Sergiusz Jozwiak

Summary

Affiliation: The Children's Memorial Health Institute
Country: Poland

Publications

  1. ncbi request reprint Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy
    S Jozwiak
    Department of Neurology, Institute Pomnik CZD, Al Dzieci Polskich 20, 04 736 Warszawa, Poland
    Seizure 9:486-92. 2000
  2. ncbi request reprint Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis
    Sergiusz Jozwiak
    Department of Neurology, Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 19:102-6. 2004
  3. ncbi request reprint Skin lesions in children with tuberous sclerosis complex: their prevalence, natural course, and diagnostic significance
    S Jozwiak
    Neurology, The Children s Memorial Health Institute, Warsaw, Poland
    Int J Dermatol 37:911-7. 1998
  4. ncbi request reprint [Tests for loss of heterozygosity in tuberous sclerosis]
    S Jozwiak
    Klinika Neurologii Instytutu Pomnik Centrum Zdrowia Dziecka w Warszawie
    Przegl Lek 58:12-5. 2001
  5. ncbi request reprint [Research advances in molecular genetics of epilepsies]
    Sergiusz Jozwiak
    Klinika Neurologii i Epileptologii, Instytut Pomnik Centrum Zdrowia Dziecka, Al Dzieci Polskich 20, 04 736 Warszawa
    Neurol Neurochir Pol 39:497-508. 2005
  6. doi request reprint Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 17:479-85. 2013
  7. ncbi request reprint Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, Children s Memorial Health Institute, Aleja Dzieci Polskich 20, 04 730 Warsaw, Poland
    Pediatrics 118:e1146-51. 2006
  8. doi request reprint Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 15:424-31. 2011
  9. ncbi request reprint Expression of tuberin and hamartin in tuberous sclerosis complex-associated and sporadic cortical dysplasia of Taylor's balloon cell type
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 46:43-8. 2008
  10. ncbi request reprint Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatr Dev Pathol 12:89-95. 2009

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy
    S Jozwiak
    Department of Neurology, Institute Pomnik CZD, Al Dzieci Polskich 20, 04 736 Warszawa, Poland
    Seizure 9:486-92. 2000
    ..An additive effect between lamotrigine and valproate was observed...
  2. ncbi request reprint Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis
    Sergiusz Jozwiak
    Department of Neurology, Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 19:102-6. 2004
    ....
  3. ncbi request reprint Skin lesions in children with tuberous sclerosis complex: their prevalence, natural course, and diagnostic significance
    S Jozwiak
    Neurology, The Children s Memorial Health Institute, Warsaw, Poland
    Int J Dermatol 37:911-7. 1998
    ..Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by widespread cutaneous and visceral hamartomas...
  4. ncbi request reprint [Tests for loss of heterozygosity in tuberous sclerosis]
    S Jozwiak
    Klinika Neurologii Instytutu Pomnik Centrum Zdrowia Dziecka w Warszawie
    Przegl Lek 58:12-5. 2001
    ..The presence of LOH in internal organ tumors is consistent with the Knudson's two-hit model in TS. The frequency of LOH depends on the type of tumor and type of mutation (TSC1 or TSC2)...
  5. ncbi request reprint [Research advances in molecular genetics of epilepsies]
    Sergiusz Jozwiak
    Klinika Neurologii i Epileptologii, Instytut Pomnik Centrum Zdrowia Dziecka, Al Dzieci Polskich 20, 04 736 Warszawa
    Neurol Neurochir Pol 39:497-508. 2005
    ..On the other hand, defects in the same locus can result in heterogeneous phenotypes. This can indicate multifactorial pathogenesis of epilepsy and implicate further revision of epilepsies and epileptic seizures classification...
  6. doi request reprint Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 17:479-85. 2013
    ..There are also some reports on the antiepileptic and antiepileptogenic potential of mTOR inhibitors in TSC. However, the data on everolimus efficacy and safety in young children are very limited...
  7. ncbi request reprint Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, Children s Memorial Health Institute, Aleja Dzieci Polskich 20, 04 730 Warsaw, Poland
    Pediatrics 118:e1146-51. 2006
    ..Our aim for this study was to characterize the incidence, progression, and clinical consequences of tuberous sclerosis complex-associated rhabdomyomas in a large cohort of patients with TSC1 and TSC2 genotypes...
  8. doi request reprint Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 15:424-31. 2011
    ..Clinical epileptic seizures are preceded by deterioration of EEG recording thus infants with high risk of epilepsy can be identified...
