Z Rogoz

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. ncbi request reprint Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: preclinical and clinical efficacy
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1535-44. 2013
  2. ncbi request reprint Effect of combined treatment with mirtazapine and risperidone on the MK-801-induced changes in the object recognition test in mice
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1401-6. 2013
  3. ncbi request reprint Effect of risperidone on the fluoxetine-induced changes in extracellular dopamine, serotonin and noradrenaline in the rat frontal cortex
    Katarzyna Kaminska
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1144-51. 2013
  4. ncbi request reprint Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 64:1567-72. 2012
  5. ncbi request reprint Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 64:1391-9. 2012
  6. ncbi request reprint Enhancement of the anti-immobility action of antidepressants by risperidone in the forced swimming test in mice
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:1533-8. 2011
  7. ncbi request reprint Anxiolytic-like effects of olanzapine, risperidone and fluoxetine in the elevated plus-maze test in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:1547-52. 2011
  8. ncbi request reprint Combined treatment with imipramine and metyrapone induces hippocampal and cortical brain-derived neurotrophic factor gene expression in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 57:840-4. 2005
  9. ncbi request reprint Repeated treatment with mirtazepine induces brain-derived neurotrophic factor gene expression in rats
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 56:661-71. 2005
  10. ncbi request reprint Effect of repeated co-treatment with imipramine and metyrapone on the behavioral reactivity of the central serotonin, dopamine and alpha 1-adrenergic systems in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:588-94. 2007

Detail Information

Publications53

  1. ncbi request reprint Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: preclinical and clinical efficacy
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1535-44. 2013
    ..The results support the conclusion that atypical antipsychotics may be effective as adjunctive therapy in treatment-resistant depression; however, their adverse effect profile may be unfavorable in some patients. ..
  2. ncbi request reprint Effect of combined treatment with mirtazapine and risperidone on the MK-801-induced changes in the object recognition test in mice
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1401-6. 2013
    ..Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve treatment of the negative and certain cognitive symptoms of schizophrenia...
  3. ncbi request reprint Effect of risperidone on the fluoxetine-induced changes in extracellular dopamine, serotonin and noradrenaline in the rat frontal cortex
    Katarzyna Kaminska
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1144-51. 2013
    ..We studied the effect of FLU and RIS, given separately or jointly on the extracellular levels of dopamine (DA), serotonin (5-HT) and noradrenaline (NA) in the rat frontal cortex...
  4. ncbi request reprint Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 64:1567-72. 2012
    ..Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve the positive, negative and some cognitive symptoms of schizophrenia...
  5. ncbi request reprint Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 64:1391-9. 2012
    ..Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression...
  6. ncbi request reprint Enhancement of the anti-immobility action of antidepressants by risperidone in the forced swimming test in mice
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:1533-8. 2011
    ..The obtained results indicate that a low dose of risperidone enhances the activity of ADs in an animal model of depression, and that, among other mechanisms, 5-HT(1A) receptors may play a role in these effects...
  7. ncbi request reprint Anxiolytic-like effects of olanzapine, risperidone and fluoxetine in the elevated plus-maze test in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:1547-52. 2011
    ..These findings indicate that olanzapine, risperidone and fluoxetine per se may be clinically effective in treating anxiety disorders, but their effects may be attenuated when they are used in combination with other medications...
  8. ncbi request reprint Combined treatment with imipramine and metyrapone induces hippocampal and cortical brain-derived neurotrophic factor gene expression in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 57:840-4. 2005
    ..Moreover, the obtained results suggested that BDNF may be involved in the mechanism of the synergistic antidepressant effect of IMI and MET in drug-resistant depressed patients...
  9. ncbi request reprint Repeated treatment with mirtazepine induces brain-derived neurotrophic factor gene expression in rats
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 56:661-71. 2005
    ....
  10. ncbi request reprint Effect of repeated co-treatment with imipramine and metyrapone on the behavioral reactivity of the central serotonin, dopamine and alpha 1-adrenergic systems in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:588-94. 2007
    ....
