Andrzej Pilc

Summary

Country: Poland

Publications

  1. doi Glutamate-based antidepressants: preclinical psychopharmacology
    Andrzej Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Biol Psychiatry 73:1125-32. 2013
  2. ncbi LY-354740 (Eli Lilly)
    Andrzej Pilc
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    IDrugs 6:66-71. 2003
  3. ncbi Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats
    A Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 43:181-7. 2002
  4. ncbi Stimulation of group II metabotropic glutamate receptors or inhibition of group I ones exerts anxiolytic-like effects in rats
    A Pilc
    Institute of Public Health, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Amino Acids 19:81-6. 2000
  5. ncbi The effect of prolonged imipramine and electroconvulsive shock treatment on calcium/calmodulin-dependent protein kinase II in the hippocampus of rat brain
    A Pilc
    Institute of Pharmacology, Polish Academy of Science, Krakow
    Neuropharmacology 38:597-603. 1999
  6. ncbi Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region
    A Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Eur J Pharmacol 349:83-7. 1998
  7. doi The use of citation indicators to identify and support high-quality research in Poland
    Andrzej Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Arch Immunol Ther Exp (Warsz) 56:381-4. 2008
  8. doi The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Pharmacol Exp Ther 334:1066-74. 2010
  9. ncbi Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist
    Agnieszka Pałucha
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Pharmacol Biochem Behav 81:901-6. 2005
  10. ncbi Zinc-induced adaptive changes in NMDA/glutamatergic and serotonergic receptors
    Agnieszka Cichy
    Collegium Medicum, Jagiellonian University, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 61:1184-91. 2009

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. doi Glutamate-based antidepressants: preclinical psychopharmacology
    Andrzej Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Biol Psychiatry 73:1125-32. 2013
    ....
  2. ncbi LY-354740 (Eli Lilly)
    Andrzej Pilc
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    IDrugs 6:66-71. 2003
    ..Lilly is developing LY-354740, the lead compound in a series of derivatives of the metabotropic glutamate receptor group II agonist L-CCG-1, for the potential treatment of anxiety [212536], [276941], [276942]...
  3. ncbi Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats
    A Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 43:181-7. 2002
    ..No tolerance to anxiolytic-like action occurs. The previously mentioned results further indicate that antagonists of group I mGlu receptors may play a role in the therapy of both anxiety and depression...
  4. ncbi Stimulation of group II metabotropic glutamate receptors or inhibition of group I ones exerts anxiolytic-like effects in rats
    A Pilc
    Institute of Public Health, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Amino Acids 19:81-6. 2000
    ..The hippocampus may be one of the neuroanatomical sites of the anxiolytic-like effects of either agent...
  5. ncbi The effect of prolonged imipramine and electroconvulsive shock treatment on calcium/calmodulin-dependent protein kinase II in the hippocampus of rat brain
    A Pilc
    Institute of Pharmacology, Polish Academy of Science, Krakow
    Neuropharmacology 38:597-603. 1999
    ..It is postulated that changes in CaM-KII activity following chronic antidepressant treatment might represent and important step in expression of its antidepressive action...
  6. ncbi Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region
    A Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Eur J Pharmacol 349:83-7. 1998
    ..Our results indicate that antidepressant treatment may induce a subsensitivity of group I mGlu receptors when assessed by electrophysiological but not biochemical measures...
  7. doi The use of citation indicators to identify and support high-quality research in Poland
    Andrzej Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Arch Immunol Ther Exp (Warsz) 56:381-4. 2008
    ..This is based on the number of individual citations, the individual h-index, the number of publications, and the priority of the discovery...
  8. doi The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Pharmacol Exp Ther 334:1066-74. 2010
    ..p.), blocked the antidepressant-like action of AMN082. Altogether, the results of our studies show that the antidepressant-like action of the mGlu7 receptor-positive modulator AMN082 depends on the activation of the serotonergic system...