  9. ncbi request reprint Expression of tuberin and hamartin in tuberous sclerosis complex-associated and sporadic cortical dysplasia of Taylor's balloon cell type
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 46:43-8. 2008
    ..In conclusion, loss of TSC1 and TSC2 products expression in balloon cells of both cortical dysplasia type IIB in TSC-related and sporadic patients suggests that FCD type IIB may represent the focal form of TSC...
  10. ncbi request reprint Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatr Dev Pathol 12:89-95. 2009
    ..Hamartin and tuberin expression was decreased in tumors versus normal heart tissues. This is the first study showing mTOR pathway dysregulation and an increased expression of proapoptotic Bax protein in CRs associated with TSC...
  11. ncbi request reprint Brain tumor formation in tuberous sclerosis depends on Erk activation
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, and Department of Pathology, The Children s Memorial Health Institute, Warsaw, Poland
    Neuromolecular Med 9:117-27. 2007
    ..Importantly, Erk inhibition leads to the decrease of proliferation potential of such lines. These results show that Erk is specifically implicated in the pathogenesis of hamartomas...
  12. doi request reprint Fibroblasts from normal skin of a tuberous sclerosis patient show upregulation of mTOR pathway
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Am J Dermatopathol 31:68-70. 2009
    ..We found that even healthy skin fibroblasts show upregulation of S6 ribosomal protein...
  13. doi request reprint Tuberous sclerosis complex: tumors and tumorigenesis
    Julita Borkowska
    Department of Child Neurology, Children s Memorial Health Institute, Warsaw, Poland
    Int J Dermatol 50:13-20. 2011
    ..The authors elucidate the variety of neoplasms seen in TSC patients, along with their clinical significance, and suggest suitable evaluation and management strategies...
  14. doi request reprint Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex
    Magdalena Kaczorowska
    Department of Neurology Radiology, MR Unit Pediatric Rehabilitation Psychology, The Children s Memorial Health Institute, Warsaw, Poland
    Epilepsia 52:22-7. 2011
    ..The aim of the study was to reveal the relationships between the tuber count of the brain found in patients with tuberous sclerosis complex (TSC) and their cognitive outcome...
  15. ncbi request reprint Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Warsaw, Poland
    Folia Neuropathol 49:39-46. 2011
    ..We suggest recognizing such cases of subependymal giant cell astrocytoma as atypical SEGAs...
  16. doi request reprint Surgical treatment of subependymal giant cell astrocytoma in tuberous sclerosis complex patients
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland Department of Science, The Children s Memorial Health Institute, Warsaw, Poland Electronic address
    Pediatr Neurol 50:307-12. 2014
    ..The analysis of outcome of subependymal giant cell astrocytoma surgery may help characterize the patients who may benefit from pharmacotherapy...
  17. doi request reprint Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex
    Marta Perek-Polnik
    Department of Oncology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 16:83-5. 2012
    ..Moreover, the therapy was well tolerated. These findings indicate that everolimus treatment should be considered as a therapeutic option alternative to surgery in patients with tuberous sclerosis complex...
  18. ncbi request reprint Giant cells: contradiction to two-hit model of tuber formation?
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw ul, Chalubinskiego, Warsaw, Poland
    Cell Mol Neurobiol 27:251-61. 2007
    ..In this paper, we review literature covering origination of giant cells and present several hypotheses explaining why in spite of the presence of hamartin and tuberin, brain lesions form in TSC patients...
  19. pmc Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications
    Magdalena Ewa Tyburczy
    The Nencki Institute of Experimental Biology, Warsaw, Poland
    Am J Pathol 176:1878-90. 2010
    ....
  20. ncbi request reprint Multiple cardiac rhabdomyomas as a sole symptom of tuberous sclerosis complex: case report with molecular confirmation
    Sergiusz Jozwiak
    Department of Neurology, The Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 20:988-9. 2005
    ..We propose that all cases of multiple cardiac rhabdomyomas in an infant be given a tentative diagnosis of tuberous sclerosis complex...
  21. doi request reprint Possible prevention of tuberous sclerosis complex lesions
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatrics 132:e239-42. 2013
    ..This observation indicates that early mTOR inhibition in TSC patients may prevent the development of TSC lesions and alter the natural history of the disease. ..
  22. doi request reprint Everolimus (RAD001): first systemic treatment for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, 04 730, Warsaw, Poland
    Future Oncol 8:1515-23. 2012
    ..The most common adverse events in clinical trials were stomatitis/mouth ulceration and upper respiratory tract infections, and most adverse events were grade 1 or 2; grade 4 events were rare...
