Zbigniew Rudzki

Summary

Country: Poland

Publications

  1. ncbi request reprint High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    Susan Branford
    Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 99:3472-5. 2002
  2. ncbi request reprint Low-level microsatellite instability colorectal carcinomas: do they really belong to a "gray zone" between high-level microsatellite instability and microsatellite-stable cancers?
    Zbigniew Rudzki
    Department of Clinical and Experimental Pathomorphology, Collegium Medicum, Jagiellonian University, Grzegorzecka 16, 30 124 Cracow, Poland
    Int J Colorectal Dis 18:216-21. 2003
  3. ncbi request reprint Enzyme replacement therapy reduces Gaucher cell burden but may accelerate osteopenia in patients with type I disease - a histological study
    Zbigniew Rudzki
    Departments of Pathomorphology and Hematology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Eur J Haematol 70:273-81. 2003
  4. ncbi request reprint ALK-positive diffuse large B-cell lymphoma: two more cases and a brief literature review
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 56:37-45. 2005
  5. ncbi request reprint Adequacy of trephine bone marrow biopsies: the doctor and the patient make a difference
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 56:187-95. 2005
  6. ncbi request reprint Objective, planimetry-based assessment of megakaryocyte histological pictures in Philadelphia-chromosome-negative chronic myeloproliferative disorders: a perspective for a valuable adjunct diagnostic tool
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Grzegorzecka 16, 31 531 Cracow, Poland
    Virchows Arch 448:59-67. 2006
  7. ncbi request reprint [Hypopituitarism and hematological abnormalities mimicking myelodysplastic syndrome. Report of four cases]
    Zbigniew Rudzki
    Katedra Patomorfologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
    Pol Arch Med Wewn 110:1003-11. 2003
  8. ncbi request reprint Chronic myeloproliferative diseases on a pathologist's desk--a dilemma of distinct entities versus a clinico-pathologic continuum. A descriptive study based on a material from the Polish population
    Zbigniew Rudzki
    Department of Clinical and Experimental Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 55:13-23. 2004
  9. ncbi request reprint The gain-of-function JAK2 V617F mutation shifts the phenotype of essential thrombocythemia and chronic idiopathic myelofibrosis to more "erythremic" and less "thrombocythemic": a molecular, histologic, and clinical study
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Int J Hematol 86:130-6. 2007
  10. ncbi request reprint Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Cracow, Poland
    Int J Colorectal Dis 17:161-70. 2002

