Joanna M Wieronska


Affiliation: Polish Academy of Sciences
Country: Poland


  1. Wieronska J, Acher F, Sławińska A, Gruca P, Lasoń Tyburkiewicz M, Papp M, et al. The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT₁A signalling. Psychopharmacology (Berl). 2013;227:711-25 pubmed publisher
    ..The action of the compound is 5-HT1A-dependent. ..
  2. Cieślik P, Wozniak M, Tokarski K, Kusek M, Pilc A, Płoska A, et al. Simultaneous activation of muscarinic and GABAB receptors as a bidirectional target for novel antipsychotics. Behav Brain Res. 2019;359:671-685 pubmed publisher
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    Wieronska J, Śmiałowska M, Branski P, Gasparini F, Kłodzińska A, Szewczyk B, et al. In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling. Neuropsychopharmacology. 2004;29:514-21 pubmed
    ..Our results indicate that the anxiolytic action of MPEP is conveyed through NPY neurons with the involvement of Y1 receptors in the amygdala and that BZD receptors do not significantly contribute to these effects. ..
  4. Wieronska J, Sławińska A, Łasoń Tyburkiewicz M, Gruca P, Papp M, Zorn S, et al. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. Psychopharmacology (Berl). 2015;232:259-73 pubmed publisher
    ..The actions of Lu AF21934 are 5-HT1A receptor-dependent. Activation of the mGlu4 receptor may be a promising mechanism for the development of novel antipsychotic drugs, efficacious toward positive, negative, and cognitive symptoms. ..
  5. Wozniak M, Cieślik P, Marciniak M, Lenda T, Pilc A, Wieronska J. Neurochemical changes underlying schizophrenia-related behavior in a modified forced swim test in mice. Pharmacol Biochem Behav. 2018;172:50-58 pubmed publisher
  6. Cieślik P, Wozniak M, Rook J, Tantawy M, Conn P, Acher F, et al. Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents. Psychopharmacology (Berl). 2018;235:2897-2913 pubmed publisher
    ..Based on our results, the simultaneous activation of M4 and mGlu4 receptors is beneficial in reversing MK-801- and amphetamine-induced schizophrenia-related changes in animals. ..
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    Wieronska J, Legutko B, Dudys D, Pilc A. Olfactory bulbectomy and amitriptyline treatment influences mGlu receptors expression in the mouse brain hippocampus. Pharmacol Rep. 2008;60:844-55 pubmed
    ..The results obtained indicate an influence of OB on mGlu receptors levels in the hippocampus, and the OB-induced effect can be reversed by chronic AMI treatment in the case of mGlu1a, mGlu2/3 and mGlu7 receptors. ..
  8. Wieronska J, Pilc A. Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs. Neurochem Int. 2009;55:85-97 pubmed publisher
    ..At present, the most potent seem to be negative allosteric modulators of the first group (mGlu1 and mGlu5), and positive allosteric modulators of the second (mGlu2 and mGlu3) and third (mGlu4/7/8) group of mGlu receptors. ..
  9. Wierońska J, Kłeczek N, Woźniak M, Gruca P, Łasoń Tyburkiewicz M, Papp M, et al. mGlu₅-GABAB interplay in animal models of positive, negative and cognitive symptoms of schizophrenia. Neurochem Int. 2015;88:97-109 pubmed publisher
    ..Summing up, an activation of both types of receptor may be a promising mechanism for the development of novel antipsychotic drugs, efficacious toward positive, negative and cognitive symptoms. ..

More Information


  1. Wieronska J, Branski P, Siwek A, Dybala M, Nowak G, Pilc A. GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus. Brain Res. 2010;1334:12-24 pubmed publisher
    ..The results suggest that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA. ..
  2. Wieronska J, Stachowicz K, Pałucha Poniewiera A, Acher F, Branski P, Pilc A. Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems. Neuropharmacology. 2010;59:627-34 pubmed publisher
    ..Moreover, the compound was not effective in 5-HT depleted animals. The results of these studies indicate that the GABAergic and serotonergic systems are involved in the potential anxiolytic action of LSP1-2111. ..
  3. Wieronska J, Stachowicz K, Branski P, Pałucha Poniewiera A, Pilc A. On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice. Neuropharmacology. 2012;62:322-31 pubmed publisher
    ..Therefore, it seems that the antagonism towards GABA(A) receptors, presynaptic 5-HT(1A) and postsynaptic 5-HT(2A/2C) receptors is responsible for the phenomenon. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  4. Wieronska J, Stachowicz K, Acher F, Lech T, Pilc A. Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia. Psychopharmacology (Berl). 2012;220:481-94 pubmed publisher
    ..Altogether, we propose that among group III mGlu receptors, mGlu4 receptor may be a promising target for the development of novel antipsychotic drugs. ..
  5. Wozniak M, Acher F, Marciniak M, Lasoń Tyburkiewicz M, Gruca P, Papp M, et al. Involvement of GABAB Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu4 Receptor, LSP4-2022. Curr Neuropharmacol. 2016;14:413-26 pubmed
  6. Wozniak M, Gołembiowska K, Noworyta Sokołowska K, Acher F, Cieślik P, Kusek M, et al. Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-2022. Neuropharmacology. 2017;115:149-165 pubmed publisher
    ..This article is part of the Special Issue entitled 'Metabotropic Glutamate Receptors, 5 years on'. ..