reprint Non-enzymatic antioxidant capacity assays: Limitations of use in biomedicine
    Grzegorz Bartosz
    Department of Molecular Biophysics, University of Łódź, University of Rzeszow, Poland
    Free Radic Res 44:711-20. 2010
  4. doi request reprint Reactive oxygen species: destroyers or messengers?
    Grzegorz Bartosz
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Pharmacol 77:1303-15. 2009
  5. ncbi request reprint Use of spectroscopic probes for detection of reactive oxygen species
    Grzegorz Bartosz
    Department of Molecular Biophysics, University of Lodz and Department of Biochemistry and Cell Biology, University of Rzeszow, Banacha 12 16, 90 237 Lodz, Poland
    Clin Chim Acta 368:53-76. 2006
  6. ncbi request reprint Simple determination of peroxyl radical-trapping capacity
    G Bartosz
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 46:519-28. 1998
  7. ncbi request reprint Effect of peroxynitrite on erythrocytes
    M Soszynski
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochim Biophys Acta 1291:107-14. 1996
  8. ncbi request reprint Luminol luminescence induced by oxidants in antioxidant-deficient yeasts Saccharomyces cerevisiae
    W Jakubowski
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 45:191-203. 1998
  9. ncbi request reprint Lack of evidence of oxidative damage in antioxidant-deficient strains of Saccharomyces cerevisiae
    A Fortuniak
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 38:1271-6. 1996
  10. ncbi request reprint Resistance to ionizing radiation and antioxidative defence in yeasts. Are antioxidant-deficient cells permanently stressed?
    E Jaruga
    Department of Molecular Biophysics, University of Lodz
    Biochem Mol Biol Int 37:467-73. 1995

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Antioxidant activity: what do we measure?
    G Bartosz
    Department of Molecular Biophysics, University of Lodz, Poland
    Acta Biochim Pol 46:23-9. 1999
    ..Reduction of oxidation products rather than inhibition of their formation may be the predominant mode of action of antioxidants in various assays of antioxidant activity...
  2. ncbi request reprint Total antioxidant capacity
    Grzegorz Bartosz
    Department of Molecular Biophysics, University of Lodz, Lodz, Poland
    Adv Clin Chem 37:219-92. 2003
  3. doi request reprint Non-enzymatic antioxidant capacity assays: Limitations of use in biomedicine
    Grzegorz Bartosz
    Department of Molecular Biophysics, University of Łódź, University of Rzeszow, Poland
    Free Radic Res 44:711-20. 2010
    ..One reason for the discrepancy of results is the use of different oxidants in NEAC assays. The use of hydroxyl radical as the oxidant is not recommended in view of the high and non-specific reactivity of this species...
  4. doi request reprint Reactive oxygen species: destroyers or messengers?
    Grzegorz Bartosz
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Pharmacol 77:1303-15. 2009
    ..Restoration of proper ROS signaling, especially inhibition of cellular sources of ROS, may thus provide new ways of therapy...
  5. ncbi request reprint Use of spectroscopic probes for detection of reactive oxygen species
    Grzegorz Bartosz
    Department of Molecular Biophysics, University of Lodz and Department of Biochemistry and Cell Biology, University of Rzeszow, Banacha 12 16, 90 237 Lodz, Poland
    Clin Chim Acta 368:53-76. 2006
    ..The limits imposed by these difficulties on the precise evaluation of the amounts and rates of formation of ROS are discussed critically...
  6. ncbi request reprint Simple determination of peroxyl radical-trapping capacity
    G Bartosz
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 46:519-28. 1998
    ..A 10-min assay allows for determination of the induction time of appropriately diluted sample. As examples of application of this method, PRTC values of several types of beverages are reported...
  7. ncbi request reprint Effect of peroxynitrite on erythrocytes
    M Soszynski
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochim Biophys Acta 1291:107-14. 1996
    ..Membranes exposed to peroxynitrite showed aggregation and nitration of proteins and changes in protein organization detectable with a maleimide spin label...
  8. ncbi request reprint Luminol luminescence induced by oxidants in antioxidant-deficient yeasts Saccharomyces cerevisiae
    W Jakubowski
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 45:191-203. 1998
    ..These results support the idea that more reactive species than hydrogen peroxide and superoxide are critical in the induction of luminol chemiluminescence...
  9. ncbi request reprint Lack of evidence of oxidative damage in antioxidant-deficient strains of Saccharomyces cerevisiae
    A Fortuniak
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 38:1271-6. 1996
    ..These results corroborate our previous results on compensatory antioxidant mechanisms in the mutant yeast strains...
  10. ncbi request reprint Resistance to ionizing radiation and antioxidative defence in yeasts. Are antioxidant-deficient cells permanently stressed?
    E Jaruga
    Department of Molecular Biophysics, University of Lodz
    Biochem Mol Biol Int 37:467-73. 1995
    ..These results suggest that compensatory induction of elements of the antioxidant defence system may occur in yeast mutants deficient in antioxidants under normal growth conditions...
