Edmund Przegalinski

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. ncbi request reprint Activation of serotonin (5-HT)1A receptors inhibits amphetamine sensitization in mice
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences
    Life Sci 66:1011-9. 2000
  2. ncbi request reprint Preclinical studies on comorbidity between depression and psychostimulant addiction
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1529-34. 2013
  3. ncbi request reprint Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropeptides 39:525-33. 2005
  4. ncbi request reprint WIN 55,212-2-induced reduction of cocaine hyperlocomotion: possible inhibition of 5-HT(3) receptor function
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Eur J Pharmacol 517:68-73. 2005
  5. ncbi request reprint Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Eur Neuropsychopharmacol 14:217-25. 2004
  6. ncbi request reprint Effect of thyrotropin-releasing hormone on the locomotor and sensitizing effects of cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Kraków 31 343, Poland
    Neuropeptides 38:48-54. 2004
  7. ncbi request reprint Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats
    Edmund Przegalinski
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:798-810. 2008
  8. ncbi request reprint Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 53:383-94. 2002
  9. ncbi request reprint Effects of 5-HT(1B) receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Eur Neuropsychopharmacol 12:387-96. 2002
  10. ncbi request reprint The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats
    E Przegalinski
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Neuropharmacology 39:1858-64. 2000

Detail Information

Publications44

  1. ncbi request reprint Activation of serotonin (5-HT)1A receptors inhibits amphetamine sensitization in mice
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences
    Life Sci 66:1011-9. 2000
    ....
  2. ncbi request reprint Preclinical studies on comorbidity between depression and psychostimulant addiction
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1529-34. 2013
    ....
  3. ncbi request reprint Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropeptides 39:525-33. 2005
    ..These findings may suggest that CRF1 receptor antagonists should be considered as possible medications in the treatment of cocaine addiction...
  4. ncbi request reprint WIN 55,212-2-induced reduction of cocaine hyperlocomotion: possible inhibition of 5-HT(3) receptor function
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Eur J Pharmacol 517:68-73. 2005
    ..Moreover, together with the literature data they may suggest that this effect of WIN 55,212-2 involves inhibition of the 5-HT(3) receptor function...
  5. ncbi request reprint Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Eur Neuropsychopharmacol 14:217-25. 2004
    ....
  6. ncbi request reprint Effect of thyrotropin-releasing hormone on the locomotor and sensitizing effects of cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Kraków 31 343, Poland
    Neuropeptides 38:48-54. 2004
    ..Moreover, cross-sensitization between cocaine and TRH has also been demonstrated. These findings also may provide an insight into the relationship between TRH and cocaine in humans exposed to the psychostimulant...
  7. ncbi request reprint Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats
    Edmund Przegalinski
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:798-810. 2008
    ....
  8. ncbi request reprint Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 53:383-94. 2002
    ..In other words, the present results suggest that the accumbal shell 5-HT1B receptors play a permissive role in the behavioural response to the psychostimulant...
  9. ncbi request reprint Effects of 5-HT(1B) receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Eur Neuropsychopharmacol 12:387-96. 2002
    ..They suggest that the inhibition of 5-HT(1B) receptors in the accumbens shell attenuates the development, whereas their pharmacological activation enhances the expression of cocaine sensitization...
  10. ncbi request reprint The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats
    E Przegalinski
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Neuropharmacology 39:1858-64. 2000
    ..The lack of effect of the benzodiazepine antagonist on the anticonvulsant activity of CGP 37849 indicates that involvement of benzodiazepine receptors in the pharmacological action of the NMDA antagonist is not a general phenomenon...
  11. ncbi request reprint Effect of adrenalectomy and corticosterone on cocaine-induced sensitization in rats
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 51:193-204. 2000
    ..Moreover, there takes place cross-sensitization between CORT and COC, which indicates a close relationship between the drug-related mechanism and behavioral sensitization...
  12. ncbi request reprint Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Behav Pharmacol 12:109-16. 2001
    ..On the other hand, they also show that pharmacological activation of 5-HT1B receptors enhances both phases of this phenomenon, and that repeated administration of cocaine leads to an increased functional reactivity of these receptors...
  13. ncbi request reprint Role of 5-HT(1B) receptors in the sensitization to amphetamine in mice
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Science, 12 Smetna Street, 31 343 Cracow, Poland
    Eur J Pharmacol 422:91-9. 2001
    ..Our results suggest that 5-HT(1B) receptors may play a permissive role in the development, but not expression, of behavioral sensitization, as well as in the acute locomotor response to amphetamine in mice...