  9. ncbi Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist
    Agnieszka Pałucha
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Pharmacol Biochem Behav 81:901-6. 2005
    ..These data suggest that MTEP, which is considered to be a potential therapeutic agent, may play a role in the therapy of depression...
  10. ncbi Zinc-induced adaptive changes in NMDA/glutamatergic and serotonergic receptors
    Agnieszka Cichy
    Collegium Medicum, Jagiellonian University, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 61:1184-91. 2009
    ..These results indicate that chronic zinc treatment alters glutamatergic and serotonergic systems, which is a hallmark of clinically effective antidepressants...
  11. ncbi Effects of GABAB receptor ligands in rodent tests of anxiety-like behavior
    Anna Partyka
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:757-62. 2007
    ..CGP 51176 (5 or 8 mg/kg) was inactive, while CGP 44532 (0.125 mg/kg) exhibited anxiogenic-like effect. These preclinical data further implicate GABA(B) receptor function in anxiety, and support the GABAergic hypothesis of this disorder...
  12. pmc The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4 receptors in rodents
    Anna Sławińska
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Br J Pharmacol 169:1824-39. 2013
    ....
  13. doi Antidepressant-like activity of zinc: further behavioral and molecular evidence
    Magdalena Sowa-Kućma
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    J Neural Transm 115:1621-8. 2008
    ..These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF...
  14. pmc On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039
    Agnieszka Pałucha-Poniewiera
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 212:523-35. 2010
    ..Although the antidepressant-like activity of MGS0039 and LY341495 is well documented, the mechanism of the antidepressant action of these compounds is still not clear...
  15. ncbi Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims
    Magdalena Sowa-Kućma
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland Electronic address
    J Affect Disord 151:924-31. 2013
    ..Zinc and magnesium, the potent antagonists of the NMDA receptor complex, are involved in the pathophysiology of depression and exhibit antidepressant activity...
  16. ncbi Anxiolytic-like effects of group III mGlu receptor ligands in the hippocampus involve GABAA signaling
    Katarzyna Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:820-6. 2006
    ..The anxiolytic-like effects of ACPT-I (7.5 nmol) or PHCCC (12 nmol) were significantly attenuated by flumazenil (10 mg/kg), indicating an involvement of GABAergic system in the anxiolytic-like response...
  17. ncbi Citalopram influences mGlu7, but not mGlu4 receptors' expression in the rat brain hippocampus and cortex
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Science, 31 343, Krakow, Poland
    Brain Res 1184:88-95. 2007
    ....
  18. doi Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu₄ receptor
    Anna Sławińska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Neuropharmacology 66:225-35. 2013
    ..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  19. ncbi Activation of the mGlu7 receptor elicits antidepressant-like effects in mice
    Agnieszka Palucha
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 194:555-62. 2007
    ..Metabotropic glutamate receptor (mGlu receptor) ligands seem to be promising agents to treat several central nervous system disorders, including psychiatric ones...
  20. doi Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Neuropharmacology 59:627-34. 2010
    ..Moreover, the compound was not effective in 5-HT depleted animals. The results of these studies indicate that the GABAergic and serotonergic systems are involved in the potential anxiolytic action of LSP1-2111...
  21. doi Group III mGlu receptor agonist, ACPT-I, attenuates morphine-withdrawal symptoms after peripheral administration in mice
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 33:1454-7. 2009
    ..These data indicate an important role of group III mGlu receptors in morphine withdrawal states and suggest that activation of group III mGlu receptors may reduce opiate withdrawal symptoms...
  22. ncbi Zinc and depression. An update
    Gabriel Nowak
    Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 57:713-8. 2005
    ..All the data indicate the important role of zinc homeostasis in psychopathology and therapy of depression and potential clinical antidepressant activity of this ion...
  23. doi Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study
    Marcin Siwek
    Department of Psychiatry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    J Affect Disord 118:187-95. 2009
    ..Zinc, a non competitive NMDA receptor antagonist exhibits preclinical antidepressant efficacy. Moreover, a preliminary clinical report suggests augmentation of antidepressant therapy by zinc in depression...
