Joanna M Wieronska

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. doi request reprint The reversal of cognitive, but not negative or positive symptoms of schizophrenia, by the mGlu₂/₃ receptor agonist, LY379268, is 5-HT₁A dependent
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland Electronic address
    Behav Brain Res 256:298-304. 2013
  2. pmc The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT₁A signalling
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Psychopharmacology (Berl) 227:711-25. 2013
  3. pmc Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 220:481-94. 2012
  4. doi request reprint On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice
    J M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 62:322-31. 2012
  5. doi request reprint Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Neuropharmacology 59:627-34. 2010
  6. doi request reprint GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology PAS, Krakow, Poland
    Brain Res 1334:12-24. 2010
  7. doi request reprint Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs
    Joanna M Wieronska
    Institute of Pharmacology PAS, Cracow, Poland
    Neurochem Int 55:85-97. 2009
  8. ncbi request reprint Olfactory bulbectomy and amitriptyline treatment influences mGlu receptors expression in the mouse brain hippocampus
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Science, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:844-55. 2008
  9. ncbi request reprint Citalopram influences mGlu7, but not mGlu4 receptors' expression in the rat brain hippocampus and cortex
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Science, 31 343, Krakow, Poland
    Brain Res 1184:88-95. 2007
  10. ncbi request reprint Anxiolytic action of group II and III metabotropic glutamate receptors agonists involves neuropeptide Y in the amygdala
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343, Krakow, Poland
    Pharmacol Rep 57:734-43. 2005

