Tomasz Szkudelski

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. ncbi request reprint Daidzein, coumestrol and zearalenone affect lipogenesis and lipolysis in rat adipocytes
    K Szkudelska
    Department of Animal Physiology and Biochemistry, University of Agriculture, Wołyńska Poznan, Poland
    Phytomedicine 9:338-45. 2002
  2. ncbi request reprint Lack of the effect of mycotoxins-aflatoxin B1 and ochratoxin A on some functions of rat adipocytes
    K Szkudelska
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wołyńska 35, Poznan, Poland
    Toxicol In Vitro 19:771-7. 2005
  3. ncbi request reprint Genistein restricts leptin secretion from rat adipocytes
    Tomasz Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wołyńska 35, Poznan, Poland
    J Steroid Biochem Mol Biol 96:301-7. 2005
  4. ncbi request reprint Genistein--a dietary compound inducing hormonal and metabolic changes
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    J Steroid Biochem Mol Biol 105:37-45. 2007
  5. doi request reprint The insulin-suppressive effect of resveratrol - an in vitro and in vivo phenomenon
    Tomasz Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    Life Sci 82:430-5. 2008
  6. ncbi request reprint Adipocyte lipolysis, hormonal and metabolic changes in ethanol-drinking rats
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    J Anim Physiol Anim Nutr (Berl) 88:251-8. 2004
  7. ncbi request reprint The influence of fasting on liver sulfhydryl groups, glutathione peroxidase and glutathione-S-transferase activities in the rat
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    J Physiol Biochem 60:1-6. 2004
  8. ncbi request reprint Short-term fasting and lipolytic activity in rat adipocytes
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    Horm Metab Res 36:667-73. 2004
  9. ncbi request reprint Leptin secretion and protein kinase A activity
    T Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wołyńska 35, Poznan, Poland
    Physiol Res 54:79-85. 2005
  10. doi request reprint Genistein, a plant-derived isoflavone, counteracts the antilipolytic action of insulin in isolated rat adipocytes
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    J Steroid Biochem Mol Biol 109:108-14. 2008

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Daidzein, coumestrol and zearalenone affect lipogenesis and lipolysis in rat adipocytes
    K Szkudelska
    Department of Animal Physiology and Biochemistry, University of Agriculture, Wołyńska Poznan, Poland
    Phytomedicine 9:338-45. 2002
    ..The influence of coumestrol on glycerides breakdown was less marked. Estradiol augmented only epinephrine-stimulated lipolysis...
  2. ncbi request reprint Lack of the effect of mycotoxins-aflatoxin B1 and ochratoxin A on some functions of rat adipocytes
    K Szkudelska
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wołyńska 35, Poznan, Poland
    Toxicol In Vitro 19:771-7. 2005
    ..This susceptibility is, however, rather weak and is exhibited by a slight restriction of the lipogenesis (in the case of both toxins) and by a slight increase of the lipolysis (in the case of AFB1)...
  3. ncbi request reprint Genistein restricts leptin secretion from rat adipocytes
    Tomasz Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wołyńska 35, Poznan, Poland
    J Steroid Biochem Mol Biol 96:301-7. 2005
    ..Results obtained in our experiments point at the restriction of glucose metabolism following formation of pyruvate as the pivotal reason of the inhibitory action of genistein on leptin release...
  4. ncbi request reprint Genistein--a dietary compound inducing hormonal and metabolic changes
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    J Steroid Biochem Mol Biol 105:37-45. 2007
    ..Moreover, the altered expression of genes engaged in lipid metabolism, disturbed glucose transport into cells, affected lipolysis and lipogenesis and changed ATP synthesis were found as a result of genistein action...
  5. doi request reprint The insulin-suppressive effect of resveratrol - an in vitro and in vivo phenomenon
    Tomasz Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    Life Sci 82:430-5. 2008
    ..These observations point to the direct insulin-suppressive action of resveratrol in the rat...
