Jaroslaw Dziadek

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. pmc Direct and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria
    Ewelina A Wojcik
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    PLoS ONE 7:e51064. 2012
  2. pmc Comparison of Ligation-Mediated PCR Methods in Differentiation of Mycobacterium tuberculosis Strains
    Anna Zaczek
    Department of Biochemistry and Cell Biology, University of Rzeszow, 35 601 Rzeszow, Poland
    Biomed Res Int 2014:782071. 2014
  3. pmc Cholesterol oxidase is indispensable in the pathogenesis of Mycobacterium tuberculosis
    Magdalena Klink
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    PLoS ONE 8:e73333. 2013
  4. doi request reprint Toxoplasma gondii: the vaccine potential of three trivalent antigen-cocktails composed of recombinant ROP2, ROP4, GRA4 and SAG1 proteins against chronic toxoplasmosis in BALB/c mice
    Bozena Dziadek
    Department of Immunoparasitology, University of Lodz, Lodz, Poland
    Exp Parasitol 131:133-8. 2012
  5. pmc AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain
    Jakub Pawelczyk
    Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    J Bacteriol 193:6960-72. 2011
  6. doi request reprint ChoD and HsdD can be dispensable for cholesterol degradation in mycobacteria
    Anna Brzostek
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    J Steroid Biochem Mol Biol 134:1-7. 2013
  7. pmc Mycobacterium tuberculosis is able to accumulate and utilize cholesterol
    Anna Brzostek
    Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    J Bacteriol 191:6584-91. 2009
  8. pmc Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin
    Anna Zaczek
    Institute for Medical Biology, Polish Academy of Sciences, Lodz, Poland
    BMC Microbiol 9:10. 2009
  9. pmc Either non-homologous ends joining or homologous recombination is required to repair double-strand breaks in the genome of macrophage-internalized Mycobacterium tuberculosis
    Anna Brzostek
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    PLoS ONE 9:e92799. 2014
  10. ncbi request reprint Distinct DNA repair pathways involving RecA and nonhomologous end joining in Mycobacterium smegmatis
    Malgorzata Korycka-Machala
    Centre of Medical Biology, Polish Academy of Sciences, Lodowa, Poland
    FEMS Microbiol Lett 258:83-91. 2006

Collaborators

Detail Information

Publications15

  1. pmc Direct and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria
    Ewelina A Wojcik
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    PLoS ONE 7:e51064. 2012
    ..Thus, direct and inverted repeats may elicit genetic instability in mycobacteria by 1) directly interfering with replication fidelity, 2) stimulating the three main DSB repair pathways, and 3) enticing L5 site-specific recombination...
  2. pmc Comparison of Ligation-Mediated PCR Methods in Differentiation of Mycobacterium tuberculosis Strains
    Anna Zaczek
    Department of Biochemistry and Cell Biology, University of Rzeszow, 35 601 Rzeszow, Poland
    Biomed Res Int 2014:782071. 2014
    ..As much as 78,7% of strains were grouped identically when differentiated by FLiP and IS6110-RFLP methods. The analysis differentiated 31, 35, and 36 groups when using FLAP, FLiP, and RFLP-IS6110 methods, respectively. ..
  3. pmc Cholesterol oxidase is indispensable in the pathogenesis of Mycobacterium tuberculosis
    Magdalena Klink
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    PLoS ONE 8:e73333. 2013
    ..In summary, we demonstrate here that ChoD is required for Mtb interference with the TLR2-mediated signaling pathway and subsequent intracellular growth and survival of the pathogen in human macrophages. ..
  4. doi request reprint Toxoplasma gondii: the vaccine potential of three trivalent antigen-cocktails composed of recombinant ROP2, ROP4, GRA4 and SAG1 proteins against chronic toxoplasmosis in BALB/c mice
    Bozena Dziadek
    Department of Immunoparasitology, University of Lodz, Lodz, Poland
    Exp Parasitol 131:133-8. 2012
    ..It makes these two mixtures of recombinant antigens very promising for further experiments...
  5. pmc AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain
    Jakub Pawelczyk
    Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    J Bacteriol 193:6960-72. 2011
    ..Our findings also highlight important differences in the mechanism of acetyl carboxylation between pathogenic and nonpathogenic mycobacterial species...
  6. doi request reprint ChoD and HsdD can be dispensable for cholesterol degradation in mycobacteria
    Anna Brzostek
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    J Steroid Biochem Mol Biol 134:1-7. 2013
    ....
  7. pmc Mycobacterium tuberculosis is able to accumulate and utilize cholesterol
    Anna Brzostek
    Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    J Bacteriol 191:6584-91. 2009
    ....
  8. pmc Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin
    Anna Zaczek
    Institute for Medical Biology, Polish Academy of Sciences, Lodz, Poland
    BMC Microbiol 9:10. 2009
    ..Among many mutations identified in the rpoB gene, few were verified by molecular genetic methods as responsible for resistance to rifampin (RMP)...
  9. pmc Either non-homologous ends joining or homologous recombination is required to repair double-strand breaks in the genome of macrophage-internalized Mycobacterium tuberculosis
    Anna Brzostek
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    PLoS ONE 9:e92799. 2014
    ..Complementation of the Δ(ku,ligD,recA) mutant with an intact recA or ku-ligD rescued the ability of Mtb to propagate inside macrophages. ..
  10. ncbi request reprint Distinct DNA repair pathways involving RecA and nonhomologous end joining in Mycobacterium smegmatis
    Malgorzata Korycka-Machala
    Centre of Medical Biology, Polish Academy of Sciences, Lodowa, Poland
    FEMS Microbiol Lett 258:83-91. 2006
    ..The results provide in vivo evidence that only NHEJ is required for the repair of noncompatible DNA ends. By contrast, the response of mycobacteria to mitomycin C preferentially involved a RecA-dependent pathway...
  11. pmc The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis
    Marta Brzezinska
    Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106 93 232, Lodz, Poland
    BMC Microbiol 13:43. 2013
    ..The aim of this study was to evaluate intracellular replication of a cholesterol degradation-deficient Mtb mutant in human macrophages (MØ) in vitro and assess the functional responses of Mtb mutant-infected MØ...
  12. ncbi request reprint Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis
    Anna Brzostek
    Centre of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    FEMS Microbiol Lett 275:106-12. 2007
    ..The mice infection experiments confirm the significance of ChoD in the pathogenesis of M. tuberculosis...
  13. pmc Evaluation of DNA primase DnaG as a potential target for antibiotics
    Aneta Kuron
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Antimicrob Agents Chemother 58:1699-706. 2014
    ..This suggests that very efficient inhibition of enzyme activity would be required for mycobacterial DnaG to be useful as an antibiotic target. ..
  14. doi request reprint Evaluation of three recombinant multi-antigenic vaccines composed of surface and secretory antigens of Toxoplasma gondii in murine models of experimental toxoplasmosis
    Bozena Dziadek
    Department of Immunoparasitology, University of Lodz, Lodz, Poland
    Vaccine 29:821-30. 2011
    ..gondii invasion...
  15. doi request reprint Trinucleotide repeat sequence-based PCR as a potential approach for genotyping Mycobacterium gordonae strains
    Arkadiusz Wojtasik
    Institute of Medical Biology PAS, 106 Lodowa Str, 93 232 Lodz, Poland
    J Microbiol Methods 85:28-32. 2011
    ..These results were compared with the Enterobacterial Repetitive Intergenic Consensus Sequences (ERIC)-PCR typing scheme which had lower discriminatory index of 0.93 and its reproducibility was only 86.3%...