Marcin Majka

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. pmc The decreased metastatic potential of rhabdomyosarcoma cells obtained through MET receptor downregulation and the induction of differentiation
    K Miekus
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
    Cell Death Dis 4:e459. 2013
  2. pmc The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua
    Pawel Basta
    Department of Gynecology and Oncology of the Jagiellonian University, Krakow, Poland
    Reprod Biol Endocrinol 8:116. 2010
  3. ncbi request reprint SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells
    Marcin Majka
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Cracow, Poland
    Folia Histochem Cytobiol 44:155-64. 2006
  4. ncbi request reprint Stem cell biology: a never ending quest for understanding
    Marcin Majka
    Department of Transplantation, Jagiellonian University Medical College, Cracow, Poland
    Acta Biochim Pol 52:353-8. 2005
  5. ncbi request reprint Evidence that platelet-derived microvesicles may transfer platelet-specific immunoreactive antigens to the surface of endothelial cells and CD34+ hematopoietic stem/ progenitor cells--implication for the pathogenesis of immune thrombocytopenias
    Marcin Majka
    Dept of Transplantation, Polish American Institute of Pediatrics, Wielicka 265, 30 663 Krak6w, Poland
    Folia Histochem Cytobiol 45:27-32. 2007
  6. doi request reprint 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion
    Katarzyna Miekus
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
    Oncol Rep 28:1903-9. 2012
  7. doi request reprint Inhibition of rhabdomyosarcoma's metastatic behavior through downregulation of MET receptor signaling
    Ewa Lukasiewicz
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Cracow, Poland
    Folia Histochem Cytobiol 47:485-9. 2009
  8. doi request reprint Genetically modified adipose tissue-derived mesenchymal stem cells overexpressing CXCR4 display increased motility, invasiveness, and homing to bone marrow of NOD/SCID mice
    Sylwia Bobis-Wozowicz
    Department of Transplantation, Collegium Medicum, Jagiellonian University, Cracow, Poland
    Exp Hematol 39:686-696.e4. 2011
  9. ncbi request reprint Role of I-TAC-binding receptors CXCR3 and CXCR7 in proliferation, activation of intracellular signaling pathways and migration of various tumor cell lines
    Katarzyna Miekus
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
    Folia Histochem Cytobiol 48:104-11. 2010
  10. ncbi request reprint Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an alternative hypothesis to stem cell plasticity
    Anna Pituch-Noworolska
    Polish American Children s Hospital, Medical College, Jagiellonian University, Cracow, Poland
    Folia Histochem Cytobiol 41:13-21. 2003

Collaborators

Detail Information

Publications44

  1. pmc The decreased metastatic potential of rhabdomyosarcoma cells obtained through MET receptor downregulation and the induction of differentiation
    K Miekus
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
    Cell Death Dis 4:e459. 2013
    ....
  2. pmc The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua
    Pawel Basta
    Department of Gynecology and Oncology of the Jagiellonian University, Krakow, Poland
    Reprod Biol Endocrinol 8:116. 2010
    ..We then compared these findings to what we observed in the normal eutopic endometrium of women during the secretory phase of the menstrual cycle (with immune cells under individual control)...
  3. ncbi request reprint SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells
    Marcin Majka
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Cracow, Poland
    Folia Histochem Cytobiol 44:155-64. 2006
    ..Thus, our data show that the SDF-1-CXCR4 axis affects biology of HCC cells. Furthermore, we postulate that this axis might become a potential target to prevent progression of cervical cancer...
  4. ncbi request reprint Stem cell biology: a never ending quest for understanding
    Marcin Majka
    Department of Transplantation, Jagiellonian University Medical College, Cracow, Poland
    Acta Biochim Pol 52:353-8. 2005
    ..Our team has identified a population of tissue committed stem cells (TCSC). These cells are present in a bone marrow and in other tissues and they can differentiate into several cell types including cardiac, neural and liver cells...
  5. ncbi request reprint Evidence that platelet-derived microvesicles may transfer platelet-specific immunoreactive antigens to the surface of endothelial cells and CD34+ hematopoietic stem/ progenitor cells--implication for the pathogenesis of immune thrombocytopenias
    Marcin Majka
    Dept of Transplantation, Polish American Institute of Pediatrics, Wielicka 265, 30 663 Krak6w, Poland
    Folia Histochem Cytobiol 45:27-32. 2007
    ..g. damage of endothelium, cytopenias)...
  6. doi request reprint 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion
    Katarzyna Miekus
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
    Oncol Rep 28:1903-9. 2012
    ..The strongest inhibitory effect was observed for GA and its analog, 17AEP-GA. Based on our results, GAs, particularly 17AEP-GA, could be considered as a new potential agent to treat glioblastoma multiforme...