  14. ncbi request reprint Withdrawal from chronic cocaine up-regulates 5-HT1B receptors in the rat brain
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna, 31 343, Krakow, Poland
    Neurosci Lett 351:169-72. 2003
    ..Our results indicate that withdrawal from chronic cocaine induces up-regulation of 5-HT(1B) receptors in a number of rat brain structures...
  15. ncbi request reprint Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats
    Edmund Przegalinski
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Eur J Pharmacol 559:165-72. 2007
    ..Furthermore, we demonstrated that 5-HT1B receptor agonist-induced enhancement of cocaine reward was independent of an alteration in natural reinforcement...
  16. ncbi request reprint Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats
    Magdalena Zaniewska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343, Krakow, 12 Smetna, Poland
    Eur J Pharmacol 540:96-106. 2006
    ..Furthermore, we excluded the involvement of either cannabinoid CB1 and CB2 receptors or increases in the endocannabinoid tone in the nicotine discrimination...
  17. ncbi request reprint Effects of serotonin (5-HT)(1B) receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31343 Krakow, Poland
    Naunyn Schmiedebergs Arch Pharmacol 366:226-34. 2002
    ..However, they do suggest that the stimulation of 5-HT(1B) receptors in the accumbens core, but not in the shell, enhances cocaine discrimination in rats...
  18. ncbi request reprint Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats
    Małgorzata Filip
    Institute of Pharmacology, Polish Academy of Sciences, Smetna Street 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 192:17-26. 2007
    ..Recent data indicate that gamma-aminobutyric acid (GABA) is a modulator of behavioral responses to cocaine...
  19. ncbi request reprint Effects of GABAB receptor ligands in animal tests of depression and anxiety
    Małgorzata Frankowska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:645-55. 2007
    ....
  20. ncbi request reprint Effect of intra-tegmental microinjections of 5-HT1B receptor ligands on the amphetamine-induced locomotor hyperactivity in rats
    Iwona Papla
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 54:351-7. 2002
    ..These findings indicate that 5-HT1B receptors located in the VTA do not play a major role in the hyperlocomotion elicited by amphetamine, whereas their activation may modulate the behavioral response to the psychostimulant...
  21. ncbi request reprint Involvement of cannabinoid CB1 receptors in drug addiction: effects of rimonabant on behavioral responses induced by cocaine
    Małgorzata Filip
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:806-19. 2006
    ..The latter observations may show that repeated cocaine treatment and the drug withdrawal produce--apart from behavioral effects--also different neural consequences in the endocannabinoid systems in rats...
  22. ncbi request reprint Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna, Poland
    Eur J Pharmacol 541:163-70. 2006
    ..The finding that vigabatrin protected against the development and the expression of cocaine sensitization further supports its therapeutic potential in the treatment of cocaine dependence...
  23. doi request reprint Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Addict Biol 15:227-49. 2010
    ..Additionally, the consequences of chronic cocaine exposure on particular 5-HT receptor-assigned functions in pre-clinical studies are presented...
  24. ncbi request reprint Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on cocaine discrimination in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343, Cracow, Poland
    Eur J Pharmacol 459:239-45. 2003
    ..25-2.5 mg/kg), increased cocaine discrimination. These results seem to indicate that tegmental 5-HT(1B) receptors are necessary to express the discriminative stimulus effects of cocaine...
  25. ncbi request reprint Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res 1077:67-80. 2006
    ..The results suggest an antagonistic role of A2ARs in D2R-mediated cocaine actions based at least in part on the existence of A2A/D2 heteromeric receptor complexes...
  26. ncbi request reprint The serotonergic system and its role in cocaine addiction
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 57:685-700. 2005
    ..The present state of knowledge of 5-HT neurotransmission justifies the opinion that pharmacological manipulation in the 5-HT system may efficiently counteract the effects of cocaine withdrawal and prevent reinstatement of its abuse...
  27. doi request reprint The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats
    Przemysław Adamczyk
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
    Brain Res 1444:45-54. 2012
    ..In contrast to CB1 receptors, neither CB2 nor TRPV1 receptors play a role in cue-induced reinstatement of cocaine-seeking behavior...
  28. ncbi request reprint Effects of agmatine on nicotine-evoked behavioral responses in rats
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:645-54. 2008
    ..However, these data do show an inhibitory effect of agmatine over the expression of nicotine-induced conditioned hyperlocomotion...
  29. ncbi request reprint Immunosuppression induced by a conditioned stimulus associated with cocaine self-administration
    Marta Kubera
    Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Pharmacol Sci 107:361-9. 2008
    ..The present study provides the first evidence that alterations of immune status can be conditioned by environmental stimuli paired with cocaine administration...