  11. ncbi request reprint Oxidative stress during aging of stationary cultures of the yeast Saccharomyces cerevisiae
    W Jakubowski
    Department of Molecular Biophysics, University of Lodz, Lodz, Poland
    Free Radic Biol Med 28:659-64. 2000
    ..The magnitude of this stress was augmented in antioxidant-deficient strains, devoid of superoxide dismutases and catalases, and of decreased glutathione content...
  12. ncbi request reprint 2,7-dichlorofluorescin oxidation and reactive oxygen species: what does it measure?
    W Jakubowski
    Department of Molecular Biophysics, University of Lodz, Banacha 12 16, Lodz, 90 237, Poland
    Cell Biol Int 24:757-60. 2000
    ....
  13. ncbi request reprint What determines the antioxidant potential of yeast cells?
    E A Lapshina
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 37:903-8. 1995
    ..These results point to the importance of other factors, apart from antioxidative enzymes and glutathione, in the determination of cellular resistance to ionizing radiation and other types of free-radical stress...
  14. doi request reprint Efficacy of antioxidants in the yeast Saccharomyces cerevisiae correlates with their effects on protein thiols
    Sabina Bednarska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Biochimie 90:1476-85. 2008
    ..The results obtained provide demonstration with respect to yeast that the ability to lower redox potential and to maintain critical thiol groups in the reduced state is an important facet of the action of antioxidants...
  15. ncbi request reprint Protection of yeast lacking the Ure2 protein against the toxicity of heavy metals and hydroperoxides by antioxidants
    Anna Lewinska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Free Radic Res 41:580-90. 2007
    ..Glutathione was unable to prevent the increase in ROS production caused by CdCl(2). The Deltaure2 disruptant was also hypersensitive to heat shock, like mutants lacking glutathione S-transferases...
  16. doi request reprint Chloric acid(I) affects antioxidant defense of lung epitelial cells
    A Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Pomorska 141 143, 90 237 Łódź, Poland
    Toxicol In Vitro 25:1328-34. 2011
    ..HOCl was found to affect the redox state of A549 by oxidation of GSH, inactivation of antioxidant enzymes and increase of ROS generation...
  17. ncbi request reprint Light-dependent generation of reactive oxygen species in cell culture media
    A Grzelak
    Department of Molecular Biophysics, , , Poland
    Free Radic Biol Med 30:1418-25. 2001
    ..These observations point to exposure of cells to ROS under in vitro culture conditions...
  18. ncbi request reprint Inactivation of antioxidant enzymes by peroxynitrite
    A Grzelak
    Department of Molecular Biophysics, University of Lodz, Poland
    Scand J Clin Lab Invest 60:253-8. 2000
    ....
  19. ncbi request reprint Assay of total antioxidant capacity: comparison of four methods as applied to human blood plasma
    A Janaszewska
    Department of Molecular Biophysics, University of Lodz, Poland
    Scand J Clin Lab Invest 62:231-6. 2002
    ..Kinetic measurements show that the reduction of indicators, especially by blood plasma, may not be complete at recommended times of the assays and the time of measurement is an important parameter when comparing the results...
  20. doi request reprint Application of a YHB1-GFP reporter to detect nitrosative stress in yeast
    Anna Lewinska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Redox Rep 13:161-71. 2008
    ..Taken together, these data suggest that yeast flavohemoglobin does not contribute to cross-protection against oxidative and nitrosative stress...
  21. ncbi request reprint Thiols as major determinants of the total antioxidant capacity
    A Balcerczyk
    Department of Molecular Biophysics, University of Lodz, Poland
    Biofactors 17:75-82. 2003
  22. doi request reprint Effect of N-chloroamino acids on the erythrocyte
    A Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Banacha, Łódź, Poland
    Free Radic Res 42:30-9. 2008
    ..Generally, the reactivity of at least some N-chloroamino acids may be not much lower with respect to HOCl/OCl(-)...
  23. ncbi request reprint Penetration of erythrocyte membrane by peroxynitrite: participation of the anion exchange protein
    M Soszynski
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 43:319-25. 1997
    ..These results demonstrate that permeation in the anionic form may be a minor pathway in the membrane transport of the peroxynitrite anion/peroxynitrous acid couple, especially in membranes reach in anion exchangers or channels...
  24. ncbi request reprint Decreased oxidant-induced proteolysis in erythrocytes with enhanced antioxidative defence enzymes due to Down's syndrome
    G Bartosz
    Department of Biophysics, University of Lodz, Poland
    Clin Chim Acta 198:239-43. 1991
    ..These results demonstrate a protective role for endogenous antioxidative enzymes in the protein damage by oxidative stress which triggers intracellular proteolysis...
