Katarzyna Kotulska

Summary

Affiliation: The Children's Memorial Health Institute
Country: Poland

Publications

  1. ncbi request reprint Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatr Dev Pathol 12:89-95. 2009
  2. doi request reprint Surgical treatment of subependymal giant cell astrocytoma in tuberous sclerosis complex patients
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland Department of Science, The Children s Memorial Health Institute, Warsaw, Poland Electronic address
    Pediatr Neurol 50:307-12. 2014
  3. ncbi request reprint "Drop attacks" as first clinical symptoms in a child carrying MTTK m.8344A>G mutation
    Piotr Buda
    Katarzyna Kotulska, Department of Child Neurology and Epileptology, The Children s Memorial Health Institute, Al Dzieci Polskich, 04 730 Warsaw, Poland, phone 48 22 815 74 04, fax 48 22 815 74 02, E mail
    Folia Neuropathol 51:347-54. 2013
  4. doi request reprint Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 17:479-85. 2013
  5. doi request reprint Possible prevention of tuberous sclerosis complex lesions
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatrics 132:e239-42. 2013
  6. ncbi request reprint TrkB deficiency increases survival and regeneration of spinal motoneurons after axotomy in mice
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 44:251-6. 2006
  7. ncbi request reprint The role of trkB receptor in the formation of post-traumatic neuroma
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 44:221-7. 2006
  8. doi request reprint APP overexpression prevents neuropathic pain and motoneuron death after peripheral nerve injury in mice
    Katarzyna Kotulska
    Department of Child Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Brain Res Bull 81:378-84. 2010
  9. ncbi request reprint Epidermal nevus syndrome and intraspinal hemorrhage
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsawa, Poland
    Brain Dev 28:541-3. 2006
  10. ncbi request reprint The influence of trkB deficiency on long-term outcome of peripheral nerve injury in mice
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 45:82-92. 2007

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatr Dev Pathol 12:89-95. 2009
    ..Hamartin and tuberin expression was decreased in tumors versus normal heart tissues. This is the first study showing mTOR pathway dysregulation and an increased expression of proapoptotic Bax protein in CRs associated with TSC...
  2. doi request reprint Surgical treatment of subependymal giant cell astrocytoma in tuberous sclerosis complex patients
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland Department of Science, The Children s Memorial Health Institute, Warsaw, Poland Electronic address
    Pediatr Neurol 50:307-12. 2014
    ..The analysis of outcome of subependymal giant cell astrocytoma surgery may help characterize the patients who may benefit from pharmacotherapy...
  3. ncbi request reprint "Drop attacks" as first clinical symptoms in a child carrying MTTK m.8344A>G mutation
    Piotr Buda
    Katarzyna Kotulska, Department of Child Neurology and Epileptology, The Children s Memorial Health Institute, Al Dzieci Polskich, 04 730 Warsaw, Poland, phone 48 22 815 74 04, fax 48 22 815 74 02, E mail
    Folia Neuropathol 51:347-54. 2013
    ..However, the random association of these factors with natural disease fluctuations cannot be excluded...
  4. doi request reprint Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 17:479-85. 2013
    ..There are also some reports on the antiepileptic and antiepileptogenic potential of mTOR inhibitors in TSC. However, the data on everolimus efficacy and safety in young children are very limited...
  5. doi request reprint Possible prevention of tuberous sclerosis complex lesions
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatrics 132:e239-42. 2013
    ..This observation indicates that early mTOR inhibition in TSC patients may prevent the development of TSC lesions and alter the natural history of the disease. ..
  6. ncbi request reprint TrkB deficiency increases survival and regeneration of spinal motoneurons after axotomy in mice
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 44:251-6. 2006
    ..The number of regenerating motoneurons after nerve grafting did not differ between groups. These results provide further evidence for the role of trkB receptor in spinal motoneuron survival and regeneration...
  7. ncbi request reprint The role of trkB receptor in the formation of post-traumatic neuroma
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 44:221-7. 2006
    ..We also noticed many more mast cells accumulated at the surgery site in trkB-deficient than in wild-type animals. These results indicate the important role of BDNF receptor in post-traumatic neuroma formation...
  8. doi request reprint APP overexpression prevents neuropathic pain and motoneuron death after peripheral nerve injury in mice
    Katarzyna Kotulska
    Department of Child Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Brain Res Bull 81:378-84. 2010
    ....
  9. ncbi request reprint Epidermal nevus syndrome and intraspinal hemorrhage
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsawa, Poland
    Brain Dev 28:541-3. 2006
    ..We report a case of a patient with diagnosed ENS without any primary CNS lesions, who developed paraplegia resulting from spinal cord hemorrhage. The patient presented many vascular and skeletal anomalies...