  24. ncbi Interaction of zinc with antidepressants in the forced swimming test in mice
    Bernadeta Szewczyk
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343, Krakow, Poland
    Pol J Pharmacol 54:681-5. 2002
    ..The present data support the notion that inhibition of the NMDA receptor participates in an antidepressant action, and further demonstrate particular role of zinc in this activity...
  25. ncbi Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats
    Katarzyna Stachowicz
    Department of New Drugs Research, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 57:856-60. 2005
    ....
  26. ncbi Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling
    Aleksandra Klodzinska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31343 Krakow, Poland
    Neuropharmacology 47:342-50. 2004
    ..These data suggest that selective mGlu5 receptor antagonists mediated anxiolysis is not dependent on GABA-ergic system and that these agents may play a role in the therapy of anxiety...
  27. doi Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test
    Piotr Branski
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Neural Transm 115:829-30. 2008
    ..This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator...
  28. ncbi NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice
    Lucyna Pomierny-Chamioło
    Department of Toxicology, Jagiellonian University, Collegium Medicum, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 62:1186-90. 2010
    ....
  29. ncbi Increase in synaptic hippocampal zinc concentration following chronic but not acute zinc treatment in rats
    Bernadeta Szewczyk
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL31 343 Krakow, Poland
    Brain Res 1090:69-75. 2006
    ..The measurement of zinc concentration in the whole hippocampus by the flame atomic absorption spectrometry method is not sensitive enough to detect such subtle alteration...
  30. ncbi Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats
    Katarzyna Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Eur J Pharmacol 498:153-6. 2004
    ..The results indicate that positive allosteric modulation of mGlu4 receptors may be a useful therapeutic approach to anxiety...
  31. ncbi MPEP, mGlu5 receptor antagonist, regulates NPYmRNA expression in hippocampal and amygdalar neurons
    Maria Śmiałowska
    Laboratory of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:709-18. 2004
    ..The obtained results suggest a positive regulatory control of NPY synthesis by mGlu5 receptors in hippocampal and amygdalar neurons...
  32. pmc The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT₁A signalling
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Psychopharmacology (Berl) 227:711-25. 2013
    ..LSP1-2111, the group III mGlu receptor orthosteric agonist, with a high affinity towards mGlu4 receptors, was previously shown to exhibit antipsychotic-like action in animal models displaying positive symptoms of schizophrenia...
  33. ncbi Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action
    Bernadeta Szewczyk
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:588-9. 2008
    ..All the available data indicate the importance of zinc and magnesium homeostasis in the psychopathology and therapy of affective disorders...
  34. ncbi Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test
    Małgorzata Dybała
    Laboratory of Pharmacobiology, Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Medyczna 9, 30 688, Krakow, Poland
    J Neural Transm 115:1519-20. 2008
    ..This is the first demonstration of the antidepressant effect of the NMDA antagonist not being dependent on the AMPA transmission...
  35. ncbi In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 29:514-21. 2004
    ..Our results indicate that the anxiolytic action of MPEP is conveyed through NPY neurons with the involvement of Y1 receptors in the amygdala and that BZD receptors do not significantly contribute to these effects...
  36. ncbi Different pattern of changes in calcium binding proteins immunoreactivity in the medial prefrontal cortex of rats exposed to stress models of depression
    Monika Zadrozna
    Chair of Pharmacobiology, Jagiellonian University, Collegium Medicum, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 63:1539-46. 2011
    ..We concluded that the mPFC reveals a different pattern of changes in neurons containing calcium binding proteins and active caspase-3 immunoreactivity in response to CUS and CMS...
  37. pmc Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 220:481-94. 2012
    ..Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity...