  6. ncbi request reprint Adipocyte lipolysis, hormonal and metabolic changes in ethanol-drinking rats
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    J Anim Physiol Anim Nutr (Berl) 88:251-8. 2004
    ..Results obtained in vitro indicate that subchronic ethanol drinking attenuates basal and stimulated lipolysis in adipocytes, however, the antilipolytic effect of insulin and the adenosine pathway are unchanged...
  7. ncbi request reprint The influence of fasting on liver sulfhydryl groups, glutathione peroxidase and glutathione-S-transferase activities in the rat
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    J Physiol Biochem 60:1-6. 2004
    ....
  8. ncbi request reprint Short-term fasting and lipolytic activity in rat adipocytes
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    Horm Metab Res 36:667-73. 2004
    ..Comparing fed and fasted rats for the antilipolytic effect of insulin in adipocytes revealed that short-term food deprivation resulted in a substantial deterioration of the ability of insulin to suppress epinephrine-induced lipolysis...
  9. ncbi request reprint Leptin secretion and protein kinase A activity
    T Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wołyńska 35, Poznan, Poland
    Physiol Res 54:79-85. 2005
    ..Moreover, it has also been shown that inhibition of PKA evokes the opposite effect and enhances leptin release...
  10. doi request reprint Genistein, a plant-derived isoflavone, counteracts the antilipolytic action of insulin in isolated rat adipocytes
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    J Steroid Biochem Mol Biol 109:108-14. 2008
    ..The ability of genistein to counteract the antilipolytic action of insulin may contribute to the decreased triglyceride accumulation in adipose tissue...
  11. ncbi request reprint Resveratrol inhibits insulin secretion from rat pancreatic islets
    Tomasz Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    Eur J Pharmacol 552:176-81. 2006
    ..Results obtained in the present investigations demonstrate that resveratrol is a compound exerting a clear-cut, but reversible inhibitory effect on insulin secretion from isolated pancreatic islets...
  12. ncbi request reprint Intracellular mediators in regulation of leptin secretion from adipocytes
    T Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Poznan, Poland
    Physiol Res 56:503-12. 2007
    ..The role of mTOR, ATP, cAMP, fatty acids, malonyl-CoA, adenosine and Ca(2+) in the regulation of leptin secretion from adipocytes is discussed...
  13. ncbi request reprint Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances
    Tomasz Szkudelski
    Dept of Animal Physiology and Biochemistry, August Cieszkowski Univ of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    Am J Physiol Endocrinol Metab 293:E901-7. 2007
    ....
  14. ncbi request reprint The effect of thyroid hormones on blood insulin level and metabolic parameters in diabetic rats
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
    J Physiol Biochem 59:71-6. 2003
    ..It can be concluded that in spite of partial restriction of hyperglycemia, thyroid hormones evoked several unfavourable changes strongly limiting their potential use in diabetes...
  15. ncbi request reprint Short-time deoxynivalenol treatment induces metabolic disturbances in the rat
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    Toxicol Lett 136:25-31. 2002
    ..Results obtained after subcutaneous DON administration indicate that its adverse effects in animals may partially result from metabolic disturbances evoked by this mycotoxin...
  16. ncbi request reprint Streptozotocin induces lipolysis in rat adipocytes in vitro
    T Szkudelski
    Physiol Res 51:255-9. 2002
    ..The obtained outcomes suggest that in studies employing STZ, it is necessary to consider its direct effect upon lipolysis in adipocytes...
  17. ncbi request reprint Effects of adenosine A1 receptor antagonism on lipogenesis and lipolysis in isolated rat adipocytes
    T Szkudelski
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznan, Poland
    Physiol Res 58:863-71. 2009
    ..The partial antagonism of adenosine A(1) receptor increased lipolysis in cells incubated with epinephrine alone and epinephrine with insulin due to the synergistic action of 0.1 microM DPCPX and epinephrine...
