Andrzej Gorski

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. ncbi request reprint The ethics of intellectual property rights in biomedicine and biotechnology: an introduction
    Andrzej Gorski
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, The Medical University of Warsaw, Poland
    Sci Eng Ethics 11:4-6. 2005
  2. doi request reprint The potential of phage therapy in bacterial infections of the eye
    Andrzej Gorski
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Ophthalmologica 223:162-5. 2009
  3. doi request reprint Phage as a modulator of immune responses: practical implications for phage therapy
    Andrzej Gorski
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Adv Virus Res 83:41-71. 2012
  4. ncbi request reprint Bacteriophage translocation
    Andrzej Gorski
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    FEMS Immunol Med Microbiol 46:313-9. 2006
  5. ncbi request reprint Introduction: the responsible conduct of basic and clinical research
    Andrzej Gorski
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Poland
    Sci Eng Ethics 12:3-4. 2006
  6. ncbi request reprint Bacteriophage therapy for the treatment of infections
    Andrzej Gorski
    Polish Academy of Sciences, Phage Therapy Unit, L Hirszfeld Institute of Immunology and Experimental Therapy, Weigla 12, Wroclaw, Poland
    Curr Opin Investig Drugs 10:766-74. 2009
  7. ncbi request reprint The potential role of endogenous bacteriophages in controlling invading pathogens
    Andrzej Gorski
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53114, Wroclaw, Poland
    Cell Mol Life Sci 62:511-9. 2005
  8. doi request reprint "Medical writing" and ghostwriting as ethical challenges in medical communication
    A Gorski
    Medical University of Warsaw, Warsaw, Poland
    Transplant Proc 42:3335-7. 2010
  9. ncbi request reprint Placebo: its action and place in health research today
    Andrzej Gorski
    Committee for Ethics in Science, Ministry of Science and Bioethics Commission, Ministry of Health, Warsaw, Poland
    Sci Eng Ethics 10:3-4. 2004
  10. ncbi request reprint Activity of bacteriophages in murine tumor models depends on the route of phage administration
    Krystyna Dabrowska
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R Weigla 12, 53 114 Wroclaw, Poland
    Oncol Res 15:183-7. 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The ethics of intellectual property rights in biomedicine and biotechnology: an introduction
    Andrzej Gorski
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, The Medical University of Warsaw, Poland
    Sci Eng Ethics 11:4-6. 2005
  2. doi request reprint The potential of phage therapy in bacterial infections of the eye
    Andrzej Gorski
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Ophthalmologica 223:162-5. 2009
    ..In recent years, a number of papers have been published suggesting its efficacy in animal and human bacterial infections, but none of them addressed the phage potential in ophthalmology, which is the subject of this mini review...
  3. doi request reprint Phage as a modulator of immune responses: practical implications for phage therapy
    Andrzej Gorski
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Adv Virus Res 83:41-71. 2012
    ..These topics are presented based on the results of experimental studies and unique data on immunomodulatory effects found in patients with bacterial infections treated with phage preparations...
  4. ncbi request reprint Bacteriophage translocation
    Andrzej Gorski
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    FEMS Immunol Med Microbiol 46:313-9. 2006
    ..In addition, phages of the gut may play a protective role by inhibiting local immune reactions to antigens derived from gut flora...
  5. ncbi request reprint Introduction: the responsible conduct of basic and clinical research
    Andrzej Gorski
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Poland
    Sci Eng Ethics 12:3-4. 2006
  6. ncbi request reprint Bacteriophage therapy for the treatment of infections
    Andrzej Gorski
    Polish Academy of Sciences, Phage Therapy Unit, L Hirszfeld Institute of Immunology and Experimental Therapy, Weigla 12, Wroclaw, Poland
    Curr Opin Investig Drugs 10:766-74. 2009
    ..This review discusses the current status of bacteriophage therapy, including the experience of one expert center specializing in this form of treatment...
  7. ncbi request reprint The potential role of endogenous bacteriophages in controlling invading pathogens
    Andrzej Gorski
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53114, Wroclaw, Poland
    Cell Mol Life Sci 62:511-9. 2005
    ..We hypothesize that phages could act in concert with the immune system in immunosurveillance against bacteria, viruses and cancer...
