Ryszard Przewlocki

Summary

Country: Poland

Publications

  1. pmc Morphine effects on striatal transcriptome in mice
    Michal Korostynski
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Smetna 12, 31 343, Krakow, Poland
    Genome Biol 8:R128. 2007
  2. ncbi request reprint Pain inhibition by endomorphins
    R Przewłocki
    Department of Molecular Neuropharmacology, Polish Academy of Sciences, Krakow, Poland
    Ann N Y Acad Sci 897:154-64. 1999
  3. ncbi request reprint Opioid abuse and brain gene expression
    Ryszard Przewlocki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 500:331-49. 2004
  4. ncbi request reprint Opioids in neuropathic pain
    Ryszard Przewlocki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, 12 Smetna Street, 31 343 Krakow, Poland
    Curr Pharm Des 11:3013-25. 2005
  5. ncbi request reprint Opioids in chronic pain
    R Przewłocki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 429:79-91. 2001
  6. doi request reprint Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain
    Ilona Obara
    Department of Pain Pharmacology, Institute of Pharmacology PAS, Smetna 12, 31 343 Krakow, Poland
    Pain 141:283-91. 2009
  7. pmc The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum
    Marcin Piechota
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Smetna 12, Krakow, 31 343, Poland
    Genome Biol 11:R48. 2010
  8. doi request reprint Motivational effects of opiates in conditioned place preference and aversion paradigm--a study in three inbred strains of mice
    Wojciech Solecki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Science, 12 Smetna Street, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 207:245-55. 2009
  9. doi request reprint Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity
    Agnieszka Gieryk
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 208:291-300. 2010
  10. pmc Gene expression profiling of blood in ruptured intracranial aneurysms: in search of biomarkers
    Joanna Pera
    Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
    J Cereb Blood Flow Metab 33:1025-31. 2013