  7. doi request reprint Inhibition of rhabdomyosarcoma's metastatic behavior through downregulation of MET receptor signaling
    Ewa Lukasiewicz
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Cracow, Poland
    Folia Histochem Cytobiol 47:485-9. 2009
    ..Since MET receptor plays a very important role in facilitating metastasis of RMS cells, blocking of HGF-MET axis might be considered as a therapeutic option for RMS patients, at more advanced and metastatic stages...
  8. doi request reprint Genetically modified adipose tissue-derived mesenchymal stem cells overexpressing CXCR4 display increased motility, invasiveness, and homing to bone marrow of NOD/SCID mice
    Sylwia Bobis-Wozowicz
    Department of Transplantation, Collegium Medicum, Jagiellonian University, Cracow, Poland
    Exp Hematol 39:686-696.e4. 2011
    ..This study evaluates usefulness of CXCR4 overexpression via retroviral transduction in adipose tissue-derived mesenchymal stem cells (AT-MSCs) as a strategy to increase their migration and engraftment ability...
  9. ncbi request reprint Role of I-TAC-binding receptors CXCR3 and CXCR7 in proliferation, activation of intracellular signaling pathways and migration of various tumor cell lines
    Katarzyna Miekus
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
    Folia Histochem Cytobiol 48:104-11. 2010
    ..Our data suggest an important role of I-TAC and its receptors in biology of solid tumors and we postulate that I-TAC-binding receptors might be used as the potential targets for antitumor therapy...
  10. ncbi request reprint Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an alternative hypothesis to stem cell plasticity
    Anna Pituch-Noworolska
    Polish American Children s Hospital, Medical College, Jagiellonian University, Cracow, Poland
    Folia Histochem Cytobiol 41:13-21. 2003
    ....
  11. ncbi request reprint Adventage of mesenchymal stem cells (MSC) expansion directly from purified bone marrow CD105+ and CD271+ cells
    Danuta Jarocha
    Center of Transplantation, University Children s Hospital, Cracow, Poland
    Folia Histochem Cytobiol 46:307-14. 2008
    ..More clonogenic CD105+ and particularly CD271+ cells, which seem to be the most homogenous fractions based on Real-Time PCR and immunostaining data, are better suited for MSC expansion...
  12. ncbi request reprint Heterogeneous populations of bone marrow stem cells--are we spotting on the same cells from the different angles?
    Mariusz Z Ratajczak
    European Stem Cell Therapeutic Excellence Center, Medical College, Jagiellonian University, Cracow, Poland
    Folia Histochem Cytobiol 42:139-46. 2004
    ....
  13. doi request reprint Fenofibrate attenuates contact-stimulated cell motility and gap junctional coupling in DU-145 human prostate cancer cell populations
    Ewa Wybieralska
    Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland
    Oncol Rep 26:447-53. 2011
    ..A novel mechanism of anti-invasive activity of fenofibrate, which depends on its interference with cell motility and the function of gap junctions regulated by reactive oxygen species, is suggested...
  14. ncbi request reprint HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo
    Ewa Lesko
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
    Anticancer Drugs 18:1173-81. 2007
    ..Our data show that the HSP90 inhibitor GA has the potential to become a new drug in RMS treatment. It blocks RMS proliferation, decreases cell survival and inhibits motility of RMS cells...
  15. doi request reprint Rapid full engraftment and successful immune reconstitution after allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in Omenn syndrome
    Jolanta Gozdzik
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Cracow, Poland
    Pediatr Transplant 13:760-5. 2009
    ..In this report, we describe a patient with OS, complicated by prolonged cytomegalovirus infection, successfully treated by reduced intensity conditioning allogeneic HSCT from sibling donor...
  16. ncbi request reprint Mesenchymal stem cells: characteristics and clinical applications
    Sylwia Bobis
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Cracow, Poland
    Folia Histochem Cytobiol 44:215-30. 2006
    ..MSCs seem to represent a future powerful tool in regenerative medicine, therefore they are particularly important in medical research...
  17. ncbi request reprint Transcoronary stem cell delivery using physiological endothelium-targeting perfusion technique: the rationale and a pilot study involving a comparison with conventional over-the-wire balloon coronary occlusions in patients after recent myocardial infarcti
    Piotr Musiałek
    Klinika Chorób Serca i Naczyń CM UJ, ul Pradnicka 80, 31 202 Krakow, Poland
    Kardiol Pol 64:489-98; discussion 499. 2006
    ..The waterfall effect of OTW-balloon inflation/deflation with reactive > or = 2-fold flow velocity increase might be partly responsible for poor BMSC retention...