  11. ncbi request reprint Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:493-500. 2006
    ..Moreover, sigma(1) receptors may constitute one of the possible mechanisms by which co-administration of pramipexole and sertraline induces antidepressant-like activity in that test...
  12. ncbi request reprint Repeated co-treatment with imipramine and amantadine induces hippocampal brain-derived neurotrophic factor gene expression in rats
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 58:219-34. 2007
    ....
  13. ncbi request reprint Amantadine as an additive treatment in patients suffering from drug-resistant unipolar depression
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:778-84. 2007
    ..The obtained results indicate that joint therapy with an antidepressant and amantadine may be effective in treatment-resistant unipolar depression...
  14. ncbi request reprint Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:817-26. 2008
    ....
  15. ncbi request reprint Effects of co-administration of fluoxetine or tianeptine with metyrapone on immobility time and plasma corticosterone concentration in rats subjected to the forced swim test
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:880-8. 2008
    ..These findings suggest that the co-administration of metyrapone and an antidepressant drug may be useful for the treatment of drug-resistant depression and/or depression associated with a high cortisol level...
  16. ncbi request reprint Effect of repeated co-treatment with fluoxetine and amantadine on the behavioral reactivity of the central dopamine and serotonin system in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:924-9. 2009
    ..Moreover, our results suggest that 5-HT(1A) receptors are useful targets for the development of more rapidly acting and more effective medication...
  17. ncbi request reprint Effect of co-administration of fluoxetine and amantadine on immunoendocrine parameters in rats subjected to a forced swimming test
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:1050-60. 2009
    ..In summary, the antidepressive efficacy of a combination of fluoxetine and amantadine given in suboptimal doses may be related to the negative immunoendocrine effects of these drugs...
  18. ncbi request reprint Potentiation of the antidepressant-like effect of desipramine or reboxetine by metyrapone in the forced swimming test in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:1173-8. 2009
    ..Furthermore, they may be of particular importance to the pharmacotherapy of drug-resistant depression...
  19. ncbi request reprint Effect of metyrapone on the fluoxetine-induced change in extracellular dopamine, serotonin and their metabolites in the rat frontal cortex
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 62:1015-22. 2010
    ....
  20. ncbi request reprint Effects of co-treatment with mirtazapine and low doses of risperidone on immobility time in the forced swimming test in mice
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 62:1191-6. 2010
    ..The obtained results indicate that risperidone applied in a low dose enhances the antidepressant-like activity of MIR and that, among other mechanisms, 5-HT(1A)-, and α(2)-adrenergic receptors may play a role in this effect...
  21. ncbi request reprint Effect of metyrapone supplementation on imipramine therapy in patients with treatment-resistant unipolar depression
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:849-55. 2004
    ....
  22. ncbi request reprint Effects of joint administration of imipramine and amantadine in patients with drug-resistant unipolar depression
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:735-42. 2004
    ..These results suggest that joint therapy with IMI and AMA may be successful in the treatment-resistant unipolar depression...
  23. ncbi request reprint Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 54:257-70. 2003
    ....
  24. ncbi request reprint Anxiolytic-like effects of preferential dopamine D3 receptor agonists in an animal model
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:449-54. 2003
    ..These data suggest that preferential dopamine D(3) agonists may play a role in the therapy of anxiety, however, further studies are necessary to elucidate the mechanism of these actions...
  25. ncbi request reprint Effects of combined treatment with imipramine and metyrapone in the forced swimming test in rats. Behavioral and pharmacokinetic studies
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:993-9. 2003
    ..These findings may be of particular importance to pharmacotherapy of drug-resistant depression...
  26. ncbi request reprint Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats
    Zofia Rogóż
    Institute of Pharmacology, Polish Academy of Sciences, Pl 31 343 Krakow, Poland
    Neuropharmacology 42:1024-30. 2002
    ..The present results suggest that the combination of traditional antidepressant drugs and NMDA receptor antagonists may produce enhanced antidepressive effects, and this is of particular relevance for antidepressant-resistant patients...