  10. ncbi request reprint The influence of trkB deficiency on long-term outcome of peripheral nerve injury in mice
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 45:82-92. 2007
    ..Our results show for the first time the possible deleterious role of trkB receptor in long-term outcome of peripheral nerve injury...
  11. doi request reprint APP/SOD1 overexpressing mice present reduced neuropathic pain sensitivity
    Katarzyna Kotulska
    Department of Child Neurology, The Children s Memorial Health Institute, Warsaw, Poland
    Brain Res Bull 85:321-8. 2011
    ..Our findings suggest that APP/SOD1 overexpressing mice are less sensitive for neuropathic pain associated with neuroma...
  12. ncbi request reprint Overexpression of copper/zinc-superoxide dismutase in transgenic mice markedly impairs regeneration and increases development of neuropathic pain after sciatic nerve injury
    Katarzyna Kotulska
    Department of Child Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    J Neurosci Res 84:1091-7. 2006
    ..This can be at least partially ascribed to disturbed inflammatory reactions at the injury site...
  13. doi request reprint Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 15:424-31. 2011
    ..Clinical epileptic seizures are preceded by deterioration of EEG recording thus infants with high risk of epilepsy can be identified...
  14. ncbi request reprint Expression of tuberin and hamartin in tuberous sclerosis complex-associated and sporadic cortical dysplasia of Taylor's balloon cell type
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 46:43-8. 2008
    ..In conclusion, loss of TSC1 and TSC2 products expression in balloon cells of both cortical dysplasia type IIB in TSC-related and sporadic patients suggests that FCD type IIB may represent the focal form of TSC...
  15. doi request reprint Tuberous sclerosis complex: tumors and tumorigenesis
    Julita Borkowska
    Department of Child Neurology, Children s Memorial Health Institute, Warsaw, Poland
    Int J Dermatol 50:13-20. 2011
    ..The authors elucidate the variety of neoplasms seen in TSC patients, along with their clinical significance, and suggest suitable evaluation and management strategies...
  16. ncbi request reprint Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Warsaw, Poland
    Folia Neuropathol 49:39-46. 2011
    ..We suggest recognizing such cases of subependymal giant cell astrocytoma as atypical SEGAs...
  17. ncbi request reprint Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, Children s Memorial Health Institute, Aleja Dzieci Polskich 20, 04 730 Warsaw, Poland
    Pediatrics 118:e1146-51. 2006
    ..Our aim for this study was to characterize the incidence, progression, and clinical consequences of tuberous sclerosis complex-associated rhabdomyomas in a large cohort of patients with TSC1 and TSC2 genotypes...
  18. ncbi request reprint Impaired regeneration of bcl-2-lacking peripheral nerves
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Neurol Res 27:843-9. 2005
    ..The aim of the present study was to establish the role of the anti-apoptotic gene bcl-2 in peripheral nerve repair...
  19. ncbi request reprint Brain tumor formation in tuberous sclerosis depends on Erk activation
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, and Department of Pathology, The Children s Memorial Health Institute, Warsaw, Poland
    Neuromolecular Med 9:117-27. 2007
    ..Importantly, Erk inhibition leads to the decrease of proliferation potential of such lines. These results show that Erk is specifically implicated in the pathogenesis of hamartomas...
  20. doi request reprint Fibroblasts from normal skin of a tuberous sclerosis patient show upregulation of mTOR pathway
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Am J Dermatopathol 31:68-70. 2009
    ..We found that even healthy skin fibroblasts show upregulation of S6 ribosomal protein...
  21. ncbi request reprint Multiple cardiac rhabdomyomas as a sole symptom of tuberous sclerosis complex: case report with molecular confirmation
    Sergiusz Jozwiak
    Department of Neurology, The Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 20:988-9. 2005
    ..We propose that all cases of multiple cardiac rhabdomyomas in an infant be given a tentative diagnosis of tuberous sclerosis complex...
  22. doi request reprint Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex
    Magdalena Kaczorowska
    Department of Neurology Radiology, MR Unit Pediatric Rehabilitation Psychology, The Children s Memorial Health Institute, Warsaw, Poland
    Epilepsia 52:22-7. 2011
    ..The aim of the study was to reveal the relationships between the tuber count of the brain found in patients with tuberous sclerosis complex (TSC) and their cognitive outcome...
  23. doi request reprint Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex
    Marta Perek-Polnik
    Department of Oncology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 16:83-5. 2012
    ..Moreover, the therapy was well tolerated. These findings indicate that everolimus treatment should be considered as a therapeutic option alternative to surgery in patients with tuberous sclerosis complex...
  24. ncbi request reprint Upregulation of the WNT pathway in tuberous sclerosis-associated subependymal giant cell astrocytomas
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Brain Dev 29:273-80. 2007
    ..At the same time, c-Myc and N-Myc proteins were detected in the same two samples. Thus, we show for the first time that aberrant WNT signaling may contribute to the pathogenesis of TS-associated SEGAs...