  25. ncbi request reprint Radiation inactivation suggests that human multidrug resistance-associated protein 1 occurs as a dimer in the human erythrocyte membrane
    M Soszynski
    Department of Molecular Biophysics, University of Lodz, Banacha 12 16, Lodz, 90 237, Poland
    Arch Biochem Biophys 354:311-6. 1998
    ....
  26. ncbi request reprint Antioxidative and prooxidative effects of quercetin on A549 cells
    Agnieszka Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Cell Biol Int 31:1245-50. 2007
    ..The cellular effects of quercetin are therefore complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium...
  27. ncbi request reprint Antioxidants protect the yeast Saccharomyces cerevisiae against hypertonic stress
    Sabina Koziol
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rejtana 16C PL 35 959, Rzeszow, Poland
    Free Radic Res 39:365-71. 2005
    ..It suggests that repair of low-redox potential targets rather than prevention of their damage by superoxide is important in the antioxidant protection against oxidative stress induced by hypertonic conditions...
  28. ncbi request reprint Apoptosis-like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes
    E Jaruga
    Department of Molecular Biophysics, University of Lodz, Poland
    FEBS Lett 433:287-93. 1998
    ....
  29. ncbi request reprint Sensitivity of antioxidant-deficient yeast Saccharomyces cerevisiae to peroxynitrite and nitric oxide
    W Jakubowski
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochim Biophys Acta 1472:395-8. 1999
    ..The results are compatible with the view that cytotoxic effects of peroxynitrite involve formation of secondary reactive oxygen species...
  30. doi request reprint Acrolein toxicity involves oxidative stress caused by glutathione depletion in the yeast Saccharomyces cerevisiae
    M Kwolek-Mirek
    Department of Biochemistry and Cell Biology, University of Rzeszow, ul Cegielniana 12, 35 959 Rzeszow, Poland
    Cell Biol Toxicol 25:363-78. 2009
    ..No increased formation of reactive oxygen species was detected in cells exposed to allyl alcohol, so oxidative stress is due to depletion of cellular thiols and thus alteration in the redox state of yeast cells...
  31. ncbi request reprint Uncouplers of mitochondrial oxidative phosphorylation are not substrates of the erythrocyte glutathione-S-conjugate pump
    A Sokal
    Department of Molecular Biophysics, University of Lodz, Poland
    Arch Biochem Biophys 349:113-21. 1998
    ....
  32. ncbi request reprint Peroxynitrite inhibits glutathione S-conjugate transport
    M Soszynski
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochim Biophys Acta 1325:135-41. 1997
    ..As the multidrug resistance-associated protein (MRP) is responsible for the transport of glutathione S-conjugates in mammalian cells, these results point to the possibility of the effect of peroxynitrite on the MRP function...
  33. doi request reprint Oxidative stress during aging of the yeast in a stationary culture and its attenuation by antioxidants
    Alina Owsiak
    Department of Biochemistry and Cell Biology, University of Rzeszow, St Pigonia 6, 35959 Rzeszów, Poland
    Cell Biol Int 34:731-6. 2010
    ..Cell survival was augmented, and changes in biochemical parameters were ameliorated, by addition of exogenous antioxidants (ascorbic acid, glutathione and melatonin) in both strains...
  34. ncbi request reprint Limited effectiveness of antioxidants in the protection of yeast defective in antioxidant proteins
    Anna Lewinska
    Department of Biochemistry and Cell Biology, University of Rzeszow, ul Cegielniana 12, PL 35 595 Rzeszów, Poland
    Free Radic Res 38:1159-65. 2004
    ..These results point to a complication of cellular effects of antioxidants by their prooxidative effects and to the usefulness of cellular tests to evaluate the biological effectiveness of antioxidants...
  35. ncbi request reprint Yeast flavohemoglobin protects against nitrosative stress and controls ferric reductase activity
    Anna Lewinska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Redox Rep 11:231-9. 2006
    ..Deletion of the YHB1 gene was found to augment the reduction of Fe(3+) by yeast cells which suggests that flavohemoglobin participates in regulation of the activity of plasma membrane ferric reductase(s)...
  36. doi request reprint A role for yeast glutaredoxin genes in selenite-mediated oxidative stress
    Anna Lewinska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Cegielniana 12, PL 35 959 Rzeszow, Poland
    Fungal Genet Biol 45:1182-7. 2008
    ..Collectively, our data demonstrate that hypersensitivity to the Deltagrx1Deltagrx2 and Deltagrx5 disruptants to selenite is mediated by altered intracellular redox equilibrium...
  37. ncbi request reprint Pro-oxidative activity of nitroxides in their reactions with glutathione
    Jolanta Głebska
    Department of Molecular Biophysics, University of Łódź, Poland
    Free Radic Biol Med 35:310-6. 2003
    ..The pro-oxidant action of nitroxides at micromolar concentrations may be important in view of the proposed use of these compounds as antioxidants...
