Przemysław Rutkowski

Summary

Country: Poland

Publications

  1. ncbi request reprint Relationship between uremic toxins and oxidative stress in patients with chronic renal failure
    Przemyslaw Rutkowski
    Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    Scand J Urol Nephrol 41:243-8. 2007
  2. ncbi request reprint [Clinical and metabolic consequences of uremic toxicity]
    Przemysław Rutkowski
    Klinika Nefrologii Transplantologii i Chorób, Wewnetrznych Akademii Medycznej w Gdarsku
    Przegl Lek 63:209-17. 2006
  3. ncbi request reprint Are so-called uremic toxins always toxic?
    Przemysław Rutkowski
    Department of Nephrology, Transplantation, and Internal Diseases, Medical University, Gdansk, Poland
    J Ren Nutr 18:7-11. 2008
  4. ncbi request reprint Nicotinamide metabolites accumulate in the tissues of uremic rats
    Przemysław Rutkowski
    Department of Nephrology, Transplantation, and Internal Diseases, Medical University Gdansk, Gdansk, Poland
    J Ren Nutr 18:56-9. 2008
  5. ncbi request reprint Interrelationship between uremic toxicity and oxidative stress
    Przemysław Rutkowski
    Department of Nephrology, Transplantology, and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    J Ren Nutr 16:190-3. 2006
  6. ncbi request reprint Low-dose dual blockade of the renin-angiotensin system in patients with primary glomerulonephritis
    Przemyslaw Rutkowski
    Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Am J Kidney Dis 43:260-8. 2004
  7. doi request reprint Dual blockade of the renin-angiotensin-aldosterone system with high-dose angiotensin-converting enzyme inhibitor for nephroprotection: an open, controlled, randomized study
    Leszek Tylicki
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Scand J Urol Nephrol 42:381-8. 2008
  8. doi request reprint The effect of N-acetylcysteine on proteinuria and markers of tubular injury in non-diabetic patients with chronic kidney disease. A placebo-controlled, randomized, open, cross-over study
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Kidney Blood Press Res 31:404-10. 2008
  9. doi request reprint Aliskiren and perindopril reduce the levels of transforming growth factor-β in patients with non-diabetic kidney disease
    Sławomir Lizakowski
    Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Am J Hypertens 25:636-9. 2012
  10. ncbi request reprint The effect of N-acetylcysteine on blood pressure and markers of cardiovascular risk in non-diabetic patients with chronic kidney disease: a placebo-controlled, randomized, cross-over study
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Med Sci Monit 16:PI13-8. 2010

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Relationship between uremic toxins and oxidative stress in patients with chronic renal failure
    Przemyslaw Rutkowski
    Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    Scand J Urol Nephrol 41:243-8. 2007
    ..The aim of this study was to elucidate potential relationships between N-methyl-2-pyridone-5-carboxamide (Me2PY) and N-methyl-4-pyridone-5-carboxamide (Me4PY), two uremic compounds, and different parameters of oxidative stress...
  2. ncbi request reprint [Clinical and metabolic consequences of uremic toxicity]
    Przemysław Rutkowski
    Klinika Nefrologii Transplantologii i Chorób, Wewnetrznych Akademii Medycznej w Gdarsku
    Przegl Lek 63:209-17. 2006
    ..Toxic action of several molecules described below is still not proved; however there are some ongoing studies aimed to find pathophysiological links between old and new described uremic toxins...
  3. ncbi request reprint Are so-called uremic toxins always toxic?
    Przemysław Rutkowski
    Department of Nephrology, Transplantation, and Internal Diseases, Medical University, Gdansk, Poland
    J Ren Nutr 18:7-11. 2008
    ..We followed these properties on the example of N-methyl-2-pyridone-5-carboxamide (Met2PY) from the nicotinamide end-products family. The aim of this study was to determine if these uremic compounds are toxic in all circumstances...
  4. ncbi request reprint Nicotinamide metabolites accumulate in the tissues of uremic rats
    Przemysław Rutkowski
    Department of Nephrology, Transplantation, and Internal Diseases, Medical University Gdansk, Gdansk, Poland
    J Ren Nutr 18:56-9. 2008
    ..The aim of this study was to establish whether the observed high concentrations of these compounds were also present in different tissues of uremic animals...