  8. doi request reprint "Medical writing" and ghostwriting as ethical challenges in medical communication
    A Gorski
    Medical University of Warsaw, Warsaw, Poland
    Transplant Proc 42:3335-7. 2010
    ....
  9. ncbi request reprint Placebo: its action and place in health research today
    Andrzej Gorski
    Committee for Ethics in Science, Ministry of Science and Bioethics Commission, Ministry of Health, Warsaw, Poland
    Sci Eng Ethics 10:3-4. 2004
  10. ncbi request reprint Activity of bacteriophages in murine tumor models depends on the route of phage administration
    Krystyna Dabrowska
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R Weigla 12, 53 114 Wroclaw, Poland
    Oncol Res 15:183-7. 2005
    ..The role of the route of bacteriophage administration should be considered in the context of the effectiveness and safety of such therapies...
  11. doi request reprint Prophylactic effect of bacteriophages on mice subjected to chemotherapy-induced immunosuppression and bone marrow transplant upon infection with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Med Microbiol Immunol 199:71-9. 2010
    ..The results suggest a potential benefit of phage therapy in immunocompromised patients subjected to bone marrow transplant procedures...
  12. ncbi request reprint Effects of bacteriophages on free radical production and phagocytic functions
    Anna Przerwa
    Transplantation Institute, Medical University of Warsaw, 02 006 Warsaw, Poland
    Med Microbiol Immunol 195:143-50. 2006
    ....
  13. doi request reprint The effects of staphylococcal bacteriophage lysates on cancer cells in vitro
    Krystyna Dabrowska
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul R Weigla 12, 53 114, Wroclaw, Poland
    Clin Exp Med 10:81-5. 2010
    ..All the studied therapeutic bacteriophage preparations were negative for the Staphylococcal enterotoxins A, B, C, D, and E (i.e., the enterotoxin content was less than 0.2-0.5 ng/ml)...
  14. ncbi request reprint Antitumor effect of combined treatment of mice with cytostatic agents and bacteriophage T4
    Katarzyna Szczaurska-Nowak
    Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53 114 Wroclaw, Poland
    Anticancer Res 29:2361-70. 2009
    ..This suggests the possibility of safe combination of bacteriophage preparations with popular antitumour drugs...
  15. doi request reprint Clinical aspects of phage therapy
    Ryszard Miedzybrodzki
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Adv Virus Res 83:73-121. 2012
    ..In addition, the whole complex procedure employed to obtain and characterize therapeutic phage preparations, as well as ethical aspects of PT, is discussed...
  16. pmc The effect of bacteriophages T4 and HAP1 on in vitro melanoma migration
    Krystyna Dabrowska
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    BMC Microbiol 9:13. 2009
    ..On the other hand, the perspective of the possible use of bacteriophage preparations for antibacterial therapies in cancer patients generates a substantial need to investigate the effects of phages on cancer processes...
  17. doi request reprint The effects of T4 and A3/R phage preparations on whole-blood monocyte and neutrophil respiratory burst
    Jan Borysowski
    Department of Clinical Immunology, Transplantation Institute, Warsaw Medical University, Warsaw, Poland
    Viral Immunol 23:541-4. 2010
    ..These results suggest that phage preparations are not likely to induce oxidative stress following their administration to patients...
  18. ncbi request reprint Hoc protein regulates the biological effects of T4 phage in mammals
    Krystyna Dabrowska
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul R Wiegla 12, 53 114 Wroclaw, Poland
    Arch Microbiol 187:489-98. 2007
    ..Although HAP1 was previously defined to bind cancer cells more effectively (than T4), its rapid elimination precluded its higher concentration in tumours...
  19. pmc Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wrocław, Poland
    BMC Microbiol 9:169. 2009
    ..In this work we investigated the prophylactic efficacy of specific bacteriophages in CBA mice treated with cyclophosphamide (CP) and infected with Staphylococcus aureus...
  20. ncbi request reprint Bacteriophage preparation inhibition of reactive oxygen species generation by endotoxin-stimulated polymorphonuclear leukocytes
    Ryszard Miedzybrodzki
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53 114 Wroclaw, Poland
    Virus Res 131:233-42. 2008
    ..It helps in understanding the role of phages in our environment and may also be of important clinical significance...
