Małgorzata Filip

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. ncbi Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 54:687-91. 2002
  2. doi Pharmacological and genetic interventions in serotonin (5-HT)(2C) receptors to alter drug abuse and dependence processes
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res 1476:132-53. 2012
  3. ncbi The importance of the adenosine A(2A) receptor-dopamine D(2) receptor interaction in drug addiction
    M Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Curr Med Chem 19:317-55. 2012
  4. ncbi Implication of the nucleus accumbens shell, but not core, in the acute and sensitizing effects of cocaine in rats
    M Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 53:459-66. 2001
  5. doi Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Addict Biol 15:227-49. 2010
  6. ncbi Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna, Poland
    Eur J Pharmacol 541:163-70. 2006
  7. ncbi Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res 1077:67-80. 2006
  8. ncbi Blocking impact of clozapine on cocaine locomotor and sensitizing effects in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:1125-30. 2003
  9. ncbi Involvement of cannabinoid CB1 receptors in drug addiction: effects of rimonabant on behavioral responses induced by cocaine
    Małgorzata Filip
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:806-19. 2006
  10. ncbi Opioid and monoamine systems mediate the discriminative stimulus of tramadol in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Eur J Pharmacol 498:143-51. 2004

Detail Information

Publications77

  1. ncbi Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 54:687-91. 2002
    ..4 mg/kg, ip) on day 10. The results indicate a role of DA D3 receptors in controlling the expression of cocaine sensitization in rats, and may suggest an importance of DA D3 receptor agonists in the therapy of cocaine abuse...
  2. doi Pharmacological and genetic interventions in serotonin (5-HT)(2C) receptors to alter drug abuse and dependence processes
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res 1476:132-53. 2012
    ..This article is part of a Special Issue entitled: Brain Integration...
  3. ncbi The importance of the adenosine A(2A) receptor-dopamine D(2) receptor interaction in drug addiction
    M Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Curr Med Chem 19:317-55. 2012
    ..Taken together, a significant amount of experimental analyses provide evidence that targeting A(2A) receptors may offer innovative translational strategies for combating drug addiction...
  4. ncbi Implication of the nucleus accumbens shell, but not core, in the acute and sensitizing effects of cocaine in rats
    M Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 53:459-66. 2001
    ..They also indicate a preferential effect for the NAc shell in expression of the acute and sensitizing effects of cocaine in rats...
  5. doi Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Addict Biol 15:227-49. 2010
    ..Additionally, the consequences of chronic cocaine exposure on particular 5-HT receptor-assigned functions in pre-clinical studies are presented...
  6. ncbi Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna, Poland
    Eur J Pharmacol 541:163-70. 2006
    ..The finding that vigabatrin protected against the development and the expression of cocaine sensitization further supports its therapeutic potential in the treatment of cocaine dependence...
  7. ncbi Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res 1077:67-80. 2006
    ..The results suggest an antagonistic role of A2ARs in D2R-mediated cocaine actions based at least in part on the existence of A2A/D2 heteromeric receptor complexes...
  8. ncbi Blocking impact of clozapine on cocaine locomotor and sensitizing effects in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:1125-30. 2003
    ..These findings seem to be in line with recent clinical reports showing that clozapine may be useful in the treatment of cocaine abuse, even in schizophrenic patients...
  9. ncbi Involvement of cannabinoid CB1 receptors in drug addiction: effects of rimonabant on behavioral responses induced by cocaine
    Małgorzata Filip
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:806-19. 2006
    ..The latter observations may show that repeated cocaine treatment and the drug withdrawal produce--apart from behavioral effects--also different neural consequences in the endocannabinoid systems in rats...
  10. ncbi Opioid and monoamine systems mediate the discriminative stimulus of tramadol in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Eur J Pharmacol 498:143-51. 2004
    ..Our results indicate that tramadol can be used as a stimulus cue in rats, and that mu opioid peptide mechanisms are involved in its effects, while noradrenergic uptake inhibitors can enhance tramadol discrimination...