  18. ncbi request reprint Adult stem cells therapy for urine incontinence in women
    Klaudia Stangel-Wójcikiewicz
    Department of Gynecology and Oncology, Collegium Medium Jagiellonian University of Kraków
    Ginekol Pol 81:378-81. 2010
    ..The stem-based therapy could be the next step in the treatment of urinary incontinence. There are still many elements of therapy such as effectiveness or long-term side effects which need to be researched...
  19. pmc Randomized transcoronary delivery of CD34(+) cells with perfusion versus stop-flow method in patients with recent myocardial infarction: Early cardiac retention of ⁹⁹(m)Tc-labeled cells activity
    Piotr Musialek
    Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Jagiellonian University, Krakow, Poland
    J Nucl Cardiol 18:104-16. 2011
    ..Flow-mediated endothelial rolling is mandatory for subsequent cell adhesion and extravasation...
  20. ncbi request reprint [Fetal CD34+ cells isolated from maternal blood and cytogenetics array as potential tools in screening, non-invasive prenatal diagnosis--preliminary research]
    Agnieszka Grabowska
    Zakład Genetyki Medycznej Katedry Pediatrii, Uniwersytetu Jagiellonskiego, Collegium Medicum, Krakow
    Przegl Lek 68:40-3. 2011
    ..We successfully used the native characteristics of fetal CD34+ cells such as strong proliferating potential and hemoglobin expression profile. Expansion of CD34+ cells reduced volume of maternal blood required to run the test...
  21. ncbi request reprint [Visualisation of early engraftment of transcoronary applied CD34+ cells in the infarct border zone]
    Piotr Musiałek
    Instytut Kardiologii, Collegium Medicum, Uniwersytet Jagiellonski, Krakow
    Kardiol Pol 66:73-7. 2008
    ..The potency of such combined high-resolution visualisation provides grounds for comparing the efficacy of different methods of cell delivery after a recent myocardial infarction in man...
  22. pmc Preliminary study of autologous bone marrow nucleated cells transplantation in children with spinal cord injury
    Danuta Jarocha
    Departments of Transplantation and Children s Neurosurgery, Jagiellonian University School of Medicine, Cracow, Poland
    Stem Cells Transl Med 3:395-404. 2014
    ..The results indicate that a certain degree of neurological and quality-of-life improvement can be attained by children with chronic complete SC injury who receive multiple BMNC implantations. ..
  23. pmc Efficient myoblast expansion for regenerative medicine use
    Danuta Jarocha
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, 30 663 Cracow, Poland
    Int J Mol Med 34:83-91. 2014
    ..Our data demonstrate that culture in the DFEFH medium leads to an approximately 90‑fold greater number of myoblasts, with improved morphology and greater fusion potential, compared with culture in the commercial SKGM-2 medium...
  24. doi request reprint Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes
    Mirosława Püsküllüoglu
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Cracow, Poland
    Folia Histochem Cytobiol 48:671-7. 2010
    ..Our findings may explain higher ARMS aggressiveness. Moreover, we suggest that further studies should be performed to verify if Snail1 can be considered as a potential target for ARMS therapy...
  25. ncbi request reprint Human monocytes both enhance and inhibit the growth of human pancreatic cancer in SCID mice
    Bozenna Mytar
    Department of Clinical Immunology and Transplantology, Polish American Institute of Paediatrics, Jagiellonian University Medical College, 30 663 Cracow, Poland
    Anticancer Res 28:187-92. 2008
    ..The purpose of this study was to determine the effect of monocytes on the growth of human pancreatic cancer (HPC-4) in severe combined immunodeficient (SCID) mice...
  26. ncbi request reprint The biological role of HGF-MET axis in tumor growth and development of metastasis
    Ewa Lesko
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
    Front Biosci 13:1271-80. 2008
    ..Thus, new therapeutic agents targeting HGF-MET signaling have been sought. Here, we will present data describing the role of HGF-MET axis in growth and metastasis of tumor cells together with the recent approaches to block this axis...
  27. pmc Downregulation of the CXCR4 receptor inhibits cervical carcinoma metastatic behavior in vitro and in vivo
    Małgorzata Sekuła
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University, 30 663 Cracow, Poland
    Int J Oncol 44:1853-60. 2014
    ..Taken together, our results indicate that CXCR4 receptor may play an important role during cervical carcinoma invasion. In our study CXCR4 influenced invasive properties of cervical carcinoma cells both in vitro and in vivo. ..
  28. ncbi request reprint Regulation of transcription in cancer
    Elzbieta Trzyna
    Departament of Transplantation, Polish American Institute of Pediatry, Jagiellonian University School of Medicine, Krakow, Poland
    Front Biosci (Landmark Ed) 17:316-30. 2012
    ..We also described transcription factors mechanism of action, and how their alteration can result in cancer...