  38. ncbi Anxiolytic-like activity of zinc in rodent tests
    Anna Partyka
    Department of Clinical Pharmacy, Jagiellonian University, Collegium Medicum, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 63:1050-5. 2011
    ..The present data demonstrate for the first time the anxiolytic-like activity of zinc in rodents and may indicate that zinc could be used as a novel therapeutic/adjunct agent in anxiolytic therapy...
  39. ncbi Effect of MPEP treatment on brain-derived neurotrophic factor gene expression
    Beata Legutko
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:427-30. 2006
    ..A significance of MPEP ability to reduce cortical BDNF needs further study. Nevertheless, this observation further indicates a potential antidepressant activity of the group I mGlu receptor antagonists in human depression...
  40. pmc Chronic treatment with zinc and antidepressants induces enhancement of presynaptic/extracellular zinc concentration in the rat prefrontal cortex
    Magdalena Sowa-Kućma
    Institute of Pharmacology, Polish Academy of Sciences and Center of Excellence in Neuropsychopharmacology, Smetna 12, 31 343, Krakow, Poland
    Amino Acids 40:249-58. 2011
    ....
  41. doi Serum zinc level in depressed patients during zinc supplementation of imipramine treatment
    Marcin Siwek
    Department of Psychiatry, Jagiellonian University, Collegium Medicum, Krakow, Poland
    J Affect Disord 126:447-52. 2010
    ..Some clinical investigations point to alterations of the zinc level in blood as a potential marker of depression...
  42. ncbi Olfactory bulbectomy and amitriptyline treatment influences mGlu receptors expression in the mouse brain hippocampus
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Science, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:844-55. 2008
    ..The results obtained indicate an influence of OB on mGlu receptors levels in the hippocampus, and the OB-induced effect can be reversed by chronic AMI treatment in the case of mGlu1a, mGlu2/3 and mGlu7 receptors...
  43. ncbi Zinc deficiency alters responsiveness to antidepressant drugs in mice
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Krakow, Poland
    Pharmacol Rep 65:579-92. 2013
    ..We examine also whether these changes are related to activity of the hypothalamic-pituitary-adrenal HPA axis...
  44. ncbi Intraamygdaloid administration of BIBO 3304 increases water intake and extends anxiolytic effects
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:867-70. 2004
    ..Water consumption was measured 1, 2, 4, 6 and 24 h after drug administration. We found that water intake was increased both after 5-HTP and BIBO 3304 administration...
  45. ncbi Anxiolytic-like activity of MGS0039, a selective group II mGlu receptor antagonist, is serotonin- and GABA-dependent
    Katarzyna Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 63:880-7. 2011
    ..The above results indicate that the mGluR2/3 antagonist MGS0039 may play a role in the therapy of anxiety and that its action may be mediated by serotonin and the GABAergic systems...
  46. doi Investigational NMDA receptor modulators for depression
    Bernadeta Szewczyk
    Institute of Pharmacology, Polish Academy of Sciences, Department of Neurobiology, Smetna 12, Pl 31 343 Krakow, Poland
    Expert Opin Investig Drugs 21:91-102. 2012
    ..Since then, there have been several clinical data in the literature indicating the efficacy of NMDA receptor antagonists of either stand-alone or as an adjunct therapy in depression and depression-related diseases...
  47. ncbi Alterations in hippocampal calcium-binding neurons induced by stress models of depression: a preliminary assessment
    Barbara Nowak
    Medical College, Jagiellonian University, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 62:1204-10. 2010
    ..These data indicate a stress-induced reduction of calcium binding neuron parameters, which may be related to the behavioral paradigms exhibited in these models...
  48. ncbi GABAergic hypotheses of anxiety and depression: focus on GABA-B receptors
    Andrzej Pilc
    Institute of Public Health, Collegium Medicum, Jagiellonian University, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Drugs Today (Barc) 41:755-66. 2005
    ..Data are accumulating in preclinical studies that show that antagonists (but not agonists) of GABAB receptors may have antidepressant effects...