  23. doi request reprint Possible mechanisms of disease development in tuberous sclerosis
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Lancet Oncol 9:73-9. 2008
    ..We postulate that ERK activation consistently detected in different tuberous-sclerosis-associated tumours is a molecular trigger for the development of these neoplasms...
  24. ncbi request reprint Upregulation of the WNT pathway in tuberous sclerosis-associated subependymal giant cell astrocytomas
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Brain Dev 29:273-80. 2007
    ..At the same time, c-Myc and N-Myc proteins were detected in the same two samples. Thus, we show for the first time that aberrant WNT signaling may contribute to the pathogenesis of TS-associated SEGAs...
  25. ncbi request reprint Clinical symptoms of tuberous sclerosis complex in patients with an identical TSC2 mutation
    Paulina Rok
    Department of Child Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Med Sci Monit 11:CR230-234. 2005
    ..We tried to discover to what extent we may expect variability in the clinical set of symptoms in patients with identical mutation of TSC2 gene...
  26. doi request reprint Progeria caused by a rare LMNA mutation p.S143F associated with mild myopathy and atrial fibrillation
    Agnieszka Madej-Pilarczyk
    Neuromuscular Unit, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, Warsaw, Poland
    Eur J Paediatr Neurol 12:427-30. 2008
    ..To our knowledge, this is the second case of such association described in the literature...
  27. ncbi request reprint The role of trkB receptor in the formation of post-traumatic neuroma
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 44:221-7. 2006
    ..We also noticed many more mast cells accumulated at the surgery site in trkB-deficient than in wild-type animals. These results indicate the important role of BDNF receptor in post-traumatic neuroma formation...
  28. ncbi request reprint [Psychomotor development rate of children with infantile neuronal ceroid lipofuscinosis]
    Tomasz Kmiec
    Klinika Neurologii i Epileptologii, Instytut Pomnik Centrum Zdrowia Dziecka 04 730 Warszawa, Aleja Dzieci Polskich 20
    Przegl Lek 63:44-7. 2006
    ..The aim of study: Cognition of psychomotor development in children with LINCL...
  29. ncbi request reprint [Usefulness of cerebral SPECT in the children with migraine]
    Tomasz Kmiec
    Klinika Neurologii i Epileptologii, Instytut Pomnik Centrum Zdrowia Dziecka w Warszawie
    Neurol Neurochir Pol 39:S36-41. 2005
    ..In all these 19 cases we observed localization of hypoperfused foci in SPECT imaging matched with the side of migraine pain...
  30. doi request reprint Management of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC): Clinical recommendations
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 17:348-52. 2013
    ..This report summarizes the clinical recommendations for the management of SEGA made by a panel of European experts in March 2012. Current treatment options and outstanding questions are outlined...
  31. ncbi request reprint [Juvenile form of Alexander's disease - a case confirmed by detection of mutation in GFAP gene]
    Tomasz Kmiec
    Klinika Neurologii i Epileptologii, Instytut Pomnik Centrum Zdrowia Dziecka w Warszawie, Warszawa, Poland
    Neurol Neurochir Pol 41:267-71. 2007
    ..This article also presents clinical symptoms and course of this degenerative disorder. The authors point out the important role of neuroimaging and the necessity of molecular examination as a new diagnostic tool...
  32. doi request reprint Successful antiepileptic drug withdrawal in infants with epilepsy and cytomegalovirus neuroinfection: longitudinal study
    Dorota Dunin-Wasowicz
    Neurology and Epileptology Department, The Children s Memorial Health Institute, Warsaw, Poland
    Epilepsia 51:1212-8. 2010
    ..A prospective study estimating antiepileptic and antiviral regimens administered to infants with symptomatic epilepsy and human cytomegalovirus (HCMV) neuroinfection followed for at least 4 years...
  33. ncbi request reprint Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Med Res Rev 26:160-80. 2006
    ..Current studies with sirolimus performed in tuberous sclerosis animal models are presented. Possible application of sirolimus for treating tuberous sclerosis, disease caused by mutations of TSC proteins, is discussed...
  34. ncbi request reprint Giant intracranial aneurysm in a 9-year-old boy with tuberous sclerosis
    Elzbieta Jurkiewicz
    MR Unit, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730, Warsaw, Poland
    Pediatr Radiol 36:463. 2006
  35. ncbi request reprint Encephalocraniocutaneous lipomatosis
    Julita Gawel
    Department of Neurology, Child s Health Center, Warsaw, Poland
    J Cutan Med Surg 7:61-5. 2003
    ....
  36. ncbi request reprint Giant cells: contradiction to two-hit model of tuber formation?