  5. ncbi request reprint Interrelationship between uremic toxicity and oxidative stress
    Przemysław Rutkowski
    Department of Nephrology, Transplantology, and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    J Ren Nutr 16:190-3. 2006
    ..Nevertheless, further complex studies are needed to elucidate closer pathogenic links...
  6. ncbi request reprint Low-dose dual blockade of the renin-angiotensin system in patients with primary glomerulonephritis
    Przemyslaw Rutkowski
    Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Am J Kidney Dis 43:260-8. 2004
    ..We compared the concomitant use of benazepril, 5 mg, and losartan, 25 mg, and monotherapy with these agents in doses 2-fold greater...
  7. doi request reprint Dual blockade of the renin-angiotensin-aldosterone system with high-dose angiotensin-converting enzyme inhibitor for nephroprotection: an open, controlled, randomized study
    Leszek Tylicki
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Scand J Urol Nephrol 42:381-8. 2008
    ..To improve renal outcome one may consider using increased dosages of ACEI above those usually recommended for hypertension...
  8. doi request reprint The effect of N-acetylcysteine on proteinuria and markers of tubular injury in non-diabetic patients with chronic kidney disease. A placebo-controlled, randomized, open, cross-over study
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Kidney Blood Press Res 31:404-10. 2008
    ..There is still no optimal therapy which can stop the progression of chronic kidney disease. Antioxidants such as N-acetylcysteine (NAC) have been reported as a promising strategy in this field...
  9. doi request reprint Aliskiren and perindopril reduce the levels of transforming growth factor-β in patients with non-diabetic kidney disease
    Sławomir Lizakowski
    Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Am J Hypertens 25:636-9. 2012
    ....
  10. ncbi request reprint The effect of N-acetylcysteine on blood pressure and markers of cardiovascular risk in non-diabetic patients with chronic kidney disease: a placebo-controlled, randomized, cross-over study
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Med Sci Monit 16:PI13-8. 2010
    ..Antioxidants, e.g., N-acetylcysteine (NAC), have been suggested as a promising medicament in this field...
  11. pmc Effect of aliskiren on proteinuria in non-diabetic chronic kidney disease: a double-blind, crossover, randomised, controlled trial
    Sławomir Lizakowski
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Int Urol Nephrol 44:1763-70. 2012
    ..To evaluate the proteinuria-lowering effect of a renin inhibitor (aliskiren), compared to placebo and to an angiotensin-converting enzyme inhibitor (perindopril), in patients with non-diabetic chronic kidney disease...
  12. doi request reprint Cellular toxicity of nicotinamide metabolites
    Bolesław Rutkowski
    Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    J Ren Nutr 22:95-7. 2012
    ..Therefore, we hypothesized that 4PYR, as a toxic compound, was actively absorbed by erythrocytes and metabolized to the 4PYMP and 4PYTP, which may interfere with function and life span of these cells...
  13. doi request reprint Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial
    Leszek Tylicki
    Department of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Am J Kidney Dis 52:486-93. 2008
    ....
  14. ncbi request reprint Renoprotective effect of small doses of losartan and enalapril in patients with primary glomerulonephritis. Short-term observation
    Leszek Tylicki
    Department of Nephrology, Medical University of Gdansk, Poland
    Am J Nephrol 22:356-62. 2002
    ..However, there is lack of data concerning renoprotective action of very small doses of these drugs...
  15. ncbi request reprint Safety of enhanced renin-angiotensin-aldosterone system inhibition with aliskiren in nondiabetic patients with chronic kidney disease
    SÅ‚awomir Lizakowski
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland
    Pol Arch Med Wewn 123:221-7. 2013
    ..Therapies involving direct renin inhibitor, aliskiren, may promote renal fibrosis by stimulating (pro)renin receptor due to increased renin levels...
  16. ncbi request reprint Atorvastatin improves tubular status in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Poland
    Acta Biochim Pol 57:547-52. 2010
    ..A number of experimental models demonstrate a beneficial effect of statins in ameliorating renal damage. However, the exact mechanism by which statins protect against renal damage remains unclear...
