Andrzej Guranowski

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. ncbi request reprint Specific and nonspecific enzymes involved in the catabolism of mononucleoside and dinucleoside polyphosphates
    A Guranowski
    Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul Wo yOska 35, 60 637, PoznaO, Poland
    Pharmacol Ther 87:117-39. 2000
  2. doi request reprint Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, University of Life Sciences, Poznan, Poland
    FEBS J 276:1546-53. 2009
  3. ncbi request reprint Metabolism of diadenosine tetraphosphate (Ap4A) and related nucleotides in plants; review with historical and general perspective
    Andrzej Guranowski
    Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul Wolynska 35, 60 637 Poznan, Poland
    Front Biosci 9:1398-411. 2004
  4. ncbi request reprint Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, Agricultural University, Poznan, Poland
    FEBS J 273:829-38. 2006
  5. ncbi request reprint Analogs of diadenosine tetraphosphate (Ap4A)
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, University of Agriculture, Poznan, Poland
    Acta Biochim Pol 50:947-72. 2003
  6. pmc Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, University of Agriculture, 60 637 Poznan, Poland
    Biochem J 373:635-40. 2003
  7. ncbi request reprint Selective splitting of 3'-adenylated dinucleoside polyphosphates by specific enzymes degrading dinucleoside polyphosphates
    Andrzej Guranowski
    Departamento de Bioquimica, Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, Facultad de Medicina, 28029 Madrid, Spain
    Acta Biochim Pol 50:123-30. 2003
  8. ncbi request reprint Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap(3)A and Ap(4)A, by two specific human dinucleoside polyphosphate hydrolases
    A Guranowski
    Department of Molecular Biology, Aarhus University, Aarhus, Denmark
    Arch Biochem Biophys 373:218-24. 2000
  9. ncbi request reprint Adenosine 5'-tetraphosphate phosphohydrolase activity is an inherent property of soluble exopolyphosphatase from yeast Saccharomyces cerevisiae
    A Guranowski
    Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul Wolynska 35, 60 637 Poznan, Poland
    Biochim Biophys Acta 1380:232-8. 1998
  10. doi request reprint Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP)
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, The University of Life Sciences, Poznan, Poland
    FEBS Lett 584:93-8. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Specific and nonspecific enzymes involved in the catabolism of mononucleoside and dinucleoside polyphosphates
    A Guranowski
    Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul Wo yOska 35, 60 637, PoznaO, Poland
    Pharmacol Ther 87:117-39. 2000
    ..In contrast, the Schizosaccharomyces pombe Ap(4)A/Ap(3)A hydrolase, the human Fhit protein, and the yeast Np(n)N' phosphorylases belong to a superfamily GAFH, which includes the histidine triad proteins...
  2. doi request reprint Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, University of Life Sciences, Poznan, Poland
    FEBS J 276:1546-53. 2009
    ..By contrast, none of the six analogs were good substrates or inhibitors of the bacterial symmetrical Ap(4)A hydrolase...
  3. ncbi request reprint Metabolism of diadenosine tetraphosphate (Ap4A) and related nucleotides in plants; review with historical and general perspective
    Andrzej Guranowski
    Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul Wolynska 35, 60 637 Poznan, Poland
    Front Biosci 9:1398-411. 2004
    ..In fact, some of the plant enzymes involved in the synthesis and degradation of these minor mono- and dinucleotides have been studied even more thoroughly than their counterparts from other organisms...
  4. ncbi request reprint Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, Agricultural University, Poznan, Poland
    FEBS J 273:829-38. 2006
    ..These novel nucleotides should prove valuable tools for further studies on the cellular functions of mono- and dinucleoside polyphosphates and on the enzymes involved in their metabolism...
  5. ncbi request reprint Analogs of diadenosine tetraphosphate (Ap4A)
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, University of Agriculture, Poznan, Poland
    Acta Biochim Pol 50:947-72. 2003
    ....
  6. pmc Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, University of Agriculture, 60 637 Poznan, Poland
    Biochem J 373:635-40. 2003
    ..All of these inhibitors were competitive with respect to Ap(4)A. These new selectively acting Ap(4)A analogues should prove to be valuable tools for further studies of Ap(4)A function and of the enzymes involved in its metabolism...
  7. ncbi request reprint Selective splitting of 3'-adenylated dinucleoside polyphosphates by specific enzymes degrading dinucleoside polyphosphates
    Andrzej Guranowski
    Departamento de Bioquimica, Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, Facultad de Medicina, 28029 Madrid, Spain
    Acta Biochim Pol 50:123-30. 2003
    ..7.7.53) from Saccharomyces cerevisiae did not degrade the three 3'-adenylated dinucleoside polyphosphates tested...