  38. ncbi request reprint Melatonin does not affect total antioxidant capacity of blood plasma in vitro
    A Grzelak
    Department of Molecular Biophysics, University of Lodz, Lodz, Poland
    Scand J Clin Lab Invest 65:77-81. 2005
    ..This study demonstrates that enrichment of blood plasma with melatonin up to micromolar concentrations does not affect TAC in vitro thus excluding any significant direct contribution of melatonin to TAC of blood plasma...
  39. ncbi request reprint Decreased antioxidant defense during replicative aging of the yeast Saccharomyces cerevisiae studied using the 'baby machine' method
    A Grzelak
    Department of Molecular Biophysics, University of Lłodź, Poland
    FEBS Lett 492:123-6. 2001
    ....
  40. ncbi request reprint Glutathione depletion in the yeast Saccharomyces cerevisiae
    A Fortuniak
    Department of Molecular Biophysics, University of Lodz, Poland
    Biochem Mol Biol Int 38:901-10. 1996
    ..There was no clear-cut dependence between the ability of various chemicals to deplete cellular GSH and their increased toxicity to a glutathione-poor mutant...
  41. ncbi request reprint Apoptosis-independent alterations in membrane dynamics induced by curcumin
    E Jaruga
    Department of Molecular Biophysics, University of Lodz, Lodz, Poland
    Exp Cell Res 245:303-12. 1998
    ..Such nonspecific effects of curcumin on cellular membranes would produce artifacts of apoptosis measurement, since several methods are based on membrane changes...
  42. ncbi request reprint The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane
    B Rychlik
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    J Membr Biol 193:79-90. 2003
    ..No inhibition of CF accumulation by cGMP, thioguanine and 6-mercaptopurine suggests also that this fluorescent marker is not a substrate for MRP5, another ABC transporter identified in the human erythrocyte membrane...
  43. ncbi request reprint Antisense hairpin loop oligonucleotides as inhibitors of expression of multidrug resistance-associated protein 1: their stability in fetal calf serum and human plasma
    G Rebowski
    Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies Polish Academy of Sciences, Lodz
    Acta Biochim Pol 48:1061-76. 2001
    ..Our studies provide strong evidence for high stability of chemically unmodified hairpin loop ODNs, making them an attractive alternative to phosphorothioate analogues commonly used in antisense strategy...
  44. ncbi request reprint Does the cellular labile iron pool participate in the oxidation of 2',7'-dichlorodihydrofluorescein?
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Lodz, Lodz, Poland
    Free Radic Res 41:563-70. 2007
    ..These results demonstrate that LIP is a significant factor determining the rate of intracellular H(2)DCF oxidation...
  45. ncbi request reprint Accumulation of oxidative damage during replicative aging of the yeast Saccharomyces cerevisiae
    Agnieszka Grzelak
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Exp Gerontol 41:813-8. 2006
    ..These results are consistent with a role for oxidative damage during replicative senescence of Saccharomyces cerevisiae...
  46. ncbi request reprint Metal chelators react also with reactive oxygen and nitrogen species
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Biochem Biophys Res Commun 352:522-5. 2007
    ..These results point to the necessity of a careful interpretation of experiments in which the inhibition of free radical reactions by antioxidants is used as a proof of involvement of metal ions in a reaction...
  47. ncbi request reprint Total anti-oxidant capacity of cell culture media
    Anna Lewinska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Clin Exp Pharmacol Physiol 34:781-6. 2007
    ..decolourization assay and the ferric ion reducing anti-oxidant power assay. 3. We found that components of the media such as cysteine, tyrosine, tryptophan and Phenol Red are important contributors to the TAC of cell culture media...
  48. doi request reprint The effects of superoxide dismutase knockout on the oxidative stress parameters and survival of mouse erythrocytes
    Agnieszka Grzelak
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Cell Mol Biol Lett 14:23-34. 2009
    ....
  49. ncbi request reprint On the specificity of 4-amino-5-methylamino-2',7'-difluorofluorescein as a probe for nitric oxide
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Free Radic Biol Med 39:327-35. 2005
    ..On the other hand, a simultaneous presence of a nitric oxide source and a superoxide or hydrogen peroxide decreases or increases the fluorescence of DAF-FM, respectively, resulting in biased estimates of nitric oxide production...
  50. ncbi request reprint Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids
    Lukasz Pułaski
    Laboratory of Transcriptional Regulation, Centre of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Łódź, Poland
    J Steroid Biochem Mol Biol 96:229-34. 2005
    ..This phenomenon has to be taken into account when designing treatments for lung cancer, especially for patients treated simultaneously with glucocorticoids against inflammatory symptoms...
  51. ncbi request reprint The influence of ferrylhemoglobin and methemoglobin on the human erythrocyte membrane
    Malgorzata Sztiller
    Department of Molecular Biophysics, University of Lodz, Lodz, Poland
    Redox Rep 11:263-71. 2006
    ..In whole erythrocytes, these changes were not stable and disappeared during longer incubation...