  49. ncbi The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test
    Bernadeta Szewczyk
    Laboratory of Trace Elements Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 33:323-9. 2009
    ..5 and 5 mg Zn/kg) indicates the serotonin pathway participation. This present data indicates that the antidepressant-like activity of zinc observed in the FST involves interaction with the serotonergic system...
  50. ncbi Selective mGlu5 receptor antagonist MTEP attenuates naloxone-induced morphine withdrawal symptoms
    Agnieszka Pałucha
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:863-6. 2004
    ..The data suggest that selective mGlu5 receptor antagonists may play a role in the therapy of drug-dependence states...
  51. ncbi Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats
    Ewa Tatarczyńska
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 3 1 343 Kraków, Poland
    Pol J Pharmacol 54:707-10. 2002
    ..These data suggest that selective group III mGlu receptor agonists may become a new class of anxiolytics and/or antidepressants...
  52. doi A selective mGlu7 receptor antagonist MMPIP reversed antidepressant-like effects of AMN082 in rats
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Behav Brain Res 238:109-12. 2013
    ..p.)-induced decrease in locomotor activity was not affected by MMPIP (10 mg/kg, i.p.), indicating on other, non-mGlu7 receptor-dependent mechanisms involved in changes in locomotor activity of rats after AMN082 administration...
  53. ncbi Reduced potency of zinc to interact with NMDA receptors in hippocampal tissue of suicide victims
    Gabriel Nowak
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:455-9. 2003
    ..The data represent the first demonstration that the alteration in zinc interaction with NMDA receptors may be involved in psychopathology underlying suicidal attempts...
  54. pmc Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    E Tatarczynska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Br J Pharmacol 132:1423-30. 2001
    ..4. These data suggest that selective mGlu5 receptor antagonists may play a role in the therapy of anxiety and/or depression, further studies are required to identify the sites and the mechanism of action of MPEP...
  55. ncbi Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats
    Gabriel Nowak
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Brain Res Bull 61:159-64. 2003
    ..These animal data further suggest antidepressant activity of zinc in human depression...
  56. doi Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 39:102-6. 2012
    ..These data suggest that acamprosate may induce antidepressant-like effect and that NMDA and mGlu5 receptors are crucial targets of acamprosate in this action...
  57. ncbi Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
    Agnieszka Palucha
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Pharmacol Ther 115:116-47. 2007
    ..However, preclinical data also indicates that ligands of these receptors, both agonists and antagonists, may have an anxiolytic-like and antidepressant-like potential...
  58. ncbi Zinc treatment induces cortical brain-derived neurotrophic factor gene expression
    Gabriel Nowak
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31 343, Cracow, Poland
    Eur J Pharmacol 492:57-9. 2004
    ..This is the first demonstration that zinc increases the BDNF gene expression, which is the effect shared by most of clinically effective antidepressants...
  59. ncbi Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study
    Gabriel Nowak
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 55:1143-7. 2003
    ..This preliminary study is the first demonstration of the benefit of zinc supplementation in antidepressant therapy. The mechanism(s) may be related to modulation of glutamatergic or immune systems by zinc ion...
  60. ncbi The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems
    K Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 57:227-34. 2009
    ..p.), the 5-HT2A/C receptor antagonist, did not change the anxiolytic-like effects of ACPT-I. The results of these studies indicate that the GABA-ergic and serotonergic systems are involved in the potential anxiolytic action of ACPT-I...
  61. ncbi Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent
    K Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 52:306-12. 2007
    ....
  62. ncbi Application of magnetic resonance diffusion anisotropy imaging for the assessment neuroprotecting effects of MPEP, a selective mGluR5 antagonist, on the rat spinal cord injury in vivo
    Tomasz Banasik
    H Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, PL 31 342 Krakow, Poland
    Pharmacol Rep 57:861-6. 2005
    ..DAI results confirm positive effect of MPEP on the limitation of secondary excitotoxic injury in the spinal cord...
