T Pawełczyk

Summary

Country: Poland

Publications

  1. ncbi request reprint Isozymes delta of phosphoinositide-specific phospholipase C
    T Pawełczyk
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Acta Biochim Pol 46:91-8. 1999
  2. ncbi request reprint Structural requirements of phospholipase C delta1 for regulation by spermine, sphingosine and sphingomyelin
    T Pawelczyk
    Department of Clinical Biochemistry, Medical University of Gdansk, Poland
    Eur J Biochem 248:459-65. 1997
  3. ncbi request reprint Expression, purification and kinetic properties of human recombinant phospholipase C delta 3
    T Pawełczyk
    Department of Clinical Biochemistry, Medical University of Gdansk, Poland
    Acta Biochim Pol 44:221-9. 1997
  4. ncbi request reprint Recombinant protein kinase C-gamma phorbol binding domain upon microinjection blocked insulin-induced maturation of Xenopus laevis oocytes
    T Pawelczyk
    Department of Clinical Biochemistry, Medical University of Gdansk, Poland
    FEBS Lett 423:31-4. 1998
  5. ncbi request reprint Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium
    T Pawelczyk
    Department of Clinical Biochemistry, Medical University of Gdansk, Poland
    Eur J Biochem 257:169-77. 1998
  6. ncbi request reprint Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes
    T Pawelczyk
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Eur J Biochem 262:291-8. 1999
  7. doi request reprint Acetyl-CoA metabolism in amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells
    D Bizon-Zygmanska
    Department of Laboratory Medicine, Medical University of Gdansk, 80 211 Gdansk, Poland
    Neurochem Int 59:208-16. 2011
  8. ncbi request reprint Altered expression of adenosine receptors in heart of diabetic rat
    M Grden
    Department of Molecular Medicine, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 56:587-97. 2005
  9. ncbi request reprint Expression level of adenosine kinase in rat tissues. Lack of phosphate effect on the enzyme activity
    M Sakowicz
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Acta Biochim Pol 48:745-54. 2001
  10. ncbi request reprint Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs
    A Szutowicz
    Department of Laboratory Medicine, Medical University of Gdansk, Gdansk 80 211, Poland
    Metab Brain Dis 21:149-61. 2006

Collaborators

  • A Szutowicz
  • T Pawelczyk
  • A Matecki
  • D Bizon-Zygmanska
  • M Grden
  • M Sakowicz
  • H Bielarczyk
  • A Ronowska
  • M Marszałł
  • A Jankowska-Kulawy
  • R Kowara
  • M Podgorska
  • E Gryckiewicz
  • A Dettlaff
  • Z Jakubowski
  • J Stepinski
  • R Skowronski
  • S Angielski
  • D Mohuczy

Detail Information

Publications12

  1. ncbi request reprint Isozymes delta of phosphoinositide-specific phospholipase C
    T Pawełczyk
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Acta Biochim Pol 46:91-8. 1999
    ..The intracellular localization of delta isozymes and distribution in various tissues are presented. Attention is given to the pathological conditions in which an abnormal protein level of PLC delta or its activity have been observed...
  2. ncbi request reprint Structural requirements of phospholipase C delta1 for regulation by spermine, sphingosine and sphingomyelin
    T Pawelczyk
    Department of Clinical Biochemistry, Medical University of Gdansk, Poland
    Eur J Biochem 248:459-65. 1997
    ..In contrast, the PH domain and the intact spanning region of the X and Y domains are not essential for inhibition of PLC delta1 by sphingomyelin...
  3. ncbi request reprint Expression, purification and kinetic properties of human recombinant phospholipase C delta 3
    T Pawełczyk
    Department of Clinical Biochemistry, Medical University of Gdansk, Poland
    Acta Biochim Pol 44:221-9. 1997
    ..The data presented indicate that the expression of PLC delta 3 in E. coli cells permits to obtain active enzyme. The catalytic and regulatory properties of PLC delta 3 are similar to those of PLC delta 1...
  4. ncbi request reprint Recombinant protein kinase C-gamma phorbol binding domain upon microinjection blocked insulin-induced maturation of Xenopus laevis oocytes
    T Pawelczyk
    Department of Clinical Biochemistry, Medical University of Gdansk, Poland
    FEBS Lett 423:31-4. 1998
    ..The proteins that interact with Cys-2 domain of PKC are essential for insulin-induced maturation program in oocytes...
  5. ncbi request reprint Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium
    T Pawelczyk
    Department of Clinical Biochemistry, Medical University of Gdansk, Poland
    Eur J Biochem 257:169-77. 1998
    ..The regulatory properties of PLC delta3 described in this report suggest that PLC delta3 has a relatively low activity in cellular conditions that fully activate PLC delta1...
  6. ncbi request reprint Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes
    T Pawelczyk
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Eur J Biochem 262:291-8. 1999
    ..We propose that binding of PLC-delta3 to PA may serve as a mechanism for dynamic membrane association and modulation of PLC-delta3 activity...
  7. doi request reprint Acetyl-CoA metabolism in amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells
    D Bizon-Zygmanska
    Department of Laboratory Medicine, Medical University of Gdansk, 80 211 Gdansk, Poland
    Neurochem Int 59:208-16. 2011
    ..These data indicate that particular sensitivity of DC to TD may result from relative shortage of acetyl-CoA due to its higher utilization in acetylcholine synthesis...
  8. ncbi request reprint Altered expression of adenosine receptors in heart of diabetic rat
    M Grden
    Department of Molecular Medicine, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 56:587-97. 2005
    ..These changes in ARs genes expression, and receptors protein content correspond to some abnormalities characteristic of the diabetic heart, suggesting involvement in pathogenesis of diabetic cardiomyopathy...
  9. ncbi request reprint Expression level of adenosine kinase in rat tissues. Lack of phosphate effect on the enzyme activity
    M Sakowicz
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Acta Biochim Pol 48:745-54. 2001
    ..The data presented indicate that in the rat tissues investigated at least two isoforms of adenosine kinase are expressed, and that the expression of the AK gene appears to have some degree of tissue specificity...
  10. ncbi request reprint Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs
    A Szutowicz
    Department of Laboratory Medicine, Medical University of Gdansk, Gdansk 80 211, Poland
    Metab Brain Dis 21:149-61. 2006
    ....
  11. ncbi request reprint Adenosine receptors in basolateral membranes of rat renal cortex
    Z Jakubowski
    Department of Clinical Biochemistry, Medical Academy, Gdansk, Poland
    Pol J Pharmacol Pharm 44:373-82. 1992
    ..These results demonstrate that both A1 and A2 adenosine receptors are present in basolatertal membranes of rat kidney...
  12. ncbi request reprint The ultraviolet studies on protein-lipid interaction of a protein kinase C-gamma phorbol-binding domain
    R Kowara
    Department of Molecular Medicine, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Poland
    Acta Biochim Pol 46:405-17. 1999
    ..The site of PIP and PIP2 interaction with PKC-gamma is distinct from that of phorbol ester binding site...