  52. ncbi request reprint MRP1-transfected cells do not show increased resistance against oxidative stress
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Lodz, 90 237 Lodz, Poland
    Free Radic Res 37:189-95. 2003
    ..These findings suggest that overexpression of MRP1 does not confer increased resistance to oxidative stress...
  53. ncbi request reprint Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Biochem Pharmacol 69:1263-73. 2005
    ..Proapoptotic action of DPI was observed 12 h after incubation with this compound...
  54. ncbi request reprint Subadditive interactions between antioxidants in the protection against lipid peroxidation
    Lukasz Piotrowski
    Department of Molecular Biophysics, University of Lodz, ul Banacha 12 16, 90 237 Lodz, Poland
    Z Naturforsch C 64:63-7. 2009
    ..A possible explanation for this effect is proposed...
  55. ncbi request reprint Hypochlorous acid inhibits glutathione S-conjugate export from human erythrocytes
    Mirosław Soszyński
    Department of Molecular Biophysics, University of Lodz, Banacha 12 16, 90 237, Lodz, Poland
    Biochim Biophys Acta 1564:479-86. 2002
    ..The stoichiometry of the MRP/HOCl reaction was 1:1. These results demonstrate that MRP can be one of the cellular targets for the inflammatory mediator hypochlorous acid...
  56. doi request reprint Estimation of antioxidant capacity against pathophysiologically relevant oxidants using Pyrogallol Red
    Agnieszka Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Biochem Biophys Res Commun 390:659-61. 2009
    ..Antioxidant capacity of blood plasma (anticoagulated with EDTA) of healthy persons was found to be 559+/-49 micromol/l and 11.6+/-1.2 mmol/l of ascorbic acid equivalents for peroxynitrite and hypochlorite, respectively...
  57. ncbi request reprint Pro-oxidative effects of Tempo in systems containing oxidants
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Lodz, Lodz, Poland
    Redox Rep 9:153-9. 2004
    ..These results point to a pro-oxidative effect of nitroxides on a range of biomolecules subjected to the action of various oxidants...
  58. ncbi request reprint Prooxidative effects of TEMPO on human erythrocytes
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Cell Biol Int 28:585-91. 2004
    ..These results indicate that TEMPO may act as an oxidant to erythrocytes, whilst extracellular ferricyanide protects against its effects...
  59. ncbi request reprint Melatonin does not react rapidly with hydrogen peroxide
    Agnieszka Grzelak
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Free Radic Res 38:1155-8. 2004
    ..Monitoring changes of concentration of hydrogen peroxide incubated with melatonin using Xylenol Orange points to poor reactivity of melatonin with H2O2...
  60. ncbi request reprint Thiols are main determinants of total antioxidant capacity of cellular homogenates
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Lodz, 90 237 Lodz, Poland
    Free Radic Res 37:537-41. 2003
    ..These results show that estimation of TAC of cell extracts may be a useful parameter of assessment of oxidative stress, primarily of oxidation of thiol groups, yielding information different than TAC of body fluids...
  61. ncbi request reprint [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]
    Joanna Drzewinska
    Katedra Biofizyki Molekularnej, Uniwersytet Łódzki, 90 237 Łódź
    Postepy Hig Med Dosw (Online) 63:318-30. 2009
    ..Apart from estrogens and androgens,thyroid hormones, and IGF-1 also take part in the stimulation of seladin-1 expression...
  62. ncbi request reprint Hemoglobin can nitrate itself and other proteins
    A Grzelak
    Department of Molecular Biophysics, , Poland
    Biochim Biophys Acta 1528:97-100. 2001
    ..These results suggest that hemoglobin and other hemoproteins may contribute to the tyrosine nitration in vivo...
  63. ncbi request reprint Peroxynitrite: mediator of the toxic action of nitric oxide
    G Bartosz
    Department of Molecular Biophysics, University of Lodz, Poland
    Acta Biochim Pol 43:645-59. 1996
    ..However, apparently beneficial effects of peroxynitrite have also been described, among them formation of nitric oxide and nitric oxide donors in reactions of peroxynitrite with thiols and alcohols...
  64. doi request reprint Effect of phosphatidylcholine chlorohydrins on human erythrocytes
    Agnieszka Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Chem Phys Lipids 163:639-47. 2010
    ..Chlorohydrins showed also a stronger hemolytic action, proportional to the lipid:erythrocyte ratio. These results are important for understanding the effects of HOCl on mammalian cells, such as might occur in inflammatory pathology...
  65. doi request reprint Nucleolus as an oxidative stress sensor in the yeast Saccharomyces cerevisiae
    Anna Lewinska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Pigonia 6, PL35 959 Rzeszow, Poland
    Redox Rep 15:87-96. 2010
    ..Additionally, we employed the PRINS technique to monitor oxidant-mediated changes in the nucleolar structure. Taken together, our results suggest the role of the yeast nucleolus in the response to oxidative stress signals...