  29. doi request reprint Autologous muscle-derived cells for the treatment of female stress urinary incontinence: a 2-year follow-up of a Polish investigation
    Klaudia Stangel-Wójcikiewicz
    Department of Gynaecology and Oncology, Jagiellonian University Collegium Medicum, Cracow, Poland
    Neurourol Urodyn 33:324-30. 2014
    ..We evaluated the safety, feasibility and initial effects of therapy with muscle-derived cells (MDCs) for women with stress urinary incontinence (SUI)...
  30. ncbi request reprint Role of the Wnt/beta-catenin network in regulating hematopoiesis
    Mirosława Wilusz
    Department of Transplantation, Polish American Institute of Pediatrics, Jagiellonian University Medical College, Cracow, Poland
    Arch Immunol Ther Exp (Warsz) 56:257-66. 2008
    ..The present review summarizes recent advances in this field...
  31. ncbi request reprint Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV
    Tomasz Rozmyslowicz
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    AIDS 17:33-42. 2003
    ..We found that peripheral blood platelet- (PMP) and megakaryocyte-derived MP (MegaMP) that highly express CXCR4 may transfer this receptor from the surface of platelets or megakaryocytes to the surface of CXCR4-null cells...
  32. ncbi request reprint Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1
    Ryan Reca
    Stem Cell Biology Program, University of Louisville, Louisville, KY 40202, USA
    Blood 101:3784-93. 2003
    ..C3a is the first positive regulator of this axis to be identified...
  33. ncbi request reprint CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
    ....
  34. ncbi request reprint CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor
    Marek Honczarenko
    Joint Program in Transfusion Medicine, Harvard Medical School, Children s Hospital Boston, MA, USA
    Blood 100:2321-9. 2002
    ..Thus, by modulation of CXCR4 function, signaling through CCR5 may influence B lymphopoiesis by affecting the migration and maturation of B-cell progenitors in the bone marrow microenvironment...
  35. ncbi request reprint Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem/progenitor cells in muscles
    Mariusz Z Ratajczak
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells 21:363-71. 2003
    ....
  36. ncbi request reprint Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets
    Marcin Majka
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Hematol 30:751-60. 2002
    ..We attempted to identify signal transduction pathways activated by these factors in normal human megakaryocytes...
  37. ncbi request reprint Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow
    Janina Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, 529 South Jackson St, KY 40202, USA
    Blood 103:2071-8. 2004
    ..The C3a-C3aR axis may prevent an uncontrolled release of HSPCs into peripheral blood. These data further suggest that the C3aR antagonist SB 290157 could be developed as a drug to mobilize HSPCs for transplantation...
  38. ncbi request reprint Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells
    Monika Baj-Krzyworzeka
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Hematol 30:450-9. 2002
    ..Peripheral blood platelet-derived microparticles (PMPs) circulate in blood and may interact directly with target cells affecting their various biological functions...
  39. ncbi request reprint Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction
    Wojciech Wojakowski
    Third Division of Cardiology, Silesian School of Medicine, 45 47 Ziołowa St, 40 635 Katowice, Poland
    Circulation 110:3213-20. 2004
    ....
  40. pmc Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction
    Magda Kucia
    Stem Cell Biology Program, University of Louisville, Louisville, Ken 40202, USA
    Circ Res 95:1191-9. 2004
    ..The present findings provide a novel paradigm that could reconcile current controversies and a rationale for investigating the use of BM-derived cardiac progenitors for myocardial regeneration...
  41. ncbi request reprint Mobilization of CD34(+), CD117(+), CXCR4(+), c-met(+) stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction
    Wojciech Wojakowski
    3rd Division of Cardiology, Silesian School of Medicine, 45 47 Ziołowa Street, 40 635 Katowice, Poland
    Eur Heart J 27:283-9. 2006
    ....
  42. ncbi request reprint The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner
    Magda Kucia
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, KY 40202, USA
    Arch Immunol Ther Exp (Warsz) 54:121-35. 2006
    ..In this study we evaluated whether TCSCs respond to other motomorphogens, such as hepatocyte growth factor (HGF) and leukemia inhibitory factor (LIF)...
  43. ncbi request reprint Biological role of the CXCR4-SDF-1 axis in normal human hematopoietic cells
    Marcin Majka
    James Graham Brown Cancer Center, University of Louisville, KY, USA
    Methods Mol Biol 332:103-14. 2006
    ..These cells can be used routinely for studying the role of the CXCR4-SDF-1 axis in normal human hematopoiesis...
  44. ncbi request reprint Biological significance of the different erythropoietic factors secreted by normal human early erythroid cells
    Janina Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leuk Lymphoma 44:767-74. 2003
    ....