  11. ncbi Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 57:35-46. 2005
    ..Since drugs that reduce cocaine seeking also alleviate cocaine craving, 5-HT(2A) receptor antagonists may be considered to be of possible clinical application for the treatment of cocaine dependence...
  12. ncbi Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats
    Małgorzata Filip
    Institute of Pharmacology, Polish Academy of Sciences, Smetna Street 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 192:17-26. 2007
    ..Recent data indicate that gamma-aminobutyric acid (GABA) is a modulator of behavioral responses to cocaine...
  13. ncbi The serotonergic system and its role in cocaine addiction
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 57:685-700. 2005
    ..The present state of knowledge of 5-HT neurotransmission justifies the opinion that pharmacological manipulation in the 5-HT system may efficiently counteract the effects of cocaine withdrawal and prevent reinstatement of its abuse...
  14. ncbi Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:761-77. 2009
    ..Additionally, we also introduce the recent knowledge about the 5-HT receptor ligands in preclinical research, clinical trials and as approved drugs...
  15. ncbi Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats
    M Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 58:625-39. 2007
    ..Moreover, a dissociation between effects of 1MeTIQ on cocaine vs. food-maintained responding was demonstrated...
  16. ncbi GABA(B) receptors in drug addiction
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:755-70. 2008
    ..It also reviews the current knowledge about the GABA(B) receptor ligands in clinical trials, with a focus on their effects on presentation of the drug-associated cues and withdrawal-induced drug craving...
  17. ncbi On the role of serotonin2A/2C receptors in the sensitization to cocaine
    M Filip
    Department of Pharmacology, Institute of Pharmacology Polish Academy of Science, Krakow, Poland
    J Physiol Pharmacol 52:471-81. 2001
    ..Since chronic use of cocaine by humans may lead to psychoses or craving for this drug of abuse, our findings also seem to indicate possible importance of 5-HT2A/2C receptor antagonists in the therapy of cocaine addiction...
  18. ncbi Does combined treatment with novel antidepressants and a dopamine D3 receptor agonist reproduce cocaine discrimination in rats?
    M Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 53:577-85. 2001
    ....
  19. ncbi Effects of GABA(B) receptor antagonist, agonists and allosteric positive modulator on the cocaine-induced self-administration and drug discrimination
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Eur J Pharmacol 574:148-57. 2007
    ..Moreover, a dissociation between effects of direct GABA(B) receptor agonists and a GABA(B) allosteric positive modulator on cocaine vs. food-maintained responding was demonstrated...
  20. ncbi Effects of GABA(B) receptor agents on cocaine priming, discrete contextual cue and food induced relapses
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Eur J Pharmacol 571:166-73. 2007
    ....
  21. ncbi Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats
    Edmund Przegalinski
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, 12 Smetna, Poland
    Eur J Pharmacol 559:165-72. 2007
    ..Furthermore, we demonstrated that 5-HT1B receptor agonist-induced enhancement of cocaine reward was independent of an alteration in natural reinforcement...
  22. ncbi Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats
    Magdalena Zaniewska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343, Krakow, 12 Smetna, Poland
    Eur J Pharmacol 540:96-106. 2006
    ..Furthermore, we excluded the involvement of either cannabinoid CB1 and CB2 receptors or increases in the endocannabinoid tone in the nicotine discrimination...
  23. ncbi Alterations in BDNF and trkB mRNAs following acute or sensitizing cocaine treatments and withdrawal
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna, 31 343 Krakow, Poland
    Brain Res 1071:218-25. 2006
    ....
  24. ncbi Effects of serotonin (5-HT)(1B) receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31343 Krakow, Poland
    Naunyn Schmiedebergs Arch Pharmacol 366:226-34. 2002
    ..However, they do suggest that the stimulation of 5-HT(1B) receptors in the accumbens core, but not in the shell, enhances cocaine discrimination in rats...