Collaborators

Detail Information

Publications31

  1. doi request reprint The reversal of cognitive, but not negative or positive symptoms of schizophrenia, by the mGlu₂/₃ receptor agonist, LY379268, is 5-HT₁A dependent
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland Electronic address
    Behav Brain Res 256:298-304. 2013
    ....
  2. pmc The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT₁A signalling
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Psychopharmacology (Berl) 227:711-25. 2013
    ..LSP1-2111, the group III mGlu receptor orthosteric agonist, with a high affinity towards mGlu4 receptors, was previously shown to exhibit antipsychotic-like action in animal models displaying positive symptoms of schizophrenia...
  3. pmc Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 220:481-94. 2012
    ..Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity...
  4. doi request reprint On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice
    J M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 62:322-31. 2012
    ..Therefore, it seems that the antagonism towards GABA(A) receptors, presynaptic 5-HT(1A) and postsynaptic 5-HT(2A/2C) receptors is responsible for the phenomenon. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  5. doi request reprint Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Neuropharmacology 59:627-34. 2010
    ..Moreover, the compound was not effective in 5-HT depleted animals. The results of these studies indicate that the GABAergic and serotonergic systems are involved in the potential anxiolytic action of LSP1-2111...
  6. doi request reprint GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology PAS, Krakow, Poland
    Brain Res 1334:12-24. 2010
    ..The results suggest that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA...
  7. doi request reprint Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs
    Joanna M Wieronska
    Institute of Pharmacology PAS, Cracow, Poland
    Neurochem Int 55:85-97. 2009
    ..At present, the most potent seem to be negative allosteric modulators of the first group (mGlu1 and mGlu5), and positive allosteric modulators of the second (mGlu2 and mGlu3) and third (mGlu4/7/8) group of mGlu receptors...
  8. ncbi request reprint Olfactory bulbectomy and amitriptyline treatment influences mGlu receptors expression in the mouse brain hippocampus
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Science, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:844-55. 2008
    ..The results obtained indicate an influence of OB on mGlu receptors levels in the hippocampus, and the OB-induced effect can be reversed by chronic AMI treatment in the case of mGlu1a, mGlu2/3 and mGlu7 receptors...
  9. ncbi request reprint Citalopram influences mGlu7, but not mGlu4 receptors' expression in the rat brain hippocampus and cortex
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Science, 31 343, Krakow, Poland
    Brain Res 1184:88-95. 2007
    ....
  10. ncbi request reprint Anxiolytic action of group II and III metabotropic glutamate receptors agonists involves neuropeptide Y in the amygdala
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343, Krakow, Poland
    Pharmacol Rep 57:734-43. 2005
    ..Our results indicate that the anxiolytic action of both compounds is conveyed by NPY neurons with the involvement of Y1 receptors in the amygdala, and that NPY neurons seem to be regulated by the glutamatergic system...
  11. ncbi request reprint In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 29:514-21. 2004
    ..Our results indicate that the anxiolytic action of MPEP is conveyed through NPY neurons with the involvement of Y1 receptors in the amygdala and that BZD receptors do not significantly contribute to these effects...
  12. ncbi request reprint Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist
    Agnieszka Pałucha
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Pharmacol Biochem Behav 81:901-6. 2005
    ..These data suggest that MTEP, which is considered to be a potential therapeutic agent, may play a role in the therapy of depression...
  13. ncbi request reprint Effects of GABAB receptor ligands in rodent tests of anxiety-like behavior
    Anna Partyka
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:757-62. 2007
    ..CGP 51176 (5 or 8 mg/kg) was inactive, while CGP 44532 (0.125 mg/kg) exhibited anxiogenic-like effect. These preclinical data further implicate GABA(B) receptor function in anxiety, and support the GABAergic hypothesis of this disorder...
  14. ncbi request reprint Involvement of CRF but not NPY in the anxiety regulation via NMDA receptors
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:1119-24. 2003
    ..Our results show that anxiogenic effect of NMDA is mediated via CRF1 receptors and anxiolytic action of MK-801 is not dependent on Y1 receptors...
  15. pmc The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4 receptors in rodents
    Anna Sławińska
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Br J Pharmacol 169:1824-39. 2013
    ....
  16. ncbi request reprint Interaction of zinc with antidepressants in the forced swimming test in mice
    Bernadeta Szewczyk
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343, Krakow, Poland
    Pol J Pharmacol 54:681-5. 2002
    ..The present data support the notion that inhibition of the NMDA receptor participates in an antidepressant action, and further demonstrate particular role of zinc in this activity...
  17. pmc On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039
    Agnieszka Pałucha-Poniewiera
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 212:523-35. 2010
    ..Although the antidepressant-like activity of MGS0039 and LY341495 is well documented, the mechanism of the antidepressant action of these compounds is still not clear...
  18. ncbi request reprint MPEP, mGlu5 receptor antagonist, regulates NPYmRNA expression in hippocampal and amygdalar neurons
    Maria Śmiałowska
    Laboratory of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:709-18. 2004
    ..The obtained results suggest a positive regulatory control of NPY synthesis by mGlu5 receptors in hippocampal and amygdalar neurons...
  19. doi request reprint Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu₄ receptor
    Anna Sławińska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Neuropharmacology 66:225-35. 2013
    ..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  20. doi request reprint Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test
    Piotr Branski
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Neural Transm 115:829-30. 2008
    ..This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator...
  21. ncbi request reprint The effect of intrahippocampal injection of group II and III metobotropic glutamate receptor agonists on anxiety; the role of neuropeptide Y
    Maria Śmiałowska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 32:1242-50. 2007
    ..It was observed that group III mGluRs and Y1 receptors were engaged in the response in the CA1 area, whereas group II mGluRs and Y2 receptors played a pivotal role in the DG region...
  22. ncbi request reprint Increase in synaptic hippocampal zinc concentration following chronic but not acute zinc treatment in rats
    Bernadeta Szewczyk
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL31 343 Krakow, Poland
    Brain Res 1090:69-75. 2006
    ..The measurement of zinc concentration in the whole hippocampus by the flame atomic absorption spectrometry method is not sensitive enough to detect such subtle alteration...
  23. doi request reprint The behavioural and electrophysiological effects of CRF in rat frontal cortex
    Barbara Zieba
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna Street 12, 31 343 Cracow, Poland
    Neuropeptides 42:513-23. 2008
    ..Moreover, the peptide inhibits locomotor and exploratory activity and depresses excitatory synaptic transmission in a NMDA receptor-dependent manner...
  24. ncbi request reprint Intraamygdaloid administration of BIBO 3304 increases water intake and extends anxiolytic effects
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:867-70. 2004
    ..Water consumption was measured 1, 2, 4, 6 and 24 h after drug administration. We found that water intake was increased both after 5-HTP and BIBO 3304 administration...
  25. ncbi request reprint Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats
    Gabriel Nowak
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Brain Res Bull 61:159-64. 2003
    ..These animal data further suggest antidepressant activity of zinc in human depression...
  26. ncbi request reprint Neuroprotective effect of NPY on kainate neurotoxicity in the hippocampus
    Maria Śmiałowska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:979-86. 2003
    ..The obtained results indicate neuroprotective action of NPY in some models of the kainate-induced hippocampal degeneration...
  27. ncbi request reprint Effect of some iono- and metabotropic glutamatergic ligands on neuropeptide Y immunoreactivity in the rat hippocampus
    Maria Śmiałowska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Pol J Pharmacol 54:723-6. 2002
    ..The obtained results indicate that glutamatergic metabotropic and NMDA receptors may regulate NPY expression in the hippocampus. This regulation may have some connection with modulation of anxiety by the studied compounds...
  28. doi request reprint Glutamate-based anxiolytic ligands in clinical trials
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Expert Opin Investig Drugs 22:1007-22. 2013
    ..On the other hand, decreasing the activity of glutamatergic neurotransmission may attenuate excitation in the CNS, thus resulting in anxiolysis...
  29. doi request reprint Glutamate-based antidepressants: preclinical psychopharmacology
    Andrzej Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Biol Psychiatry 73:1125-32. 2013
    ....
  30. ncbi request reprint Is the mGlu5 receptor a possible target for new antidepressant drugs?
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology Polish Academy of Sciences, Department of Neurobiology, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1506-11. 2013
    ..Here, we review data supporting the potential antidepressant activity of mGlu5 receptor antagonists as well as the involvement of mGlu5 receptors in the pathophysiology of depression. ..
  31. doi request reprint Changes in the NPY immunoreactivity in gerbil hippocampus after hypoxic and ischemic preconditioning
    Malgorzata Duszczyk
    Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, Warsaw 02 106, Poland
    Neuropeptides 43:31-9. 2009
    ..Although induced tolerance to ischemia 2 days after ischemic or hypoxic preconditioning was accompanied by increased immunoreactivity of NPY, there was no correlation between its intensity and the level of neuroprotection...