Agnieszka Palucha

Summary

Country: Poland

Publications

  1. ncbi The involvement of glutamate in the pathophysiology of depression
    A Palucha
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Drug News Perspect 18:262-8. 2005
  2. ncbi Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology Polish Academy of Sciences, Department of Neurobiology, Smetna 12, 31 343 Krakow, Poland Electronic address
    Neuropharmacology 82:59-68. 2014
  3. ncbi Is the mGlu5 receptor a possible target for new antidepressant drugs?
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology Polish Academy of Sciences, Department of Neurobiology, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1506-11. 2013
  4. doi A selective mGlu7 receptor antagonist MMPIP reversed antidepressant-like effects of AMN082 in rats
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Behav Brain Res 238:109-12. 2013
  5. ncbi Chronic imipramine treatment reduces inhibitory properties of group II mGlu receptors without affecting their density or affinity
    Agnieszka Pałucha
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:525-30. 2007
  6. ncbi Activation of the mGlu7 receptor elicits antidepressant-like effects in mice
    Agnieszka Palucha
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 194:555-62. 2007
  7. doi Group III mGlu receptor agonist, ACPT-I, attenuates morphine-withdrawal symptoms after peripheral administration in mice
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 33:1454-7. 2009
  8. ncbi Are compounds acting at metabotropic glutamate receptors the answer to treating depression?
    Agnieszka Palucha
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12 Street, 31343 Krakow, Poland
    Expert Opin Investig Drugs 15:1545-53. 2006
  9. ncbi Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist
    Agnieszka Pałucha
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Pharmacol Biochem Behav 81:901-6. 2005
  10. pmc On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039
    Agnieszka Pałucha-Poniewiera
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 212:523-35. 2010

Collaborators

Detail Information

Publications17

  1. ncbi The involvement of glutamate in the pathophysiology of depression
    A Palucha
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Drug News Perspect 18:262-8. 2005
    ..In this review, current knowledge and crucial hypotheses concerning the role of glutamate in the pathophysiology of depression are discussed...
  2. ncbi Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology Polish Academy of Sciences, Department of Neurobiology, Smetna 12, 31 343 Krakow, Poland Electronic address
    Neuropharmacology 82:59-68. 2014
    ....
  3. ncbi Is the mGlu5 receptor a possible target for new antidepressant drugs?
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology Polish Academy of Sciences, Department of Neurobiology, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 65:1506-11. 2013
    ..Here, we review data supporting the potential antidepressant activity of mGlu5 receptor antagonists as well as the involvement of mGlu5 receptors in the pathophysiology of depression...
  4. doi A selective mGlu7 receptor antagonist MMPIP reversed antidepressant-like effects of AMN082 in rats
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Behav Brain Res 238:109-12. 2013
    ..p.)-induced decrease in locomotor activity was not affected by MMPIP (10 mg/kg, i.p.), indicating on other, non-mGlu7 receptor-dependent mechanisms involved in changes in locomotor activity of rats after AMN082 administration...
  5. ncbi Chronic imipramine treatment reduces inhibitory properties of group II mGlu receptors without affecting their density or affinity
    Agnieszka Pałucha
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 59:525-30. 2007
    ..However, no changes in the density or affinity of the mGlu2 and mGlu3 receptor ligand for group II mGlu receptors were observed...
  6. ncbi Activation of the mGlu7 receptor elicits antidepressant-like effects in mice
    Agnieszka Palucha
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 194:555-62. 2007
    ..Metabotropic glutamate receptor (mGlu receptor) ligands seem to be promising agents to treat several central nervous system disorders, including psychiatric ones...
  7. doi Group III mGlu receptor agonist, ACPT-I, attenuates morphine-withdrawal symptoms after peripheral administration in mice
    Agnieszka Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 33:1454-7. 2009
    ..These data indicate an important role of group III mGlu receptors in morphine withdrawal states and suggest that activation of group III mGlu receptors may reduce opiate withdrawal symptoms...
  8. ncbi Are compounds acting at metabotropic glutamate receptors the answer to treating depression?
    Agnieszka Palucha
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12 Street, 31343 Krakow, Poland
    Expert Opin Investig Drugs 15:1545-53. 2006
    ....
  9. ncbi Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist
    Agnieszka Pałucha
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Pharmacol Biochem Behav 81:901-6. 2005
    ..These data suggest that MTEP, which is considered to be a potential therapeutic agent, may play a role in the therapy of depression...
  10. pmc On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039
    Agnieszka Pałucha-Poniewiera
    Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 212:523-35. 2010
    ..Although the antidepressant-like activity of MGS0039 and LY341495 is well documented, the mechanism of the antidepressant action of these compounds is still not clear...
  11. ncbi Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats
    Gabriel Nowak
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Brain Res Bull 61:159-64. 2003
    ..These animal data further suggest antidepressant activity of zinc in human depression...
  12. ncbi Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test
    Piotr Branski
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Neural Transm 115:829-30. 2008
    ..This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator...
  13. ncbi Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
    Agnieszka Palucha
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Pharmacol Ther 115:116-47. 2007
    ..However, preclinical data also indicates that ligands of these receptors, both agonists and antagonists, may have an anxiolytic-like and antidepressant-like potential...
  14. ncbi Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats
    J M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Amino Acids 23:213-6. 2002
    ..The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats...
  15. ncbi Antidepressant-like properties of zinc in rodent forced swim test
    B Kroczka
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res Bull 55:297-300. 2001
    ..The results obtained indicate that zinc induces an antidepressant-like effect and enhances the effect of imipramine in the forced swim test, suggesting a potential antidepressant activity of zinc in humans...
  16. ncbi The effect of prolonged imipramine and electroconvulsive shock treatment on calcium/calmodulin-dependent protein kinase II in the hippocampus of rat brain
    A Pilc
    Institute of Pharmacology, Polish Academy of Science, Krakow
    Neuropharmacology 38:597-603. 1999
    ..It is postulated that changes in CaM-KII activity following chronic antidepressant treatment might represent and important step in expression of its antidepressive action...
  17. pmc Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    E Tatarczynska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Br J Pharmacol 132:1423-30. 2001
    ..4. These data suggest that selective mGlu5 receptor antagonists may play a role in the therapy of anxiety and/or depression, further studies are required to identify the sites and the mechanism of action of MPEP...