  25. ncbi Neuroadaptive changes in the rat brain GABA(B) receptors after withdrawal from cocaine self-administration
    Małgorzata Frankowska
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Eur J Pharmacol 599:58-64. 2008
    ..Furthermore, withdrawal from cocaine self-administration evoked changes in the GABA(B) receptor binding in several rat brain areas that may indicate neurobiological adaptations...
  26. ncbi Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Eur Neuropsychopharmacol 14:217-25. 2004
    ....
  27. ncbi Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats
    Edmund Przegalinski
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:798-810. 2008
    ....
  28. ncbi Effect of intra-tegmental microinjections of 5-HT1B receptor ligands on the amphetamine-induced locomotor hyperactivity in rats
    Iwona Papla
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 54:351-7. 2002
    ..These findings indicate that 5-HT1B receptors located in the VTA do not play a major role in the hyperlocomotion elicited by amphetamine, whereas their activation may modulate the behavioral response to the psychostimulant...
  29. doi Effects of imipramine or GABA(B) receptor ligands on the immobility, swimming and climbing in the forced swim test in rats following discontinuation of cocaine self-administration
    Małgorzata Frankowska
    Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Eur J Pharmacol 627:142-9. 2010
    ....
  30. ncbi Conditioned rewarding stimulus associated with cocaine self-administration reverses the depression of catecholamine brain systems following cocaine withdrawal in rats
    Lucyna Antkiewicz-Michaluk
    Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Smetna, Poland
    Int J Neuropsychopharmacol 9:37-50. 2006
    ..The stimulus associated with cocaine availability activates the catecholaminergic system in animals after extinction procedure...
  31. ncbi Effects of GABAB receptor ligands in animal tests of depression and anxiety
    Małgorzata Frankowska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:645-55. 2007
    ....
  32. doi Differential effects of serotonin (5-HT)2 receptor-targeting ligands on locomotor responses to nicotine-repeated treatment
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Synapse 64:511-9. 2010
    ..Repeated treatment with the 5-HT(2) receptor ligands within the second nicotine withdrawal does not inhibit previously established sensitization...
  33. ncbi Accumbal and pallidal dopamine, glutamate and GABA overflow during cocaine self-administration and its extinction in rats
    Karolina Wydra
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Poland
    Addict Biol 18:307-24. 2013
    ..Depending on acute (24 hours) or late (10 days) cocaine withdrawal, different neurotransmitter systems (i.e. glutamate or GABA) seem to be involved...
  34. ncbi Immunosuppression induced by a conditioned stimulus associated with cocaine self-administration
    Marta Kubera
    Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Pharmacol Sci 107:361-9. 2008
    ..The present study provides the first evidence that alterations of immune status can be conditioned by environmental stimuli paired with cocaine administration...
  35. ncbi Alterations in gamma-aminobutyric acid(B) receptor binding in the rat brain after reinstatement of cocaine-seeking behavior
    Małgorzata Frankowska
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Science, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:834-43. 2008
    ..Increases in GABA(B) receptor binding in limbic regions during cocaine-induced reinstatement likely reflect motivational states that were present during active drug self-administration...
  36. ncbi Effects of serotonin (5-HT)6 receptor ligands on responding for cocaine reward and seeking in rats
    Katarzyna Fijał
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 62:1005-14. 2010
    ..WAY 181187 at the highest dose used (30 mg/kg) reduced basal locomotor activity. Despite current results, the precise function and therapeutic relevance of 5-HT(6) receptors need further clarification...
  37. doi Interactions of serotonin (5-HT)2 receptor-targeting ligands and nicotine: locomotor activity studies in rats
    Magdalena Zaniewska
    Department of Pharmacology, Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Synapse 63:653-61. 2009
    ..Pharmacological stimulation of 5-HT(2A) receptors enhances the conditioned hyperlocomotion, while activation of 5-HT(2C) receptors decreases both the response to acute nicotine and conditioned hyperactivity...