  18. ncbi request reprint Glucose as a lipolytic agent: studies on isolated rat adipocytes
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    Physiol Res 49:213-7. 2000
    ..However, short-term exposure of adipocytes to higher glucose concentrations did not restrict the inhibitory action of insulin on lipolysis induced by epinephrine...
  19. doi request reprint Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, University of Life Sciences in Poznan, 60 637 Wolynska 35, Poznan, Poland
    J Steroid Biochem Mol Biol 113:17-24. 2009
    ..The obtained results provided evidence that resveratrol affects lipogenesis and lipolysis in adipocytes contributing to reduced lipid accumulation in these cells...
  20. doi request reprint Resveratrol and genistein as adenosine triphosphate-depleting agents in fat cells
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Wolynska 35, 60 637 Poznan, Poland
    Metabolism 60:720-9. 2011
    ..Because numerous cellular events are strongly ATP dependent, the ATP-depleting effects of resveratrol and genistein may have pleiotropic consequences for adipocyte functions...
  21. doi request reprint Does somatostatin confer insulinostatic effects of neuromedin u in the rat pancreas?
    Przemyslaw Kaczmarek
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Poznan, Poland
    Pancreas 38:208-12. 2009
    ..We have recently demonstrated that NmU reduces insulin secretion from isolated pancreatic islets. Aim of our current study is to investigate the role of somatostatin at mediating the effects of NmU on insulin secretion...
  22. ncbi request reprint Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets
    Przemyslaw Kaczmarek
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Poznan, Poland
    Int J Mol Med 18:951-5. 2006
    ..Thus, NmU can be included in that group of anorectic peptides, which are also involved in the regulation of insulin secretion...
  23. doi request reprint Short-term effects of palmitate and 2-bromopalmitate on the lipolytic activity of rat adipocytes
    Tomasz Szkudelski
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Wolynska 35, 60 637 Poznan, Poland
    Life Sci 89:450-5. 2011
    ..The present study aimed to determine the short-term influence of palmitate and its non-metabolisable analogue, 2-bromopalmitate, on the lipolytic activity of adipocytes...
  24. ncbi request reprint The effect of myo-inositol on ethanol-induced metabolic changes and insulin concentration in the rat
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, 60 637, Poland
    Arch Physiol Biochem 107:334-7. 1999
    ..Myo-inositol did not cause any undesirable metabolic changes in the rats. The results indicate that myo-inositol may be useful in the treatment of some metabolic consequences of alcohol drinking...
  25. ncbi request reprint In vivo metabolic effects of naringenin in the ethanol consuming rat and the effect of naringenin on adipocytes in vitro
    K Szkudelska
    Department of Animal Physiology and Biochemistry, University of Agriculture, Wołyńska, Poznan, Poland
    J Anim Physiol Anim Nutr (Berl) 91:91-9. 2007
    ..Results obtained in our studies demonstrate that naringenin exerts a very weak influence on carbohydrate and lipid metabolism of normal and ethanol-consuming rats and on metabolism of isolated rat adipocytes...
  26. doi request reprint Anti-diabetic effects of resveratrol
    Tomasz Szkudelski
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Wolynska, Poland
    Ann N Y Acad Sci 1215:34-9. 2011
    ..These data indicate that resveratrol may be useful in preventing and treating diabetes...
  27. ncbi request reprint Phytic acid-induced metabolic changes in the rat
    T Szkudelski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Poznan, Poland
    J Anim Physiol Anim Nutr (Berl) 89:397-402. 2005
    ..These changes seem to result not only from reduced bioavailability of minerals but also from interactions of PA with nutrients and enzymes in the liver...
  28. ncbi request reprint Expression of the beacon gene in the rat pancreatic islets: opposite effects of beacon (47-73) protein (ubiquitin-like protein 5) on insulin secretion in vivo and insulin release by isolated islets
    Krzysztof W Nowak
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Poznan, Poland
    Pancreas 29:99-103. 2004
    ..We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible beacon protein effects on insulin secretion...