Collaborators

Detail Information

Publications33

  1. pmc Morphine effects on striatal transcriptome in mice
    Michal Korostynski
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Smetna 12, 31 343, Krakow, Poland
    Genome Biol 8:R128. 2007
    ....
  2. ncbi request reprint Pain inhibition by endomorphins
    R Przewłocki
    Department of Molecular Neuropharmacology, Polish Academy of Sciences, Krakow, Poland
    Ann N Y Acad Sci 897:154-64. 1999
    ..The most interesting finding is a strong effect of endomorphins in neuropathic pain, which opens up a possibility of using these compounds in pain therapy...
  3. ncbi request reprint Opioid abuse and brain gene expression
    Ryszard Przewlocki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 500:331-49. 2004
    ..The latter link in this chain of reactions may modify synthesis of target genes and in this manner, it may be responsible for opiate-induced long-lasting neural plasticity...
  4. ncbi request reprint Opioids in neuropathic pain
    Ryszard Przewlocki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, 12 Smetna Street, 31 343 Krakow, Poland
    Curr Pharm Des 11:3013-25. 2005
    ....
  5. ncbi request reprint Opioids in chronic pain
    R Przewłocki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 429:79-91. 2001
    ....
  6. doi request reprint Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain
    Ilona Obara
    Department of Pain Pharmacology, Institute of Pharmacology PAS, Smetna 12, 31 343 Krakow, Poland
    Pain 141:283-91. 2009
    ..The obtained results differentiate inflammatory and neuropathic pain and provide a novel insight into the peripheral effectiveness of opioids in both types of pain...
  7. pmc The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum
    Marcin Piechota
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Smetna 12, Krakow, 31 343, Poland
    Genome Biol 11:R48. 2010
    ..To reveal genes common and distinct for different classes of drugs of abuse, we compared the effects of nicotine, ethanol, cocaine, morphine, heroin and methamphetamine on gene expression profiles in the mouse striatum...
  8. doi request reprint Motivational effects of opiates in conditioned place preference and aversion paradigm--a study in three inbred strains of mice
    Wojciech Solecki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Science, 12 Smetna Street, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 207:245-55. 2009
    ..Yet, interstrain differences in the motivational effects of naloxone have not been described...
  9. doi request reprint Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity
    Agnieszka Gieryk
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 208:291-300. 2010
    ..A body of evidence suggests that endogenous opioid peptide systems may influence rewarding effects of addictive substances, and thus, their individual expression levels may contribute to drug abuse liability...
  10. pmc Gene expression profiling of blood in ruptured intracranial aneurysms: in search of biomarkers
    Joanna Pera
    Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
    J Cereb Blood Flow Metab 33:1025-31. 2013
    ..A specific pattern of these changes suggests suppression in lymphocyte response and enhancements in monocyte and neutrophil activities. This is probably related to the immunodepression observed in SAH. ..
  11. doi request reprint Interleukin-1 alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Pain 138:587-97. 2008
    ..Together with the antiallodynic and antihyperalgesic effects observed after IL-1alpha administration, this finding indicates an important role for IL-1alpha in the development of neuropathic pain symptoms...
  12. doi request reprint Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 623:65-72. 2009
    ..These findings implicate a glial regulation of the pain response and suggest that pharmacologically targeting microglia could effectively prevent clinical pain syndromes in programmed and/or anticipated injury...
  13. ncbi request reprint Spinal and local peripheral antiallodynic activity of Ro64-6198 in neuropathic pain in the rat
    Ilona Obara
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Pain 116:17-25. 2005
    ..Therefore, besides spinal, also peripheral ORL1 receptors may be targeted by drugs designed for the long-term treatment of chronic pain...
  14. doi request reprint Increased analgesic tolerance to acute morphine in fosB knock-out mice: a gender study
    Wojciech Solecki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Science, 12 Smetna Street, 31 343 Krakow, Poland
    Pharmacol Biochem Behav 90:512-6. 2008
    ..In conclusion, we show that fosB gene is important to analgesia but not hypothermia phenotype indicating its role in morphine effects...
  15. ncbi request reprint Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat
    Ilona Obara
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland
    Eur J Pharmacol 558:60-7. 2007
    ..Opioid drugs with peripheral site of action can be an important target for the treatment of long lasting pain...
  16. pmc Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes
    Michal Korostynski
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Cracow, Poland
    BMC Genomics 7:146. 2006
    ..In this study, we attempted to investigate the relationships between genetic background and basal gene expression profile in the striatum, a brain region involved in the mechanism of opioid action...
  17. ncbi request reprint Modulation of melanocortin-induced changes in spinal nociception by mu-opioid receptor agonist and antagonist in neuropathic rats
    Katarzyna Starowicz
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31 343 Cracow, Poland
    Neuroreport 13:2447-52. 2002
    ..In conclusion, it seems that the endogenous opioidergic system acts as a functional antagonist of melanocortinergic system, and mu-opioid receptor activity appears to be involved in the modulation of melanocortin system function...
  18. doi request reprint Regulation of ERK1/2 phosphorylation by acute and chronic morphine - implications for the role of cAMP-responsive element binding factor (CREB)-dependent and Ets-like protein-1 (Elk-1)-dependent transcription; small interfering RNA-based strategy