  38. ncbi Effect of thyrotropin-releasing hormone on the locomotor and sensitizing effects of cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Kraków 31 343, Poland
    Neuropeptides 38:48-54. 2004
    ..Moreover, cross-sensitization between cocaine and TRH has also been demonstrated. These findings also may provide an insight into the relationship between TRH and cocaine in humans exposed to the psychostimulant...
  39. doi The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats
    Przemysław Adamczyk
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
    Brain Res 1444:45-54. 2012
    ..In contrast to CB1 receptors, neither CB2 nor TRPV1 receptors play a role in cue-induced reinstatement of cocaine-seeking behavior...
  40. doi Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 58:1140-6. 2010
    ..These drugs should be considered as adjuncts to smoking cessation therapy, to ameliorate abstinence-induced depressive symptoms...
  41. ncbi Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats
    Małgorzata Frankowska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:1042-9. 2009
    ....
  42. ncbi Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on cocaine discrimination in rats
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343, Cracow, Poland
    Eur J Pharmacol 459:239-45. 2003
    ..25-2.5 mg/kg), increased cocaine discrimination. These results seem to indicate that tegmental 5-HT(1B) receptors are necessary to express the discriminative stimulus effects of cocaine...
  43. doi Long-lasting increase in [³H]CP55,940 binding to CB1 receptors following cocaine self-administration and its withdrawal in rats
    Przemysław Adamczyk
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
    Brain Res 1451:34-43. 2012
    ..In conclusion, we demonstrated that chronic cocaine self-administration leads to increased CB1 receptor levels in numerous brain areas and that this neuroadaptation is maintained over a long-lasting extinction period...
  44. doi Changes in the level of calcyon mRNA in the brain of rats exposed to cocaine, self-administered or received passively
    Agata Faron-Górecka
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, Krakow, Poland
    Eur J Pharmacol 634:33-9. 2010
    ..Such a result together with the brain areas involved in these effects might suggest the role of calcyon similar to the CART peptides and special vulnerability of calcyon expression rather to acute than chronic stimuli...
  45. ncbi Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropeptides 39:525-33. 2005
    ..These findings may suggest that CRF1 receptor antagonists should be considered as possible medications in the treatment of cocaine addiction...
  46. ncbi Serotonin1B receptor ligands in the nucleus accumbens shell do not affect the discriminative stimulus effects of amphetamine in rats
    M Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences,
    Pol J Pharmacol 53:449-57. 2001
    ..These findings also show that pharmacological stimulation of those receptors does not affect the amphetamine discrimination in rats...
  47. ncbi Role of opioidergic mechanisms and GABA uptake inhibition in the heroin-induced discriminative stimulus effects in rats
    Wojciech Solecki
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 57:744-54. 2005
    ....
  48. ncbi WIN 55,212-2-induced reduction of cocaine hyperlocomotion: possible inhibition of 5-HT(3) receptor function
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Eur J Pharmacol 517:68-73. 2005
    ..Moreover, together with the literature data they may suggest that this effect of WIN 55,212-2 involves inhibition of the 5-HT(3) receptor function...
  49. ncbi Effects of agmatine on nicotine-evoked behavioral responses in rats
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:645-54. 2008
    ..However, these data do show an inhibitory effect of agmatine over the expression of nicotine-induced conditioned hyperlocomotion...
  50. ncbi Effects of 5-HT(1B) receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Eur Neuropsychopharmacol 12:387-96. 2002
    ..They suggest that the inhibition of 5-HT(1B) receptors in the accumbens shell attenuates the development, whereas their pharmacological activation enhances the expression of cocaine sensitization...