  21. ncbi request reprint Etanercept immunotherapy in women with a history of recurrent reproductive failure
    Małgorzata Jerzak
    Department of Gynecology and Gynecological Oncology, Military Institute of Medicine, Warsaw, Poland
    Ginekol Pol 83:260-4. 2012
    ..The aim of the study was to evaluate the effect of etanercept immunotherapy on peripheral natural killer (NK) cell activity in women with a history of recurrent miscarriage (RM) or failed in vitro fertilization (IVF)...
  22. ncbi request reprint Bacteriophage therapy in children: facts and prospects
    Wojciech Fortuna
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Med Sci Monit 14:RA126-32. 2008
    ..It seems clear that bacteriophages need further evaluation regarding the control of bacterial infection in children...
  23. ncbi request reprint The concerted action of lactoferrin and bacteriophages in the clearance of bacteria in sublethally infected mice
    Michał Zimecki
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
    Postepy Hig Med Dosw (Online) 62:42-6. 2008
    ..Both lactoferrin (LF) and bacteriophages are potent antibacterial agents. LF is contained in the secretory fluids of mammals and bacteriophages are specific bacterial viruses...
  24. ncbi request reprint Effect of phage therapy on the turnover and function of peripheral neutrophils
    Beata Weber-Dabrowska
    Institute of Immunology and Experimental Therapy of the Polish Academy of Science, Rudolfa Weigla 12, 53 114, Wroclaw, Poland
    FEMS Immunol Med Microbiol 34:135-8. 2002
    ..0) and after 3 months (mean 59.6). The results of this investigation indicate that successful phage therapy accelerates the turnover of neutrophils, accompanied by a decrease in their ability to phagocytize bacteria...
  25. doi request reprint The perspectives of the application of phage therapy in chronic bacterial prostatitis
    Sławomir Letkiewicz
    Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    FEMS Immunol Med Microbiol 60:99-112. 2010
    ..The advantages of therapeutic phages, including their interactions with bacterial biofilm, as well as the safety of PT are discussed...
  26. doi request reprint A retrospective analysis of changes in inflammatory markers in patients treated with bacterial viruses
    Ryszard Miedzybrodzki
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53 114, Wroclaw, Poland
    Clin Exp Med 9:303-12. 2009
    ..This is the first report suggesting that the application of phage preparations may probably influence and diminish the inflammatory reaction that accompanies bacterial infection...
  27. doi request reprint Bacteriophage interactions with phagocytes and their potential significance in experimental therapy
    Aneta Kurzepa
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul Weigla 12, 53 114 Wrocław, Poland
    Clin Exp Med 9:93-100. 2009
    ..We believe that continuation of such research is indispensable...
  28. ncbi request reprint Bacteriophage endolysins as a novel class of antibacterial agents
    Jan Borysowski
    Department of Clinical Immunology, Institute of Transplantology, The Medical University of Warsaw, 02 006 Warsaw, Poland
    Exp Biol Med (Maywood) 231:366-77. 2006
    ..Additionally, we outline current knowledge regarding the structure and natural function of the enzymes in phage biology, including the most recent findings...
  29. doi request reprint Bacteriophages and cancer
    Paulina Budynek
    Institute of Immunology and Experimental Therapy, Wroclaw, Poland
    Arch Microbiol 192:315-20. 2010
    ....
  30. doi request reprint Is phage therapy acceptable in the immunocompromised host?
    Jan Borysowski
    Department of Clinical Immunology, Transplantation Institute, The Medical University of Warsaw, Nowogrodzka 59, 02 006 Warsaw, Poland
    Int J Infect Dis 12:466-71. 2008
    ..The available data suggest that bacteriophages could also be an efficacious and safe therapeutic modality in such patients...
  31. ncbi request reprint Phage therapy of staphylococcal infections (including MRSA) may be less expensive than antibiotic treatment
    Ryszard Miedzybrodzki
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 61:461-5. 2007
    ..We now present data showing that efficient phage therapy of staphylococcal infections is no longer a treatment of last resort (when all antibiotics fail), but allows for significant savings in the costs of healthcare...
  32. ncbi request reprint Anticancer activity of bacteriophage T4 and its mutant HAP1 in mouse experimental tumour models
    Krystyna Dabrowska
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R Weigla 12, 53 114 Wroclaw, Poland
    Anticancer Res 24:3991-5. 2004
    ..Here, we investigated the potential phage anticancer activity in primary tumour models...