Collaborators

Detail Information

Publications30

  1. ncbi request reprint High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    Susan Branford
    Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 99:3472-5. 2002
    ..Certain mutations may respond to higher doses of imatinib, whereas other mutations may mandate switching to another therapeutic strategy...
  2. ncbi request reprint Low-level microsatellite instability colorectal carcinomas: do they really belong to a "gray zone" between high-level microsatellite instability and microsatellite-stable cancers?
    Zbigniew Rudzki
    Department of Clinical and Experimental Pathomorphology, Collegium Medicum, Jagiellonian University, Grzegorzecka 16, 30 124 Cracow, Poland
    Int J Colorectal Dis 18:216-21. 2003
    ..Colorectal carcinomas demonstrating low-level microsatellite instability (MSI-L) may form a distinct group differing both from high-level MSI (MSI-H) and microsatellite-stable (MSS) tumors...
  3. ncbi request reprint Enzyme replacement therapy reduces Gaucher cell burden but may accelerate osteopenia in patients with type I disease - a histological study
    Zbigniew Rudzki
    Departments of Pathomorphology and Hematology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Eur J Haematol 70:273-81. 2003
    ..The clinical significance of this phenomenon remains to be established. Its mechanism may be linked to increased osteolytic activity exerted directly or indirectly by regenerating hemopoietic cells...
  4. ncbi request reprint ALK-positive diffuse large B-cell lymphoma: two more cases and a brief literature review
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 56:37-45. 2005
    ..Genetic studies showed that the majority of ALK+DLBCL cases are characterized by the clathrin (CLTC)-ALK fusion and in a few cases the NPM-ALK rearrangement has been found...
  5. ncbi request reprint Adequacy of trephine bone marrow biopsies: the doctor and the patient make a difference
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 56:187-95. 2005
    ..Prior to the biopsy it is possible to estimate the level of difficulty posed by an individual patient and use this information to minimize the risk of obtaining an inadequate core...
  6. ncbi request reprint Objective, planimetry-based assessment of megakaryocyte histological pictures in Philadelphia-chromosome-negative chronic myeloproliferative disorders: a perspective for a valuable adjunct diagnostic tool
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Grzegorzecka 16, 31 531 Cracow, Poland
    Virchows Arch 448:59-67. 2006
    ..Objective measurements of megakaryocyte sizes and shapes may assist the diagnosis of Ph- CMPDs...
  7. ncbi request reprint [Hypopituitarism and hematological abnormalities mimicking myelodysplastic syndrome. Report of four cases]
    Zbigniew Rudzki
    Katedra Patomorfologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
    Pol Arch Med Wewn 110:1003-11. 2003
    ..Detailed bone marrow examination, including the trephine bone marrow biopsy, is useful in differentiation with true MDS, which was also reported in the literature in the patients with pituitary insufficiency...
  8. ncbi request reprint Chronic myeloproliferative diseases on a pathologist's desk--a dilemma of distinct entities versus a clinico-pathologic continuum. A descriptive study based on a material from the Polish population
    Zbigniew Rudzki
    Department of Clinical and Experimental Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 55:13-23. 2004
    ..A special attention should be paid to the CMPD-U group. Its current nosological status (early phases of IMF/ET/PV or distinct entity or entities?) is still unclear and requires further research...
  9. ncbi request reprint The gain-of-function JAK2 V617F mutation shifts the phenotype of essential thrombocythemia and chronic idiopathic myelofibrosis to more "erythremic" and less "thrombocythemic": a molecular, histologic, and clinical study
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Int J Hematol 86:130-6. 2007
    ..The JAK2 V617F mutation is prevalent in all Ph- MPD and may skew their presenting phenotype, including bone marrow histology, toward a more "erythremic" and less "thrombocythemic" phenotype...
  10. ncbi request reprint Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Cracow, Poland
    Int J Colorectal Dis 17:161-70. 2002
    ..The findings might be compatible with the loss of importance of the microsatellite instability of the carcinogenic pathway...
  11. ncbi request reprint CDX-2 expression is reduced in colorectal carcinomas with solid growth pattern and proximal location, but is largely independent of MSI status
    Krzysztof Okon
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Grzegorzecka, Krakow
    Pol J Pathol 55:9-14. 2004
    ..The results suggest that the major factors that determine the presence of CDX-2 in colorectal carcinomas at the protein product level may include cancer location and the solid phenotype of the tumor...
  12. ncbi request reprint Generalized crystal-storing histiocytosis as a presentation of multiple myeloma: a case with a possible pro-aggregation defect in the immunoglobulin heavy chain
    Bolesław Papla
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Grzegorzecka 16, 31 531, Krakow, Poland
    Virchows Arch 445:83-9. 2004
    ..Massive accumulation of crystal-storing histiocytes surpassed the myeloma tumor burden and markedly contributed to the severity of the disease...
  13. ncbi request reprint Clonal lymphocytic populations in Philadelphia-negative chronic myeloproliferative disorders: is the T-cell clonality of 'undetermined' significance (TCUS) linked to a worse clinical outcome?
    Anastazja Stój
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Leuk Lymphoma 47:2351-8. 2006
    ..This surprising negative prognostic impact of lymphocyte clonality in Ph-MPD may result from this phenomenon to be a better measure of the 'hematopoietic biologic age' than the metrical age itself...
  14. ncbi request reprint Fatal post-transplant lymphoproliferative disorder following allogeneic bone marrow transplantation for aplastic anemia
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 53:35-40. 2002
    ..The patient died on the 65th day of multiple organ failure. We discuss the diagnostics and management of PTLD in the setting of bone marrow transplantation...