    Agnieszka Ligeza
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    FEBS J 275:3836-49. 2008
    ....
  19. ncbi request reprint Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats
    Jan Rodriguez Parkitna
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, 12 Smetna St, 31 343 Krakow, Poland
    J Pharmacol Exp Ther 319:832-9. 2006
    ..In conclusion, our data indicate that chronic morphine treatment activates a highly efficient pathway by means of which Cdk5 regulates GSK3beta activity...
  20. doi request reprint Alterations of prodynorphin gene expression in the rat mesocorticolimbic system during heroin self-administration
    Wojciech Solecki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Brain Res 1255:113-21. 2009
    ..These neuroalterations probably occur as an adaptation to long-lasting heroin exposure and may underlie changes leading to compulsive drug use and addiction...
  21. doi request reprint alpha-Synuclein expression in the brain and blood during abstinence from chronic alcohol drinking in mice
    Barbara Ziolkowska
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 54:1239-46. 2008
    ..Although alpha-synuclein expression in the blood seems unrelated to that in the brain, it may serve as a peripheral biomarker of chronic alcohol consumption...
  22. doi request reprint A polymorphism in exon 2 of the delta-opioid receptor affects nociception in response to specific agonists and antagonists in mice selectively bred for high and low analgesia
    Mariusz Sacharczuk
    Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 1 Postepu Str, Wolka Kosowska, Poland
    Pain 149:506-13. 2010
    ..Our results indicate that the C320T polymorphism in the delta-opioid receptor gene is at least partly responsible for the divergent nociceptive thresholds in HA and LA mice under both basal and post-stress conditions...
  23. ncbi request reprint Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats
    Katarzyna Starowicz
    Institute of Pharmacology, Polish Academy of Sciences, Department of Molecular Neuropharmacology, 12 Smetna Street, 31 343 Cracow, Poland
    Neurosci Lett 358:79-82. 2004
    ..The MC4-R adaptation in DRG observed in neuropathic rats indicates their important role in presynaptic modulation of activity of the primary afferents in neuropathic pain...
  24. doi request reprint Gene expression profiles in human ruptured and unruptured intracranial aneurysms: what is the role of inflammation?
    Joanna Pera
    Department of Neurology, Jagiellonian University, Krakow, Poland
    Stroke 41:224-31. 2010
    ..The majority of studies on human tissue have focused on predefined pathways. We sought to analyze global gene expression patterns of ruptured IA, unruptured IA, and control vessels...
  25. doi request reprint Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors
    Jan Rodriguez Parkitna
    Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Krakow, Poland
    Biol Psychiatry 73:263-70. 2013
    ..Here, we show that metabotropic glutamate receptor 5 (mGluR5) signaling on dopaminoceptive neurons is necessary for both novelty-seeking behavior and the abstinence-induced escalation of alcohol drinking...
  26. doi request reprint Astrocytes are a neural target of morphine action via glucocorticoid receptor-dependent signaling
    Michal Slezak
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Glia 61:623-35. 2013
    ..Identification of this mechanism opens new directions for research on the role of astrocytes in the central effects of opioids...
  27. ncbi request reprint Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice
    Barbara Ziolkowska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    J Neurosci 25:4996-5003. 2005
    ..The observed changes in alpha-synuclein levels are discussed in connection with their putative role in mediating suppression of dopaminergic neurotransmission during opiate withdrawal...
  28. ncbi request reprint Local peripheral effects of mu-opioid receptor agonists in neuropathic pain in rats
    Ilona Obara
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Neurosci Lett 360:85-9. 2004
    ..These results have shown that opioid peptides are effective also after local treatment, and that their peripheral use may be of therapeutic interest in long-term management of chronic pain...
  29. ncbi request reprint Knockdown of spinal opioid receptors by antisense targeting beta-arrestin reduces morphine tolerance and allodynia in rat
    Barbara Przewlocka
    Department of Molecular Neuropharmacology, Institute of Pharmacology, 12 Smetna Street, 31 343, Krakow, Poland
    Neurosci Lett 325:107-10. 2002
    ..g. receptor desensitization. Moreover, the antisense oligonucleotides targeting beta-arrestin may constitute a new approach to the therapy of neuropathic pain...
  30. doi request reprint Role of fosB in behaviours related to morphine reward and spatial memory
    Wojciech Solecki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Science, 12 Smetna Street, 31 343 Krakow, Poland
    Behav Brain Res 190:212-7. 2008
    ....
  31. ncbi request reprint Activation of AP-1 and CRE-dependent gene expression via mu-opioid receptor
    Wiktor Bilecki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Neurochem 90:874-82. 2004
    ..These results provide evidence that both single opioid administration and opioid withdrawal activate CREB and CRE-dependent transcriptional mechanisms via distinct intracellular signaling pathways...
  32. pmc Identification of cis-regulatory elements in the mammalian genome: the cREMaG database
    Marcin Piechota
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    PLoS ONE 5:e12465. 2010
    ..Our previous experience with microarray data led to the development of a database suitable for the examination of regulatory motifs in the promoters of co-expressed genes...
  33. ncbi request reprint Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat
    Susanna Furst
    Department of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Nagyvarad ter 4, P O Box 370, H 1445 Budapest, Hungary
    J Pharmacol Exp Ther 312:609-18. 2005
    ..Also, they might find clinical application when the central actions of opioids are unwanted...