  17. ncbi request reprint Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Acta Biochim Pol 57:119-23. 2010
    ..Pentoxifylline (PTE) is a non-specific phosphodiesterase inhibitor with anti-inflammatory properties. It has been reported to have promising effects in CKD treatment...
  18. ncbi request reprint Randomized, controlled study of the effects of losartan versus enalapril in small doses on proteinuria and tubular injury in primary glomerulonephritis
    Leszek Tylicki
    Department of Nephrology, Medical University of Gdansk, 80 211 Gdansk, Poland
    Med Sci Monit 11:PI31-7. 2005
    ..The aim of this study was to evaluate the effects of low-dose (25 mg) losartan on proteinuria and tubular injury extent...
  19. doi request reprint Distribution of purine nucleotides in uremic fluids and tissues
    Bolesław Rutkowski
    Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    J Ren Nutr 20:S7-10. 2010
    ..Summarizing, end products of the nicotinamide family are members of uremic toxins; however, exact pathophysiological role of these compounds in the development of uremic syndrome needs further studies...
  20. ncbi request reprint Disturbances of purine nucleotide metabolism in uremia
    Bolesław Rutkowski
    Department of Nephrology, Transplantology and Internal Medicine, Medical University, Gdansk, Poland
    Semin Nephrol 24:479-83. 2004
    ..Our findings suggest that 2PY could be a novel uremic toxin. Disturbances of nucleotide metabolism are one of the important components of uremic syndrome...
  21. doi request reprint The enhanced renin-angiotensin-aldosteron system pharmacological blockade--which is the best?
    Leszek Tylicki
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Poland
    Kidney Blood Press Res 36:335-43. 2012
    ..The aim was to compare the effects on albuminuria of the therapy with either: (i) telmisartan 80 mg and aliskiren 300 mg, (ii) telmisartan 80 mg and eplerenone 50 mg, (iii) telmisartan 160 mg as monotherapy...
  22. ncbi request reprint Activities of lipogenic enzymes in subcutaneous adipose tissue are not increased in patients with chronic kidney failure
    Wojciech Wołyniec
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Pol Arch Med Wewn 123:45-50. 2013
    ..Previous studies performed in our center has provided evidence that lipogenesis is increased in the animal model of ESRD. ..
  23. ncbi request reprint [Alcohol dependent patients in family doctor's practice in Gdańsk]
    Zygmunt Chodorowski
    I Klinika Chorób Wewnetrznych i Ostrych Zatruć, Akademii Medycznej w Gdansku
    Przegl Lek 61:307-9. 2004
    ..It seems that there is an urgent need to provide further education for general practitioners and make better use of the existing structures engaged in the diagnosis and therapy of alcohol abusers...
  24. ncbi request reprint [Preparedness of Pomeranian Region hospitals for a possible attack with chemical weapons]
    Zygmunt Chodorowski
    I Klinika Chorób Wewnetrznych i Ostrych Zatruć, Akademii Medycznej w Gdansku
    Przegl Lek 61:359-60. 2004
    ..It is important to make bank of antidotes which could be placed in the regional poison control centres. All these procedures could be carried out without too much expenditure...
  25. ncbi request reprint [Pentoxifylline old drug or new hope for nephrology?]
    Marcin Renke
    Katedra i Klinika Nefrologii Transplantologii i Chorób Wewnetrznych Akademia Medyczna, Gdansk
    Przegl Lek 65:358-61. 2008
    ..This may occur due to inhibition of proinflammatory cytokine production. Probably in the next few years we will get answer to the question of PTF role in nephrology...
  26. ncbi request reprint [Clinical state of a patient with nephrotic proteinuria successfully treated with combined therapy with angiotensin II receptor antagonists and angiotensin II converting enzyme inhibitors and pentoxifylline]
    Marcin Renke
    Katedra i Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych AM, Gdansk 80 211, ul Debinki 7
    Przegl Lek 65:312-4. 2008
    ..8 g, serum creatinine was 1.4 mg/dl and potassium 5.4 mmol/l. Next PTF 800 mg/day was added and DPE fell to 0.55 g after 2 months' therapy. Similar DPE was after 6 months (0.53 g) since we started with combination of IKA, ARA and PTF...