  66. ncbi request reprint The nitroxide antioxidant Tempol affects metal-induced cyto- and genotoxicity in human lymphocytes in vitro
    Anna Lewinska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rejtana 16C, PL 35 959, Rzeszow, Poland
    Mutat Res 649:7-14. 2008
    ..05). Collectively, we demonstrated that Tempol can be considered as a potent anti-apoptotic and antigenotoxic agent, but also as a cytotoxic and clastogenic chemical, depending on the concentration applied...
  67. doi request reprint N-Chloroamino acids mediate the action of hypochlorite on A549 lung cancer cells in culture
    Agnieszka Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Toxicology 270:112-20. 2010
    ..Although amino acids act as scavengers of hypochlorite in plasma, the chlorinated products formed stay reactive and the pattern of their action on cells in vitro is similar to that of hypochlorite...
  68. doi request reprint Oxidant-induced decrease of the expression of nucleolar organizer regions in pig lymphocytes can be useful for monitoring the cellular effects of oxidative stress
    Maciej Wnuk
    Department of Genetics, University of Rzeszow, Rejtana 16C, PL 35 959 Rzeszow, Poland
    Mutat Res 653:124-9. 2008
    ....
  69. ncbi request reprint Is the yeast a relevant model for aging of multicellular organisms? An insight from the total lifespan of Saccharomyces cerevisiae
    Renata Zadrag
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Curr Aging Sci 1:159-65. 2008
    ..cerevisiae...
  70. doi request reprint The antioxidant properties of carnitine in vitro
    Katarzyna Solarska
    Department of Biochemistry and Cell Biology, University of Rzeszow, Pigonia 6, 35 959, Rzeszow, Poland
    Cell Mol Biol Lett 15:90-7. 2010
    ..These results show that carnitine has a direct antioxidant action against physiologically relevant oxidants...
  71. doi request reprint N-chloroamino acids cause oxidative protein modifications in the erythrocyte membrane
    Agnieszka Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Mech Ageing Dev 129:572-9. 2008
    ..The destruction of amine groups content was evident for AlaCl, LysCl and SerCl. The formation of protein aggregates was observed, due mainly but not exclusively to the formation of disulphide bonds...
  72. doi request reprint Estimation of antioxidant capacity against peroxynitrite and hypochlorite with fluorescein
    Agnieszka Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Talanta 80:2196-8. 2010
    ....
  73. doi request reprint Interaction between antioxidants in assays of total antioxidant capacity
    Andrzej Błauz
    Department of Molecular Biophysics, University of Łódź, ul Banacha 12 16, 90 237 Łódź, Poland
    Food Chem Toxicol 46:2365-8. 2008
    ..The subadditive interactions between antioxidants may affect quantitative considerations drawn from in vitro assays of antioxidant capacity of biological samples...
  74. ncbi request reprint Low concentration of oxidant and nitric oxide donors stimulate proliferation of human endothelial cells in vitro
    Katarzyna Łuczak
    Department of Molecular Biophysics, University of Łódź, Banacha 12 13, 90 237 Lodz, Poland
    Cell Biol Int 28:483-6. 2004
    ..These results point to another type of possible artefact of cell culture, viz. stimulation of cell proliferation by low concentrations of oxidants...
  75. ncbi request reprint Ascorbate abolishes auxotrophy caused by the lack of superoxide dismutase in Saccharomyces cerevisiae. Yeast can be a biosensor for antioxidants
    Ewa Zyracka
    University of Rzeszow, ul Rejtana 16, PL 35 310 Rzeszów, Poland
    J Biotechnol 115:271-8. 2005
    ..5 mM and 6 mM, respectively, disappearing at higher concentrations of these compounds, pointing to the detection of not only protective but also toxic cellular effects of the compounds studied by the test proposed...
  76. ncbi request reprint Effect of carminomycin on the viability of fibroblasts from patients with regular trisomy 21
    B Rozga
    Department of Biophysics, University of Lodz, Poland
    Free Radic Res Commun 8:79-83. 1990
    ..These results suggest a role for superoxide-mediated membrane damage in the cytotoxic action of anthracycline antibiotics...
  77. pmc The Role of Polyphenols, β-Carotene, and Lycopene in the Antioxidative Action of the Extracts of Dried, Edible Mushrooms
    A Robaszkiewicz
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    J Nutr Metab 2010:173274. 2010
    ..Beta-carotene did not contribute discernibly to the antioxidative properties of the extracts, while lycopene had a significant contribution to the scavenging activity of methanolic mushroom extracts...
  78. ncbi request reprint Peroxynitrite activates K+-Cl- cotransport in human erythrocytes
    A Grzelak
    Department of Molecular Biophysics, University of Lodz, Poland
    Cell Biol Int 25:1163-5. 2001
    ..Peroxynitrite was found to induce the release of K+ via the Na+/Cl- cotransport system, as do other oxidants. Since peroxynitrite is formed in vivo, its presence could contribute to a pathological dehydration of red blood cells...