  63. pmc Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents
    G Nowak
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Br J Pharmacol 149:581-90. 2006
    ..Therefore we decided to investigate the antidepressant-like activity of the selective GABAB receptor antagonists CGP 36742 and CGP 51176, and a selective agonist CGP 44532 in models of depression in rats and mice...
  64. ncbi Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent
    K Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 53:741-8. 2007
    ....
  65. ncbi Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats
    J M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Amino Acids 23:213-6. 2002
    ..The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats...
  66. doi Glutamate-based anxiolytic ligands in clinical trials
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Expert Opin Investig Drugs 22:1007-22. 2013
    ..On the other hand, decreasing the activity of glutamatergic neurotransmission may attenuate excitation in the CNS, thus resulting in anxiolysis...
  67. ncbi Prolonged administration of antidepressant drugs leads to increased binding of [(3)H]MPEP to mGlu5 receptors
    Gabriel Nowak
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Neuropharmacology 84:46-51. 2014
    ..Increases in mGlu5 expression were also observed, though they did not always parallel the increase in binding. The results indicate that adaptive up-regulation of mGlu5 receptors may be a common change induced by antidepressant drugs. ..
  68. ncbi Glutamate receptor ligands as anxiolytics
    E Chojnacka-Wojcik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Smetna
    Curr Opin Investig Drugs 2:1112-9. 2001
    ..Therefore mGlu receptor ligands may become the anxiolytics of the future, free from the side effects characteristic of benzodiazepines...
  69. ncbi The involvement of glutamate in the pathophysiology of depression
    A Palucha
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Drug News Perspect 18:262-8. 2005
    ..In this review, current knowledge and crucial hypotheses concerning the role of glutamate in the pathophysiology of depression are discussed...
  70. ncbi Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats
    A Pałucha
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Neuropharmacology 46:151-9. 2004
    ..In conclusion, the results of our studies indicate that group III mGlu receptor agonists may play a role in the therapy of both anxiety and depression...
  71. ncbi Combined administration of PHCCC, a positive allosteric modulator of mGlu4 receptors and ACPT-I, mGlu III receptor agonist evokes antidepressant-like effects in rats
    K Kłak
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Amino Acids 32:169-72. 2007
    ..Results of our studies indicate that a combined administration positive allosteric modulation of mGlu4 receptor and agonists of group III mGlu receptors may be a promising target in the future treatment of depressive disorder...
  72. ncbi Antidepressant-like properties of zinc in rodent forced swim test
    B Kroczka
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res Bull 55:297-300. 2001
    ..The results obtained indicate that zinc induces an antidepressant-like effect and enhances the effect of imipramine in the forced swim test, suggesting a potential antidepressant activity of zinc in humans...
  73. ncbi The antianxiety-like effects of antagonists of group I and agonists of group II and III metabotropic glutamate receptors after intrahippocampal administration
    E Tatarczynska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Psychopharmacology (Berl) 158:94-9. 2001
    ..Substances acting as agonists of group II mGlu receptors with joint group I mGlu receptor antagonist effects, or group II mGlu receptors agonists, were shown to induce antianxiety-like effect in rats after intrahippocampal administration...
  74. pmc Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Br J Pharmacol 130:1425-31. 2000
    ..4. The present results are the first to suggest that the development of antinociceptive morphine tolerance may be inhibited by metabotropic group II glutamate agonist...
  75. ncbi LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats
    J Konieczny
    Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Naunyn Schmiedebergs Arch Pharmacol 358:500-2. 1998
    ..LY354740 (5 and 10 mg/kg i.p.) dose-dependently diminished the haloperidol-induced muscle rigidity. The present results suggest that LY354740 counteracts the muscle rigidity in an animal model of parkinsonism...
  76. ncbi Effect of chronic imipramine or electroconvulsive shock on the expression of mGluR1a and mGluR5a immunoreactivity in rat brain hippocampus
    M Śmiałowska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Cracow, Poland
    Neuropharmacology 42:1016-23. 2002
    ..The results obtained indicate an influence of antidepressant treatment on group I mGluR. This increase in the receptor protein level may be a compensatory mechanism developing after chronic treatment...