  8. ncbi request reprint Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap(3)A and Ap(4)A, by two specific human dinucleoside polyphosphate hydrolases
    A Guranowski
    Department of Molecular Biology, Aarhus University, Aarhus, Denmark
    Arch Biochem Biophys 373:218-24. 2000
    ....
  9. ncbi request reprint Adenosine 5'-tetraphosphate phosphohydrolase activity is an inherent property of soluble exopolyphosphatase from yeast Saccharomyces cerevisiae
    A Guranowski
    Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul Wolynska 35, 60 637 Poznan, Poland
    Biochim Biophys Acta 1380:232-8. 1998
    ..08, 0.3 and 0.4 mM, respectively). This newly recognized 'acidic' adenosine tetraphosphatase activity from yeast is compared with two 'pH 8' adenosine tetraphosphatases described earlier in rabbit and yellow lupin...
  10. doi request reprint Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP)
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, The University of Life Sciences, Poznan, Poland
    FEBS Lett 584:93-8. 2010
    ..A mechanism for these activities is proposed and the possible role of some HIT-proteins in APS metabolism is discussed...
  11. ncbi request reprint Uridine 5'-polyphosphates (p4U and p5U) and uridine(5')polyphospho(5')nucleosides (Up(n)Ns) can be synthesized by UTP:glucose-1-phosphate uridylyltransferase from Saccharomyces cerevisiae
    Andrzej Guranowski
    Departamento de Bioquimica, Instituto de Investigaciones Biomedicas Alberto Sols, UAM CSIC, Facultad de Medicina, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    FEBS Lett 561:83-8. 2004
    ..Occurrence of such dinucleotides in S. cerevisiae and Escherichia coli has been previously reported (Coste et al., J. Biol. Chem. 262 (1987) 12096-12103)...
  12. ncbi request reprint Plant nucleoside 5'-phosphoramidate hydrolase; simple purification from yellow lupin (Lupinus luteus) seeds and properties of homogeneous enzyme
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, Poznan, University of Life Sciences, Poznan, Poland
    Acta Biochim Pol 58:131-6. 2011
    ..At the optimum pH of 7.0, the K(m) for NH₂-pA was 0.5 µM and k(cat) 0.8 s⁻¹ (per monomer active site). The properties of the lupin nucleoside 5'-phosphoramidase are compared with those of its counterparts from other organisms...
  13. doi request reprint Fhit proteins can also recognize substrates other than dinucleoside polyphosphates
    Andrzej Guranowski
    Department of Biochemistry and Biotechnology, The University of Life Sciences, 60 637 Poznan, Poland
    FEBS Lett 582:3152-8. 2008
    ..Some kinetic parameters and implications of the novel reactions catalyzed by the human and plant (Arabidopsis thaliana) Fhit proteins are presented...
  14. ncbi request reprint Calcium-stimulated guanosine--inosine nucleosidase from yellow lupin (Lupinus luteus)
    Maciej Szuwart
    Department of Biochemistry and Biotechnology, Agricultural University, 35 Wołyńska Street, 60 637 Poznan, Poland
    Phytochemistry 67:1476-85. 2006
    ..The lupin nucleosidase has been compared with other nucleosidases...
  15. pmc P alpha-chiral phosphorothioate analogues of bis(5'-adenosyl)tetraphosphate (Ap4A); their enzymatic synthesis and degradation
    D Lazewska
    Katedra Biochemii, Akademia Rolnicza, Poznan, Poland
    Nucleic Acids Res 18:6083-8. 1990
    ..5, respectively. Basic kinetic parameters of the degradation reactions are presented and structural requirements of the Ap4A-metabolizing enzymes with respect to the potential substrates modified at the Ap4A-P alpha are discussed...
  16. ncbi request reprint Hint2, the mitochondrial nucleoside 5'-phosphoramidate hydrolase; properties of the homogeneous protein from sheep (Ovis aries) liver
    Ewa Bretes
    Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Poznan, Poland
    Acta Biochim Pol 60:249-54. 2013
    ..Studies of the rates of hydrolysis of different NH2-pA derivatives show that Hint2 is more specific towards compounds with a P-N bond than Hint1. The thermostability of these two proteins is also compared. ..
  17. ncbi request reprint Synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate (AppppA) from adenosine 5'-phosphosulfate and adenosine 5'-triphosphate catalyzed by yeast AppppA phosphorylase
    A Guranowski
    Katedra Biochemii, Akademia Rolnicza, Poznan, Poland
    Biochemistry 27:2959-64. 1988
    ....
