Research Topics
| Joanna M WieronskaSummaryAffiliation: Polish Academy of Sciences Country: Poland Publications
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Detail Information
Publications
Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophreniaJoanna M Wieronska
Institute of Pharmacology, Polish Academy of Sciences, 31 343, Krakow, Poland
Psychopharmacology (Berl) 220:481-94. 2012..Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity...
Citalopram influences mGlu7, but not mGlu4 receptors' expression in the rat brain hippocampus and cortexJoanna M Wieronska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Science, 31 343, Krakow, Poland
Brain Res 1184:88-95. 2007....
Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugsJoanna M Wieronska
Institute of Pharmacology PAS, Cracow, Poland
Neurochem Int 55:85-97. 2009..At present, the most potent seem to be negative allosteric modulators of the first group (mGlu1 and mGlu5), and positive allosteric modulators of the second (mGlu2 and mGlu3) and third (mGlu4/7/8) group of mGlu receptors...- GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampusJoanna M Wieronska
Department of Neurobiology, Institute of Pharmacology PAS, Krakow, Poland
Brain Res 1334:12-24. 2010..The results suggest that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA... - Anxiolytic action of group II and III metabotropic glutamate receptors agonists involves neuropeptide Y in the amygdalaJoanna M Wieronska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343, Krakow, Poland
Pharmacol Rep 57:734-43. 2005..Our results indicate that the anxiolytic action of both compounds is conveyed by NPY neurons with the involvement of Y1 receptors in the amygdala, and that NPY neurons seem to be regulated by the glutamatergic system... - Olfactory bulbectomy and amitriptyline treatment influences mGlu receptors expression in the mouse brain hippocampusJoanna M Wieronska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Science, Smetna 12, Pl 31 343 Krakow, Poland
Pharmacol Rep 60:844-55. 2008..The results obtained indicate an influence of OB on mGlu receptors levels in the hippocampus, and the OB-induced effect can be reversed by chronic AMI treatment in the case of mGlu1a, mGlu2/3 and mGlu7 receptors... - On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed miceJ M Wieronska
Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
Neuropharmacology 62:322-31. 2012..Therefore, it seems that the antagonism towards GABA(A) receptors, presynaptic 5-HT(1A) and postsynaptic 5-HT(2A/2C) receptors is responsible for the phenomenon. This article is part of a Special Issue entitled 'Anxiety and Depression'... - Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systemsJoanna M Wieronska
Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
Neuropharmacology 59:627-34. 2010..Moreover, the compound was not effective in 5-HT depleted animals. The results of these studies indicate that the GABAergic and serotonergic systems are involved in the potential anxiolytic action of LSP1-2111... - In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signalingJoanna M Wieronska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Neuropsychopharmacology 29:514-21. 2004..Our results indicate that the anxiolytic action of MPEP is conveyed through NPY neurons with the involvement of Y1 receptors in the amygdala and that BZD receptors do not significantly contribute to these effects... - Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonistAgnieszka Pałucha
Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
Pharmacol Biochem Behav 81:901-6. 2005..These data suggest that MTEP, which is considered to be a potential therapeutic agent, may play a role in the therapy of depression... - Effects of GABAB receptor ligands in rodent tests of anxiety-like behaviorAnna Partyka
Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
Pharmacol Rep 59:757-62. 2007..CGP 51176 (5 or 8 mg/kg) was inactive, while CGP 44532 (0.125 mg/kg) exhibited anxiogenic-like effect. These preclinical data further implicate GABA(B) receptor function in anxiety, and support the GABAergic hypothesis of this disorder... - Involvement of CRF but not NPY in the anxiety regulation via NMDA receptorsJoanna M Wieronska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
Pol J Pharmacol 55:1119-24. 2003..Our results show that anxiogenic effect of NMDA is mediated via CRF1 receptors and anxiolytic action of MK-801 is not dependent on Y1 receptors... - On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039Agnieszka Pałucha-Poniewiera
Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
Psychopharmacology (Berl) 212:523-35. 2010..Although the antidepressant-like activity of MGS0039 and LY341495 is well documented, the mechanism of the antidepressant action of these compounds is still not clear... - MPEP, mGlu5 receptor antagonist, regulates NPYmRNA expression in hippocampal and amygdalar neuronsMaria Śmiałowska
Laboratory of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
Pol J Pharmacol 56:709-18. 2004..The obtained results suggest a positive regulatory control of NPY synthesis by mGlu5 receptors in hippocampal and amygdalar neurons... - Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim testPiotr Branski
Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
J Neural Transm 115:829-30. 2008..This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator... - The effect of intrahippocampal injection of group II and III metobotropic glutamate receptor agonists on anxiety; the role of neuropeptide YMaria Śmiałowska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Neuropsychopharmacology 32:1242-50. 2007..It was observed that group III mGluRs and Y1 receptors were engaged in the response in the CA1 area, whereas group II mGluRs and Y2 receptors played a pivotal role in the DG region... - Intraamygdaloid administration of BIBO 3304 increases water intake and extends anxiolytic effectsJoanna M Wieronska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
Pol J Pharmacol 56:867-70. 2004..Water consumption was measured 1, 2, 4, 6 and 24 h after drug administration. We found that water intake was increased both after 5-HTP and BIBO 3304 administration... - The behavioural and electrophysiological effects of CRF in rat frontal cortexBarbara Zieba
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna Street 12, 31 343 Cracow, Poland
Neuropeptides 42:513-23. 2008..Moreover, the peptide inhibits locomotor and exploratory activity and depresses excitatory synaptic transmission in a NMDA receptor-dependent manner... - Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in ratsGabriel Nowak
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
Brain Res Bull 61:159-64. 2003..These animal data further suggest antidepressant activity of zinc in human depression... - Neuroprotective effect of NPY on kainate neurotoxicity in the hippocampusMaria Śmiałowska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
Pol J Pharmacol 55:979-86. 2003..The obtained results indicate neuroprotective action of NPY in some models of the kainate-induced hippocampal degeneration... - Effect of some iono- and metabotropic glutamatergic ligands on neuropeptide Y immunoreactivity in the rat hippocampusMaria Śmiałowska
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
Pol J Pharmacol 54:723-6. 2002..The obtained results indicate that glutamatergic metabotropic and NMDA receptors may regulate NPY expression in the hippocampus. This regulation may have some connection with modulation of anxiety by the studied compounds... - Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu₄ receptorAnna Sławińska
Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
Neuropharmacology 66:225-35. 2013..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'... - Changes in the NPY immunoreactivity in gerbil hippocampus after hypoxic and ischemic preconditioningMalgorzata Duszczyk
Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, Warsaw 02 106, Poland
Neuropeptides 43:31-9. 2009..Although induced tolerance to ischemia 2 days after ischemic or hypoxic preconditioning was accompanied by increased immunoreactivity of NPY, there was no correlation between its intensity and the level of neuroprotection... - Increase in synaptic hippocampal zinc concentration following chronic but not acute zinc treatment in ratsBernadeta Szewczyk
Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL31-343 Krakow, Poland
Brain Res 1090:69-75. 2006..The measurement of zinc concentration in the whole hippocampus by the flame atomic absorption spectrometry method is not sensitive enough to detect such subtle alteration... - Interaction of zinc with antidepressants in the forced swimming test in miceBernadeta Szewczyk
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343, , Poland
Pol J Pharmacol 54:681-5. 2002..The present data support the notion that inhibition of the NMDA receptor participates in an antidepressant action, and further demonstrate particular role of zinc in this activity...