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, and Department of Pediatric Neurology, Children s Memorial Hospital, Warsaw, Poland
    Cell Mol Neurobiol 25:795-805. 2005
    ..3. In the present paper we review literature covering origination of giant cells and present several hypotheses explaining why in spite of the presence of hamartin and tuberin, brain lesions form in TSC patients...
  37. ncbi request reprint Dietary treatment of epilepsy: rebirth of an ancient treatment
    Sergiusz Jozwiak
    Department of Neurology and Epileptology of the Children s Memorial Health Institute, Warsaw, Poland
    Neurol Neurochir Pol 45:370-8. 2011
    ..This dietary treatment for epilepsy has undergone a rebirth. Its widespread use in Poland and Europe is a welcome additional treatment for those with drug-resistant epilepsy...
  38. doi request reprint Gene table: monogenic determined neurocutaneous disorders
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 783 Warszawa, Poland
    Eur J Paediatr Neurol 14:449-51. 2010
    ..Recently, a great progress has been achieved in understanding the pathogenesis of many neurocutaneous disorders. This work presents very concise review of molecular background of monogenic determined neurocutaneous disorders...
  39. ncbi request reprint Cyst-like cortical tubers in patients with tuberous sclerosis complex: MR imaging with the FLAIR sequence
    Elzbieta Jurkiewicz
    MR Unit, The Children s Memorial Health Institute, Al Dzieci Polskich 20, Warsaw, Poland
    Pediatr Radiol 36:498-501. 2006
    ..Tuberous sclerosis complex (TSC) is an inherited disorder characterized by the presence of cortical tubers, the majority of which are solid and show high signal on FLAIR images. Low-signal tubers are less frequent...
  40. ncbi request reprint Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology
    Magdalena Kaczorowska
    Department of Child Neurology, The Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 23:1455-9. 2008
    ..Due to the availability of reliable laboratory testing, confirmation of the diagnosis was made without the life-threatening trial of pyridoxine withdrawal...
  41. ncbi request reprint Epidermal nevus syndrome and intraspinal hemorrhage
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsawa, Poland
    Brain Dev 28:541-3. 2006
    ..We report a case of a patient with diagnosed ENS without any primary CNS lesions, who developed paraplegia resulting from spinal cord hemorrhage. The patient presented many vascular and skeletal anomalies...
  42. ncbi request reprint Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
    M van Slegtenhorst
    Department of Clinical Genetics, Erasmus University and University Hospital, Rotterdam, Netherlands
    Science 277:805-8. 1997
    ..In one of these six, a somatic mutation in the wild-type allele was found in a TSC-associated renal carcinoma, which suggests that hamartin acts as a tumor suppressor...
  43. ncbi request reprint Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1
    J Kwiatkowska
    Experimental Medicine Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genomics 44:350-4. 1997
    ..Through SSCP and heteroduplex analysis of genomic DNA, we found two intragenic polymorphisms but no evidence for significant mutations in patients with tuberous sclerosis in this gene...
  44. ncbi request reprint Comprehensive mutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance
    J Kwiatkowska
    Division of Experimental Medicine and Medical Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Hum Genet 62:277-85. 1998
    ..The observations indicate that TSC1 mutations are all inactivating, suggest that TSC1 disease occurs in only 15-20% of the sporadic TSC population, and demonstrate that presymptomatic TSC does occur...
  45. ncbi request reprint Novel mutations detected in the TSC2 gene from both sporadic and familial TSC patients
    P J Wilson
    Molecular Neurogenetics Unit, MGH East, Charlestown, MA 02129, USA
    Hum Mol Genet 5:249-56. 1996
    ..These data confirm that TSC2 is indeed the relevant gene, and that a substantial number of sporadic cases arise from mutations in the TSC2 gene...
  46. pmc Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
    S L Dabora
    Genetics Laboratory, Division of Hematology, Brigham and Women s Hospital, Boston, MA, 02115, USA
    Am J Hum Genet 68:64-80. 2001
    ....
  47. pmc Somatic mosaicism is rare in unaffected parents of patients with sporadic tuberous sclerosis
    P S Roberts
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Med Genet 41:e69. 2004
  48. ncbi request reprint Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1
    E P Henske
    Division of Experimental Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Hum Genet 59:25-37. 1995
    ..VAV2 is likely to serve a similar role more generally in mammalian cells, but is not the TSC1 gene...
  49. ncbi request reprint Immunohistochemical and microscopic studies on giant cells in tuberous sclerosis
    J Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Poland
    Histol Histopathol 20:1321-6. 2005
    ..We conclude that giant cells in cortical tubers and SEGAs are the same undifferentiated cells that, depending on individual determination, can show neural or glial features...