  27. ncbi request reprint Synergistic effect of imipramine and amantadine in the forced swimming test in rats. Behavioral and pharmacokinetic studies
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polsih Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:179-85. 2004
    ..The pharmacokinetic interaction can be excluded, since AMA did not change significantly the antidepressant level in the rat plasma and brain, measured 1 h after exposure to the forced swimming test...
  28. ncbi request reprint Anxiolytic- and antidepressant-like effects of 7-OH-DPAT, preferential dopamine D3 receptor agonist, in rats
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:519-26. 2004
    ..These data suggest that preferential D(3) receptor agonists may play a role in the therapy of anxiety and/or depression, however, further studies are necessary to elucidate the mechanism of these actions...
  29. ncbi request reprint Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system
    Z Rogoz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Neuropharmacology 41:360-8. 2001
    ..On the other hand, FLU did not affect any behavioural and biochemical changes in this system...
  30. ncbi request reprint Some behavioral effects of 1,3-di-o-tolylguanidine, opipramol and sertraline, the sigma site ligands
    J Maj
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Pol J Pharmacol 48:379-95. 1996
    ..The above results indicate that the sigma site ligands studied differ in their pharmacological profile; however, it is still difficult to determine unequivocally whether they show agonistic or antagonistic properties...
  31. ncbi request reprint Effect of repeated treatment with tianeptine and fluoxetine on central dopamine D(2) /D(3) receptors
    M Dziedzicka-Wasylewska
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Behav Pharmacol 13:127-38. 2002
    ..However, the question of whether this increased responsiveness is important for clinical antidepressant efficacy remains open...
  32. ncbi request reprint The effect of combined treatment with imipramine and amantadine on the behavioral reactivity of central alpha1-adrenergic system in rats
    M Dziedzicka-Wasylewska
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Behav Pharmacol 15:159-65. 2004
    ....
  33. ncbi request reprint Pharmacological action of zotepine and other antipsychotics on central 5-hydroxytryptamine receptor subtypes
    A Czyrak
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Arzneimittelforschung 44:113-8. 1994
    ..abstract truncated at 250 words)..
  34. ncbi request reprint A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist
    G Skuza
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Behav Pharmacol 13:537-43. 2002
    ..The results presented in this paper support the suggestion that SA4503 may have potential antidepressive properties...
  35. ncbi request reprint The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats
    G Skuza
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 57:217-29. 2006
    ..Combined treatment with sigma ligands and AMA or MEM (applied in the clinic) may be an alternative to the treatment of antidepressant-resistant depressive patients in the future...
  36. ncbi request reprint Repeated imipramine treatment enhances the 7-OH-DPAT-induced hyperactivity in rats: the role of dopamine D2 and D3 receptors
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 53:571-6. 2001
    ..The above results indicate that both types of dopamine receptors, D3 and D2, may play a substantial role in the mechanism of the 7-OH-DPAT-induced hyperactivity, as well as in the increase evoked by repeated treatment with IMI in rats...
  37. ncbi request reprint Repeated trimipramine induces dopamine D2/D3 and alpha1-adrenergic up-regulation
    J Maj
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Neural Transm 105:329-42. 1998
    ..A question arises whether the reuptake inhibition is of any importance to the adaptive changes induced by repeated antidepressants, suggested to be responsible for the antidepressant activity...
  38. ncbi request reprint Neuropsychopharmacological profile of remoxipride in comparison with clozapine
    G Skuza
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Pol J Pharmacol 49:5-15. 1997
    ....
  39. ncbi request reprint Effect of combined treatment with imipramine and metyrapone on the immobility time, the activity of hypothalamo-pituitary-adrenocortical axis and immunological parameters in the forced swimming test in the rat
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    J Physiol Pharmacol 56:49-61. 2005
    ..These finding suggest that a combination of metyrapone and an antidepressant drug may be useful for the treatment drug-resistant depression and/or depression associated with a high cortisol level...