  33. ncbi request reprint Bacterial viruses against viruses pathogenic for man?
    Ryszard Miedzybrodzki
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Centre of Excellence IMMUNE, Polish Academy of Sciences, Rudolfa Weigla 12, 53 114 Wroclaw, Poland
    Virus Res 110:1-8. 2005
    ....
  34. pmc T4 phage and its head surface proteins do not stimulate inflammatory mediator production
    Paulina Miernikiewicz
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    PLoS ONE 8:e71036. 2013
    ..These observations are of importance for any medical or veterinary application of bacteriophages. ..
  35. pmc Characterising the biology of novel lytic bacteriophages infecting multidrug resistant Klebsiella pneumoniae
    Agata Kęsik-Szeloch
    Institute of Genetics and Microbiology, University of Wroclaw, Przybyszewskiego 63 77, Wroclaw, Poland
    Virol J 10:100. 2013
    ..The increased incidence of antimicrobial resistance in these species has propelled the need for alternate/combination therapeutic regimens to aid clinical treatment. Bacteriophage therapy forms one of these alternate strategies...
  36. doi request reprint Influence of bacteriophage preparations on intracellular killing of bacteria by human phagocytes in vitro
    Aneta Kurzepa-Skaradzinska
    Laboratory of Bacteriophages, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Viral Immunol 26:150-62. 2013
    ..Although the results of our study are preliminary, they support previous data indicating safety of therapeutic application of phages...
  37. doi request reprint First successful pregnancy after addition of enoxaparin to sildenafil and etanercept immunotherapy in woman with fifteen failed IVF cycles - case report
    Małgorzata Jerzak
    Department of Gynecology and Gynecological Oncology, Military Institute of Health Services, Warsaw, Poland
    Am J Reprod Immunol 64:93-6. 2010
    ..Does addition of enoxaparin to sildenafil and etanercept immunotherapy improve IVF outcome?..
  38. doi request reprint Bacteriophages support anti-tumor response initiated by DC-based vaccine against murine transplantable colon carcinoma
    Elzbieta Pajtasz-Piasecka
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Immunol Lett 116:24-32. 2008
    ..Therefore, pretreatment of DCs with the phages may be considered as a beneficial element of a novel strategy in anti-tumor immunotherapy...
  39. ncbi request reprint Nec Soli Cedit (article dedicated to Professor Ludwik Hirszfeld)
    Andrzej Gorski
    Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 59:570-2. 2005
  40. ncbi request reprint [Olfactory glial cells: hope in the treatment of spinal cord injuries]
    Włodzimierz Jarmundowicz
    Katedra i Klinika Neurochirurgii, Akademia Medyczna we Wrocławiu, Wrocław, Poland
    Neurol Neurochir Pol 38:413-20; discussion 421-2. 2004
    ....
  41. doi request reprint Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury
    Pawel Tabakow
    Department of Neurosurgery, Wroclaw Medical University, Wroclaw, Poland
    Cell Transplant 22:1591-612. 2013
    ..The significance of the neurological improvement in the transplant recipients and the extent to which the cell transplants contributed to it will require larger numbers of patients. ..
  42. ncbi request reprint Preparation of endotoxin-free bacteriophages
    Janusz Boratynski
    Laboratory of Biomedical Chemistry, Department of Experimental Oncology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53 114 Wrocław, Poland
    Cell Mol Biol Lett 9:253-9. 2004
    ..The procedure yielded bacteriophages contaminated with as little as 0.4-7 EU/ml (Limulus assay). This value lies within the permitted level for intravenous applications (5 EU/kg/h by European Pharmacopoeia, 1997)...
  43. ncbi request reprint Influence of clindamycin, metronidazole and polymyxin B on the expression of cell adhesion molecules stimulated by endotoxin and enterotoxin of Bacteroides fragilis
    Felicja Meisel-Mikołajczyk
    Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland
    Acta Microbiol Pol 52:361-72. 2003
    ..The expression of VCAM-1 was augmented by antimicrobials when endothelium was stimulated with LPS or enterotoxin preparations. The expression of E-selectin was differentiated...