  18. pmc 4-Coumarate:coenzyme A ligase has the catalytic capacity to synthesize and reuse various (di)adenosine polyphosphates
    Małgorzata Pietrowska-Borek
    Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul Wołyńska 35, 60 637 Poznan, Poland
    Plant Physiol 131:1401-10. 2003
    ....
  19. ncbi request reprint 5'-methylthioadenosine nucleosidase from yellow lupine (Lupinus luteus): molecular characterization and mutational analysis
    Ewa Bretes
    Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Poznan, Poland
    Protein Pept Lett 18:817-24. 2011
    ..We also analyzed the sequence of the LlMTAN promoter region. It appeared that there may be a direct link between LlMTAN expression regulation and sulfate metabolism...
  20. ncbi request reprint Human placental (Asymmetrical) diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase: purification to homogeneity and some properties
    D Lazewska
    Katedra Biochemii i Biotechnologii, Akademia Rolnicza, Poznan, Poland
    Protein Expr Purif 4:45-51. 1993
    ..Diadenosine tetraphosphate analogues with P2-P3 bridges such as -CF2-, -CCl2-, and -CH2- were hydrolyzed to adenosine 5'-phosphate and the corresponding adenosine 5'-triphosphate analogue.(ABSTRACT TRUNCATED AT 250 WORDS)..
  21. pmc Diadenosine polyphosphates (Ap3A and Ap4A) behave as alarmones triggering the synthesis of enzymes of the phenylpropanoid pathway in Arabidopsis thaliana
    Małgorzata Pietrowska-Borek
    Department of Plant Physiology, Poznan University of Life Sciences, 60 637 Poznan, Poland
    FEBS Open Bio 1:1-6. 2011
    ..Neither adenine mononucleotides (AMP, ADP or ATP) nor adenosine evoked such effects. Reactions catalyzed in vitro by these enzymes were not affected by Ap3A or Ap4A...
  22. pmc Studies on some specific Ap4A-degrading enzymes with the use of various methylene analogues of P1P4-bis-(5',5'''-adenosyl) tetraphosphate
    A Guranowski
    Katedra Biochemii, Akademia Rolnicza, Poznan, Poland
    Biochem J 262:241-4. 1989
    ..As expected, these analogues were not hydrolysed by the symmetrical hydrolase, which was also unable to act on analogues having P1-P2 and P3-P4 carbon bridges...
  23. ncbi request reprint Fluoride is a strong and specific inhibitor of (asymmetrical) Ap4A hydrolases
    A Guranowski
    Katedra Biochemii, Akademia Rolnicza, Poznan, Poland
    FEBS Lett 262:205-8. 1990
    ..1.29) and phosphodiesterase (EC 3.1.4.1). None of halogenic anions but fluoride affects the activity of (asymmetrical) Ap4A hydrolases. Usefulness of the fluoride effect for the in vivo studies on the Ap4A metabolism is shortly discussed...
  24. ncbi request reprint Metabolism of homocysteine-thiolactone in plants
    Hieronim Jakubowski
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School, International Center for Public Health, Newark, New Jersey 07101, USA
    J Biol Chem 278:6765-70. 2003
    ..Thus, Hcy-thiolactone and Hcy bound to protein by an amide (or peptide) linkage (Hcy-N-protein) are significant components of plant Hcy metabolism...
  25. ncbi request reprint Substrate specificity and products of side-reactions catalyzed by jasmonate:amino acid synthetase (JAR1)
    Andrzej Guranowski
    Leibniz Institute of Plant Biochemistry, Weinberg 3, D 06120 Halle Saale, Germany
    FEBS Lett 581:815-20. 2007
    ....
  26. ncbi request reprint Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase
    Jaroslaw Zimny
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, International Center for Public Health, Newark, New Jersey 07101, USA
    J Biol Chem 281:22485-92. 2006
    ..Our data suggest that BLH protects cells against Hcy toxicity by hydrolyzing intracellular Hcy-thiolactone...
  27. ncbi request reprint Synthesis and enzymatic characterization of methylene analogs of adenosine 5'-tetraphosphate (P4A)
    Jacek Jemielity
    Department of Biophysics, Institute of Experimental Physics, Warsaw University, Zwirki i Wigury 93, Warsaw 02 089, Poland
    Nucleosides Nucleotides Nucleic Acids 24:589-93. 2005
    ..The structures of the synthesized compounds were confirmed by NMR spectroscopy. They were tested as potential substrates and inhibitors of several hydrolases...