  15. ncbi request reprint Synchronous serrated adenoma of the appendix and high-grade ovarian carcinoma: a case demonstrating different origin of the two neoplasms
    Zbigniew Rudzki
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 53:29-34. 2002
    ..To the best of our knowledge this is the first report of synchronous serrated adenoma of the appendix and ovarian carcinoma...
  16. pmc Familial occurrence of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome
    Maciej Siedlar
    Department of Clinical Immunology, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Wielicka 265, 30 663 Cracow, Poland
    Arch Immunol Ther Exp (Warsz) 56:419-25. 2008
    ..Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare immunodeficiency disorder with an autosomal-dominant pattern of inheritance and low fatality rate but significant lifelong morbidity...
  17. ncbi request reprint ABL-kinase domain point mutation as a cause of imatinib (STI571) resistance in CML patient who progress to myeloid blast crisis
    Tomasz Sacha
    Department of Haematology, Jagiellonian University Medical College, Cracow, Poland
    Leuk Res 27:1163-6. 2003
    ..Additionally, clonal evolution could lead to BCR-ABL-independent proliferation. Early detection of ABL-kinase mutation could predict the progression of CML treated with imatinib...
  18. ncbi request reprint EBV-positive gastric carcinomas in Poland
    Jacek P Czopek
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 54:123-8. 2003
    ..In our series EBV has been detected in five cases of forty (12.5%) gastric carcinomas. It may indicate that Poland is one of the countries with the highest EBV-induced gastric carcinoma incidence worldwide...
  19. ncbi request reprint Pure red cell aplasia due to treatment with epoietin beta: first case report of PRCA from Poland
    Władysław Sułowicz
    Department of Nephrology, Jagiellonian University, Cracow, Poland
    Przegl Lek 63:810-4. 2006
    ..In the last section of the paper the current epidemiological, diagnostic and therapeutic aspect of PRCA were discussed...
  20. ncbi request reprint BCR-ABL messenger RNA levels continue to decline in patients with chronic phase chronic myeloid leukemia treated with imatinib for more than 5 years and approximately half of all first-line treated patients have stable undetectable BCR-ABL using strict se
    Susan Branford
    Institute of Medical and Veterinary Science, Adelaide, Australia
    Clin Cancer Res 13:7080-5. 2007
    ..We determined whether BCR-ABL continues to decline with longer imatinib exposure and the incidence and consequence of undetectable BCR-ABL...
  21. ncbi request reprint [Concomitant myeloid sarcoma and plasma cell myeloma--case report of a hitherto undescribed association of two neoplasms]
    Alicja Nowakowska-Kopera
    Uniwersytet Jagielloński w Krakowie, Collegium Medicum, Katedra i Klinika Hematologii
    Pol Merkur Lekarski 23:120-3. 2007
    ..While the association of plasma cell myeloma and various myeloid leukaemias is well documented, this is a first report of simultaneous occurrence of a myeloma and a myeloid sarcoma...
  22. ncbi request reprint Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations
    Susan Branford
    Division of Molecular Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 104:2926-32. 2004
    ..0001. Thus, a more than 2-fold rise identified 34 (97%) of 35 patients with a mutation. We conclude that a rise in BCR-ABL of more than 2-fold can be used as a primary indicator to test patients for BCR-ABL kinase domain mutations...
  23. ncbi request reprint Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    Susan Branford
    Division of Molecular Pathology, Institute of Medical and Veterinary Science, South Australia 5000, Australia
    Blood 102:276-83. 2003
    ..0001. In conclusion, the detection of kinase domain mutations using a direct sequencing technique was almost always associated with imatinib resistance, and patients with mutations in the P-loop had a particularly poor prognosis...
  24. ncbi request reprint Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    Tim P Hughes
    Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    N Engl J Med 349:1423-32. 2003
    ..We measured levels of BCR-ABL transcripts in the blood of all patients in this trial who had a complete cytogenetic remission...
  25. ncbi request reprint High prevalence of non-Hodgkin's lymphomas in Polish population--1106 new cases diagnosed according to WHO classification in only one district
    Wojciech Jurczak
    Department of Hematology, Collegium Medicum Jagiellonian University, Krakow
    Pol J Pathol 57:45-52. 2006
    ..The present report indicate the lymphomas become growing diagnostic and clinical challenge, as they place among the most frequent neoplasms in population...
  26. pmc The JAK2 V617F mutation is frequently present in buccal swabs from patients suffering from Philadelphia-negative chronic myeloproliferative disorders, who carry the mutation detected in bone marrow or peripheral blood cells [corrected]
    Anastazja Stój
    J Clin Pathol 60:1070-1. 2007
  27. ncbi request reprint Dual transcription of b2a2 and b3a2 BCR-ABL transcripts in chronic myeloid leukaemia is confined to patients with a linked polymorphism within the BCR gene
    Susan Branford
    Division of Molecular Pathology, Institute of Medical and Veterinary Science, Box 14, Rundle Mall, Adelaide, SA 5000, Australia
    Br J Haematol 117:875-7. 2002
    ..We conclude that the BCR intronic polymorphism is associated with activation of a cryptic branchpoint resulting in reduced efficiency of RNA splicing and exon 14 (b3) skipping in BCR and BCR-ABL...
  28. ncbi request reprint Idiopathic myelofibrosis with fatty bone marrow: an issue of sampling? A propos an unusual case
    Zbigniew Rudzki
    Haematologica 88:ELT05. 2003
  29. doi request reprint A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family
    Kun Liu
    Department of Biomedicine, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
    Haematologica 93:706-14. 2008
    ..Germline mutations in families with hereditary thrombocythemia have been identified in the gene for thrombopoietin (TPHO) and its receptor, MPL...
  30. doi request reprint Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials
    Susan Branford
    Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 112:3330-8. 2008
    ..This indicates that the IS can deliver accurate comparison of molecular response rates between clinical trials when measured by different laboratories...