  30. ncbi request reprint Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Eur J Pharmacol 571:156-65. 2007
    ....
  31. ncbi request reprint Conditioned rewarding stimulus associated with cocaine self-administration reverses the depression of catecholamine brain systems following cocaine withdrawal in rats
    Lucyna Antkiewicz-Michaluk
    Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Smetna, Poland
    Int J Neuropsychopharmacol 9:37-50. 2006
    ..The stimulus associated with cocaine availability activates the catecholaminergic system in animals after extinction procedure...
  32. doi request reprint The effect of serotonin 5HT1B receptor ligands on amphetamine self-administration in rats
    Joanna Miszkiel
    Laboratory of Drug Addiction, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Eur J Pharmacol 677:111-5. 2012
    ..5 mg/kg. These results indicate that tonic activation of 5-HT(1B) receptors is not involved in the self-administration of amphetamine, while pharmacological stimulation of these receptors attenuates this behavioral phenomenon...
  33. doi request reprint Effect of varenicline on the acute and repeated locomotor responses to nicotine in rats
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Synapse 62:935-9. 2008
    ....
  34. ncbi request reprint Effects of GABA(B) receptor antagonist, agonists and allosteric positive modulator on the cocaine-induced self-administration and drug discrimination
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Eur J Pharmacol 574:148-57. 2007
    ..Moreover, a dissociation between effects of direct GABA(B) receptor agonists and a GABA(B) allosteric positive modulator on cocaine vs. food-maintained responding was demonstrated...
  35. ncbi request reprint Blocking impact of clozapine on cocaine locomotor and sensitizing effects in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:1125-30. 2003
    ..These findings seem to be in line with recent clinical reports showing that clozapine may be useful in the treatment of cocaine abuse, even in schizophrenic patients...
  36. ncbi request reprint Effects of the histamine H3 receptor antagonist ABT-239 on acute and repeated nicotine locomotor responses in rats
    Joanna Miszkiel
    Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:1553-9. 2011
    ..Our findings implicate a limited role for H(3) receptors in locomotor responses to nicotine...
  37. doi request reprint Effects of cycloheximide on extinction in an appetitively motivated operant conditioning task depend on re-exposure duration
    Pawel Mierzejewski
    Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9 St, PL 02957, Warsaw, Poland
    Neurosci Lett 441:307-10. 2008
    ....
  38. ncbi request reprint Opioid and monoamine systems mediate the discriminative stimulus of tramadol in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Eur J Pharmacol 498:143-51. 2004
    ..Our results indicate that tramadol can be used as a stimulus cue in rats, and that mu opioid peptide mechanisms are involved in its effects, while noradrenergic uptake inhibitors can enhance tramadol discrimination...
  39. doi request reprint Pharmacological and genetic interventions in serotonin (5-HT)(2C) receptors to alter drug abuse and dependence processes
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res 1476:132-53. 2012
    ..This article is part of a Special Issue entitled: Brain Integration...
  40. ncbi request reprint Role of serotonin 5-HT1B receptors in psychostimulant addiction
    Joanna Miszkiel
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:1310-5. 2011
    ..Moreover, the effect of long-term treatment with psychostimulants on 5-HT(1B) receptors is also discussed...
  41. ncbi request reprint Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:957-65. 2009
    ..Since several pharmacotherapies have failed to be efficacious in all patients, we also assess the clinical effectiveness of newer agents in relation to existing drugs...
  42. ncbi request reprint The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats
    P Adamczyk
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland
    J Physiol Pharmacol 60:119-25. 2009
    ..Our results indicate that FAAH inhibitors could be potent modulators of motivational and conditioned aspects of goal-directed behaviors with less prominent effects on consumatory behaviors...
  43. ncbi request reprint Effects of serotonin (5-HT)1B receptor ligands on amphetamine-seeking behavior in rats
    Joanna Miszkiel
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:813-22. 2013
    ..Numerous studies have indicated that serotonin (5-HT)1B receptor ligands affect the behavioral effects of psychostimulants (cocaine, amphetamine), including the reinforcing activities of these drugs...
  44. ncbi request reprint N-oleoyl-dopamine decreases muscle rigidity induced by reserpine in rats
    J Konieczny
    Department of Neuropsychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland
    Int J Immunopathol Pharmacol 22:21-8. 2009
    ..However, the lack of influence on akinesia suggests that the compound has myorelaxant rather than anti-Parkinsonian properties...