  79. ncbi request reprint A comparison of the total antioxidant capacity of some human body fluids
    Anna Ziobro
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rejtana 16A, 35 959 Rzeszow, Poland
    Cell Mol Biol Lett 8:415-9. 2003
    ..Lower TAC values were found for the saliva of smokers than for that of non-smokers. Drinking of a cup of instant coffee increased the hydrogen peroxide content of urine but did not decrease the TAC of urine...
  80. doi request reprint Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae
    Renata Zadrag-Tecza
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Biogerontology 10:481-8. 2009
    ..These results indicate that the increase in the mother cell volume, intrinsic to the asymmetric cell division in S. cerevisiae, may be the main mechanism limiting the reproductive capacity of in this organism...
  81. ncbi request reprint Hypothesis: cell volume limits cell divisions
    Tomasz Bilinski
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Acta Biochim Pol 53:833-5. 2006
    ..A similar phenomenon may limit the number of cell divisions of cultured mammalian cells. The term replicative (generative) aging may be therefore illegitimate...
  82. ncbi request reprint Replicative aging of the yeast does not require DNA replication
    Renata Zadrag
    Department of Biochemistry and Cell Biology, University of Rzeszow, Poland
    Biochem Biophys Res Commun 333:138-41. 2005
    ..These results suggest that limitation of the division potential in the yeast is not due to a counter of cell divisions but is of growth/metabolic nature, perhaps involving attaining a limitation of cell volume...
  83. ncbi request reprint Cytotoxicity, cytoprotection and neurotoxicity of novel deprenyl-related propargylamines, stable nitroxide free radicals, in vitro and in vivo
    Michal Namiecinski
    Department of Molecular Biophysics, University of Lodz, Poland
    In Vivo 18:171-80. 2004
    ..Taken together, it can be concluded with great certainty that novel deprenyl-related JSAKs might be especially good candidates for further anticancer investigations in vitro and in vivo and future pharmacological applications...
  84. doi request reprint Evaluation of the cyto- and genotoxic activity of yerba mate (Ilex paraguariensis) in human lymphocytes in vitro
    Maciej Wnuk
    Department of Genetics, University of Rzeszow, Rejtana 16C, PL 35 959, Poland
    Mutat Res 679:18-23. 2009
    ..We showed that caffeine used at the same concentrations manifests a more potent cyto- and genotoxic effect that may account, at least in part, for the disadvantageous effects observed for yerba mate extract...
  85. doi request reprint A pharmacological solution for a conspecific conflict: ROS-mediated territorial aggression in sea anemones
    Grzegorz Bartosz
    Department of Biophysics, University of Lodz, Banacha 12 16, 90237 Lodz, Poland
    Toxicon 51:1038-50. 2008
    ....
  86. ncbi request reprint Yeast as a biosensor for antioxidants: simple growth tests employing a Saccharomyces cerevisiae mutant defective in superoxide dismutase
    Ewa Zyracka
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Acta Biochim Pol 52:679-84. 2005
    ....
  87. ncbi request reprint A novel test for identifying genes involved in aldehyde detoxification in the yeast. Increased sensitivity of superoxide-deficient yeast to aldehydes and their metabolic precursors
    Tomasz Bilinski
    Department of Biochemistry and Cell Biology, University of Rzeszow, Poland
    Biofactors 24:59-65. 2005
    ..We interpret this finding as due to inactivation of some important element of aldehyde detoxification by increased flux of superoxide in DeltaCuZnSOD mutants...
  88. ncbi request reprint EDTA loses its antioxidant properties upon storage in buffer
    Jolanta Głebska
    Department of Molecular Biophysics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Anal Biochem 311:87-9. 2002
  89. ncbi request reprint Relationship between the replicative age and cell volume in Saccharomyces cerevisiae
    Renata Zadrag
    Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland
    Acta Biochim Pol 53:747-51. 2006
    ..This phenomenon indicates that attaining an excessive volume may be a factor contributing to the limitation of cellular divisions of yeast cells...
  90. ncbi request reprint Does yeast shmooing mean a commitment to apoptosis?
    Renata Zadrag
    Department of Biochemistry and Cell Biology, University of Rzeszow, ul Rejtana 16c, 35 959 Rzeszow, Poland
    Cell Biol Int 30:205-9. 2006
    ..These findings are followed by a general discussion of the biological relevance of apoptosis in yeast...
  91. doi request reprint Helicobacter pylori cagA gene polymorphism affects the total antioxidant capacity of human saliva
    Maciej Wnuk
    Department of Genetics, University of Rzeszow, Rzeszow, Poland
    Helicobacter 15:53-7. 2010
    ..We aimed to evaluate the total antioxidant capacity (TAC) of saliva in healthy Helicobacter pylori-positive and negative saliva individuals...