  25. ncbi request reprint Effect of oblique nerve grafting on peripheral nerve regeneration in rats
    Katarzyna Kotulska
    Department of Neurology, Medical University of Silesia, Katowice, Poland
    Microsurgery 26:579-84. 2006
    ..These data indicate that joining or grafting the nerve stumps at acute angle is a more profitable method of nerve repair than the standard procedure performed at right angle...
  26. pmc Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications
    Magdalena Ewa Tyburczy
    The Nencki Institute of Experimental Biology, Warsaw, Poland
    Am J Pathol 176:1878-90. 2010
    ....
  27. ncbi request reprint Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis
    Sergiusz Jozwiak
    Department of Neurology, Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 19:102-6. 2004
    ....
  28. doi request reprint Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response
    Malgorzata Sielska
    Laboratory of Molecular Neurobiology, Neurobiology Center, Nencki Institute of Experimental Biology, Warsaw, Poland
    J Pathol 230:310-21. 2013
    ..Therefore we propose that GM-CSF triggers and drives the alternative activation of tumour-infiltrating microglia/macrophages in which these cells support tumour growth and angiogenesis and shape the immune microenvironment of gliomas...
  29. ncbi request reprint Brain lesions in tuberous sclerosis complex. Review
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Aleja Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 48:139-49. 2010
    ..Oral rapamycin therapy may induce regression of astrocytomas associated with TSC. In this review, the clinicopathological features of TCS and recent advantages in the diagnosis and genetics of TSC are presented...
  30. doi request reprint Everolimus (RAD001): first systemic treatment for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, 04 730, Warsaw, Poland
    Future Oncol 8:1515-23. 2012
    ..The most common adverse events in clinical trials were stomatitis/mouth ulceration and upper respiratory tract infections, and most adverse events were grade 1 or 2; grade 4 events were rare...
  31. ncbi request reprint MR venography in children and adolescents with multiple sclerosis does not show increased prevalence of extracranial veins anomalies
    Elzbieta Jurkiewicz
    Department of Diagnostic Imaging, The Children s Memorial Health Institute, Warsaw, Poland Electronic address
    Eur J Paediatr Neurol 18:218-22. 2014
    ..The aim of this study was the evaluate the prevalence of extracranial venous system anomalies in children and adolescents with multiple sclerosis in comparison to age-matched controls...
  32. pmc Drug-resistant epilepsia and fulminant valproate liver toxicity. Alpers-Huttenlocher syndrome in two children confirmed post mortem by identification of p.W748S mutation in POLG gene
    Ewa Pronicka
    Department of Metabolic Diseases, Endocrinology and Diabetology, Children s Memorial Health Institute Warsaw, Poland
    Med Sci Monit 17:CR203-9. 2011
    ..The diagnostic triad of AHS is: resistant epilepsy, liver impairment triggered by sodium valproate (VA), and mitochondrial DNA depletion...
  33. doi request reprint Gene table: monogenic determined neurocutaneous disorders
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 783 Warszawa, Poland
    Eur J Paediatr Neurol 14:449-51. 2010
    ..Recently, a great progress has been achieved in understanding the pathogenesis of many neurocutaneous disorders. This work presents very concise review of molecular background of monogenic determined neurocutaneous disorders...
  34. ncbi request reprint Do peripheral nerve extracts protect retinal ganglion cells from axotomy-induced death?
    Ewa Swiech-Sabuda
    Department of Physiology, Medical University of Silesia, Katowice, Poland
    Restor Neurol Neurosci 22:11-8. 2004
    ..Study the effect of peripheral nerve extracts and BDNF on retinal ganglion cell (RGC) regeneration in adult rats...
  35. ncbi request reprint Influence of nerve growth factor upon the injured peripheral nerve in the absence of its distal part
    Wiesław Marcol
    Department of Physiology, Medical University of Silesia, Katowice, Poland
    Ital J Anat Embryol 109:199-208. 2004
    ..In both groups parallelly arranged acetylcholinesterase-positive nerve fibers were present. The obtained results show that NGF has no influence on regeneration of the motor component of the rat sciatic nerves in adult animals...
  36. ncbi request reprint Extracts obtained from predegenerated nerves improve functional recovery after sciatic nerve transection
    Wieslaw Marcol
    Department of Physiology, Medical University of Silesia, Katowice, Poland
    Microsurgery 25:486-94. 2005
    ..We conclude that autologous connective-tissue chambers filled with fibrin and predegenerated peripheral nerve extracts or BDNF seem to be a promising tool in peripheral nerve gap injury treatment, with likely clinical implications...