  51. ncbi Withdrawal from chronic cocaine up-regulates 5-HT1B receptors in the rat brain
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna, 31 343, Krakow, Poland
    Neurosci Lett 351:169-72. 2003
    ..Our results indicate that withdrawal from chronic cocaine induces up-regulation of 5-HT(1B) receptors in a number of rat brain structures...
  52. ncbi Role of 5-hydroxytryptamine1B receptors and 5-hydroxytryptamine uptake inhibition in the cocaine-evoked discriminative stimulus effects in rats
    M Filip
    Department of Pharmacology, Polish Academy of Science, Krakow
    J Physiol Pharmacol 52:249-63. 2001
    ..On the other hand, they indicate that pharmacological stimulation of 5-HT receptors--that also seem to be a target for fluoxetine-mediated increase in 5-HT neurotransmission--can enhance the overall effects of cocaine...
  53. doi N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: behavioral and biochemical analyses in rats
    Irena Smaga
    Department of Toxicology, Faculty of Pharmacy, Jagiellonian University, Medical College, Krakow, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 39:280-7. 2012
    ..Our study further supports the antidepressant-like activity of NAC and links its effect as well as IMI actions with the enhancement of brain SOD activity...
  54. doi The effect of serotonin 5HT1B receptor ligands on amphetamine self-administration in rats
    Joanna Miszkiel
    Laboratory of Drug Addiction, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Eur J Pharmacol 677:111-5. 2012
    ..5 mg/kg. These results indicate that tonic activation of 5-HT(1B) receptors is not involved in the self-administration of amphetamine, while pharmacological stimulation of these receptors attenuates this behavioral phenomenon...
  55. doi Effect of varenicline on the acute and repeated locomotor responses to nicotine in rats
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Synapse 62:935-9. 2008
    ....
  56. ncbi Adenosine (A)(2A)receptor modulation of nicotine-induced locomotor sensitization. A pharmacological and transgenic approach
    Joanna Jastrzębska
    Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropharmacology 81:318-26. 2014
    ..It is suggested that treatment with A(2A) receptor agonists can help counteract the abuse actions of nicotine...
  57. ncbi Effects of the histamine H3 receptor antagonist ABT-239 on acute and repeated nicotine locomotor responses in rats
    Joanna Miszkiel
    Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:1553-9. 2011
    ..Our findings implicate a limited role for H(3) receptors in locomotor responses to nicotine...
  58. ncbi The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats
    P Adamczyk
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland
    J Physiol Pharmacol 60:119-25. 2009
    ..Our results indicate that FAAH inhibitors could be potent modulators of motivational and conditioned aspects of goal-directed behaviors with less prominent effects on consumatory behaviors...
  59. ncbi Stimulation of serotonin (5-HT)1A receptors attenuates the locomotor, but not the discriminative, effects of amphetamine and cocaine in rats
    E Przegalinski
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Behav Pharmacol 8:699-706. 1997
    ..On the other hand, the lack of the antidiscriminative effects of 8-OH-DPAT suggests that the two effects of amphetamine and cocaine are not modified in the same way by 5-HT1A receptors...
  60. ncbi The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain
    Joanna Miszkiel
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Pharmacol Rep 66:630-7. 2014
    ..Our findings suggest that cortical ERK is involved in cocaine seeking behavior in rats. They also indicate the time and regional adaptations in this enzyme activity after cocaine withdrawal. ..
  61. ncbi Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives
    Magdalena Zaniewska
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:957-65. 2009
    ..Since several pharmacotherapies have failed to be efficacious in all patients, we also assess the clinical effectiveness of newer agents in relation to existing drugs...
  62. ncbi Effect of cocaine sensitization on alpha1-adrenoceptors in brain regions of the rat: an autoradiographic analysis
    Irena Nalepa
    Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:827-35. 2006
    ....
