Research Topics
| Jan WrzesinskiSummaryAffiliation: Polish Academy of Sciences Country: Poland Publications
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Detail Information
Publications
Characterization of structure and metal ions specificity of Co2+-binding RNA aptamersJan Wrzesinski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12 14, 61 704 Poznan, Poland
Biochemistry 44:6257-68. 2005..Among many factors that influence metal specificity of the Co(2+)-binding pocket, chemical properties of metal ions, such as their hardness as well as the structure of the coordination site, seem to be particularly important...- Inhibition of the catalytic activity of trans-acting antigenomic delta ribozyme by selected antibiotics and their Cu2+ complexesJan Wrzesinski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12 14, 61 704 Poznan, Poland
Biochem Biophys Res Commun 349:1394-400. 2006..These observations indicate that coordination of metal ions to antibiotics substantially changes their properties which might also have a biological relevance inside the cell... 
Structural basis for recognition of Co2+ by RNA aptamersJan Wrzesinski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12 14, Poznan, Poland
FEBS J 275:1651-62. 2008....- tRNAPhe cleavage by aminoglycosides is triggered off by formation of an abasic siteJan Wrzesinski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12 14, 61 704 Poznan, Poland
Biochem Biophys Res Commun 331:267-71. 2005..The results suggest that the phenomenon, previously considered as selective with respect to the presence of tRNA hypermodification, may concern far more RNA molecules, namely the ones carrying abasic sites... - DNA and RNA damage by Cu(II)-amikacin complexMałgorzata Jeżowska-Bojczuk
Faculty of Chemistry, University of Wrocław, Wrocław, Poland Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
Eur J Biochem 269:5547-56. 2002..The complex underwent autooxidation as well, with amikacin hydroperoxides as likely major products. This reactivity pattern was found to be due to a combination of metal-bound and free hydroxyl radicals... - Capreomycin and hygromycin B modulate the catalytic activity of the delta ribozyme in a manner that depends on the protonation and complexation with Cu2+ ions of these antibioticsMilena Szafraniec
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12 14, 61 704 Poznan, Poland
Dalton Trans 41:9728-36. 2012..Possibly, the amino functions of these antibiotics might be involved in a general acid-base catalysis performed by the ribozyme, acting as proton acceptors/donors... - Trans-acting antigenomic HDV ribozyme for production of in vitro transcripts with homogenous 3' endsMilena Szafraniec
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
Methods Mol Biol 941:99-111. 2012..The highest concentration of RNA substrate suggested for practical applications turns out to be 3 μM. The procedure is an alternative to the use of ribozymes as cis-cleaving autocatalytic cassettes attached to transcript 3' ends... - Translational and structural analysis of the shortest legume ENOD40 gene in Lupinus luteusJan Podkowinski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
Acta Biochim Pol 56:89-102. 2009..The differences between L. luteus and Glycine max ENOD40 RNA models suggest the possibility of a switch between two structural states of ENOD40 transcript... - Selection of RNA oligonucleotides that can modulate human dicer activity in vitroAgata Tyczewska
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
Nucleic Acid Ther 21:333-46. 2011..Moreover, we found that sequences similar to those of the selected oligomers can be found within the molecules composing human transcriptome...