  37. ncbi request reprint Regeneration of sciatic nerves of adult rats induced by extracts from distal stumps of pre-degenerated peripheral nerves
    Wieslaw Marcol
    Department of Physiology, Medical University of Silesia, Katowice, Poland
    J Neurosci Res 72:417-24. 2003
    ..In addition, the length of fibers regrowing within the chambers was measured. We found that extracts obtained from distal stumps of 7-day-pre-degenerated peripheral nerves enhanced nerve regeneration as strongly as BDNF...
  38. ncbi request reprint Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations
    Piotr Kozlowski
    Genetics Laboratory, Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Genet 121:389-400. 2007
    ..We conclude that large deletions in TSC1 and TSC2 account for about 0.5 and 6% of mutations seen in TSC patients, respectively, and MLPA is a highly sensitive and accurate detection method, including for mosaicism...
  39. ncbi request reprint Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation
    Jennifer A Chan
    Division of Neuropathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 63:1236-42. 2004
    ..We conclude that TSC SEGAs likely arise through a two-hit mechanism of biallelic inactivation of TSC1 or TSC2, leading to activation of the mTOR kinase...
  40. ncbi request reprint Bcl-2 deficiency deprives peripheral nerves of neurotrophic activity against injured optic nerve
    Katarzyna Kotulska
    Neurology Department, Medical University of Silesia, Katowice, Poland
    J Neurosci Res 73:846-52. 2003
    ..These results indicate that the lack of bcl-2 gene does not deprive retinal ganglion cells of their regenerative potential. At the same time, we found that bcl-2 knock-out dispossesses peripheral nerves of their neurotrophic activity...
  41. ncbi request reprint Prevention and management of painful neuroma
    Joanna Lewin-Kowalik
    Department of Physiology, Medical University of Silesia, Katowice, Poland
    Neurol Med Chir (Tokyo) 46:62-7; discussion 67-8. 2006
    ..Surgical resection of recurrent neuroma followed by implantation of the nerve into the muscle or capping the nerve stump with epineural graft seems to be the most effective method of prevention...
  42. ncbi request reprint Prevention of painful neuromas by oblique transection of peripheral nerves
    Wieslaw Marcol
    Department of Physiology, Division of Neurosurgery, Medical University of Silesia, Katowice, Poland
    J Neurosurg 104:285-9. 2006
    ..Most such neuromas cause therapy-resistant neuropathic pain. The purpose of this study was to determine whether oblique transection of the proximal stump of the sciatic nerve can prevent neuroma formation...
  43. ncbi request reprint Similarity of balloon cells in focal cortical dysplasia to giant cells in tuberous sclerosis
    Jaroslaw Jozwiak
    Epilepsia 47:805. 2006
  44. doi request reprint Hypothalamic papillary tumor in a patient with tuberous sclerosis
    Martin Hasselblatt
    Institutes of Neuropathology, University Hospital Munster, Munster, Germany
    Am J Surg Pathol 32:1578-80. 2008
    ..This hitherto undescribed low-grade hypothalamic tumor extends the spectrum of tumors associated with the tuberous sclerosis complex...
  45. ncbi request reprint Are all prenatally diagnosed multiple cardiac rhabdomyomas a sign of tuberous sclerosis?
    Sergiusz Jozwiak
    Prenat Diagn 26:867-9. 2006
  46. ncbi request reprint Treatment before seizures: new indications for antiepileptic therapy in children with tuberous sclerosis complex
    Sergiusz Jozwiak
    Epilepsia 48:1632; author reply 1632-4. 2007
  47. ncbi request reprint Tuberous sclerosis complex: advances in diagnosis, genetics, and management
    Robert A Schwartz
    Department of Dermatology, New Jersey Medical School, Newark, NJ 07103, USA
    J Am Acad Dermatol 57:189-202. 2007
    ..Since the death of its describer, Thomas Fitzpatrick, we call each a "Fitzpatrick patch." Special attention is paid in this work to TSC treatment options, including therapeutic trials with rapamycin, also known as sirolimus...
  48. ncbi request reprint Quantitative and qualitative analysis of proteins in rat peripheral nerves predegenerated for 7 days
    Marita Pietrucha-Dutczak
    Department of Physiology, Medical University of Silesia, Katowice, Poland
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:249-54. 2006
    ..Non-predegenerated nerves show much weaker neurotrophic activity. The aim of the present work was to examine quantitatively and qualitatively the protein composition of rat sciatic nerve extracts...
  49. ncbi request reprint BDNF contributes to animal model neuropathic pain after peripheral nerve transection
    Wiesław Marcol
    Department of Physiology, Medical University of Silesia, 18 Medykow St, 40 752, Katowice, Poland
    Neurosurg Rev 30:235-43; discussion 243. 2007
    ..These results indicate that BDNF plays a locally crucial role in neuropathic pain development after peripheral nerve injury...