  63. ncbi The effects of N-acetylcysteine on cocaine reward and seeking behaviors in a rat model of depression
    Małgorzata Frankowska
    Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland Electronic address
    Behav Brain Res 266:108-18. 2014
    ..The last finding demonstrates the potential clinical utility of NAC to reduce cocaine seeking enhanced by co-existing depression. ..
  64. ncbi Role of serotonin 5-HT1B receptors in psychostimulant addiction
    Joanna Miszkiel
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:1310-5. 2011
    ..Moreover, the effect of long-term treatment with psychostimulants on 5-HT(1B) receptors is also discussed...
  65. ncbi Effects of ethylene glycol ethers on cell viability in the human neuroblastoma SH-SY5Y cell line
    Magdalena Regulska
    Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 62:1243-9. 2010
    ....
  66. ncbi The effect of cocaine sensitization on mouse immunoreactivity
    Marta Kubera
    Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343 Cracow, Poland
    Eur J Pharmacol 483:309-15. 2004
    ....
  67. ncbi Activation of serotonin (5-HT)1A receptors inhibits amphetamine sensitization in mice
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences
    Life Sci 66:1011-9. 2000
    ....
  68. ncbi Effect of adrenalectomy and corticosterone on cocaine-induced sensitization in rats
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 51:193-204. 2000
    ..Moreover, there takes place cross-sensitization between CORT and COC, which indicates a close relationship between the drug-related mechanism and behavioral sensitization...
  69. ncbi Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Behav Pharmacol 12:109-16. 2001
    ..On the other hand, they also show that pharmacological activation of 5-HT1B receptors enhances both phases of this phenomenon, and that repeated administration of cocaine leads to an increased functional reactivity of these receptors...
  70. ncbi Role of 5-HT(1B) receptors in the sensitization to amphetamine in mice
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Science, 12 Smetna Street, 31 343 Cracow, Poland
    Eur J Pharmacol 422:91-9. 2001
    ..Our results suggest that 5-HT(1B) receptors may play a permissive role in the development, but not expression, of behavioral sensitization, as well as in the acute locomotor response to amphetamine in mice...
  71. ncbi The effect of amphetamine sensitization on mouse immunoreactivity
    M Kubera
    Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 53:233-42. 2002
    ..Our findings seem to indicate possible importance of monitoring and correcting immune changes in the therapy of amphetamine addiction...
  72. ncbi Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats
    E Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 53:383-94. 2002
    ..In other words, the present results suggest that the accumbal shell 5-HT1B receptors play a permissive role in the behavioural response to the psychostimulant...
  73. ncbi An endogenous neuroprotectant substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), prevents the behavioral and neurochemical effects of cocaine reinstatement in drug-dependent rats
    L Antkiewicz-Michaluk
    Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Cracov, Poland
    J Neural Transm 114:307-17. 2007
    ..Our results strongly support the view that 1-methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous compound, has considerable potential as a drug for combating substance abuse disease through the attenuation of craving...
  74. ncbi Preclinical studies on comorbidity between depression and psychostimulant addiction
    Małgorzata Filip
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1529-34. 2013
    ....
  75. ncbi Activation of endocannabinoid transmission induces antidepressant-like effects in rats
    P Adamczyk
    Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 59:217-28. 2008
    ..Moreover, they also indicate that agents activating eCB transmission enhance the anti-immobility responses to antidepressant drugs...
  76. ncbi N-oleoyl-dopamine increases locomotor activity in the rat
    E Przegalinski
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Int J Immunopathol Pharmacol 19:897-904. 2006
    ..We conclude that OLDA is a potential brain modifier of motor behavior, the biological consequences of which remain to be explored...
  77. pmc Oxidative stress biomarkers in some rat brain structures and peripheral organs underwent cocaine
    Lucyna Pomierny-Chamioło
    Department of Toxicology, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30 688 Krakow, Poland
    Neurotox Res 23:92-102. 2013
    ..Therefore, further studies are necessary to address protective mechanisms against cocaine-induced brain and peripheral tissue damage...