  27. ncbi request reprint [Renal replacement therapy in the elderly patients in the Gdansk Pomeranian region]
    Bolesław Rutkowski
    Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych Akademii Medycznej, 80 211 Gdansk, ul Debinki 7
    Przegl Lek 59:234-8. 2002
    ..Increasing number of patients with diabetic nephropathy and in advanced age will require great effort both from nephrological community and health care system...
  28. ncbi request reprint [Heart and kidneys]
    Bolesław Rutkowski
    Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych Akademii Medycznej w Gdańsku
    Przegl Lek 62:3-6. 2005
    ..So the main important issue is early prevention and after recognition of their existence early specific therapy...
  29. ncbi request reprint Low-dose angiotensin II receptor antagonists and angiotensin II-converting enzyme inhibitors alone or in combination for treatment of primary glomerulonephritis
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Scand J Urol Nephrol 38:427-33. 2004
    ..Clinical data comparing the renal effects of ACEIs and ARBs, either singly or in combination, are scarce and usually concern the use of standard or high doses...
  30. ncbi request reprint Methylenetetrahydrofolate reductase gene polymorphisms in essential hypertension relation: with the development of hypertensive end-stage renal disease
    Leszek Tylicki
    Department of Nephrology, Transplantology and Internal Medicine Medical University of Gdansk, Gdansk, Poland
    Am J Hypertens 18:1442-8. 2005
    ....
  31. ncbi request reprint Low-dose dual blockade of the renin-angiotensin system improves tubular status in non-diabetic proteinuric patients
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Scand J Urol Nephrol 39:511-7. 2005
    ..This therapeutic strategy is not used for proteinuric patients who are not able to receive high doses of angiotensin-converting enzyme inhibitor or angiotensin II receptor antagonists...
  32. ncbi request reprint Smoking as a risk factor for renal injury in essential hypertension
    Leszek Tylicki
    Department of Nephrology Transplantology and Internal Medicine, Medical University, Gdansk, Poland
    Nephron Clin Pract 103:c121-8. 2006
    ..The dependence of kidney lesions on the 'extent' of smoking was determined as well...
  33. doi request reprint Effects of renal-specific oral supplementation in malnourished hemodialysis patients
    Sylwia Małgorzewicz
    Department of Clinical Nutrition, Medical University of Gdansk, Gdansk, Poland
    J Ren Nutr 21:347-53. 2011
    ..The aim of the present study was to estimate the influence of oral supplementation on the nutritional status of malnourished hemodialysis (HD) patients depending on the existence of an inflammatory state...
  34. ncbi request reprint Short-term effects of angiotensin II receptor blockade in patients with primary glomerulonephritis: pilot study
    Leszek Tylicki
    Department of Nephrology, Transplantology and Internal Medicine, Medical University, Gdansk, Poland
    J Ren Nutr 12:122-5. 2002
    ..The aim of the present study was to investigate renal and metabolic effects of specific AT-1 receptor blocker-losartan in patients with primary glomerulonephritis...
  35. ncbi request reprint Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure
    Ewa M Slominska
    Department of Biochemistry, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Pediatr Nephrol 21:800-6. 2006
    ..NAD metabolites could be particularly harmful in children due to higher DNA turnover than in adults...
  36. ncbi request reprint Renal disease in obesity: the need for greater attention
    Przemyslaw Rutkowski
    Department of Nephrology, Transplantology, and Internal Diseases, Medical University of Gdansk, Poland
    J Ren Nutr 16:216-23. 2006
    ..In the presence of glomerulopathy and/or hypertension, angiotensin converting enzyme inhibitors or angiotensin II type I receptor blockers are the drugs of choice to improve glomerular hyperfiltration...
  37. ncbi request reprint The age-related increase in N-methyl-2-pyridone-5-carboxamide (NAD catabolite) in human plasma
    Ewa M Slominska
    Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
    Mol Cell Biochem 267:25-30. 2004
    ..This could be a consequence of both decreased renal excretion and increased production in the the liver or other organs. Our results indicate that age should be taken into consideration in the interpretation of plasma 2PY concentration...
  38. ncbi request reprint Mechanisms of enhanced carbohydrate and lipid metabolism in adipose tissue in uremia
    Marek Szolkiewicz
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    J Ren Nutr 15:166-72. 2005
    ..The background is partially determined, however, our knowledge in this matter is not yet satisfactory...