  29. doi request reprint The inhibitory effect of resveratrol on leptin secretion from rat adipocytes
    K Szkudelska
    Poznan University of Life Sciences, 60 637 Poznan, Poland
    Eur J Clin Invest 39:899-905. 2009
    ..In this study, the direct effect of resveratrol on leptin secretion from isolated adipocytes was investigated...
  30. ncbi request reprint Acute leptin action on insulin blood level and liver insulin receptor in the rat
    K W Nowak
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Poznan, Poland
    Life Sci 63:1347-52. 1998
    ..It seems legitimate to suggest that leptin-induced decrease of insulin receptor binding capacity may be one of several causes of insulin resistance...
  31. ncbi request reprint Genistein affects lipogenesis and lipolysis in isolated rat adipocytes
    K Szkudelska
    Department of Animal Physiology and Biochemistry, University of Agriculture, 60 637 Wołyńska 35, Poznan, Poland
    J Steroid Biochem Mol Biol 75:265-71. 2000
    ..e. on protein kinase A or hormone sensitive lipase. Estradiol, added to the incubation medium, did not affect lipolysis. It can be concluded that genistein significantly affects lipogenesis and lipolysis in isolated rat adipocytes...
  32. ncbi request reprint The influence of hypo- and hyperthyreosis on insulin receptors and metabolism
    P Mackowiak
    Department of Animal Phsiology and Biochemistry, University of Agriculture, Poznan, Poland
    Arch Physiol Biochem 107:273-9. 1999
    ..As a result of these disturbances the adaptive mechanisms appear. One of them is change in the number of insulin membrane receptors taking place even against the well known "down-regulation" theory...
  33. ncbi request reprint Lipolysis induced by alloxan in rat adipocytes is not inhibited by insulin
    K Kandulska
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    Physiol Res 48:113-7. 1999
    ..Addition of 20 mmol/l of alloxan strongly inhibited glycerol release in the presence of adrenaline. The results presented here clearly indicate that the action of alloxan concerns cells of the white adipose tissue...
  34. ncbi request reprint Effect of some phytoestrogens on metabolism of rat adipocytes
    K Kandulska
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    Reprod Nutr Dev 39:497-501. 1999
    ..Zearalenone reduced stimulated lipolysis, particularly at the highest concentration...
  35. ncbi request reprint Genistein-induced changes in lipid metabolism of ovariectomized rats
    L Nogowski
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    Ann Nutr Metab 42:360-6. 1998
    ..This effect of genistein may be attributed, at least in part, to its direct influence on lipid metabolism in the liver and adipose tissue...
  36. doi request reprint Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model
    Tomasz Szkudelski
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Wolynska 35, 60 637 Poznan, Poland
    Exp Biol Med (Maywood) 237:481-90. 2012
    ..This is due to reduced B-cell mass as well as metabolic defects in the insulin-secreting cells. Results of numerous experiments have demonstrated that this model of diabetes is useful in studies of different aspects of diabetes...
  37. ncbi request reprint The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    Physiol Res 50:537-46. 2001
    ..Furthermore, streptozotocin liberates toxic amounts of nitric oxide that inhibits aconitase activity and participates in DNA damage. As a result of the streptozotocin action, B cells undergo the destruction by necrosis...
  38. doi request reprint Adipocyte dysfunction in rats with streptozotocin-nicotinamide-induced diabetes
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznan, Poland
    Int J Exp Pathol 95:86-94. 2014
    ..Simultaneously, adiponectin and leptin secretion is significantly impaired. ..
  39. doi request reprint Resveratrol, obesity and diabetes
    Katarzyna Szkudelska
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznan, Poland
    Eur J Pharmacol 635:1-8. 2010
    ..These data point to the potential possibility of use of resveratrol in preventing and/or treating both obesity and diabetes...
  40. ncbi request reprint Mechanism of phytoestrogens action in reproductive processes of mammals and birds
    Luiza Dusza
    Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10 718 Olsztyn
    Reprod Biol 6:151-74. 2006
    ....