  40. ncbi request reprint Opposite influence of MPEP, an mGluR5 antagonist, on the locomotor hyperactivity induced by PCP and amphetamine
    M Pietraszek
    Department of Neuropsychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 55:587-93. 2004
    ..The opposite effect of MPEP in the two above-mentioned models questions significance of the blockade of mGluR5 receptors to antipsychotic effects...
  41. ncbi request reprint Effect of repeated treatment with reboxetine on the central alpha1-adrenergic system
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 53:663-7. 2001
    ..However, the question whether the increased functional responsiveness found in the present study is important for the clinical antidepressant efficacy, remains open...
  42. ncbi request reprint Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 53:105-16. 2002
    ..However, the question whether the increased functional responsiveness found in the present study is important for the clinical antidepressant efficacy, remains open...
  43. ncbi request reprint Some central effects of opipramol given repeatedly
    G Skuza
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol Pharm 42:425-31. 1990
    ..e. enhancement of the responses mediated by dopamine receptors (probably in the limbic system, but not in the striatum) and alpha 1-adrenoceptors in the brain...
  44. ncbi request reprint Effect of tianeptine and fluoxetine on the levels of Met-enkephalin and mRNA encoding proenkephalin in the rat
    M Dziedzicka-Wasylewska
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 53:117-25. 2002
    ....
  45. ncbi request reprint Concomitant administration of fluoxetine and amantadine modulates the activity of peritoneal macrophages of rats subjected to a forced swimming test
    Adam Roman
    Department of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:1069-77. 2009
    ....
  46. ncbi request reprint Effect of acute and repeated treatment with mirtazapine on the immunity of noradrenaline transporter knockout C57BL/6J mice
    Marta Kubera
    Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetn 12, Poland
    Pharmacol Biochem Behav 85:813-9. 2006
    ..The present paper postulates an essential role of noradrenergic system in the immunological and behavioral effects of mirtazapine...
  47. ncbi request reprint Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity
    Grazyna Skuza
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:626-35. 2006
    ..Summing up, BD 1047 shows a moderate activity in models used in this study suggesting that its usefulness as an antipsychtic drug is doubtful. However, more detailed studies are required for definitive confirmation of this conclusion...
  48. ncbi request reprint Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice
    Grazyna Skuza
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:1179-83. 2009
    ..These results support the idea that sigma(1)-receptors, but not sigma(2)-receptors, contribute to the mechanism of antidepressant activity of sigma agonists in FST...
  49. ncbi request reprint Inhibitory effects of amantadine on the production of pro-inflammatory cytokines by stimulated in vitro human blood
    Marta Kubera
    Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:1105-12. 2009
    ..The above data provide additional rationale for the treatment of patients suffering from depression with a combination of AMA and a selective serotonin reuptake inhibitor...
  50. ncbi request reprint Antidepressant-like effect of combined treatment with selective sigma receptor agonists and a 5-HT1A receptor agonist in the forced swimming test in rats
    Grazyna Skuza
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:773-7. 2007
    ..1 mg/kg) as well as by BD 1047 (3 mg/kg), a 5-HT(1A) and sigma(1) receptor antagonists, respectively, suggesting the involvement of both receptor types in the anti-immobility effect in rats...
  51. ncbi request reprint Effect of antidepressant drugs in mice lacking the norepinephrine transporter
    Marta Dziedzicka-Wasylewska
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 31:2424-32. 2006
    ....
  52. ncbi request reprint Effect of amantadine and imipramine on immunological parameters of rats subjected to a forced swimming test
    Marta Kubera
    Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Int J Neuropsychopharmacol 9:297-305. 2006
    ..In summary, the antidepressive efficacy of a combination of amantadine and imipramine given in suboptimal doses may be related to their negative immunoendocrine effects...
  53. ncbi request reprint Effects of selective sigma receptor ligands on glucocorticoid receptor-mediated gene transcription in LMCAT cells
    Grazyna Skuza
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:889-95. 2008
    ..Therefore, the attenuation of GR function induced by sigma receptor antagonists remains ambiguous and requires further study...