  92. ncbi request reprint There is no evidence for the existence of complex formation between doxorubicin and glutathione
    Małgorzata Marszałek
    Department of Molecular Biophysics, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Cell Mol Biol Lett 8:311-5. 2003
    ..No evidence of an effect of glutathione (at levels up to 20 microM) on the partition coefficient of doxorubicin was found in the pH range of 4.0-7.4. These results indicate that non-covalent doxorubicin-glutathione complexes do not form...
  93. ncbi request reprint Vacuolar accumulation and extracellular extrusion of electrophilic compounds by wild-type and glutathione-deficient mutants of the methylotrophic yeast Hansenula polymorpha
    Vira M Ubiyvovk
    Institute of Cell Biology, National Academy of Sciences of Ukraine, 79005 Lviv, Ukraine
    Cell Biol Int 27:785-9. 2003
    ..Conjugates of GSH and N-acetylcysteine with monobromobimane and N-[1-pyrene]maleimide were observed among the HPLC fractions, along with unidentified derivatives...
  94. ncbi request reprint Hypochlorous acid-induced oxidative damage of human red blood cells: effects of tert-butyl hydroperoxide and nitrite on the HOCl reaction with erythrocytes
    Ilya B Zavodnik
    Institute of Biochemistry Academy of Sciences of Belarus, 230017 Grodno, Belarus
    Bioelectrochemistry 58:127-35. 2002
    ..The presence of other oxidants, nitrite or tert-butyl hydroperoxide (t-BHP), promoted the oxidative damage induced by HOCl and led to new oxidative reactions...
  95. ncbi request reprint Biomarkers
    Helen R Griffiths
    Pharmaceutical Sciences, Aston University, Birmingham, UK
    Mol Aspects Med 23:101-208. 2002
  96. ncbi request reprint Indices of oxidative stress in pregnancy with fetal growth restriction
    Agata Karowicz-Bilinska
    High Risk Pregnancy Unit, Medical University of Łódź, Lodz, Poland
    Free Radic Res 41:870-3. 2007
    ..This study confirms the occurrence of oxidative stress in IUGR and demonstrates the beneficial effect of arginine/acetylsalicylic acid therapy in reducing oxidative stress in IUGR...
  97. doi request reprint Changes of markers of oxidative stress during menstrual cycle
    Agata Karowicz-Bilinska
    High Risk Pregnancy Unit, Medical University of Łódź, Łódź, Poland
    Redox Rep 13:237-40. 2008
    ..These results give further evidence for the usefulness of urinary hydrogen peroxide and thiobarbituric acid reactive substances as potential biomarkers of oxidative stress and for the antioxidant action of estrogens...
  98. ncbi request reprint The total antioxidant capacity of blood plasma during cardiovasculary bypass surgery in patients with coronary heart disease
    Kornelia Kedziora-Kornatowska
    Department and Clinic of Geriatry, Medical University of Bydgoszcz, M Skłodowskiej Curie 9, 85 094 Bydgoszcz, Poland
    Cell Mol Biol Lett 8:973-7. 2003
    ..TAC was determined using the FRAP method. TAC decreased during surgery, but no further decrease in TAC was observed during reperfusion, indicating that it is a relatively stable parameter of the antioxidative barrier of the body...
  99. ncbi request reprint Effect of superoxide dismutase deficiency on the life span of the yeast Saccharomyces cerevisiae. An oxygen-independent role of Cu,Zn-superoxide dismutase
    Jarosław Wawryn
    Zamosc College of Agriculture, ul Szczebrzeska 102, PL 22 400 Zamosc, Poland
    Biochim Biophys Acta 1570:199-202. 2002
    ..These results indicate that deleterious consequences of the lack of CuZnSOD are not limited to elevation of superoxide concentration and involve function(s) other than superoxide scavenging...
  100. ncbi request reprint Accumulation of cadmium ions in the methylotrophic yeast Hansenula polymorpha
    Oleksandra V Blazhenko
    Institute of Cell Biology, Nat Acad Sci of Ukraine, Drahomanov Str 14 16, Lviv, 79005, Ukraine
    Biometals 19:593-9. 2006
    ..We suggest that MgATP dependent transporter involved in Cd-GSH uptake in H. polymorpha, is similar to S. cerevisiae Ycf1-mediated vacuolar transporter responsible for accumulation of organic GS-conjugates and Cd-GSH complex...
  101. ncbi request reprint Elevated exhalation of hydrogen peroxide and thiobarbituric acid reactive substances in patients with community acquired pneumonia
    Edyta Majewska
    Department of Experimental and Clinical Physiology, Institute of Physiology and Biochemistry, Medical University of Lodz, Mazowiecka St 6 8, 92 215 Lodz, Poland
    Respir Med 98:669-76. 2004
    ..These cells release oxidants including H2O2, that may be exhaled or induce peroxidative damage to lung tissues with formation of thiobarbituric reactive substances (TBARs)...