  77. ncbi On the role of metabotropic glutamate receptors in the mechanisms of action of antidepressants
    Agnieszka Pałucha
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 54:581-6. 2002
    ..Recent studies, showing that antidepressant treatment may influence mGlu receptors, together with the findings that group I mGluR antagonists, may possess antidepressant-like action, support this hypothesis...
  78. ncbi Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice
    Ewa Kozela
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Psychopharmacology (Berl) 165:245-51. 2003
    ..The role of metabotropic receptors for glutamate (mGluR) in opiate tolerance is less known...
  79. ncbi Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice
    Aleksandra Kłodzińska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Cracow, Smetna 12, Poland
    Pharmacol Biochem Behav 73:327-32. 2002
    ..The data indicate that Group II mGlu receptor agonists may counteract the effects of hallucinogenic drugs...
  80. ncbi Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression
    J M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 53:659-62. 2001
    ..Our results indicate that mGluR5 can possibly be engaged in the mechanism of depression...
  81. ncbi Peripheral administration of group III mGlu receptor agonist ACPT-I exerts potential antipsychotic effects in rodents
    A Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 55:517-24. 2008
    ..These data demonstrate that ACPT-I is a brain-penetrating compound and illustrates its promising therapeutic role for the treatment of schizophrenia...
  82. ncbi Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats
    K Ossowska
    Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St, 31 343 Krakow, Poland
    Neuropharmacology 41:413-20. 2001
    ..The present results suggest that blockade of mGluR5 receptors may be important to amelioration of both parkinsonian akinesia and muscle rigidity...
  83. ncbi An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats
    K Ossowska
    Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Amino Acids 32:179-88. 2007
    ....
  84. doi Simultaneous alterations of brain and plasma serotonin concentrations and liver cytochrome P450 in rats fed on a tryptophan-free diet
    Marta Kot
    Polish Academy of Sciences, Institute of Pharmacology, Smetna 12, 31 343 Krakow, Poland
    Pharmacol Res 66:292-9. 2012
    ..In conclusion, a deficit in tryptophan in the diet may be responsible for very serious food-cytochrome P450 and food-drug metabolism interactions. Interactions of this type may also refer to drugs acting via serotonergic system...
  85. doi Mood disorders: regulation by metabotropic glutamate receptors
    Andrzej Pilc
    Institute of Pharmacology, Polish Academy of Sciences and Collegium Medicum, Jagiellonian University, Krakow, Poland
    Biochem Pharmacol 75:997-1006. 2008
    ....
  86. ncbi The striatum as a target for anti-rigor effects of an antagonist of mGluR1, but not an agonist of group II metabotropic glutamate receptors
    Krystyna Ossowska
    Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res 950:88-94. 2002
    ..In contrast, 2R,4R-APDC injections were ineffective. The present results may suggest that the blockade of striatal mGluR1, but not the stimulation of group II mGluRs, may ameliorate parkinsonian muscle rigidity...
  87. ncbi (S)-4C3HPG, a mixed group I mGlu receptor antagonist and a group II agonist, administered intrastriatally, counteracts parkinsonian-like muscle rigidity in rats
    E Lorenc-Koci
    Department of Neuropsychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Brain Res 903:177-84. 2001
    ..The present results suggest that blockade of mGluR1 receptors and/or activation of mGluR2 ones, localized in the rostral part of the striatum, may be responsible for the anti-parkinsonian effect of (S)-4C3HPG...
  88. ncbi The role of striatal metabotropic glutamate receptors in Parkinson's disease
    K Ossowska
    Department of Neuro Psychopharmacology, Institute of Pharmacology, kraksów, Poland
    Amino Acids 23:193-8. 2002
    ..The obtained results suggest that blockade of group I mGluRs, or stimulation of group II mGluRs may be important to ameliorate parkinsonian symptoms. Striatal mGluRs may contribute to at least some of these effects...
  89. ncbi The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats
    J Konieczny
    Department of Neuropsychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Neuroscience 145:611-20. 2007
    ....
  90. ncbi The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test
    B Szewczyk
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Amino Acids 39:205-17. 2010
    ..The present study further suggests the antidepressant properties of zinc and indicates the involvement of the NMDA and AMPA glutamatergic receptors in this activity...
  91. ncbi MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats
    K Ossowska
    Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St, 31 343 Krakow, Poland
    Neuropharmacology 49:447-55. 2005
    ..However, selective mGluR5 antagonists may be more effective in inhibiting parkinsonian muscle rigidity than parkinsonian akinesia...
  92. ncbi Effects of anxiolytic drugs on some behavioral consequences in olfactory bulbectomized rats
    J M Wieronska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 53:517-25. 2001
    ..We also evaluated behavior of animals in conditioned place aversion procedure. Our results show the decreased level of anxiety in bulbectomized animals comparing with sham-operated rats. Anxiolytic drugs further deepen this effect...
  93. ncbi Developmental changes in the modulation of cyclic amp accumulation by activation of metabotropic glutamate receptors
    A Pałucha
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 53:481-6. 2001
    ..On the basis of our studies, we conclude that the activation of mGluRs resulting in cAMP accumulation depends on the age of an animal...
  94. ncbi GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus
    Joanna M Wieronska
    Department of Neurobiology, Institute of Pharmacology PAS, Krakow, Poland
    Brain Res 1334:12-24. 2010
    ..The results suggest that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA...
  95. ncbi Pretreatment with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline accelerates the electroshock-induced decrease in density of beta-adrenoceptors but not functional downregulation
    A Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Neuropharmacology 29:469-73. 1990
    ....
  96. ncbi Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men
    J A Zoladz
    Department of Physiology and Biochemistry, University School of Physical Education, Krakow, Poland
    J Physiol Pharmacol 59:119-32. 2008
    ..This adaptive response, contrariwise to the recent findings in patients with metabolic disorders, was accompanied by a slight decrease in insulin resistance...
  97. ncbi An in vivo procedure for the selective inactivation of rat brain cerebral cortical alpha-adrenoceptors using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)
    A Pilc
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Brain Res 493:8-13. 1989
    ....
  98. ncbi Antidepressant- and anxiolytic-like activity of magnesium in mice
    Ewa Poleszak
    Department of Pharmacodynamics, Medical University School, Staszica 4, PL 20 081 Lublin, Poland
    Pharmacol Biochem Behav 78:7-12. 2004
    ....
  99. ncbi Enhancement of antidepressant-like activity by joint administration of imipramine and magnesium in the forced swim test: Behavioral and pharmacokinetic studies in mice
    Ewa Poleszak
    Department of Pharmacodynamics, Medical University School, Staszica 8, PL 20 081 Lublin, Poland
    Pharmacol Biochem Behav 81:524-9. 2005
    ....
  100. ncbi Effects of acute and chronic treatment with magnesium in the forced swim test in rats
    Ewa Poleszak
    Department of Pharmacology and Pharmacodynamics, Medical University School, Staszica 4, PL 20 081 Lublin, Poland
    Pharmacol Rep 57:654-8. 2005
    ..The results confirmed that magnesium administered acutely induced the antidepressant-like effects also in rats. However, contrary to mice, chronic treatment with magnesium induced tolerance to this effect in rats...
  101. ncbi NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice
    Ewa Poleszak
    Department of Pharmacology and Pharmacodynamics, Skubiszewski Medical University of Lublin, Staszica 4, PL 20 081 Lublin, Poland
    Pharmacol Biochem Behav 88:158-64. 2007
    ..The present study indicates the involvement of NMDA/glutamate pathway in the antidepressant-like activity of magnesium in mouse FST and further suggests antidepressant properties of magnesium...